Drug profile form

1. DRUG NAME Inj. Perinorm / Metoclopramide
PHARMACOLOGICAL
CLASS
Prokinetic agent THERAPEUTIC
CLASS
Anti-emetic agent
INDICATIONS
Used in the treatment of chemotherapy induced nausea and vomiting,
gastroparesis and GERD.
DRUG PREGNANCY
CATEGORY
A B C D X

TERATOGENIC EFFECT No significant effect is reported.
DOSAGE
(AS PER BNF)
ADULT
GERIATRI
C
PREGNANCY
RENAL
IMP.
HEPATIC
IMP.
2mg/kg 2mg/kg 2mg/kg 2mg/kg 2mg/kg
ADMINISTRATION
INFORMATION
To be taken before food and take dose as instructed by the physician.
ADMINISTRATION
PRECAUTION
Do not use this medication in patient with gastrointestinal disorder.
Monitor blood pressure and symptoms like involuntary movements of the
tongue , lips , face and trunk is necessary while consuming this drug.
LETHAl / FATAL DOSE 1000mg/kg
PREFERRED TIME OF
DRUG ADMINISTRATION
AND REASON
Drug should be taken 30mins before food and bedtime or only with food that
usually cause heartburn.
PHARMACOKINETICS
ORAL
BA
PROTEIN
BINDING
METABOLISM T1/2 EXCRETION
32-100% 50% Liver 5-6 hr 85%
PHARMACODYNAMICS /
MOA
It antagonist the activity at D2 receptors in the chemoreceptor zone in the
CNS.
CONTRAINDICATIONS
Allergy
Gastrointestinal disorder
Seizure disorder
Pheochromocytoma

2. MAJOR DRUG
INTERACTIONS
Drug 1 Drug 2 Drug 3 Drug 4 Drug 5
NAME OF THE DRUG(S) Phenytoin Atropine
Chlorpromazin
e
Haloperidol Rivastigmine
EFFECT OF INTERACTIONS Moderate Moderate Severe Moderate Severe
MANAGEMENT
Alter the
frequency
of the drug
Alter the
frequency of
the drug
Stop using the
drug
Decrease
then dose of
the drug
Stop using
the drug
ADVERSE DRUG
REACTIONS (ADRS)
MILD MODERATE SEVERE
Confusion
Anxiety
Depression
Muscle spasm
Parkinson like
symptoms
Abnormal breast milk
production , changes in
menstruation in women.
ADDITIONAL
INFORMATION/
PRECAUTIONS OF ADRs
This drug can cause
dizzy or drowsy.Do not
drive , use machinery
until patient feel safe in
using it. Limit alcohol.
Avoid taking more
drug than it is
prescribed.
Discuss the risk and benefits
with doctor before using it.
PREFERRED DURATION
(MIN-MAX) &
DESCRIPTION
Drug can be administered to three days to ten days.
THERAPY TERMINATION
PROCEDURE
Stop drug whenever patient experience side effects.
ALTERING LABORATORY
PARAMETERS
Electrolytes imbalance , hormonal changes.
OVER DOSE / POISON’S
SYMPTOMS & EFFECT
Extra pyramidal reactions mat occur.
MANAGEMENT OF
OVER DOSE
Administer activated charcoal to the patient immediately.