Di Lauro

BEVACIZUMAB (AVASTIN) IN OFTALMOLOGIA Div. di Oculistica Osp. C.T.O. – Napoli Dir. dott. R. di Lauro R. di Lauro, P. De Ruggiero, M.T. di Lauro, Ra. di Lauro GIVRE – Bari 2007

BEVACIZUMAB (AVASTIN) ,[object Object]

AVASTIN ,[object Object],Bakri S.J., Retina 2006 Beer P.M., Retina 2006

AVASTIN ,[object Object],Beer P.M., Wong S.I., Retina 2006 Shahor J.S., Avery R.L., Retina 2006

AVASTIN ,[object Object],[object Object],[object Object]

BEVACIZUMAB IN OFTALMOLOGIA ,[object Object],[object Object],[object Object],[object Object],Michels S. e Coll., Ophthalmology, 2005

BEVACIZUMAB (AVASTIN) ,[object Object],[object Object]

AVASTIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Avastin nella DMLE essudativa ,[object Object],[object Object],[object Object],[object Object]

Avastin nella DMLE essudativa ,[object Object]

Avastin nella DMLE essudativa ,[object Object],266 Pz. – follow up 3 mesi A.V. ↑ 38,3 % Media da 20/184 a 20/109 (p < 0,001) OCT ↓ Media 340 micron a 213 micron (p < 0,001)

Avastin nella DMLE essudativa ,[object Object],[object Object]

Avastin nella DMLE essudativa ,[object Object],[object Object],A.V. ↑ 47,6% A.V. = 42,4% A.V. ↓ 10% OCT Da 389 μ m a 231 μ m (p < 0,001)

Avastin nella DMLE essudativa ,[object Object],A.V. ↑ 39% = 53% ↓ 8% OCT ↓ 99% (da 335 μ m a 232 μ m) Rich, 2006 – Pieramici, 2006 – Yoganathan, 2006 - Avery, 2006 – Dhalla, 2006 – Bashshur, 2006 - Spaide, 2007 – Muldoon, 2007 – Bauker, 2007 – Khan, 2007 – Fromow-Guerra, 2007 – Castellarin, 2007 – Williams, 2007 – Thomas, 2007 – Goff, 2007 – Emerson, 2007 - New York Eye & Ear Infirmary, 2007 – Chen, 2007 – Meyerle, 2007 – Morales, 2007 – Lyon, 2007 – Argawal, 2007 – Melamud, 2007 – Ladewig, 2007 – Ladas, 2007 – Cleari, 2007 – Bolz, 2007 – Mackiewicz, 2007 – Costagliola, 2007 – Lazic, 2007 – Augustin, 2007 – Zolf, 2007 – Giraud, 2007 – Rauber, 2007 – Nochez, 2007 – Razavi, 2007.

Avastin nella DMLE essudativa Pretrattamento Dopo 1 mese Dopo 3 mesi EFFICACIA

CNV IN MIOPE ,[object Object],[object Object],Nguyen, Br. J. Ophthalmol., 2005 - Tewari, Retina 2006 – Laud, Retina 2006 - Mandel, Em. J. Ophthalmol., 2007 - Yamamoto, Br. J. Ophthalmol., 2007 - Mones, 2007 - Sakaguchi, Br. J. Ophthalmol., 2007 – Hernandez-Rojas, Retina 2007 – Reichel Br. J . Ophthalmol. 2007 – Conrath J. Fr. Ophtalmol. 2007.

AVASTIN IN CRVO E BRVO ,[object Object],[object Object],[object Object],Rosenfeld, 2005 – Iturralde, 2006 – Jaissle, 2006 – Roca, 2007 – Dudani, 2007 – Costa, 2007 – Robena, 2007 – Kalogeropoulos, 2007 – Guerrero-Naranjo, 2007 – Nielsen, 2007 – Pai, 2007 – Schaal, 2007 – Byeon, 2007.

AVASTIN NELLA RETINOPATIA DIABETICA PROLIFERANTE ,[object Object]

AVASTIN NELLA RETINOPATIA DIABETICA PROLIFERANTE Chen E., Retina 2006 – Jorge R., Retina 2006 – di Lauro R. GIVRE Venezia 2006 – Fromow-Guerra J., PACORES Group 2007 – Messaoud R., J. Fr. Ophtalmol. 2007 – Arevalo J.F., Ophthalmology 2007.

AVASTIN NELLA CHIRURGIA DELLA RETINOPATIA DIABETICA PROLIFERANTE di Lauro e Coll, J. Fr. Ophtalmol., 2007 – Retina, in press c.s.s. = +121 c.s.s. =+129 c.s.s. =+125 c.s.s.: complexity surgery score 3 12 4 5 2 7 9 6 4 9 7 4 Amount of previous retinal photocoagulation Complete PRP 0 Incomplete PRP +1 Focal +2 None +3 2 19 3 0 1 17 5 1 3 18 2 1 Configuration of retinal detachment None 0 “ Hammock” +1 Central diffuse +2 Table-top +3 0 2 7 15 0 3 10 11 0 1 5 18 Vitreous haemorrhage c.s.s. None 0 Mild +1 Moderate +2 Severe +3 Group III 24 patients (bevacizumab 20 days before surgery) Group II 24 patients (bevacizumab 7 days before surgery) Group I (control) 24 patients

AVASTIN NELLA CHIRURGIA DELLA RETINOPATIA DIABETICA PROLIFERANTE di Lauro e Coll, J. Fr. Ophtalmol., 2007 – Retina, in press Results 69 minutes 65 minutes 84 minutes Surgical mean time p < 0,001 p < 0,001 3 (12,5%) 2 (8,3%) 19 (79,1%) Silicone-oil tamponade p = 1.000 p = 1.000 0 0 1 (4,1%) Relaxing retinotomy p = 0,348 p = 0,109 1 (4,1%) 0 4 (16,6%) Iatrogenic breaks p < 0,001 p < 0,001 2 (8,3%) 2 (8,3%) 13 (54,1%) Endodiathermy p < 0,001 p < 0,001 3 (12,5%) 2 (8,3%) 19 (79,1%) Intraoperative bleeding Contr. vs Gr III Contr. vs Gr II Group III (bevacizumab 20 days before surgery) Group II (bevacizumab 7 days before surgery) Group I (control)

AVASTIN NELL’ EDEMA MACULARE DIABETICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Haritoglou, Retina 2006 – Jorge, Retina 2006 – Byeon, J. Ocul. Pharmacol. Ther., 2007 – Lattanzio, Eur. J. Ophthalmol. 2007 – Alessi J. Fr. Ophtalmol.

AVASTIN E GLAUCOMA NEOVASCOLARE Avery R. L., Retina 2006 – Mason J.O., Retina 2006 – Davidorf F.M., Retina 2006 – Agarwal, 2007 – Alessi G., J. Fr. Ophtalmol., 2007.

AVASTIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mason, Retina 2006 - Travassos, Ophthalmic Surg. Lasers & Imaging 2007 – Bhatnagar, Retina 2007 – Maia Jr., Am. J. Ophthalmol. 2007 – Issa, Ophthalmology 2007 – Ahmadieh, Graefes Arch. Clin., 2007 – Finger, Arch. Ophthalmol. 2007 – Solano, Can. J. Ophthalmol. 2007 – Cordero Coma, Ophthalmology 2007 – Amselem, Am. J. Ophthalmol. 2007 – Metge J. Fr. Ophtalmol. 2207 – Alessi J. Fr. Ophtalmol. 2007.

AVASTIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fung A.E., The International Intravitreal Bevacizumab safety survey, Br. J. Ophthalmol. 2006

AVASTIN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fung A.E., The International Intravitreal Bevacizumab safety survey, Br. J. Ophthalmol. 2006

AVASTIN ,[object Object],Spandau U.H., Am. J. Ophthalmol. 2006 – Shah C.P., Am. J. Ophthalmol., 2006 – Nicolò M., Eur. J. Ophthalmol. 2006 – Weinberger A.W., Am. J. Ophthalmol. 2007 – Ronan S.M., Retina 2007 – Chan C.K., Retina 2007.

GRAZIE DELL’ ATTENZIONE R. di Lauro, P. De Ruggiero, M.T. di Lauro, Ra. di Lauro

Di Lauro

Recommended

Recommended

More Related Content

Similar to Di Lauro

Similar to Di Lauro (20)

Di Lauro