Doctrine 2 is an enterprise persistence layer for PHP 5.3, offering improvements over its predecessors with enhanced performance and the ability for developers to specify mapping information more flexibly. It introduces a clean domain model approach by allowing developers to define their entities using various techniques like annotations, YAML, or XML, without the need for a base class. The framework also features a powerful database abstraction layer (DBAL) and a Doctrine Query Language (DQL) that is designed for ease of use and expansion.