This paper analyzes factors that affect drunk-driving crashes in the U.S. from 1994 to 2010 through a literature review and regression analysis. The model constructed shows macroeconomic conditions like unemployment rate and per capita income, along with microeconomic variables including gasoline prices and alcohol taxes, significantly impact drunk-driving crashes. Previous studies mostly focused on the effects of public policies, while this paper integrates both macro/micro economic variables and policies to examine their combined impacts. Regression analysis is used to quantify the relationships between drunk-driving crashes and selected economic factors.