Question 14: 14A) What are homologous chromosome and when do they depart? 14B) What is crossing over and when does it take place? Solution 14A) Homologous= same loci. these chromosomes have the same set of genes at the same loci and they depart during anaphase, being pulled apart by centromeres. 14B) when homologous chromosomes pair up during meiosis, the sister chromatids gets exchanged at their respective loci to provide a new mix of the trait. this exchange of genes or segments of chromatids among homologous chromosomes is known as crossing over and it takes place during metaphase of meiosis I..