This chapter discusses how information systems and strategy are related. It covers Porter's five competitive forces model and how IS can impact each force. The value chain and how IS can optimize primary and support activities are explained. Business strategy options like low cost leadership and differentiation are presented. The role of IS in supporting various strategies is described. The chapter also addresses how nonprofits and governments can use IS to achieve their missions and provide services. It emphasizes that human factors are critical for realizing strategic advantages from IS.