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A study on the Granthigna effect of Chincha
Beeja Yoga (Tamarindus indica l.) Paint W.S.R to
Tundikeri (Tonsillitis).
Dr M. PARAMKUSHA RAO
M.D.(Ayu),Ph.D.
P.G.Professor& H.O.D.
Department of Dravyaguna
S.V.Ayurvedic college,
Tirupati,
Andhrapradesh
By-
Dr K.RAGHU RAMUDU,
Final year P.G Scholar
Department of Dravyaguna
S.V.Ayurvedic college,Tirupati,
Andhrapradesh
 Tundikeri is commonly encountered now a days
due to the dietary habits of taking spicy food, cold
beverages, refrigerated milk products and cold
climate.
 Lower socio-economic group people are
particularly prone as the immunity status is low in
them. These factors coupled together results in
recurrent episodes of disease.
Tundikeri not only cripples children from majority
of their enjoyable and learning movement but also
makes adults to feel uneasy, restless.
INTRODUCTION
Antibiotics are the main stay in
treatment of tonsillitis as far as the
conventional medicine is concerned. They
can give temporary relief to the patient but
cannot check the frequent reoccurrence of the
disease.
Their surgical removal put a straight
forward attack on respiratory, gastrointestinal
tract and immunity. Further surgical
procedure has its own complications also.
INTRODUCTION
Late Sri Balaraj Maharshi the
Former advisor on Ayurveda
to the government of Andhra
Pradesh, India & Brazil
founder of this college has
suggested Chincha beeja
Lepa in Tonsillitis.
My guide Dr M. Param
kusha Rao close associated
of Balaraj maharshi was
observing its promising
effect.
Therefore Chincha beeja is
taken to study its
Grandhighna effect in
Tundikeri.
Why CHINCHA BEEJA is taken?
Dr. Balraj Maharishi (1917-1998)
AIMS & OBJECTIVES
•To study the efficacy of chincha beeja lepa in
tonsillitis
•To develop a safe single drug for management of
tonsillitis
•To find out economical therapy for tonsillitis with
minimum or with out side effects
Kingdom Plantae
Phylum Spermatophyte
Class Angiosperm
Sub class Dicotyledone
Family Leguminosae
Subfamily Caesalpiniaceae
Genus Tamarindus
Species Indica
Taxonomical classification of chincha
DRUG REVIEW
Rasa Kasaya
Reference
Vasthuguna
Dipika
Guna Not mentioned
Vipaka Not mentioned
Virya Not mentioned
Doshaghnata Kapha hara
Karma Sukra sthambaka
Rakta sthambaka
Upayukta Vyadhi Krimi roga,
Grahani,
Sukra nasta,
Raktatisara,
Rakta pradaram
Properties of chincha bheeja
PHARMACO THERAPEUTIC
APPLICATIONS
(DRAVYAGUNA KRIYAYOGA)
1.Gudha Bramsha: Fried amlika seeds are rubbed with water and
pasted on anus after setting the tract in position. By this it dose not
prolapse again. (S.B.4.919)
2.Somaroga: The seeds of amlika are soaked with water the
previous day and then pounded with milk. This past, if taken
regularly, alleviates somaroga. (VD.2.13 )
3.Rakta arshas: burn the seeds of chincha and make bhasma give in
1-2 masha curd. (G.P.113)
4.Amaatisara:
Remove the outer covering of ripened chincha seed, white jeeraka
and mishri each 6 masha. Make a churna of all make a dose in 3
parts and give at every 3 hour interval with honey. This will cure old
disease also. G.P.109 (a)
5.Sweta pradara ( in other pradara also): Soak seeds in water
and next day remove seed coat and make a paste of 4 seeds
administered with mishri will cure sweeta pradara. (G.P.110)
6.Jwara: If daha and palpitations is there seeds of chincha and
kharjura 2-2 tola are boiled in sera milk on low flame, sieve it and
given to patient. No other food or medication should be given on
that day. (G.P.111 )
7.Kanta sotha: 6 masha of chincha in 2 sera of jala is boiled till
the jala remains half then 2 tola of rose water is added and sieved.
Gargling with this will cure kanta sotha. (G.P.112 )
8.Athisara: Seed coat of Amlika seeds, Sunthi, Rock salt and
Yavani are mixed together and taken with fresh buttermilk it
checks Athisara quickly. (VD.6.5)
PHARMACO THERAPEUTIC APPLICATIONS
(DRAVYAGUNA KRIYAYOGA)
Mineral
mg/100g
Tamarind
Seed
Calcium 9.3-786.0
Phosphorus 68.4-165.0
Magnesium 17.5-118.3
Potassium 272.8-610.0
Sodium 19.2-28.8
Copper 1.6-19.0
Iron 6.5
Zinc 2.8
Manganese 0.9
Mineral content of tamarind seed
Source: Marangoni et al. (1988); Ishola et al. (1990); Bhattacharya et al. (1994); Parvez et al.
(2003).
Amino acid content of tamarind seed
There are 20 amino acids present in the human body.
9 Essential Amino acids and 11 Non-Essential Amino acids
Chincha bheeja contain 8 Essential amino acids and 9 Non-
Essential amino acids.
Amino
Acid
Tamarind
mg/g N (Total
N)
Isoleucine 313
Leucine 531
Lycine 475
Methionine 113
Cystine 106
Phenylalani
n 318
Tyrosine 287
Threonine 200
Valine 306
Arginine 450
Histidine 143
Alanine 312
Aspartic 768
Glutamic 1056
Glycine 331
Proline 287
Serine 350
Source: FAO (1970); de Lumen et
al. (1986, 1990).
Reported Pharmacological Activity of
Tamarindus indica seed
Antidiabetic activity
Antioxidant activity
Anti Inflammatory activity
Antimicrobial activity
Antipyretic activity
Anticancer activity
Antitumor and Immunopotentiating Activity
Antiemetic activity
Hepato protective activity
Analgesic activity
Anti Diarrheal activity
Laxative activity
Anti venom activity
Anti ulcer activity
Anti obesity activity
Hypolipidemic activity
Granthi
Any localised swelling looking like a knot caused by vitiated
Tridoshas, Rakta, Mamsa and medas with the Predominance of
Kapha and Vata.
Vagbhata also opinion that Kapha Pradhana doshas along with
Rakta, Mamsa and Medas cause a swelling which is vritta, unnata
and gradhita(Round, elevated and compact).
REVIEW OF GRANTHIGHNA KARMA
ON TUNDIKERI
Tundikeri
शॊफः स्थुलस्तोददाह प्रपाकि ।
प्रागुिताभ्ाां तुण्डििे रि मता तु ॥ (Su.Ni.16/44)
Tundikeri is that disease caused by the vitiation of Kapha and
Rakta. There is Sthula Shotha (oedema), Toda (pricking type of pain),
Daha (burning sensation), Prapaki (Suppuration).
According to Acharya Vagbhatta, Tundikeri is having the shape
of Karpasiphala and is Hanusandhi Asrita Kanta (root of the
temperomandibular joint) It is Picchila (Slimy), Manda Ruk (Mild
pain) and a firm swelling.
The definition given by Acharya Sushruta resembles the acute
stage of tonsillitis.
where as the definition by Acharya Vagbhatta is featuring
probably the chronic stage of tonsillitis.
 Involvement of Mamsa dhatu could be at the
level of poshaka mamsa dhatu level.
 Rakta dhatu Marghavarodha caused by the either
sotha (caused by Bacteria, virus, allergens) or
Kapha dosha produced by Nidhana.
They obstruct the flow of Rasa Rakta dhatu and
inhibit the further dhatu posana (metabolism).
The nutrients fraction of Mamsa dhatu retained in
the blood accumulate in Tonsils.
The accumulated mamsa dhatu produces a
Granthi.
Tundikeri is modified Granthi*
Samprapthi
*Dr. M. Rama Sunder rao, text book of ShalyaTantraVignamam,2002,page No.397
Samprapthi vighatana ( Dravya Karma)
20x Image of Chincha beeja 200x image of chincha beeja
MEANOSCOPIC EVALUATION OF CHINCHA BEEJA
Pharmacognostic study
T.S of Chincha beeja
DRAVYA RASA GUNA VIPAKA VIRYA
CUMULATIVE
SANKHYA
CHINCHA
BHEEJA
Kashaya
P1K1
Picchala
Ruksha
V1
K1P1
Katu
K2
Sheeta
P3
V1P5K4
Vata, 1
Pitta, 5
Kapha,
4
Doshaghna Gunaganana of chincha bheeja
Reference : Doshagna Guna Ganana (DGG) By Dr M.Paramkusha Rao A new
arithmetic assessment of drugs effect on dosha based on Guna prabhava,
International Journal of Ayurvedic Medicine, 2012,3 (3), 130-139, published
online in http://ijam.co.in.
S.N
o.
Test
Type of test
used
FP
PP PDP
I Alkaloids Mayer’s test - - -
II Carbohydrates Molisch test + + +
III Starch Iodine test + + +
IV Tannins
Ferric
chloride test
+
+ +
V Protein and Amino Acid Biuret Test - - -
VI Flavonoids Led acetate - - -
VII Saponins Foam test - - -
VIII Acid test (pH) 7 7 7
Results and observations:
Carbohydrates, Starch and Tannins are present in PF Group
drug, PP group drug & PDP group drug. Ph is 7 in three groups.
Phytochemical analysis results
Pharmaceutical preparation
Chincha beeja yoga
Preparation – 1
Paste of powder (PP)
Preparation -2
Paste of dried paste (PDP)
Preparation -3
Fresh paste (FP)
Microbiological study
Materials:
•Bacteria- Staphylococcus aureus
• Agar plate
•Test tube
•Dropper
•Test tube stand
•Incubator
Method followed: Disc diffusion method.
Procedure of culture & sensitivity
Sensitivity Streptococcus aureus to Chincha beeja fresh paste (FP),
Paste of Powder (PP) and paste of Dry powder (PDP).
Sensitivity of FP Sensitivity of PP
Sensitivity of PDP
Sample Sensitivity
FP + + +
PP + +
PDP +
The result shows that Chincha beeja fresh paste (FP) was
more effective on Streptococcus aureus than the Paste of Powder
(PP), paste of Dry powder (PDP).
REPORT
Chincha bheeja
Distilled water
Hot Water
Sandalwood stone(which is used for chandan paste
preparation)
 Sterilized cotton
Thundikeri salaka(Tonsil cops)
Spirit lamp
Water heater
Glass bowl
Glass tumbler
MATERIALAND METHODS
CLINICAL STUDY
Distilled water
Sandalwood stone
Sterilized cotton
Thundikeri salaka
(Tonsil cops)Spirit lamp
Water heater
Chincha bheeja churna
Glass bowl
Glass tumbler
Patients selected from P.G department
of Dravyaguna and Kaumarabhritya OPD.
A Health checkup camp conducted for the
students of Nehru municipal school, Thirupati
And examined 300 students and picked up few
patients and gave treatment to them.
MATERIALAND METHODS
HEALTH CHECKUP CAMP
In this study 40 patients were divided in to 4
groups.
Groups Treated With
Group-1 Fresh paste (FP)
Group-2 Paste of dried paste
(PDP)
Group-3 Paste of powder (PP)
Group-4 Placebo (PL) Wheat
Powder with water
Patient allowed to gargle with lukewarm
water
Applied the chincha bheeja lepa on affected
tonsils with the help of tonsil cops.
Same procedure continued for 3 days
DRUG ADMINISTRATION
12 c.m
THUNDIKERI SALAKA (TONSIL COPS)
THUNDIKERI SALAKA (TONSIL COPS)
Thundikeri salaka(Tonsil cops) is a arrow shaped
instrument which is made up of silver
Head of this instrument have rough surfaced edges
this type of edges useful for holding Cotton with
out escaping.
This instrument is very comfortable for applying the
medicine on surface of tonsils
Inclusion criteria
Age group of 2years to 60years
Patient having symptoms of tonsillitis viz. throat
pain, dysphagia ,fever etc
Patient willing for treatment
Patients of either sex will be included
Exclusion criteria
Tonsillitis with complications e.g. Quincy, laryngeal
edema, abscess
Age group below 2 years and above 60 years
Other conditions which mimic tonsillitis e.g.
diphtheria, herpes etc
Dysphagia Score
No difficulty in swallowing 0
Patient feels difficulty in Swallowing of
solid matters
1
Patient unable to swallow even Saliva 2
Patient unable to open his mouth completely
due to severe pain
3
ASSESSMENT CRITERIA
Improvement in temperature (as
observed by its fall):
Score
Normal temperature i.e., 98.6°F 0
Temperature rises from 98. 6°F - 100°F 1
Temperature rises from 100°F - 102°F 2
Temperature more than 102°F 3
Enlargement of tonsils Score
No enlargement 0
Enlarged within anterior pillars 1
Enlarged within posterior pillars 2
Kissing tonsils 3
Halitosis (Bad Breath) Score
Halitosis absent 0
Halitosis present only when opening of
mouth angle completely
1
Halitosis present even during talking 2
Pricking Pain Score
No pain 0
Pain during food intake 1
Continuous pain 2
Symptoms No of patients
with grade-0
(Nil)
No of patients
with grade-1
(Mild)
No of patients
with grade-2
(Moderate)
No of patients
with grade-3
(severe)
Dysphagia B.T 0 8 2 0
A.T 9 1 0 0
Redness in
Mucus
Membrane
B.T 0 6 4 0
A.T 9 1 0 0
Temperature B.T 4 5 1 0
A.T 10 0 0 0
Enlargement of
Tonsils
B.T 0 3 7 0
A.T 7 3 0 0
Halitosis (Bad
Breath)
B.T 3 2 5 0
A.T 9 1 0 0
Pricking Pain B.T 2 5 3 0
A.T 9 1 0 0
OBSERVATION & RESULTS
GRADIATION OF SYMPTOMS BEFORE AND AFTER TREATMENT
GRADATION OF SYMPTOMS BEFORE AND AFTER TREATMENT IN GROUP -1(FP)
SYMPTOMS BEFORE AND AFTER
TREATMENT OF GROUP-1 (FP)
0
1
2
3
4
5
6
7
8
9
10
B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T
1 2 3 4 5 6
0
9
0
9
4
10
0
7
3
9
2
9
8
1
6
1
5
0
3 3
2
1
5
1
2
0
4
0
1
0
7
0
5
0
3
00 0 0 0 0 0 0 0 0 0 0 0
No of patients with grade-0 (Nil) No of patients with grade-1 (Mild)
No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia 1
Redness in Mucus
Membrane
2
Temperature 3
Enlargement of Tonsils 4
Halitosis (Bad Breath) 5
Pricking Pain 6
GRADATION OF SYMPTOMS BEFORE AND
AFTER TREATMENT IN GROUP -2 (PDP)
Symptoms No of
patients with
grade-0
(Nil)
No of
patients with
grade-1
(Mild)
No of
patients with
grade-2
(Moderate)
No of
patients with
grade-3
(severe)
Dysphagia B.T 1 7 2 0
A.T 7 3 0 0
Redness in
Mucus
Membrane
B.T 0 9 1 0
A.T 9 1 0 0
Temperature B.T 6 2 2 0
A.T 8 2 0 0
Enlargement
of Tonsils
B.T 0 7 3 0
A.T 4 6 0 0
Halitosis
(Bad Breath)
B.T 5 5 0 0
A.T 8 2 0 0
Pricking
Pain
B.T 5 5 0 0
A.T 9 1 0 0
SYMPTOMS BEFORE AND AFTER TREATMENT OF
GROUP-2 (PDP)
0
1
2
3
4
5
6
7
8
9
B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T
1 2 3 4 5 6
1
7
0
9
6
8
0
4
5
8
5
9
7
3
9
1
2 2
7
6
5
2
5
1
2
0
1
0
2
0
3
0 0 0 0 00 0 0 0 0 0 0 0 0 0 0 0
No of patients with grade-0 (Nil) No of patients with grade-1 (Mild)
No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia 1
Redness in Mucus
Membrane
2
Temperature 3
Enlargement of Tonsils 4
Halitosis (Bad Breath) 5
Pricking Pain 6
GRADATION OF SYMPTOMS BEFORE AND
AFTER TREATMENT IN GROUP -3 (PP)
Symptoms No of
patients with
grade-0
(Nil)
No of
patients with
grade-1
(Mild)
No of
patients with
grade-2
(Moderate)
No of
patients with
grade-3
(severe)
Dysphagia B.T 1 7 2 0
A.T 8 2 0 0
Redness in
Mucus
Membrane
B.T 0 6 4 0
A.T 8 2 0 0
Temperature B.T 6 3 1 0
A.T 10 0 0 0
Enlargement
of Tonsils
B.T 0 8 2 0
A.T 6 4 0 0
Halitosis
(Bad Breath)
B.T 4 5 1 0
A.T 8 2 0 0
Pricking
Pain
B.T 6 4 0 0
A.T 10 0 0 0
SYMPTOMS BEFORE AND AFTER TREATMENT OF
GROUP-3 (PP)
0
1
2
3
4
5
6
7
8
9
10
B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T
1 2 3 4 5 6
1
8
0
8
6
10
0
6
4
8
6
10
7
2
6
2
3
0
8
4
5
2
4
0
2
0
4
0
1
0
2
0
1
0 0 00 0 0 0 0 0 0 0 0 0 0 0
No of patients with grade-0 (Nil) No of patients with grade-1 (Mild)
No of patients with grade-2 (Moderate) No of patients with grade-3 (severe)
Dysphagia 1
Redness in Mucus
Membrane
2
Temperature 3
Enlargement of Tonsils 4
Halitosis (Bad Breath) 5
Pricking Pain 6
GRADATION OF SYMPTOMS BEFORE AND AFTER
TREATMENT IN GROUP -4 (PL)
Symptoms No of
patients with
grade-0
(Nil)
No of
patients with
grade-1
(Mild)
No of
patients with
grade-2
(Moderate)
No of
patients with
grade-3
(severe)
Dysphagia B.T 0 8 2 0
A.T 2 6 2 0
Redness in
Mucus
Membrane
B.T 0 9 1 0
A.T 3 7 0 0
Temperature B.T 10 0 0 0
A.T 9 1 0 0
Enlargement
of Tonsils
B.T 0 10 0 0
A.T 0 8 2 0
Halitosis
(Bad Breath)
B.T 6 4 0 0
A.T 7 3 0 0
Pricking
Pain
B.T 5 5 0 0
A.T 5 5 0 0
SYMPTOMS BEFORE AND AFTER TREATMENT OF
GROUP-4 (PL)
0
1
2
3
4
5
6
7
8
9
10
B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T
1 2 3 4 5 6
0
2
0
3
10
9
0 0
6
7
5 5
8
6
9
7
0
1
10
8
4
3
5 5
2 2
1
0 0 0 0
2
0 0 0 00 0 0 0 0 0 0 0 0 0 0 0
No of patients with grade-0 (Nil) No of patients with grade-1 (Mild)
No of patients with grade-2 (Moderate) No of patients with grade-3 (severe)
Dysphagia 1
Redness in Mucus
Membrane
2
Temperature 3
Enlargement of Tonsils 4
Halitosis (Bad Breath) 5
Pricking Pain 6
Parameter
Mean
Mean
Diff
% of
relief
S.D S.E
t-value P value Significance
B.T A.T B.T A.T B.T A.T
Dysphagia 1.20 0.10 1.10 91.67 0.42 0.32 0.13 0.10
11.000
0
<0.000
1
Extremely
significant
Redness in
Mucus
Membrane
1.40 0.10 1.30 92.85 0.52 0.32 0.16 0.10 8.5105
<0.000
1
Extremely
significant
body
temperature
0.70 0.00 0.70 100 0.67 0.00 0.21 0.00 3.2796 0.0095
Very
significant
Enlargement
of tonsils
1.70 0.30 1.40 82.35 0.48 0.48 0.15 0.15 8.5732
<0.000
1
Extremely
significant
Halitosis 1.20 0.10 1.10 91.67 0.92 0.32 0.29 0.10 3.9727 0.0032
Very
significant
Pricking
pain
1.10 0.10 1.00 90.90 0.74 0.32 0.23 0.10 4.7434 0.0011
Very
significant
STATISTICAL ANALYSIS OF DATA
STATISTICAL COMPARISON OF GROUP-1
STATISTICAL COMPARISON OF GROUP-2 (PDP)
Parameter
Mean
Mean
Diff
% of
relief
S.D S.E
t-value P value Significance
B.T A.T B.T A.T B.T A.T
Dysphagia 1.10 0.30 0.80 72.72 0.57 0.48 0.18 0.15 6.0000 0.0002
Extremely
significant
Redness in
Mucus
Membrane
1.10 0.10 1.00 90.90 0.32 0.32 0.10 0.10 6.7082 <0.0001
extremely
significant
body
temperature
0.60 0.20 0.40 66.67 0.84 0.42 0.27 0.13 2.4495 0.0368 Significant
enlargement
of tonsils
1.30 0.60 0.70 53.84 0.48 0.52 0.15 0.16 4.5826 0.0013
Very
significant
Halitosis 0.50 0.20 0.30 60 0.53 0.42 0.17 0.13 1.9640 0.0811
Not
significant
pricking
pain
0.50 0.10 0.40 80 0.53 0.32 0.17 0.10 2.4495 0.0368 Significant
STATISTICAL COMPARISON OF GROUP-3 (PP)
Parameter Mean Mean
Diff
% of
relief
S.D S.E t-
value
P value Significance
B.T A.T B.T A.T B.T A.T
Dysphagia 1.10 0.20 0.90 81.81 0.57 0.42 0.18 0.13 5.0138 0.0007 Extremely
significant
Redness in
Mucus
Membrane
1.40 0.20 1.20 85.71 0.52 0.42 0.16 0.13 9.0000 <0.0001 Extremely
significant
body
Temperature
0.50 0.10 0.40 80 0.71 0.32 0.22 0.10 2.4495 0.0368 Significant
enlargement
of tonsils
1.20 0.40 0.80 66.67 0.42 0.52 0.13 0.16 6.0000 0.0002 Extremely
significant
Halitosis 0.70 0.20 0.50 71.42 0.67 0.42 0.21 0.13 3.0000 0.0150 Significant
Pricking
Pain
0.40 0.00 0.40 100 0.52 0.00 0.16 0.00 2.4495 0.0368 Significant
STATISTICAL COMPARISON OF GROUP-4 (PL)
Parameter Mean Mean
Diff
% of
relief
S.D S.E t-value P value Signific
anceB.T A.T B.T A.T B.T A.T
Dysphagia 1.20 1.00 0.20 16.67 0.42 0.67 0.13 0.21 1.0000 0.3434 Not
signific
ant
Redness in
Mucus
Membrane
1.10 0.70 0.40 36.37 0.32 0.48 0.10 0.15 2.4495 0.0368 Signific
ant
Temperature 0.00 0.10 0.10 0 0.00 0.32 0.00 0.10 1.0000 0.3434 Not
signific
ant
enlargement
of tonsils
1.00 1.20 0.20 20 0.00 0.42 0.00 0.13 1.5000 0.1679 Not
signific
ant
Halitosis 0.40 0.30 0.10 25 0.52 0.48 0.16 0.15 1.0000 0.3434 Not
signific
ant
pricking pain 0.40 0.50 0.10 25 0.52 0.53 0.16 0.17 1.0000 0.3434 Not
signific
ant
OVER ALL RESULT OF THE STUDY ACCORDING TO
% OF RELIEF
Parameter % of Relief (B.T-A.T/B.T 100)
Group-1
Fresh paste
(FP)
Group-2
Paste of dried
paste (PDP)
Group-3
Paste of
powder (PP)
Group-4
Placebo (PL)
Wheat Powder
with water
Dysphagia 91.67 72.72 81.81 16.67
Redness in Mucus
Membrane 92.85 90.9 85.71 36.37
body temperature
100 66.67 80 0
Enlargement of
tonsils
82.35 53.84 66.67 20
Halitosis 91.67 60 71.42 25
Pricking pain 90.9 80 100 25
OVERALL RESULT OF THE STUDY ACCORDING TO %
OF RELIEF
0
10
20
30
40
50
60
70
80
90
100
Dysphagia Redness in
Mucus
Membrane
body
temperature
Enlargement of
tonsils
Halitosis Pricking pain
%ofRelief
Symptoms
OVER ALL RESULT OF THE STUDY ACCORDING TO % OF RELIEF
Grup-1
Group-2
Group-3
Group-4
INTER GROUP COMPARISON (ANOVA SINGLE FACTOR
RESULT)
S.No Symptom F-Value P-Value Significanc
e
1
Dysphagia 6.000 0.0020
Very
significant
2 Redness in Mucus
Membrane
7.222 0.0006
Extremely
significant
3 Temperature 4.041 0.014 Significant
4 Enlargement of
Tonsils
22.46 <0.0001
Extremely
significant
5 Halitosis (Bad
Breath)
5.419 0.0035
Very
significant
6.
Pricking Pain 7.515 0.0005
Extremely
significant
BEFORE TREATMENT AFTERTREATMENT
Group:3 Pt No: 5
BEFORE TREATMENT AFTERTREATMENT
Group:1 Pt No: 2
BEFORE TREATMENT AFTERTREATMENT
Group:1 Pt No: 8
BEFORE TREATMENT AFTERTREATMENT
Group:3 Pt No: 7
BEFORE TREATMENT AFTERTREATMENT
Group:2 Pt No: 5
DISCUSSION
• Chincha is found in all Nighantus. Cincha Bija description is
found only in Vastuguna deepika.
• Sri Balraj maharshi (20th December 1917- 28th August 1998) had
demonstrated several single drug applications in various clinical
conditions.
•Chincha beeja also a clinical application suggested by him to Dr M.
Paramkusha Rao he has treated several tonsillitis patients with this
medicine. It has been tried in this study to establish a scientific
evidence for a successful practice. Chincha bheeja is Kashaya in
rasa, Ruksha in guna promotes absorption, and Kaphahara action
removes obstruction. Krimi hara Karma of Chincha bheeja destroys
Bacteria, Virus invaded in to tonsils.
•The chemical composition of Chincha beeja is found peculiar with
chemical named as Xyloglucan (XG) . It is very hydroscopic in
nature and found to be effective. To prove it another study is
required.
CONCLUSION
•Group-1 patients have shown better results
when compared with other 3 Groups. That
means Fresh Paste is more effective than other
forms.
•The result with 3rd group Chincha beeja
powder mixed with water has shown next better
results. 2nd group chincha beeja dry powder has
not given satisfactory result. But better than
Placebo Group.
ACKNOWLEDGEMENT
I am thankful to TTD, Late Sri Balaraj
Maharshi, Principal S.V Ayurvedic college
Tirupathi, and my guide & Professor Dr M.
Paramkusha Rao garu and my teachers for kind
support.
Dr Parvathi Devi garu S.V Ayurvedic
hospital for providing Dravyaguna theater to
conduct the study along with many other
dravyaguna kriyayogas.
A study on the efficacy of Tamarind seed paste in tonsillitis

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A study on the efficacy of Tamarind seed paste in tonsillitis

  • 1.
  • 2. A study on the Granthigna effect of Chincha Beeja Yoga (Tamarindus indica l.) Paint W.S.R to Tundikeri (Tonsillitis). Dr M. PARAMKUSHA RAO M.D.(Ayu),Ph.D. P.G.Professor& H.O.D. Department of Dravyaguna S.V.Ayurvedic college, Tirupati, Andhrapradesh By- Dr K.RAGHU RAMUDU, Final year P.G Scholar Department of Dravyaguna S.V.Ayurvedic college,Tirupati, Andhrapradesh
  • 3.  Tundikeri is commonly encountered now a days due to the dietary habits of taking spicy food, cold beverages, refrigerated milk products and cold climate.  Lower socio-economic group people are particularly prone as the immunity status is low in them. These factors coupled together results in recurrent episodes of disease. Tundikeri not only cripples children from majority of their enjoyable and learning movement but also makes adults to feel uneasy, restless. INTRODUCTION
  • 4. Antibiotics are the main stay in treatment of tonsillitis as far as the conventional medicine is concerned. They can give temporary relief to the patient but cannot check the frequent reoccurrence of the disease. Their surgical removal put a straight forward attack on respiratory, gastrointestinal tract and immunity. Further surgical procedure has its own complications also. INTRODUCTION
  • 5. Late Sri Balaraj Maharshi the Former advisor on Ayurveda to the government of Andhra Pradesh, India & Brazil founder of this college has suggested Chincha beeja Lepa in Tonsillitis. My guide Dr M. Param kusha Rao close associated of Balaraj maharshi was observing its promising effect. Therefore Chincha beeja is taken to study its Grandhighna effect in Tundikeri. Why CHINCHA BEEJA is taken? Dr. Balraj Maharishi (1917-1998)
  • 6. AIMS & OBJECTIVES •To study the efficacy of chincha beeja lepa in tonsillitis •To develop a safe single drug for management of tonsillitis •To find out economical therapy for tonsillitis with minimum or with out side effects
  • 7. Kingdom Plantae Phylum Spermatophyte Class Angiosperm Sub class Dicotyledone Family Leguminosae Subfamily Caesalpiniaceae Genus Tamarindus Species Indica Taxonomical classification of chincha DRUG REVIEW
  • 8. Rasa Kasaya Reference Vasthuguna Dipika Guna Not mentioned Vipaka Not mentioned Virya Not mentioned Doshaghnata Kapha hara Karma Sukra sthambaka Rakta sthambaka Upayukta Vyadhi Krimi roga, Grahani, Sukra nasta, Raktatisara, Rakta pradaram Properties of chincha bheeja
  • 9. PHARMACO THERAPEUTIC APPLICATIONS (DRAVYAGUNA KRIYAYOGA) 1.Gudha Bramsha: Fried amlika seeds are rubbed with water and pasted on anus after setting the tract in position. By this it dose not prolapse again. (S.B.4.919) 2.Somaroga: The seeds of amlika are soaked with water the previous day and then pounded with milk. This past, if taken regularly, alleviates somaroga. (VD.2.13 ) 3.Rakta arshas: burn the seeds of chincha and make bhasma give in 1-2 masha curd. (G.P.113) 4.Amaatisara: Remove the outer covering of ripened chincha seed, white jeeraka and mishri each 6 masha. Make a churna of all make a dose in 3 parts and give at every 3 hour interval with honey. This will cure old disease also. G.P.109 (a)
  • 10. 5.Sweta pradara ( in other pradara also): Soak seeds in water and next day remove seed coat and make a paste of 4 seeds administered with mishri will cure sweeta pradara. (G.P.110) 6.Jwara: If daha and palpitations is there seeds of chincha and kharjura 2-2 tola are boiled in sera milk on low flame, sieve it and given to patient. No other food or medication should be given on that day. (G.P.111 ) 7.Kanta sotha: 6 masha of chincha in 2 sera of jala is boiled till the jala remains half then 2 tola of rose water is added and sieved. Gargling with this will cure kanta sotha. (G.P.112 ) 8.Athisara: Seed coat of Amlika seeds, Sunthi, Rock salt and Yavani are mixed together and taken with fresh buttermilk it checks Athisara quickly. (VD.6.5) PHARMACO THERAPEUTIC APPLICATIONS (DRAVYAGUNA KRIYAYOGA)
  • 11. Mineral mg/100g Tamarind Seed Calcium 9.3-786.0 Phosphorus 68.4-165.0 Magnesium 17.5-118.3 Potassium 272.8-610.0 Sodium 19.2-28.8 Copper 1.6-19.0 Iron 6.5 Zinc 2.8 Manganese 0.9 Mineral content of tamarind seed Source: Marangoni et al. (1988); Ishola et al. (1990); Bhattacharya et al. (1994); Parvez et al. (2003).
  • 12. Amino acid content of tamarind seed There are 20 amino acids present in the human body. 9 Essential Amino acids and 11 Non-Essential Amino acids Chincha bheeja contain 8 Essential amino acids and 9 Non- Essential amino acids. Amino Acid Tamarind mg/g N (Total N) Isoleucine 313 Leucine 531 Lycine 475 Methionine 113 Cystine 106 Phenylalani n 318 Tyrosine 287 Threonine 200 Valine 306 Arginine 450 Histidine 143 Alanine 312 Aspartic 768 Glutamic 1056 Glycine 331 Proline 287 Serine 350 Source: FAO (1970); de Lumen et al. (1986, 1990).
  • 13. Reported Pharmacological Activity of Tamarindus indica seed Antidiabetic activity Antioxidant activity Anti Inflammatory activity Antimicrobial activity Antipyretic activity Anticancer activity Antitumor and Immunopotentiating Activity Antiemetic activity Hepato protective activity Analgesic activity Anti Diarrheal activity Laxative activity Anti venom activity Anti ulcer activity Anti obesity activity Hypolipidemic activity
  • 14. Granthi Any localised swelling looking like a knot caused by vitiated Tridoshas, Rakta, Mamsa and medas with the Predominance of Kapha and Vata. Vagbhata also opinion that Kapha Pradhana doshas along with Rakta, Mamsa and Medas cause a swelling which is vritta, unnata and gradhita(Round, elevated and compact). REVIEW OF GRANTHIGHNA KARMA ON TUNDIKERI
  • 15. Tundikeri शॊफः स्थुलस्तोददाह प्रपाकि । प्रागुिताभ्ाां तुण्डििे रि मता तु ॥ (Su.Ni.16/44) Tundikeri is that disease caused by the vitiation of Kapha and Rakta. There is Sthula Shotha (oedema), Toda (pricking type of pain), Daha (burning sensation), Prapaki (Suppuration). According to Acharya Vagbhatta, Tundikeri is having the shape of Karpasiphala and is Hanusandhi Asrita Kanta (root of the temperomandibular joint) It is Picchila (Slimy), Manda Ruk (Mild pain) and a firm swelling. The definition given by Acharya Sushruta resembles the acute stage of tonsillitis. where as the definition by Acharya Vagbhatta is featuring probably the chronic stage of tonsillitis.
  • 16.  Involvement of Mamsa dhatu could be at the level of poshaka mamsa dhatu level.  Rakta dhatu Marghavarodha caused by the either sotha (caused by Bacteria, virus, allergens) or Kapha dosha produced by Nidhana. They obstruct the flow of Rasa Rakta dhatu and inhibit the further dhatu posana (metabolism). The nutrients fraction of Mamsa dhatu retained in the blood accumulate in Tonsils. The accumulated mamsa dhatu produces a Granthi. Tundikeri is modified Granthi* Samprapthi *Dr. M. Rama Sunder rao, text book of ShalyaTantraVignamam,2002,page No.397
  • 17.
  • 18. Samprapthi vighatana ( Dravya Karma)
  • 19. 20x Image of Chincha beeja 200x image of chincha beeja MEANOSCOPIC EVALUATION OF CHINCHA BEEJA Pharmacognostic study
  • 20. T.S of Chincha beeja
  • 21. DRAVYA RASA GUNA VIPAKA VIRYA CUMULATIVE SANKHYA CHINCHA BHEEJA Kashaya P1K1 Picchala Ruksha V1 K1P1 Katu K2 Sheeta P3 V1P5K4 Vata, 1 Pitta, 5 Kapha, 4 Doshaghna Gunaganana of chincha bheeja Reference : Doshagna Guna Ganana (DGG) By Dr M.Paramkusha Rao A new arithmetic assessment of drugs effect on dosha based on Guna prabhava, International Journal of Ayurvedic Medicine, 2012,3 (3), 130-139, published online in http://ijam.co.in.
  • 22. S.N o. Test Type of test used FP PP PDP I Alkaloids Mayer’s test - - - II Carbohydrates Molisch test + + + III Starch Iodine test + + + IV Tannins Ferric chloride test + + + V Protein and Amino Acid Biuret Test - - - VI Flavonoids Led acetate - - - VII Saponins Foam test - - - VIII Acid test (pH) 7 7 7 Results and observations: Carbohydrates, Starch and Tannins are present in PF Group drug, PP group drug & PDP group drug. Ph is 7 in three groups. Phytochemical analysis results
  • 23. Pharmaceutical preparation Chincha beeja yoga Preparation – 1 Paste of powder (PP)
  • 24. Preparation -2 Paste of dried paste (PDP)
  • 26. Microbiological study Materials: •Bacteria- Staphylococcus aureus • Agar plate •Test tube •Dropper •Test tube stand •Incubator Method followed: Disc diffusion method.
  • 27. Procedure of culture & sensitivity
  • 28. Sensitivity Streptococcus aureus to Chincha beeja fresh paste (FP), Paste of Powder (PP) and paste of Dry powder (PDP). Sensitivity of FP Sensitivity of PP Sensitivity of PDP
  • 29. Sample Sensitivity FP + + + PP + + PDP + The result shows that Chincha beeja fresh paste (FP) was more effective on Streptococcus aureus than the Paste of Powder (PP), paste of Dry powder (PDP). REPORT
  • 30. Chincha bheeja Distilled water Hot Water Sandalwood stone(which is used for chandan paste preparation)  Sterilized cotton Thundikeri salaka(Tonsil cops) Spirit lamp Water heater Glass bowl Glass tumbler MATERIALAND METHODS CLINICAL STUDY
  • 31. Distilled water Sandalwood stone Sterilized cotton Thundikeri salaka (Tonsil cops)Spirit lamp Water heater Chincha bheeja churna Glass bowl Glass tumbler
  • 32. Patients selected from P.G department of Dravyaguna and Kaumarabhritya OPD. A Health checkup camp conducted for the students of Nehru municipal school, Thirupati And examined 300 students and picked up few patients and gave treatment to them. MATERIALAND METHODS
  • 34. In this study 40 patients were divided in to 4 groups. Groups Treated With Group-1 Fresh paste (FP) Group-2 Paste of dried paste (PDP) Group-3 Paste of powder (PP) Group-4 Placebo (PL) Wheat Powder with water
  • 35. Patient allowed to gargle with lukewarm water Applied the chincha bheeja lepa on affected tonsils with the help of tonsil cops. Same procedure continued for 3 days DRUG ADMINISTRATION
  • 36.
  • 37. 12 c.m THUNDIKERI SALAKA (TONSIL COPS)
  • 38. THUNDIKERI SALAKA (TONSIL COPS) Thundikeri salaka(Tonsil cops) is a arrow shaped instrument which is made up of silver Head of this instrument have rough surfaced edges this type of edges useful for holding Cotton with out escaping. This instrument is very comfortable for applying the medicine on surface of tonsils
  • 39. Inclusion criteria Age group of 2years to 60years Patient having symptoms of tonsillitis viz. throat pain, dysphagia ,fever etc Patient willing for treatment Patients of either sex will be included Exclusion criteria Tonsillitis with complications e.g. Quincy, laryngeal edema, abscess Age group below 2 years and above 60 years Other conditions which mimic tonsillitis e.g. diphtheria, herpes etc
  • 40. Dysphagia Score No difficulty in swallowing 0 Patient feels difficulty in Swallowing of solid matters 1 Patient unable to swallow even Saliva 2 Patient unable to open his mouth completely due to severe pain 3 ASSESSMENT CRITERIA
  • 41. Improvement in temperature (as observed by its fall): Score Normal temperature i.e., 98.6°F 0 Temperature rises from 98. 6°F - 100°F 1 Temperature rises from 100°F - 102°F 2 Temperature more than 102°F 3
  • 42. Enlargement of tonsils Score No enlargement 0 Enlarged within anterior pillars 1 Enlarged within posterior pillars 2 Kissing tonsils 3
  • 43. Halitosis (Bad Breath) Score Halitosis absent 0 Halitosis present only when opening of mouth angle completely 1 Halitosis present even during talking 2
  • 44. Pricking Pain Score No pain 0 Pain during food intake 1 Continuous pain 2
  • 45. Symptoms No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia B.T 0 8 2 0 A.T 9 1 0 0 Redness in Mucus Membrane B.T 0 6 4 0 A.T 9 1 0 0 Temperature B.T 4 5 1 0 A.T 10 0 0 0 Enlargement of Tonsils B.T 0 3 7 0 A.T 7 3 0 0 Halitosis (Bad Breath) B.T 3 2 5 0 A.T 9 1 0 0 Pricking Pain B.T 2 5 3 0 A.T 9 1 0 0 OBSERVATION & RESULTS GRADIATION OF SYMPTOMS BEFORE AND AFTER TREATMENT GRADATION OF SYMPTOMS BEFORE AND AFTER TREATMENT IN GROUP -1(FP)
  • 46. SYMPTOMS BEFORE AND AFTER TREATMENT OF GROUP-1 (FP) 0 1 2 3 4 5 6 7 8 9 10 B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T 1 2 3 4 5 6 0 9 0 9 4 10 0 7 3 9 2 9 8 1 6 1 5 0 3 3 2 1 5 1 2 0 4 0 1 0 7 0 5 0 3 00 0 0 0 0 0 0 0 0 0 0 0 No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia 1 Redness in Mucus Membrane 2 Temperature 3 Enlargement of Tonsils 4 Halitosis (Bad Breath) 5 Pricking Pain 6
  • 47. GRADATION OF SYMPTOMS BEFORE AND AFTER TREATMENT IN GROUP -2 (PDP) Symptoms No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia B.T 1 7 2 0 A.T 7 3 0 0 Redness in Mucus Membrane B.T 0 9 1 0 A.T 9 1 0 0 Temperature B.T 6 2 2 0 A.T 8 2 0 0 Enlargement of Tonsils B.T 0 7 3 0 A.T 4 6 0 0 Halitosis (Bad Breath) B.T 5 5 0 0 A.T 8 2 0 0 Pricking Pain B.T 5 5 0 0 A.T 9 1 0 0
  • 48. SYMPTOMS BEFORE AND AFTER TREATMENT OF GROUP-2 (PDP) 0 1 2 3 4 5 6 7 8 9 B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T 1 2 3 4 5 6 1 7 0 9 6 8 0 4 5 8 5 9 7 3 9 1 2 2 7 6 5 2 5 1 2 0 1 0 2 0 3 0 0 0 0 00 0 0 0 0 0 0 0 0 0 0 0 No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia 1 Redness in Mucus Membrane 2 Temperature 3 Enlargement of Tonsils 4 Halitosis (Bad Breath) 5 Pricking Pain 6
  • 49. GRADATION OF SYMPTOMS BEFORE AND AFTER TREATMENT IN GROUP -3 (PP) Symptoms No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia B.T 1 7 2 0 A.T 8 2 0 0 Redness in Mucus Membrane B.T 0 6 4 0 A.T 8 2 0 0 Temperature B.T 6 3 1 0 A.T 10 0 0 0 Enlargement of Tonsils B.T 0 8 2 0 A.T 6 4 0 0 Halitosis (Bad Breath) B.T 4 5 1 0 A.T 8 2 0 0 Pricking Pain B.T 6 4 0 0 A.T 10 0 0 0
  • 50. SYMPTOMS BEFORE AND AFTER TREATMENT OF GROUP-3 (PP) 0 1 2 3 4 5 6 7 8 9 10 B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T 1 2 3 4 5 6 1 8 0 8 6 10 0 6 4 8 6 10 7 2 6 2 3 0 8 4 5 2 4 0 2 0 4 0 1 0 2 0 1 0 0 00 0 0 0 0 0 0 0 0 0 0 0 No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia 1 Redness in Mucus Membrane 2 Temperature 3 Enlargement of Tonsils 4 Halitosis (Bad Breath) 5 Pricking Pain 6
  • 51. GRADATION OF SYMPTOMS BEFORE AND AFTER TREATMENT IN GROUP -4 (PL) Symptoms No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia B.T 0 8 2 0 A.T 2 6 2 0 Redness in Mucus Membrane B.T 0 9 1 0 A.T 3 7 0 0 Temperature B.T 10 0 0 0 A.T 9 1 0 0 Enlargement of Tonsils B.T 0 10 0 0 A.T 0 8 2 0 Halitosis (Bad Breath) B.T 6 4 0 0 A.T 7 3 0 0 Pricking Pain B.T 5 5 0 0 A.T 5 5 0 0
  • 52. SYMPTOMS BEFORE AND AFTER TREATMENT OF GROUP-4 (PL) 0 1 2 3 4 5 6 7 8 9 10 B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T B.T A.T 1 2 3 4 5 6 0 2 0 3 10 9 0 0 6 7 5 5 8 6 9 7 0 1 10 8 4 3 5 5 2 2 1 0 0 0 0 2 0 0 0 00 0 0 0 0 0 0 0 0 0 0 0 No of patients with grade-0 (Nil) No of patients with grade-1 (Mild) No of patients with grade-2 (Moderate) No of patients with grade-3 (severe) Dysphagia 1 Redness in Mucus Membrane 2 Temperature 3 Enlargement of Tonsils 4 Halitosis (Bad Breath) 5 Pricking Pain 6
  • 53. Parameter Mean Mean Diff % of relief S.D S.E t-value P value Significance B.T A.T B.T A.T B.T A.T Dysphagia 1.20 0.10 1.10 91.67 0.42 0.32 0.13 0.10 11.000 0 <0.000 1 Extremely significant Redness in Mucus Membrane 1.40 0.10 1.30 92.85 0.52 0.32 0.16 0.10 8.5105 <0.000 1 Extremely significant body temperature 0.70 0.00 0.70 100 0.67 0.00 0.21 0.00 3.2796 0.0095 Very significant Enlargement of tonsils 1.70 0.30 1.40 82.35 0.48 0.48 0.15 0.15 8.5732 <0.000 1 Extremely significant Halitosis 1.20 0.10 1.10 91.67 0.92 0.32 0.29 0.10 3.9727 0.0032 Very significant Pricking pain 1.10 0.10 1.00 90.90 0.74 0.32 0.23 0.10 4.7434 0.0011 Very significant STATISTICAL ANALYSIS OF DATA STATISTICAL COMPARISON OF GROUP-1
  • 54. STATISTICAL COMPARISON OF GROUP-2 (PDP) Parameter Mean Mean Diff % of relief S.D S.E t-value P value Significance B.T A.T B.T A.T B.T A.T Dysphagia 1.10 0.30 0.80 72.72 0.57 0.48 0.18 0.15 6.0000 0.0002 Extremely significant Redness in Mucus Membrane 1.10 0.10 1.00 90.90 0.32 0.32 0.10 0.10 6.7082 <0.0001 extremely significant body temperature 0.60 0.20 0.40 66.67 0.84 0.42 0.27 0.13 2.4495 0.0368 Significant enlargement of tonsils 1.30 0.60 0.70 53.84 0.48 0.52 0.15 0.16 4.5826 0.0013 Very significant Halitosis 0.50 0.20 0.30 60 0.53 0.42 0.17 0.13 1.9640 0.0811 Not significant pricking pain 0.50 0.10 0.40 80 0.53 0.32 0.17 0.10 2.4495 0.0368 Significant
  • 55. STATISTICAL COMPARISON OF GROUP-3 (PP) Parameter Mean Mean Diff % of relief S.D S.E t- value P value Significance B.T A.T B.T A.T B.T A.T Dysphagia 1.10 0.20 0.90 81.81 0.57 0.42 0.18 0.13 5.0138 0.0007 Extremely significant Redness in Mucus Membrane 1.40 0.20 1.20 85.71 0.52 0.42 0.16 0.13 9.0000 <0.0001 Extremely significant body Temperature 0.50 0.10 0.40 80 0.71 0.32 0.22 0.10 2.4495 0.0368 Significant enlargement of tonsils 1.20 0.40 0.80 66.67 0.42 0.52 0.13 0.16 6.0000 0.0002 Extremely significant Halitosis 0.70 0.20 0.50 71.42 0.67 0.42 0.21 0.13 3.0000 0.0150 Significant Pricking Pain 0.40 0.00 0.40 100 0.52 0.00 0.16 0.00 2.4495 0.0368 Significant
  • 56. STATISTICAL COMPARISON OF GROUP-4 (PL) Parameter Mean Mean Diff % of relief S.D S.E t-value P value Signific anceB.T A.T B.T A.T B.T A.T Dysphagia 1.20 1.00 0.20 16.67 0.42 0.67 0.13 0.21 1.0000 0.3434 Not signific ant Redness in Mucus Membrane 1.10 0.70 0.40 36.37 0.32 0.48 0.10 0.15 2.4495 0.0368 Signific ant Temperature 0.00 0.10 0.10 0 0.00 0.32 0.00 0.10 1.0000 0.3434 Not signific ant enlargement of tonsils 1.00 1.20 0.20 20 0.00 0.42 0.00 0.13 1.5000 0.1679 Not signific ant Halitosis 0.40 0.30 0.10 25 0.52 0.48 0.16 0.15 1.0000 0.3434 Not signific ant pricking pain 0.40 0.50 0.10 25 0.52 0.53 0.16 0.17 1.0000 0.3434 Not signific ant
  • 57. OVER ALL RESULT OF THE STUDY ACCORDING TO % OF RELIEF Parameter % of Relief (B.T-A.T/B.T 100) Group-1 Fresh paste (FP) Group-2 Paste of dried paste (PDP) Group-3 Paste of powder (PP) Group-4 Placebo (PL) Wheat Powder with water Dysphagia 91.67 72.72 81.81 16.67 Redness in Mucus Membrane 92.85 90.9 85.71 36.37 body temperature 100 66.67 80 0 Enlargement of tonsils 82.35 53.84 66.67 20 Halitosis 91.67 60 71.42 25 Pricking pain 90.9 80 100 25
  • 58. OVERALL RESULT OF THE STUDY ACCORDING TO % OF RELIEF 0 10 20 30 40 50 60 70 80 90 100 Dysphagia Redness in Mucus Membrane body temperature Enlargement of tonsils Halitosis Pricking pain %ofRelief Symptoms OVER ALL RESULT OF THE STUDY ACCORDING TO % OF RELIEF Grup-1 Group-2 Group-3 Group-4
  • 59. INTER GROUP COMPARISON (ANOVA SINGLE FACTOR RESULT) S.No Symptom F-Value P-Value Significanc e 1 Dysphagia 6.000 0.0020 Very significant 2 Redness in Mucus Membrane 7.222 0.0006 Extremely significant 3 Temperature 4.041 0.014 Significant 4 Enlargement of Tonsils 22.46 <0.0001 Extremely significant 5 Halitosis (Bad Breath) 5.419 0.0035 Very significant 6. Pricking Pain 7.515 0.0005 Extremely significant
  • 65. DISCUSSION • Chincha is found in all Nighantus. Cincha Bija description is found only in Vastuguna deepika. • Sri Balraj maharshi (20th December 1917- 28th August 1998) had demonstrated several single drug applications in various clinical conditions. •Chincha beeja also a clinical application suggested by him to Dr M. Paramkusha Rao he has treated several tonsillitis patients with this medicine. It has been tried in this study to establish a scientific evidence for a successful practice. Chincha bheeja is Kashaya in rasa, Ruksha in guna promotes absorption, and Kaphahara action removes obstruction. Krimi hara Karma of Chincha bheeja destroys Bacteria, Virus invaded in to tonsils. •The chemical composition of Chincha beeja is found peculiar with chemical named as Xyloglucan (XG) . It is very hydroscopic in nature and found to be effective. To prove it another study is required.
  • 66. CONCLUSION •Group-1 patients have shown better results when compared with other 3 Groups. That means Fresh Paste is more effective than other forms. •The result with 3rd group Chincha beeja powder mixed with water has shown next better results. 2nd group chincha beeja dry powder has not given satisfactory result. But better than Placebo Group.
  • 67. ACKNOWLEDGEMENT I am thankful to TTD, Late Sri Balaraj Maharshi, Principal S.V Ayurvedic college Tirupathi, and my guide & Professor Dr M. Paramkusha Rao garu and my teachers for kind support. Dr Parvathi Devi garu S.V Ayurvedic hospital for providing Dravyaguna theater to conduct the study along with many other dravyaguna kriyayogas.