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07.12.2014 
1 
Hangi Protokolle IUI yapalım ? 
Dr. Tevfik Yoldemir 
Marmara Üniversitesi 
Kadın Hastalıkları ve Dogum A.D. 
Üreme Endokrinolojisi ve Infertilite B.D. 
tevfik@yoldemir.com 
KS – IUI 
OF 
EF 
PKOS 
KS 
Hangi protokol? 
Tmx + FSH altern. 
40 mg D3-9 100 mg D3-7 
Hangi protokol? 
Hangi protokol? Aİ 
Aİ – KS vs LTZ KS 
LTZ 
Canlı doğum -KS vs Met vs Kombine 
PKOS 
KS 
KS+M 
Hangi protokol? 
Hangi protokol? PKOS 
PKOS- KS vs AI 
7.5 mg 150 mg
07.12.2014 
2 
Optimal Folikül çapı – 
KS (n=777) LTZ (n=211) 
KS = LTZ 
OF 
EF 
TF 
PKOS 
KS 
LTZ 
Hangi protokol? Erkek subfertilitesi/ Açıklanamayan 
KS vs rFSH (+ IUI) 
EF 
Aİ 
KS 
rFSH 
Hangi protokol? 
Açıklanamayan 
Erkek subfertilitesi 
Aİ 
EF 
Hangi protokol? 
FSH / HMG - IUI 
OF 
EF 
MF 
FSH 
rFSH 
HMG 
Hangi protokol? 
FSH / HMG - IUI 
OF 
EF 
MF 
FSH 
rFSH 
HMG 
Hangi protokol? 
Rek vs hp FSH - IUI 
hpFSH 
rFSH 
EF 
EF 
OF 
EF 
TF 
Aİ 
Hangi protokol?
07.12.2014 
3 
Siklus başına gebelik oranı hpFSH 
rFSH 
Hangi protokol? 
Kadın başına gebelik oranı hpFSH 
rFSH 
Hangi protokol? 
Hangi protokol? Aİ 
Hangi protokol? Açıklanamayan 
İlk siklusta gebelik oranı hpFSH 
rFSH 
rFSH vs uFSH vs HMG (+ IUI ) 
Erkek subfertilitesi/ Açıklanamayan 
HP-HMG vs rFSH (+IUI) 
EF 
Aİ 
Hangi protokol? 
Hangi protokol? PKOS 
Anovulatuar DSÖ II – FSH eşik değeri 
75 IU 112.5 IU 150 IU 187.5 IU
07.12.2014 
4 
Hangi protokol? PKOS 
IUI için FSH doz nomogramı – düzenli 
siklusu olan 
N=159 
Hangi protokol? PKOS 
DSÖ II Anovulatuar (HP-FSH vs rFSH) 
Hangi protokol? PKOS 
Hangi protokol? PKOS 
Günlük vs günaşırı Gnd 
OF 
Aİ 
rFSH 
FSH vs FSH+Anta 
Hangi protokol? EF 
LH surge 
Aİ IUI- Cetrorelix 
100 mg 75 IU DD 
OF 
EF 
Aİ 
rFSH 
Hangi protokol?
07.12.2014 
5 
Erkek subfertilitesi/ Açıklanamayan 
rFSH vs rFSH+ Anta (+IUI) 
rFSH 
EF 
Aİ 
Hangi protokol? 
GnRH-anta 
Aİ 
EF 
rFSH 
Hangi protokol? 
Erkek subfertilitesi/ Açıklanamayan 
Gnd vs Gnd + Anta (+IUI) 
EF 
Aİ 
Hangi protokol? 
Hangi protokol? Aİ 
Açıklanamayan infertilite 
5 mg letrozol D3-7 
150IU rFSH D4,6,8 
5 mg letrozol D3-7 
150IU rFSH D4,6,8 
cetrorelix 
Hangi protokol? 
Gebelik- rFSH vs rFSH + AI 
GnRHa - implantasyon günü 
EF 
rFSH 
Hangi protokol?
07.12.2014 
6 
GnRHa implantasyon günü 
EF 
rFSH 
Hangi protokol? 
GnRH-anta ile zamanlama 
NNT klinik gebelik 19 
Hangi protokol? 
Hangi protokol? Hcg vs LH monitor- 
Hcg vs LH monitor- 
Gebelik olasılığı 
OF 
EF 
Aİ 
KS 
Gebelik olasılığı 
EF 
OF 
Hangi protokol? 
Hcg vs LH monitor- 
Gebelik olasılığı 
Aİ 
Hangi protokol? 
Hangi protokol? 
Abstinans – Gebelik oranı
07.12.2014 
7 
Tek / çift aşılama 
Aİ 
KS 
Hangi protokol? 
Prog eklenmesi –Klinik gebelik 
Aİ 
KS 
FSH 
KS+HMG 
LTZ+HMG 
Hangi protokol? 
Prog eklenmesi – Canlı doğum 
Aİ 
KS 
FSH 
KS+HMG 
LTZ+HMG 
Hangi protokol? 
Gnd / KS siklusları 
Aİ 
KS 
FSH 
KS+HMG 
LTZ+HMG 
Hangi protokol? 
Gnd+ KS siklusları 
Aİ 
KS 
FSH 
KS+HMG 
LTZ+HMG 
Hangi protokol?

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Which protocol should be used for intrauterine insemination?

  • 1. 07.12.2014 1 Hangi Protokolle IUI yapalım ? Dr. Tevfik Yoldemir Marmara Üniversitesi Kadın Hastalıkları ve Dogum A.D. Üreme Endokrinolojisi ve Infertilite B.D. tevfik@yoldemir.com KS – IUI OF EF PKOS KS Hangi protokol? Tmx + FSH altern. 40 mg D3-9 100 mg D3-7 Hangi protokol? Hangi protokol? Aİ Aİ – KS vs LTZ KS LTZ Canlı doğum -KS vs Met vs Kombine PKOS KS KS+M Hangi protokol? Hangi protokol? PKOS PKOS- KS vs AI 7.5 mg 150 mg
  • 2. 07.12.2014 2 Optimal Folikül çapı – KS (n=777) LTZ (n=211) KS = LTZ OF EF TF PKOS KS LTZ Hangi protokol? Erkek subfertilitesi/ Açıklanamayan KS vs rFSH (+ IUI) EF Aİ KS rFSH Hangi protokol? Açıklanamayan Erkek subfertilitesi Aİ EF Hangi protokol? FSH / HMG - IUI OF EF MF FSH rFSH HMG Hangi protokol? FSH / HMG - IUI OF EF MF FSH rFSH HMG Hangi protokol? Rek vs hp FSH - IUI hpFSH rFSH EF EF OF EF TF Aİ Hangi protokol?
  • 3. 07.12.2014 3 Siklus başına gebelik oranı hpFSH rFSH Hangi protokol? Kadın başına gebelik oranı hpFSH rFSH Hangi protokol? Hangi protokol? Aİ Hangi protokol? Açıklanamayan İlk siklusta gebelik oranı hpFSH rFSH rFSH vs uFSH vs HMG (+ IUI ) Erkek subfertilitesi/ Açıklanamayan HP-HMG vs rFSH (+IUI) EF Aİ Hangi protokol? Hangi protokol? PKOS Anovulatuar DSÖ II – FSH eşik değeri 75 IU 112.5 IU 150 IU 187.5 IU
  • 4. 07.12.2014 4 Hangi protokol? PKOS IUI için FSH doz nomogramı – düzenli siklusu olan N=159 Hangi protokol? PKOS DSÖ II Anovulatuar (HP-FSH vs rFSH) Hangi protokol? PKOS Hangi protokol? PKOS Günlük vs günaşırı Gnd OF Aİ rFSH FSH vs FSH+Anta Hangi protokol? EF LH surge Aİ IUI- Cetrorelix 100 mg 75 IU DD OF EF Aİ rFSH Hangi protokol?
  • 5. 07.12.2014 5 Erkek subfertilitesi/ Açıklanamayan rFSH vs rFSH+ Anta (+IUI) rFSH EF Aİ Hangi protokol? GnRH-anta Aİ EF rFSH Hangi protokol? Erkek subfertilitesi/ Açıklanamayan Gnd vs Gnd + Anta (+IUI) EF Aİ Hangi protokol? Hangi protokol? Aİ Açıklanamayan infertilite 5 mg letrozol D3-7 150IU rFSH D4,6,8 5 mg letrozol D3-7 150IU rFSH D4,6,8 cetrorelix Hangi protokol? Gebelik- rFSH vs rFSH + AI GnRHa - implantasyon günü EF rFSH Hangi protokol?
  • 6. 07.12.2014 6 GnRHa implantasyon günü EF rFSH Hangi protokol? GnRH-anta ile zamanlama NNT klinik gebelik 19 Hangi protokol? Hangi protokol? Hcg vs LH monitor- Hcg vs LH monitor- Gebelik olasılığı OF EF Aİ KS Gebelik olasılığı EF OF Hangi protokol? Hcg vs LH monitor- Gebelik olasılığı Aİ Hangi protokol? Hangi protokol? Abstinans – Gebelik oranı
  • 7. 07.12.2014 7 Tek / çift aşılama Aİ KS Hangi protokol? Prog eklenmesi –Klinik gebelik Aİ KS FSH KS+HMG LTZ+HMG Hangi protokol? Prog eklenmesi – Canlı doğum Aİ KS FSH KS+HMG LTZ+HMG Hangi protokol? Gnd / KS siklusları Aİ KS FSH KS+HMG LTZ+HMG Hangi protokol? Gnd+ KS siklusları Aİ KS FSH KS+HMG LTZ+HMG Hangi protokol?