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ISMRM 2009, Honolulu

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ABSTRACT Phase II trial of bevacizumab for recurrent Calculation of the impulse response function, h(t): two methods grade III-IV glioblastoma Analytical solution Numerical deconvolution (model based) (model independent) h(t) calculated directly from h(t) expressed as function Postcontrast static T1 weighted blood (Ca) & tissue (C t) curves of model parameters DCE-MRI image. Tumor via matrix computation region (ROI) outlined in red. 1 2 4 3 Automation of numerical deconvolution analysis Numerical deconvolution results Noncompartmental analysis of h(t) Sensitivity of noncompartmental analysis to truncation and lag-time correction of Ca and Ct All h(t)’s shown h(t) >0 for all t A screenshot

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ISMRM 2009, Honolulu

  • 1. ABSTRACT Phase II trial of bevacizumab for recurrent Calculation of the impulse response function, h(t): two methods grade III-IV glioblastoma Analytical solution Numerical deconvolution (model based) (model independent) h(t) calculated directly from h(t) expressed as function Postcontrast static T1 weighted blood (Ca) & tissue (C t) curves of model parameters DCE-MRI image. Tumor via matrix computation region (ROI) outlined in red. 1 2 4 3 Automation of numerical deconvolution analysis Numerical deconvolution results Noncompartmental analysis of h(t) Sensitivity of noncompartmental analysis to truncation and lag-time correction of Ca and Ct All h(t)’s shown h(t) >0 for all t A screenshot