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Allopurinol in angina

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Subbu Raj
Subbu Raj
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D . SUBBURAJ PROF. G.ELANGOVAN UNIT ,[object Object],[object Object],[object Object],[object Object],Copyright © 2010 Elsevier Ltd
OLD GOUT DRUG – NEW TRICKS ON ANGINA ,[object Object],[object Object],[object Object],[object Object],[object Object]
Why Allopurinol ,[object Object],[object Object],[object Object]
Why Allopurinol ,[object Object],[object Object]
Study Design ,[object Object],[object Object],[object Object],[object Object]
Inclusion Criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Exclusion criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Figure 1 Source: The 6(10)60391-1)
Baseline Characters
Figure 4 Source: The Lancet 2010; 375:2161-2167 (DOI:10.1016/S0140-6736(10)60391-1) Terms and Conditions RESULTS: Time To Chest Pain BASE LINE PLACEBO ALLOPURINOL P VALUE TIME TO CHEST PAIN 234 (189-382) 272 (200-421) 304 (272-421) 0.001
Figure 3 total exercise time from baseline BASE LINE ALLOPURINOL PLACEBO P VALUE TOTAL EXERCISE TIME 301 (251-441) 393 (290-519) 307(222-420) 0.003
Time To ST Depression From Baseline BASELINE PLACEBO ALLOPURINOL P VALUE TIME TO ST DEPRESSION 232 (182-380) 249(200-375) 298 (211-408) 0.002
 
ANGINA EPISODES PER WK
BNP & CRP ,[object Object],[object Object]
CONCLUSIONS ,[object Object],[object Object]
Interpretation ,[object Object]
What is the mechanism of the anti-ischaemic effect of allopurinol? ,[object Object],[object Object],[object Object],[object Object],[object Object]
ADVANTAGES OVER OTHER ANTI ANGINAL DRUS ,[object Object],[object Object],[object Object],[object Object]
Anti ischemic effects similar to other anti anginal drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Allopurinol could be another second agent option for angina symptoms ,[object Object],[object Object]
OTHER SIMILLAR STUDIES
1.Mechanistic Insights Into the Therapeutic Use of High-Dose Allopurinol in Angina Pectoris Narasimharajapura S. Rajendra, MD*,Sheila Ireland, RGN, RM, Jacob George, MD,Jill J.F. Belch, MD, Chim C. Lang, MD andAllan D. Struthers, MD ,[object Object]
2.The Effect of Allopurinol on B-Type Natriuretic Peptide Levels in Patients with Chronic Stable Angina Awsan Noman; Maheshwar Pauriah; Allan D Struthers Ninewells Hosp, Dundee, United Kingdom ,[object Object]
3.Allopurinol regresses left ventricular hypertrophy in chronic kidney disease JULY 7, 2010 |  Daniel M Keller ,[object Object]
OPT CHF TRIAL: Allopurinol - exercise capacity in CHF NOT EFFECTIVE ?? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Thank U ,[object Object],[object Object],[object Object]

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Allopurinol in angina

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  • 8. Figure 1 Source: The 6(10)60391-1)
  • 10. Figure 4 Source: The Lancet 2010; 375:2161-2167 (DOI:10.1016/S0140-6736(10)60391-1) Terms and Conditions RESULTS: Time To Chest Pain BASE LINE PLACEBO ALLOPURINOL P VALUE TIME TO CHEST PAIN 234 (189-382) 272 (200-421) 304 (272-421) 0.001
  • 11. Figure 3 total exercise time from baseline BASE LINE ALLOPURINOL PLACEBO P VALUE TOTAL EXERCISE TIME 301 (251-441) 393 (290-519) 307(222-420) 0.003
  • 12. Time To ST Depression From Baseline BASELINE PLACEBO ALLOPURINOL P VALUE TIME TO ST DEPRESSION 232 (182-380) 249(200-375) 298 (211-408) 0.002
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  • 14. ANGINA EPISODES PER WK
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  • 22. OTHER SIMILLAR STUDIES
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Editor's Notes

  1. Trial profile
  2. Change in time to chest pain symptoms from baseline Data are median (IQR).
  3. Change in time to ST depression from baseline Data are median (IQR).