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Essentials of Human Anatomy & Physiology
Seventh Edition
Elaine N. Marieb
The Cardiovascular
System
(Chapter 15)
Adapted by H. Goon, North HS, Phoenix, AZ
Overview of the Cardiovascular System
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 The cardiovascular system is a closed
system of the heart and blood vessels
 the heart pumps blood into blood
vessels
 blood vessels circulate the blood to
all parts of the body, to ALL cells
 Functions: to deliver oxygen and nutrients
to all body cells, transport enzymes and
hormones, and to remove carbon dioxide
and other waste products from the cells
External Heart Anatomy
A) Anatomy of the Heart
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
1. Location
 thoracic cavity
 in the mediastinum, between the lungs
Can you describe the location of
the heart?
 The heart is ________ to the lungs,
________ to the sternum, ________ to
the vertebral column, and ________ to
the diaphragm.
 Its ________ end, the apex, points to
the left, terminating at the level of the 5th
intercostal space.
 The heart is medial to the lungs,
posterior to the sternum, anterior to
the vertebral column, and superior to
the diaphragm.
 Its distal end, the apex, points to
the left, terminating at the level of
the 5th intercostal space.
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
2. Size
 approximately the size of a person’s
fist & less than 1 pound
~ 14 cm long; 9 cm wide
3. Coverings of the heart
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
a) pericardium (or pericardial sac)
1) fibrous pericardium—sac made of
tough connective tissue
2) double layered serous membrane:
a. parietal pericardium
b. visceral pericardium (a.k.a.
epicardium)--covers the heart
b) serous fluid fills the pericardial cavity
between parietal & visceral layers
4. Heart wall
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
a) epicardium (aka visceral pericardium)
outside layer of connective tissue on
surface of the heart
b) myocardium = thick wall of cardiac
muscle
c) endocardium—inner epithelial &
connective tissue lining of heart and
valves
5. Chambers of the heart (4)
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 atrium (R & L)—receive blood
 each atria extends into a smaller,
external chamber called an auricle
 ventricle (R & L)—inferior to the atria;
expel blood out of the heart
 The chambers on the left are separated
from the chambers on the right by a
septum (wall of cardiac muscle)
 interatrial septum
 interventricular septum
External Heart Anatomy
1
2
3
4
5
Can you name each numbered part of the heart?
6. Heart Valves
a) are flaps that allow blood to flow
in only one direction
Slide 11.8
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
b) atrioventricular (AV) valves – between
each atrium and ventricle; allow blood flow
from each atrium down into the ventricle
 bicuspid/mitral valve (left side)
 tricuspid valve (right side)
Slide 11.8
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
c) semilunar valves - between ventricle and
major heart artery; allow blood flow out of
each ventricle through one of the major
heart arteries; 3 cusps
 pulmonary valve (R ventricle & pulmonary
trunk)
 aortic valve (L ventricle & aorta)
d) The valve cusps are held in place by
chordae tendineae (“heart strings”) which
originate from papillary muscles
protruding from the inside of the ventricle
wall
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
e) valve function
 when a chamber wall contracts blood is
pumped through a valve
 any backflow increases pressure on the
cusps and closes the valves
 AV valves close during ventricular
contraction; papillary muscles also
contract pulling the chordae tendineae
which keep the valve cusps from
prolapsing back into the atrium
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
f) heartbeat sound
“lub” = when AV valves close
“dup” = when semilunar valves close
g) valve pathology
• an incompetent valve can lead to
backflow, heard as a “heart murmur”
and repumping (regurgitation) of the
same blood
• stenosis = narrowing of valve increases
workload on heart to pump out blood
• Treatment: valve repair or replacement
http://www.bing.com/videos/search?q=blood+circulation&FORM=HDRSC3#v
iew=detail&mid=D7FC584D7C3259E0686DD7FC584D7C3259E0686D
• Video clip Overview of Circulation
B) Paths of Blood Circulation
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
1. Major Blood Vessels of the Heart
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 aorta carries _________________ blood
from the left ventricle to upper & lower body
 pulmonary arteries (L & R): carries
_________________ blood from right
ventricle to lungs
 vena cava (superior & inferior): carries
_________________ blood from upper &
lower body into right atria
 pulmonary veins (2 pairs, L & R): carry
_________________ blood from lungs into
left atria
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 aorta carries oxygenated blood from the left
ventricle to upper & lower body
 pulmonary arteries : carries deoxygenated
blood from right ventricle to lungs
 vena cava: carries deoxygenated blood
from upper & lower body into right atria
 pulmonary veins: carry oxygenated blood
from lungs into left atria
2. Systemic circuit
Slide 11.7
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
3. Pulmonary circuit
Slide 11.7
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
3. Coronary circuit
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 The heart has its own
network of blood
vessels to supply the
cardiac muscle cells
coronary arteries &
veins, capillaries
 NOTE: The blood flowing through the
heart chambers does NOT nourish the
myocardium
http://www.medmovie.com/mmdatabase/MediaPlayer.aspx?
ClientID=65&TopicID=773
* Video clip of mitral valve disease
http://www.bing.com/videos/search?q=video+of+coronary+circulation&view=detail&mid=8B
64DE6E57407A5A5E1B8B64DE6E57407A5A5E1B&first=0&FORM=LKVR&adlt=strict#vi
ew=detail&mid=7B67DD929983076406EC7B67DD929983076406EC
• Video clip Coronary Heart Bypass surgery
Heart Physiology
How does the heart function?
Slide
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
A) The Cardiac Cycle
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
1. A cardiac cycle refers to the
series of contractions & relaxations
of the heart to produce a complete
heartbeat
systole = contraction
diastole = relaxation
2. Events of the cardiac cycle
Diastole
I. Atria and ventricles fill with blood
II. Atria contract (simultaneously) to
complete the filling of ventricles;
ventricles are relaxed
Systole
III. Ventricles contract forcing blood
up and out of the heart arteries; AV
valves shut (“lup”)
IV. Backflow in the aorta & pulmonary
arteries cause semilunar valves to shut
(“dup”)
Video: systole & diastole
http://highered.mcgraw-
hill.com/sites/0072495855/student_view0/chapter22
/animation__the_cardiac_cycle__quiz_2_.html
B) Conduction System
Slide
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 is an intrinsic, nodal conduction system
that regulates heart wall contractions via
electrical impulses
 Specialized muscle tissue regulates
contractions by carrying nerve impulses
i. sinoatrial (SA) node = “pacemaker”
(located in the wall of the right atrium)
ii. atrioventricular (AV) node (in septum at
the junction of the R & L atria)
iii. atrioventricular bundle or Bundle of His
(in the interventricular septum)
iv. bundle branches (right and left)
v. Purkinje fibers (in the myocardium wall)
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Video: Conduction
http://highered.mcgraw-
hill.com/sites/0072495855/student_view0/chapter22
/animation__conducting_system_of_the_heart.html
• is a recording of the electrical changes in
the myocardium during a cardiac cycle
C) electrocardiogram (ECG or EKG)
P wave: atria depolarize
QRS complex: ventricles depolarize
T wave: end of electrical activity in ventricles;
repolarization of ventricular muscles
mV
Time, msec
Figure 8.15B, C
D) Pathology of the Conduction
System
• fibrillation =an irregular & often rapid
heart rate; decreases blood flow
• tachycardia = more than 100 beats/min
• bradycardia = less than 60 beats/min
Possible causes of atrial fibrillation
Abnormalities /damage to the heart's structure due to:
• High blood pressure or Heart attacks
• Abnormal heart valves
• Congenital heart defects (you're born with)
• An overactive thyroid gland
• Stimulants (medications, caffeine, tobacco, alcohol)
• improper functioning of SA node
• Emphysema or other lung diseases
• Viral infections
• Stress due to pneumonia, surgery
• Sleep apnea
E) Cardiac Output
1. is the amount of blood pumped by
the ventricle in one minute
2. Formula for cardiac output
= (heart rate) x (stroke volume*)
* volume of blood pumped by a
ventricle in one contraction
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
3. Normal cardiac output
= (75 beats/min) x (70 mL/beat)
= 5000 mL/min
= 5 L/min
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
4. Cardiac output varies with demands
of the body
e.g.
Cardiac Output Regulation
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
5. The entire blood supply passes
through body once every minute.
Q. How long does it take for a
RBC to make a roundtrip
through the body (via systemic
circuit)?
F) Regulation of Heart Rate
1. Stroke volume usually remains
relatively constant
2. The most common way the body
changes cardiac output is by changing
the heart rate.
Slide
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 Increases heart rate
Sympathetic nervous system
Crisis
Low blood pressure
Hormones
Epinephrine
Thyroxine
Exercise
Decreased blood volume
Slide
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
 Decreases heart rate
Parasympathetic nervous system
High blood pressure or blood volume
Decreased venous return
In congestive heart failure the heart is
worn out and pumps weakly. Digitalis
works to provide a slow, steady, but
stronger beat.
Cardiac Pathology
• Rapid heart beat
• = Inadequate blood
• = Angina Pectoris
Congestive Heart Failure (CHF)
• Decline in pumping efficiency of heart
• Inadequate circulation
• Progressive, also coronary atherosclerosis, high
blood pressure and history of multiple Myocardial
Infarctions
• Left side fails = pulmonary congestion and
suffocation
• Right side fails = peripheral congestion and edema

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Cardiovascular System Marieb.ppt

  • 1. Essentials of Human Anatomy & Physiology Seventh Edition Elaine N. Marieb The Cardiovascular System (Chapter 15) Adapted by H. Goon, North HS, Phoenix, AZ
  • 2. Overview of the Cardiovascular System Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  The cardiovascular system is a closed system of the heart and blood vessels  the heart pumps blood into blood vessels  blood vessels circulate the blood to all parts of the body, to ALL cells  Functions: to deliver oxygen and nutrients to all body cells, transport enzymes and hormones, and to remove carbon dioxide and other waste products from the cells
  • 4. A) Anatomy of the Heart Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings 1. Location  thoracic cavity  in the mediastinum, between the lungs
  • 5. Can you describe the location of the heart?  The heart is ________ to the lungs, ________ to the sternum, ________ to the vertebral column, and ________ to the diaphragm.  Its ________ end, the apex, points to the left, terminating at the level of the 5th intercostal space.
  • 6.  The heart is medial to the lungs, posterior to the sternum, anterior to the vertebral column, and superior to the diaphragm.  Its distal end, the apex, points to the left, terminating at the level of the 5th intercostal space.
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  • 8. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings 2. Size  approximately the size of a person’s fist & less than 1 pound ~ 14 cm long; 9 cm wide
  • 9. 3. Coverings of the heart Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings a) pericardium (or pericardial sac) 1) fibrous pericardium—sac made of tough connective tissue 2) double layered serous membrane: a. parietal pericardium b. visceral pericardium (a.k.a. epicardium)--covers the heart b) serous fluid fills the pericardial cavity between parietal & visceral layers
  • 10. 4. Heart wall Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings a) epicardium (aka visceral pericardium) outside layer of connective tissue on surface of the heart b) myocardium = thick wall of cardiac muscle c) endocardium—inner epithelial & connective tissue lining of heart and valves
  • 11. 5. Chambers of the heart (4) Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  atrium (R & L)—receive blood  each atria extends into a smaller, external chamber called an auricle  ventricle (R & L)—inferior to the atria; expel blood out of the heart  The chambers on the left are separated from the chambers on the right by a septum (wall of cardiac muscle)  interatrial septum  interventricular septum
  • 13. 1 2 3 4 5 Can you name each numbered part of the heart?
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  • 15. 6. Heart Valves a) are flaps that allow blood to flow in only one direction
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  • 17. Slide 11.8 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings b) atrioventricular (AV) valves – between each atrium and ventricle; allow blood flow from each atrium down into the ventricle  bicuspid/mitral valve (left side)  tricuspid valve (right side)
  • 18. Slide 11.8 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings c) semilunar valves - between ventricle and major heart artery; allow blood flow out of each ventricle through one of the major heart arteries; 3 cusps  pulmonary valve (R ventricle & pulmonary trunk)  aortic valve (L ventricle & aorta)
  • 19. d) The valve cusps are held in place by chordae tendineae (“heart strings”) which originate from papillary muscles protruding from the inside of the ventricle wall
  • 20. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings e) valve function  when a chamber wall contracts blood is pumped through a valve  any backflow increases pressure on the cusps and closes the valves  AV valves close during ventricular contraction; papillary muscles also contract pulling the chordae tendineae which keep the valve cusps from prolapsing back into the atrium
  • 21. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings f) heartbeat sound “lub” = when AV valves close “dup” = when semilunar valves close
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  • 23. g) valve pathology • an incompetent valve can lead to backflow, heard as a “heart murmur” and repumping (regurgitation) of the same blood • stenosis = narrowing of valve increases workload on heart to pump out blood • Treatment: valve repair or replacement
  • 25. B) Paths of Blood Circulation Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
  • 26. 1. Major Blood Vessels of the Heart Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  aorta carries _________________ blood from the left ventricle to upper & lower body  pulmonary arteries (L & R): carries _________________ blood from right ventricle to lungs  vena cava (superior & inferior): carries _________________ blood from upper & lower body into right atria  pulmonary veins (2 pairs, L & R): carry _________________ blood from lungs into left atria
  • 27. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  aorta carries oxygenated blood from the left ventricle to upper & lower body  pulmonary arteries : carries deoxygenated blood from right ventricle to lungs  vena cava: carries deoxygenated blood from upper & lower body into right atria  pulmonary veins: carry oxygenated blood from lungs into left atria
  • 28. 2. Systemic circuit Slide 11.7 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
  • 29. 3. Pulmonary circuit Slide 11.7 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
  • 30. 3. Coronary circuit Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  The heart has its own network of blood vessels to supply the cardiac muscle cells coronary arteries & veins, capillaries  NOTE: The blood flowing through the heart chambers does NOT nourish the myocardium
  • 31. http://www.medmovie.com/mmdatabase/MediaPlayer.aspx? ClientID=65&TopicID=773 * Video clip of mitral valve disease http://www.bing.com/videos/search?q=video+of+coronary+circulation&view=detail&mid=8B 64DE6E57407A5A5E1B8B64DE6E57407A5A5E1B&first=0&FORM=LKVR&adlt=strict#vi ew=detail&mid=7B67DD929983076406EC7B67DD929983076406EC • Video clip Coronary Heart Bypass surgery
  • 32. Heart Physiology How does the heart function? Slide Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
  • 33. A) The Cardiac Cycle Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings 1. A cardiac cycle refers to the series of contractions & relaxations of the heart to produce a complete heartbeat systole = contraction diastole = relaxation
  • 34. 2. Events of the cardiac cycle Diastole I. Atria and ventricles fill with blood II. Atria contract (simultaneously) to complete the filling of ventricles; ventricles are relaxed
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  • 36. Systole III. Ventricles contract forcing blood up and out of the heart arteries; AV valves shut (“lup”) IV. Backflow in the aorta & pulmonary arteries cause semilunar valves to shut (“dup”)
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  • 38. Video: systole & diastole http://highered.mcgraw- hill.com/sites/0072495855/student_view0/chapter22 /animation__the_cardiac_cycle__quiz_2_.html
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  • 40. B) Conduction System Slide Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  is an intrinsic, nodal conduction system that regulates heart wall contractions via electrical impulses  Specialized muscle tissue regulates contractions by carrying nerve impulses
  • 41. i. sinoatrial (SA) node = “pacemaker” (located in the wall of the right atrium) ii. atrioventricular (AV) node (in septum at the junction of the R & L atria) iii. atrioventricular bundle or Bundle of His (in the interventricular septum) iv. bundle branches (right and left) v. Purkinje fibers (in the myocardium wall)
  • 42. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
  • 44. • is a recording of the electrical changes in the myocardium during a cardiac cycle C) electrocardiogram (ECG or EKG)
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  • 46. P wave: atria depolarize QRS complex: ventricles depolarize T wave: end of electrical activity in ventricles; repolarization of ventricular muscles mV Time, msec
  • 48. D) Pathology of the Conduction System • fibrillation =an irregular & often rapid heart rate; decreases blood flow • tachycardia = more than 100 beats/min • bradycardia = less than 60 beats/min
  • 49. Possible causes of atrial fibrillation Abnormalities /damage to the heart's structure due to: • High blood pressure or Heart attacks • Abnormal heart valves • Congenital heart defects (you're born with) • An overactive thyroid gland • Stimulants (medications, caffeine, tobacco, alcohol) • improper functioning of SA node • Emphysema or other lung diseases • Viral infections • Stress due to pneumonia, surgery • Sleep apnea
  • 50. E) Cardiac Output 1. is the amount of blood pumped by the ventricle in one minute 2. Formula for cardiac output = (heart rate) x (stroke volume*) * volume of blood pumped by a ventricle in one contraction
  • 51. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings 3. Normal cardiac output = (75 beats/min) x (70 mL/beat) = 5000 mL/min = 5 L/min
  • 52. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings 4. Cardiac output varies with demands of the body e.g.
  • 54. Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings 5. The entire blood supply passes through body once every minute. Q. How long does it take for a RBC to make a roundtrip through the body (via systemic circuit)?
  • 55. F) Regulation of Heart Rate 1. Stroke volume usually remains relatively constant 2. The most common way the body changes cardiac output is by changing the heart rate.
  • 56. Slide Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Increases heart rate Sympathetic nervous system Crisis Low blood pressure Hormones Epinephrine Thyroxine Exercise Decreased blood volume
  • 57. Slide Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Decreases heart rate Parasympathetic nervous system High blood pressure or blood volume Decreased venous return In congestive heart failure the heart is worn out and pumps weakly. Digitalis works to provide a slow, steady, but stronger beat.
  • 58. Cardiac Pathology • Rapid heart beat • = Inadequate blood • = Angina Pectoris
  • 59. Congestive Heart Failure (CHF) • Decline in pumping efficiency of heart • Inadequate circulation • Progressive, also coronary atherosclerosis, high blood pressure and history of multiple Myocardial Infarctions • Left side fails = pulmonary congestion and suffocation • Right side fails = peripheral congestion and edema

Editor's Notes

  1. Base is at the 2nd rib, apex at the 5th intercostal space
  2. Atrial septal defects occur in about 10% of children born with congenital heart defects. Atrial septal defects occur during fetal life when the partitioning process (during the formation of the heart chambers) does not occur completely, leaving an opening in the interatrial septum. Most children have no symptoms and seem healthy. The mixing of blood through the ASD produces an overload of blood in the right heart. This is usually well tolerated. Some of the atrial septal defects, if small enough, may become smaller with time and even close spontaneously. Patients with small to moderate ASD are usually asymptomatic.  If the ASD is large or moderately large then it will allow a large amount of blood to pass through the opening into the right heart and the right ventricle and lungs will become overworked, and symptoms may be noted. Symptoms may include: Delayed weight gain and poor growth Child tires easily, especially when playing Fatigue Excessive sweating Rapid breathing Poor feeding Shortness of breath Frequent respiratory infections including pneumonia http://mykentuckyheart.com/information/AtrialSeptalDefect.htm
  3. http://www.medmovie.com/mmdatabase/MediaPlayer.aspx?ClientID=65&TopicID=773 Incompetent valves may be damaged and not close tightly, or prolapse back into the chamber Mitral valve prolapse affects up to 6% of population—caused by Streptococcus strain; infected patients need antibiotic treatment prior to dental surgery Stenosis may be caused by congenital heart defect of valve, rheumatic fever, with age—calcium deposit build up on valve
  4. http://www.medmovie.com/mmdatabase/MediaPlayer.aspx?ClientID=65&TopicID=
  5. NOTE: Heart muscle cells contract without nerve impulses in a regular, continuous way; the pacemaker “overrides” and sets the heart rate  
  6. Possible causes of atrial fibrillation Abnormalities or damage to the heart's structure are the most common cause of atrial fibrillation. Possible causes of atrial fibrillation include: High blood pressure Heart attacks Abnormal heart valves Heart defects you're born with (congenital) An overactive thyroid gland or other metabolic imbalance Exposure to stimulants such as medications, caffeine or tobacco, or to alcohol Sick sinus syndrome — improper functioning of the heart's natural pacemaker Emphysema or other lung diseases Previous heart surgery Viral infections Stress due to pneumonia, surgery or other illnesses Sleep apnea