1. DRUG NAME Efcorlin Inj / Hydrocortisone sodium succinate
PHARMACOLOGICAL CLASS Glucorticoid
THERAPEUTIC
CLASS
Adrenocorticoid
replacement
INDICATIONS Severe allergic reactions , arthritis , blood diseases and skin disease
DRUG PREGNANCY
CATEGORY
A B C D X
TERATOGENIC EFFECT No significant teratogenic effect
DOSAGE
(AS PER BNF)
ADULT
GERIAT
RIC
PREGNANCY
RENAL
IMP.
HEPATIC
IMP.
50 mg 6
times a
day
30-50
mg 6
times a
day
160 mg per day
50 mg 6
times a day
50 mg 6
times a day
ADMINISTRATION
INFORMATION
Drug has to be taken 1- 4 times a day or take single dose every other
day.
ADMINISTRATION
PRECAUTION
Warnings on special populations : pregnancy and breast feeding.
This drug should not be given to this patient unless it is necessary
and use with caution for liver , infections and psychotic disorder.
LETHAl / FATAL DOSE 2000 mg/kg
PREFERRED TIME OF DRUG
ADMINISTRATION AND
REASON
Drug has to be given every 6 hours in a divided dose.
PHARMACOKINETICS
BA
PROTEIN
BINDING
METABOLIS
M
T1/2 EXCRETION
78 % 90 % Liver 6 – 8 hrs NA
PHARMACODYNAMICS /
MOA
Drug has potential anti-inflammatory actions and also suppress the
immune response.
CONTRAINDICATION IN
YES/NO
PEDIAT
RIC
GERIAT
RIC
PREGNANCY
LACTATIO
N
RI HI
No No Not known
Not
known
Yes Yes
2. MAJOR DRUG
INTERACTIONS
Drug 1 Drug 2 Drug 3 Drug 4 Drug 5
NAME OF THE DRUG(S)
Albutero
l
Aspirin Ibuprofen
Paracetam
ol
Benedryl
EFFECT OF INTERACTIONS
Moderat
e
Severe Severe Mild Mild
MANAGEMENT
Avoid
using
this
medicati
on
Stop using
this
medication
Stop using
this
medication
Change
the
frequency
Taper the dose
of the drug
ADVERSE DRUG REACTIONS
(ADRS)
MILD MODERATE SEVERE
Headache
Sore throat
Black / tarry stools
Changes in
vision
Depression
Changes in mood
Delayed wound
healing
Convulsions
Edema
Severe allergic reaction
ADDITIONAL INFORMATION/
PRECAUTIONS OF ADRs
Not to use this
medication when
patient have
infection which is
untreated or
treatment in
progress
Not
recommended in
patients having
low immune
power that
causes decrease
in blood cells
This medication is not
recommended for use if
patient have known allergy
to the drug
PREFERRED DURATION
(MIN-MAX) & DESCRIPTION
From weeks to maximum 2 months of patient recovery
THERAPY TERMINATION
PROCEDURE
Do not suddenly stop using it without physician knowledge
ALTERING LABORATORY
PARAMETERS
Fluid and electrolytes imbalances : sodium , potassium , fluid
retention and high blood pressure.
OVER DOSE / POISON’S
SYMPTOMS & EFFECT
A single large dose of hydrocortisone is not expected to produce life
threatening symptoms. However high doses taken can cause weight
gain, roundness of face increased facial hair growth and muscle pain.
3. MANAGEMENT OF
OVER DOSE
Take this medication exactly as it was prescribed. Do not take the
medication in larger amount or take it longer than recommended by
the physician.