2. Etiology
• • above the GE junction
• ■ epistaxis
• ■ esophageal varices (10-30%)
• ■ esophagitis
• ■ esophageal cancer
• ■ Mallory-Weiss tear (10%)
• • stomach
• ■ gastric ulcer (20%) (see Peptic Ulcer Disease, G11)
• ■ erosive gastritis (e.g. from EtOH or post-surgery) (20%)
• ■ gastric cancer
• ■ gastric antral vascular ectasia (rare, associated with cirrhosis and CTD)
• ■ Dieulafoy’s lesion (very rare)
• • duodenum
• ■ ulcer in bulb (25%)
• ■ aortoenteric fistula: usually only if previous aortic graft (see sidebar)
• • coagulopathy (drugs, renal disease, liver disease)
• • vascular malformation (Dieulafoy’s lesion, AVM)
If there is a history of
abdominal aortic aneurysm
repair in the past 6 months
to 1 year, consider
aortoenteric fistula.
3. Clinical Features
• in order of decreasing severity of the bleed: hematochezia (brisk upper GI bleed) >
hematemesis > coffee ground emesis > melena > occult blood in stool
Clinical Presentation. Typically, upper GI bleed presents with black stool or melena, while
lower GI bleed presents with red blood in the stool.
In upper GI bleed,
• occult blood–positive brown stool can occur with
as little as 5–10 mL of blood loss.
• Melena develops when at least 100 mL of blood
has been lost.
Diagnosis. Endoscopy is the most accurate test to determine the etiology of both upper and
lower GI bleed. Barium study is always less accurate. Should biopsy be needed, an endoscopy
must be performed.
4. Treatment
• stabilize patient (1-2 large bore IVs, IV fluids, monitor)
• send blood for CBC, cross and type, platelets, PT, PTT, electrolytes, BUN, Cr, LFTs
• keep NPO
• consider NG tube to determine upper vs. lower GI bleeding in some cases
• IV PPI: decrease risk of rebleed if endoscopic predictors of rebleeding seen (see prognosis section)
■ given to stabilize clot, not to accelerate ulcer healing
■ if given before endoscopy, decreases need for endoscopic therapeutic intervention
• for variceal bleeds, octreotide 50 μg loading dose followed by constant infusion of 50 μg/h
• consider IV erythromycin (or metoclopramide) to accelerate gastric emptying prior to gastroscopy to
remove clots from stomach
• endoscopy (OGD): establish bleeding site + treat lesion
■ if bleeding peptic ulcer: most commonly used method of controlling bleeding is injection of
epinephrine around bleeding point + thermal hemostasis (bipolar electrocoagulation or heater
probe); less often thermal hemostasis may be used alone, but injection alone not recommended
■ endoclips
■ hemospray
5. Prognosis
• 80% stop spontaneously
• peptic ulcer bleeding:
• low mortality (2%) unless rebleeding occurs (25%
of patients, 10% mortality)
• endoscopic predictors of rebleeding (Forrest
classification): spurt or ooze, visible vessel, fibrin clot
• can send home if clinically stable, bleed is minor, no
comorbidities, endoscopy shows clean ulcer with
no high risk predictors of rebleeding
• H2-antagonists should not be used since they impact
minimally on rebleeding rates and need for surgery
• esophageal varices have a high rebleeding rate (55%)
and mortality (29%)