contentserver__5_.pdf
Aging & Mental Health, January 2007; 11(1): 89–98
ORIGINAL ARTICLE
The relationship of optimism, pain and social support to well-being in
older adults with osteoarthritis
V. M. FERREIRA & A. M. SHERMAN
Brandeis University, Waltham, MA, US
(Received 30 August 2005; accepted 13 March 2006)
Abstract
Improving the psychological well-being of individuals with osteoarthritis (OA) is an important concern because the
condition is highly prevalent and has no known cure. Few studies have assessed the joint contribution of social, personality,
and physical factors in relation to well-being for OA patients. In a cross-sectional sample of older adults with OA (n ¼ 73,
73% female), we assessed the role of support perceptions, optimism and pain in depressive symptoms and life satisfaction.
Greater optimism and support were significantly related to both greater life satisfaction and lower depressive symptoms.
Further, optimism partially mediated the relationship of pain to life satisfaction, while support partially mediated the role of
pain in depressive symptoms. The interplay of these variables in relation to well-being is discussed in the context of chronic
illness and older adulthood.
Introduction
Many older adults (85% of those over 75) currently
experience a painful and often disabling disease,
osteoarthritis (OA), for which there is no known cure
(Sack, 1995). Osteoarthritis can negatively impact
many aspects of life, including both social and
physical functioning (Bookwala, Harralson, &
Parmalee, 2003) through pain, physical and psycho-
social limitations on valued activities, as well as
comorbid depressive symptoms (Penninx et al.,
1998). It is important to investigate factors that
relate to psychological health outcomes of OA
patients in order to better understand how to
improve well-being. As Keefe and his colleagues
suggest (Keefe & Bonk, 1999; Keefe et al., 2002),
there exists a complex interplay of symptomology,
social and psychological factors in arthritis patients.
In the following sections, we review the role of
optimism, social support, and pain as important
correlates of psychological well-being, particularly
for older adults.
Pain
The common and persistent nature of pain asso-
ciated with OA (Schumacker, 1988) may be a reason
for the variability in the well-being of OA patients
(e.g., de Vellis et al., 1986; Klinger, Spaulding,
Polatajko, MacKinnon, & Miller, 1999). Pain has a
strong relationship with many other health-
related variables in older adults with arthritis
(Roberts, Matecjyck, & Anthony, 1996). In OA
samples, greater pain is a stressor linked to lower
social support and well-being (de Vellis et al., 1986).
Pain is also associated with greater depressive
symptoms (Bookwala et al., 2003; Klinger et al.,
1999) and lower life satisfaction (Laborde & Powers,
1985) in patients with OA. However, Blixen and
Kippes (1999) present contrasting evidence showing
that pain from OA is unrelated to life sat.
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contentserver__5_.pdfAging & Mental Health, January 2007; .docx
1. contentserver__5_.pdf
Aging & Mental Health, January 2007; 11(1): 89–98
ORIGINAL ARTICLE
The relationship of optimism, pain and social support to well-
being in
older adults with osteoarthritis
V. M. FERREIRA & A. M. SHERMAN
Brandeis University, Waltham, MA, US
(Received 30 August 2005; accepted 13 March 2006)
Abstract
Improving the psychological well-being of individuals with
osteoarthritis (OA) is an important concern because the
condition is highly prevalent and has no known cure. Few
studies have assessed the joint contribution of social,
personality,
and physical factors in relation to well-being for OA patients.
In a cross-sectional sample of older adults with OA (n ¼ 73,
73% female), we assessed the role of support perceptions,
optimism and pain in depressive symptoms and life satisfaction.
Greater optimism and support were significantly related to both
greater life satisfaction and lower depressive symptoms.
Further, optimism partially mediated the relationship of pain to
life satisfaction, while support partially mediated the role of
pain in depressive symptoms. The interplay of these variables in
2. relation to well-being is discussed in the context of chronic
illness and older adulthood.
Introduction
Many older adults (85% of those over 75) currently
experience a painful and often disabling disease,
osteoarthritis (OA), for which there is no known cure
(Sack, 1995). Osteoarthritis can negatively impact
many aspects of life, including both social and
physical functioning (Bookwala, Harralson, &
Parmalee, 2003) through pain, physical and psycho-
social limitations on valued activities, as well as
comorbid depressive symptoms (Penninx et al.,
1998). It is important to investigate factors that
relate to psychological health outcomes of OA
patients in order to better understand how to
improve well-being. As Keefe and his colleagues
suggest (Keefe & Bonk, 1999; Keefe et al., 2002),
there exists a complex interplay of symptomology,
social and psychological factors in arthritis patients.
In the following sections, we review the role of
optimism, social support, and pain as important
correlates of psychological well-being, particularly
for older adults.
Pain
The common and persistent nature of pain asso-
ciated with OA (Schumacker, 1988) may be a reason
for the variability in the well-being of OA patients
(e.g., de Vellis et al., 1986; Klinger, Spaulding,
Polatajko, MacKinnon, & Miller, 1999). Pain has a
strong relationship with many other health-
related variables in older adults with arthritis
3. (Roberts, Matecjyck, & Anthony, 1996). In OA
samples, greater pain is a stressor linked to lower
social support and well-being (de Vellis et al., 1986).
Pain is also associated with greater depressive
symptoms (Bookwala et al., 2003; Klinger et al.,
1999) and lower life satisfaction (Laborde & Powers,
1985) in patients with OA. However, Blixen and
Kippes (1999) present contrasting evidence showing
that pain from OA is unrelated to life satisfaction
when social support is accounted for, suggesting that
support mediates the negative impact of pain.
Such a finding suggests that the role of psycho-
social factors in the well-being of OA patients may be
important to investigate. While the pain associated
with OA is difficult to control, often with negative
effects on well-being, understanding factors that may
serve as points of intervention would allow for a better
understanding of how to improve patients’ well-
being. Thus, in the following sections, we review
optimism and social support, two factors commonly
linked to psychological well-being outcomes such as
life satisfaction and depressive symptoms.
Optimism
Optimism, defined as an individual’s positive
outlook on life (Scheier, Carver, & Bridges, 1994),
is a dispositional (i.e., temperament) variable related
to adaptation to chronic illness (Lazarus & Folkman,
1984). Optimism is related to both improved
Correspondence: V. M. Ferreira, Brandeis University, Waltham,
MA, US. E-mail: [email protected]
ISSN 1360-7863 print/ISSN 1364-6915 online/07/010089–98 �
2007 Taylor & Francis
4. DOI: 10.1080/13607860600736166
psychosocial and physical health outcomes
(Barnwell & Kavanaugh, 1997; Brenner, Melamed,
& Panush, 1994), as well as less frequent harmful
health behaviours (i.e., frequent and excessive
drinking in college students; Harju & Bolen, 1998).
Greater optimism is also related to greater
self-reported quality of life in adult samples
(Barnwell & Kavanaugh, 1997).
Scheier and Carver (1987) argue that optimism
plays a protective role in chronic illness by promot-
ing more beneficial health outcomes, health habits,
and effective disease coping. For example, optimism
is not only associated with less severe physical
symptomology (Reker & Wong, 1985), but also
with electing to follow health-promoting practices
as well as coping in healthy, helpful ways with
chronic illness (Fournier, deRidder, & Bensing,
2002). However, the beneficial role of optimism
differs across chronic illnesses.
For example, Fournier et al. (2002) report
differing beneficial effects of optimistic beliefs on
various facets of coping with chronic diseases such as
type I diabetes, rheumatoid arthritis (RA), and
multiple sclerosis (MS) in adults. That is, in the
chronic illnesses which are controllable (type I
diabetes), or at least in part controllable (MS),
positive outcome expectancies are associated with
greater physical functioning. This is not the case
with the much less controllable illness of RA.
Further, in a study comparing patients with
5. Parkinson’s disease to those with MS, greater
optimism was related to greater physical adjustment
to disease symptoms as well as greater use of
effective coping strategies (deRidder, Scheier, &
Bensing, 2000). However, the relationship between
optimism and coping was stronger among MS
patients, compared to patients experiencing
Parkinson’s. The authors suggest the need to focus
on a specific chronic illness in understanding the role
of optimism in disease.
Fournier et al. (2002) discuss the several types of
optimism that have been established and that, when
the illness is controllable (i.e., when symptoms or
side effects can be controlled by patients’ behaviors),
positive outcome expectancies are the most bene-
ficial type of optimism for chronically ill patients.
Holding positive outcome expectancies suggests that
individuals are generally oriented towards positive
expectations of future events (Scheier & Carver,
1992). Fournier et al. (2002) discuss the benefit of
positive outcome expectancies in the cases of such
illnesses as Type I diabetes and, to some extent, RA,
because in such cases optimistic (i.e., positive
outcome) beliefs may lead to effective-self care as
well as physical and mental health. In the present
study, positive outcome expectancies were assessed.
Although OA is not necessarily controllable, the pain
experienced from OA can often be controlled
through self-management strategies such as exercise
or the use of pain medication, behaviours closely
associated with optimistic beliefs, even though the
occurrence of pain is often unpredictable (Sack,
1995), thus making positive outcome expectancies
an appropriate choice for this sample.
6. Positive outcome expectancies, also known as
dispositional optimism, are predictive of more
positive affect and less negative affect over time in
older adults (Isaacowitz & Seligman, 2002).
Optimism is also predictive of psychological well-
being. For example, greater optimism predicts less
depression three years after baseline in menopausal
women after controlling for initial depression
(Bromberger & Matthews, 1996). Dispositional
optimism is related to greater psychological well-
being in older adults, including fewer depressive
symptoms and greater life satisfaction (Peterson &
Bossio, 1991). Optimism is believed to be related
to greater psychological well-being because being
optimistic is associated with effective coping strate-
gies (e.g., Carver, Scheier, & Weintraub, 1989).
For example, optimists are more likely to use
problem-focused coping strategies (e.g., Scheier &
Carver, 1987).
In Long and Sangster’s (1993) work on optimism
and coping specifically in the context of arthritis,
greater optimism influenced the use of active
or problem-solving coping techniques, a type of
effective coping beneficial to health and well-being.
This active coping reduced negative symptoms such
as depressive symptoms in RA patients. In looking
specifically at an OA sample of older adults,
greater dispositional optimism was related to use of
pain-coping strategies more frequently, even when
level of pain was controlled (Benyamini, 2005).
However, little research currently explores the
relationship between optimism and the pain asso-
ciated with OA, especially in later life. In one study
7. that specifically addressed the role of dispositional
optimism in the physical functioning of older adults
with knee OA, Brenes and colleagues (2002) report
that optimism was positively related to task perfor-
mance in walking. However, optimism was not
related to performance in lifting objects, climbing
stairs, or getting in and out of cars in their sample.
Brenes, Rapp, and Rejeski (2002) did not explore
the role of optimism and physical factors such
as pain, or psychological well-being in their investi-
gation. These factors will be addressed in the present
study.
Stability of optimism. While optimism is considered
to be generally stable (Scheier & Carver, 1987),
Benyamini (2005) suggests that reports of optimism,
as measured by items on the LOT-R, the measure
used in the present study, may be dependent on the
time-frame and/or context within which the measure
was administered. Benyamini (2005) argues that,
in his sample of older adults experiencing OA,
optimism may be more easily influenced than with
other samples for two reasons; because participants
90 V. M. Ferreira & A. M. Sherman
are experiencing late life as well as a stressful health
context. If this is the case, it is conceivable that
perceived social support, reported to both affect and
be affected by health stressors such as physical
functioning (Reinhardt & Blieszner, 2000), may play
a role in reports of optimism. In addition, adaptation
to chronic illness (Gil, Keefe, Crisson, & Van
Dalfsen, 1987) as well as pain (de Vellis et al.,
8. 1986) may both be contextual factors affecting
reports of optimism. In an example of the less-
stable nature of optimism in chronic illness samples,
Symister and Friend (2003) report that in a sample
of end-stage renal disease patients, social support
was predictive of optimism. The role of optimism
along with other psychosocial as well as symptomol-
ogy variables such as pain in the well-being of older
adults has not yet thoroughly been investigated.
Understanding such relationships is important in
that these variables together may play a more
complex role in well-being than is currently believed
to be the case. For example, health-related interven-
tions may need to be sensitive to personality
dimensions such as optimism. In addition, beliefs
in optimistic expectancies do decrease in the context
of significant, repetitive stress (e.g., Bandura, 1988;
Carver et al., 1998) such as the disability and
persistent pain associated with OA. While not yet
thoroughly investigated, some literature does suggest
that reports of optimism may be influenced by health
context (Schulz, Tompkins, & Rau, 1988). Schulz
et al. (1988) report that in stroke victims and their
support persons, optimism scores dropped over the
six month period after the stroke. In addition,
Benyamini (2005) discusses the possibility that,
particularly in older adults, reports of optimistic
expectations may be dependent upon more short-
term contextual factors, such as the health context of
pain. While an individual’s disposition, including
optimism, is an important predictor of well-being,
so too is the social aspect of one’s life (Finch &
Graziano, 2001). Thus, social support perceptions,
one facet of social support, will be reviewed in the
following section.
9. Social support
Social support is defined as the resources perceived
as available from others in social networks
(Antonucci, 1993; Berkman, Glass, Brissette, &
Seeman, 2000; Bisconti & Bergeman, 1999).
Support involves the beneficial receipt of provisions
in relationships, including informational, emotional,
or tangible aid. Support is often assessed subjectively
as an individual’s perception of the support they
perceive as available to them. Perceptions of support
are related to health, including symptoms associated
with chronic illness, in addition to well-being
variables such as life satisfaction (Antonucci &
Knipscheer, 1990; Cummins & Nistico, 2002).
In older adults, perceived support is linked to
fewer depressive symptoms (Finch & Graziano,
2001; Russell & Cutrona, 1991) and greater life
satisfaction (Walen & Lachman, 2000). Looking
specifically at older adults with OA, social support
is associated with fewer depressive symptoms
(Sherman, 2003) as well as less arthritis pain
(Evers, Kraaimaat, Geenen, & Bijlsma, 1998).
Research also suggests that perceptions of social
support may contribute to positive well-being
(Blixen & Kippes, 1999) by positively affecting
such facets of coping as support seeking as a resource
(e.g., Scheier & Carver, 1987).
There has been some speculation about the
combined role of optimism and social support in
psychological functioning. For example, Finch and
Graziano (2001) reported that greater optimism and
social support were each uniquely related to lower
depressive symptoms in a general sample of older
10. adults. That is, more optimistic older adults, and
those reporting higher social support, reported fewer
depressive symptoms. However, physical stressors,
such as pain, have not been investigated jointly with
support and optimism in relation to well-being,
particularly for OA. This is a gap that should not
be ignored because physical stressors are strongly
related to poor psychological outcomes such as
greater depressive symptoms (e.g., Evers et al.,
1998).
We suggest that experiencing more pain may be
related to individuals’ tendencies not to view their
world in an optimistic, positive light and thus, these
individuals may report less well-being. While this
hypothesis has not yet been tested in the literature,
less pain, like greater optimism in older adults, is
associated with better psychological well-being in
OA samples (de Vellis et al., 1986). In addition,
we suggest that experiencing more pain may be
related to individuals’ tendencies not to view their
relationships as positive and supportive and thus,
these individuals may report less well-being.
Thus, in the present study, the stressor of pain,
a common symptom of OA, as well as social support
and dispositional optimism were investigated in an
effort to understand the role that these different
factors play in the depressive symptoms and life
satisfaction reported by older adults with OA.
Hypotheses
1. Greater pain is hypothesized to be associated
with less life satisfaction and greater depressive
symptoms.
11. 2. Greater optimism and social support are
expected to relate to less depressive symptoms
and greater life satisfaction after accounting
for pain.
3. Two possible mediation models will be tested.
The first will assess the role of optimism in
mediating the relationship of pain to life satisfac-
tion and depressive symptoms. The second will
Optimism, pain, social support in well-being 91
assess the role of support in mediating the
relationship of pain to life satisfaction and
depressive symptoms.
Method
Participants and procedure
Ninety-five potential participants were contacted by
telephone from a list of participants from a previous
OA study (see Ferreira & Sherman, 2006).
The original sample had been recruited through
newspaper advertisements, fliers, and recruitment
through a continuing education program for older
adults. Of the original participants, 72 older adults
(52 women and 20 men, ranging in age from 60
to 84, mean age ¼ 72.4 years) volunteered to
participate in the present study (response rate of
76%). Participants completed and returned the
mailed survey. Follow-up data were used rather
than baseline data because optimism was not
12. measured at baseline.
There were no significant demographic differences
between responders and non-responders.
Participants all resided in the greater Boston area
and spoke fluent English. The majority (92.6%) of
participants considered themselves Caucasian.
Nearly half of the participants (45.2%, n ¼ 33)
were married, 27.4% (n ¼ 20) were widowed, and
26% (n ¼ 19) were single, divorced or separated. See
Table I for additional demographic information.
There were no significant differences in depressive
symptoms (t ¼ �0.80, ns) or pain (t ¼ 1.28, ns) in
those who did or did not respond.
Measures
Optimism was assessed using the Life Orientation
Test-Revised (LOT-R; Scheier, Carver, & Bridges,
1994), which examines outcome expectancies. The
measure consists of 12 items, including four filler
items not included in the analyses, for a total of
eight items. Great debate has surrounded the use of
the LOT in its entirety as a measure of optimism
(with negatively worded items being reverse coded)
or as a measure of both optimism and pessimism
(with two subscales being conceptualized as separate
constructs. While Scheier and Carver (1987) have
suggested the scale may be used as a bipolar
measure, research has suggested that optimism and
pessimism are very different constructs (e.g., Brenes,
Rapp, Rejeski, & Miller, 2002; Lai, 1994; Marshall,
Wortman, Kusulas, Hervig, & Vickers, 1992). In
light of this controversy, the four positively worded
items assessing optimism were used. Response
13. options utilized a five-point Likert scale. Higher
scores indicate greater optimism (M ¼ 13.26,
SD ¼ 2.89, high score ¼ 20). Reliability was 0.76
with this sample.
Social support was assessed using the Medical
Outcomes Study (MOS) Social Support Survey
(Sherbourne & Stewart, 1991) which examines
perceived social support (M ¼ 65.06, SD ¼ 18.44,
high score ¼ 95). Higher scores indicate greater
perceived support. Sherbourne & Stewart (1991)
report high internal consistency (Cronbach’s
alpha ¼ 0.97), which was replicated in this sample
(Cronbach’s alpha ¼ 0.97).
Pain was assessed using the pain subscale of the
Medical Outcomes Study (MOS) 36-item short-
form survey (SF-36; Ware & Sherbourne, 1992).
The SF-36 includes self-report items of health
perceptions, physical functioning, role limitations
and pain. The pain subscale includes two items,
which are summed so that a higher score indicates
more pain (M ¼ 5.85, SD ¼ 1.91, high score ¼ 10).
Depressive symptoms were assessed using the
20-item Centre for Epidemiological Studies
Depression scale (CES-D; Radloff, 1977).
The CES-D includes 20 items assessing emotional
(‘I could not stop crying’) and somatic symptoms
(‘I had trouble sleeping’) characteristic of depressed
mood. Response options are on a four-point Likert
type scale with possible responses ranging from
‘all of the time’ to ‘rarely’ (M ¼ 26.25, SD ¼ 8.8,
high score ¼ 40). Reliability was 0.84 with this
sample. Higher scores indicate more depressive
symptomatology.
14. Life satisfaction was assessed with the Life
Satisfaction Index (LSI; Neugarten, Havinghurst, &
Tobin, 1961). The scale consists of 13 items using a
five-point Likert-type format for response options
(M ¼ 41.31, SD ¼ 10.14, high score ¼ 61). A higher
score means more life satisfaction. Reliability was
0.89 with this sample.
Data analysis
In order to investigate the role of pain, optimism and
perceived social support in depressive symptoms and
life satisfaction, hierarchical multiple regression
analyses were conducted. In the first step of each
Table I. Demographic characteristics, n ¼ 73.
No. (%)
Marital status
Married 33 (45.2)
Widowed 20 (27.4)
Single/divorced/separated 19 (26.0)
No response 1 (1.4)
Education
Bachelor’s degree or greater 42 (57.5)
Some college 13 (17.8)
Associate’s degree 4 (5.5)
High school diploma or less 10 (13.7)
No response 4 (5.5)
Income (annual)
�20,000 23 (31.5)
>20,001 48 (65.8)
15. No response 2 (2.7)
92 V. M. Ferreira & A. M. Sherman
regression, age was entered. In the second step for
each regression, pain was entered.
To assess the potentially mediating roles of
optimism and support to pain, two multiple regres-
sion models were developed. In these two regression
analyses, life satisfaction and depressive symptoms
were each assessed as an outcome. In each of these
models, after age and pain were entered in steps one
and two, support was entered at the third step of
the model, followed by optimism at the fourth step.
This model investigated the role of either optimism
or support as mediators of pain in relation to the
outcomes (see Figure 1).
In order to assess the role of either support or
optimism as a mediator of pain, three aspects to the
mediation model must be assessed (Baron & Kenny,
1986). In the first leg of the model, the association of
pain to the outcome must be significant. Next, pain
must significantly predict the mediator (support or
optimism). Finally, in the third leg of the model,
the relationship of pain to the outcome must be
reduced to non-significance once the mediator
(support or optimism) is entered into the model.
Only when all three of these criteria are met
will mediation be demonstrated (see Figure 1;
Baron & Kenny, 1986). Follow-up Sobel tests will
then be conducted to test for partial mediation
16. (Preacher & Leonardelli, 2003).
Results
Bivariate analyses
Correlations between the variables measured in the
present study are reported in Table II. Gender,
marital status, and income were excluded from
further multivariate analyses to conserve power
because they were not related to any of the other
measures. Age was used as a control variable because
older age was correlated with lower life satisfaction.
Pain was significantly correlated with greater depres-
sive symptoms and less life satisfaction. Support
and optimism were both significantly correlated
with fewer depressive symptoms and greater life
satisfaction.
Multivariate analyses
Life satisfaction. In the first hierarchical multiple
regression model with life satisfaction as an outcome,
(a)
(b)
Pain
Social support
Depressive symptoms
Life satisfaction
Pain
17. Optimism
Depressive symptoms
Life satisfaction
Figure 1. (a) Role of optimism as a mediator; (b) Role of social
support as a mediator.
Table II. Correlations of measures.
1 2 3 4 5 6 7 8 9
Age – �0.12 0.04 �0.04 0.14 �0.14 �0.04 0.10 �0.29*
Gender – – �0.13 0.09 �0.17 0.03 0.01 0.02 �0.09
Income – – – �0.18 �0.06 0.08 0.10 �0.16 0.12
Marital status – – – – �0.01 �0.14 0.01 0.22 0.03
Pain – – – – – �0.28* �0.30* 0.43** �0.46**
Social support – – – – – – 0.07 �0.44** 0.41**
Optimism – – – – – – – �0.53** 0.64**
Depressive symptoms – – – – – – – – �0.64**
Life satisfaction – – – – – – – – –
*p50.05; **p50.01.
Optimism, pain, social support in well-being 93
we assessed the role of pain, perceptions of social
support, and optimism, with optimism as a possible
mediator of the relationship of pain to life
satisfaction. The final model was significant
(F (4,63) ¼ 20.13, p50.01, adjusted R2 ¼ 0.53;
see Table III). Greater age was significantly related
to higher life satisfaction at the first step and
18. throughout the model (R2 ¼ 0.08, F (1,66) ¼ 5.36,
p50.05). In the second step, less pain was related to
greater life satisfaction (�R2 ¼ 0.12, F (1,65) ¼ 9.69,
p50.01). Perceived social support explained addi-
tional variance (�R2 ¼ 0.06, F (1,64) ¼ 4.98,
p50.01) when entered at the third step. Greater
support was related to more life satisfaction, while
pain remained significant. Support remained sig-
nificant at the fourth step (t ¼ 2.75, p50.01).
However, the relationship of pain to life satisfaction
was reduced to non-significance once optimism was
entered in the fourth step of the model (t ¼ 1.46, ns).
Greater optimism was significantly related
to life satisfaction at this step (�R2 ¼ 0.31,
F (1,63) ¼ 45.08, p50.01). This model suggests
that optimism should be tested as a partial mediator
of pain (Baron & Kenny, 1986). The relationship of
pain as a predictor of optimism was significant
(F (1, 70) ¼ 7.69, p50.01, adjusted R2 ¼ 0.09). This
finding suggests that pain may be partially mediated
by optimism in relation to life satisfaction. A
mediation analysis was conducted assessing opti-
mism as a mediator of pain. The Sobel mediation
test was significant (t ¼ �2.54, p ¼ 0.01), suggesting
that optimism does partially mediate the relationship
of pain to life satisfaction (Preacher & Leonardelli,
2003). Full mediation is not demonstrated because
the beta values were not reduced to zero (Baron &
Kenny, 1986). There was no evidence that support
mediated pain in the analysis.
Depressive symptoms. In the hierarchical multiple
regression model assessing the role of optimism, pain
and support in their relationship to depressive
symptoms, we assessed the possible role of optimism
19. as a mediator of pain. The final model was
significant (F (4,62) ¼ 14.68, p50.01, adjusted
R
2
¼ 0.45; see Table IV). Age was not significantly
related to depressive symptoms at the first step, or
throughout the model. In the second step, more pain
was related to greater depressive symptoms
(�R2 ¼ 0.16, F (1,64) ¼ 12.13, p50.01). Perceived
social support explained additional variance
(�R2 ¼ 0.12, F (1,63) ¼ 10.85, p50.01) when
entered at the third step. Less support was related
to greater depressive symptoms, while pain remained
significant though was reduced in its statistical
relationship. The relationship of pain to depression
was reduced to non-significance once optimism was
entered in the fourth step of the model, where lower
optimism and support were both related to higher
depressive symptoms (�R2 ¼ 0.45, F (1,62) ¼ 24.06,
p50.01). This model suggests that both optimism
and pain should be tested as possible mediators of
pain in relation to depressive symptoms (Baron &
Kenny, 1986).
Table III. Summary of hierarchical regression analysis for life
satisfaction showing optimism as a mediator (n ¼ 70).
1 2 3 4
Step B SE B � B SE B � B SE B � B SE B �
Age 0.46 0.20 0.27* 0.37 0.19 0.22* 0.34 0.14 0.20* 0.33 0.14
0.20*
Pain – – – �1.62 0.52 �0.35** �1.34 0.52 �0.29* �0.61 0.42
20. �0.13
Support – – – – – – 0.13 0.06 0.25* 0.12 0.05 0.24**
Optimism – – – – – – – – – 1.93 0.29 0.58**
Adjusted R2 – – – 0.06* – – – 0.17** – – – 0.22* – – – 0.53**
*p50.05; **p50.01.
Table IV. Summary of hierarchical regression analysis for
depressive symptoms showing optimism as a mediator (n ¼ 70).
1 2 3 4
Step B SE B � B SE B � B SE B � B SE B �
Age �0.12 0.19 �0.08 �0.30 0.18 �0.02 0.02 0.17 0.01 0.02
0.14 0.01
Pain – – – 1.74 0.50 0.40** 1.35 0.48 0.31 0.81 0.43 0.19
Support – – – – – – �0.18 0.05 �0.36** �0.17 0.05 �0.35**
Optimism – – – – – – – – – �1.45 0.30 �0.46**
Adjusted R2 – – – 0.01* – – – 0.14** – – – 0.25* – – – 0.45**
*p50.05; **p50.01.
94 V. M. Ferreira & A. M. Sherman
Support as a mediator. The relationship of pain to
support was significant (F (1, 70) ¼ 5.16, p50.05,
adjusted R2 ¼ 0.06). Finally, because the first two
legs of the mediation model were significant, a Sobel
test was used to assess the final leg of the mediation
model. The mediation test was significant (t ¼ 1.98,
p ¼ 0.05). This finding suggests that pain is partially
mediated by support in relation to depressive
symptoms. There was no evidence that optimism
21. mediated pain in this analysis.
Optimism as a mediator. The relationship of pain
to optimism was assessed to be significant
(F (1, 70) ¼ 7.69, p50.01, adjusted R2 ¼ 0.09).
As was done in the previous analysis, because
the first two legs of the mediation model were
significant, a Sobel test was used to assess the final
leg of the mediation model. The mediation test was
not significant (t ¼ 0.06, ns). This finding suggests
that pain is not mediated by optimism in relation to
depressive symptoms.
Discussion
In the present study, we investigated the role of
social relations, optimism and the common symp-
tom of pain in the well-being of older adults
experiencing OA. The findings suggest that pain,
social support and optimism, are related in complex
ways for this sample. Furthermore, these findings
suggest that these factors relate in unique ways
depending upon the outcome being investigated.
Life satisfaction
In investigating life satisfaction, pain was partially
mediated by optimism, while support was indepen-
dently related to life satisfaction. These results
suggest that optimism is partially responsible for
the relationship between pain and life satisfaction,
possibly by negatively influencing the optimistic
outlook that is associated with life satisfaction. This
finding that optimism partially mediated pain has
important implications for our understanding of the
process by which pain is related to psychological
22. well-being (Bookwala et al., 2003; Klinger et al.,
1999; Labourde & Powers, 1985; Robert et al.,
1996). An optimistic disposition appears to at least
be partially diminished by reports of pain, a
contextual factor which OA patients may struggle
with on a daily basis through the rest of their lives
(Schumacker, 1988). As discussed previously in our
literature review, although considered to be generally
stable (Scheier & Carver, 1987), research suggests
that optimism may be dependent upon the context
within which it was assessed (Benyamini, 2005).
Optimism may be salient for well-being in older
adults because, similar to personality constructs such
as hardiness (Wallace, Bisconti, & Bergeman, 2001),
an optimistic personality may act as a resource in
helping older adults to compensate for other losses in
resources as they age (Baltes, 1996).
Support did not mediate the relationship of pain
to life satisfaction. Instead, support was directly
linked to this outcome. This finding is consistent
with much research suggesting the strong relation-
ship of support to greater well-being (e.g., Cummins
& Nistico, 2002; Russell & Cutrona, 1991; Walen &
Lachman, 2000). As discussed in the introduction,
support has been demonstrated to play an important
role in both physical health as well as well-being
(Antonucci & Knipscheer, 1990; Cummins &
Nistico, 2002).
Depressive symptoms
In contrast to the findings for life satisfaction, for
depressive symptoms, there was no evidence of
mediation of pain by optimism. However, support
23. partially mediated pain in relation to depressive
symptoms. That is, the relationship of greater pain to
greater depressive symptoms appears to at least in
part be accounted for by the relationship of less
support to greater depressive symptoms where older
adults experiencing more pain may perceive their
social networks as less supportive and thus, report
greater depressive symptoms.
This mediational role of perceived support con-
tributes support to the work of Antonucci, Langfahl,
and Akiyama (2004) who suggest that new research
should investigate predictors of support perceptions
as many contextual factors may play a role in
perceptions of social relations. In the case of our
findings, the context of consistent pain associated
with OA is demonstrated as a contextual fact playing
a role in support perceptions.
Support seems to be a powerful resource for this
sample, with pain working indirectly through sup-
port to influence depressive symptoms. This finding
is consistent with a wealth of research suggesting not
only that perceived social support cyclically affects
and is affected by health stressors (e.g., Gil et al.,
1987; Reinhardt & Blieszner, 2000), but also that
social support plays a complex role in the relation-
ship of health variables to psychological well-being
outcomes (e.g., Bisconti & Bergeman, 1999).
In summary, in this sample, optimism partially
mediated pain perceptions in relation to life satisfac-
tion while support partially mediated pain percep-
tions in relation to depressive symptoms. Taken
together, the findings of the present study are
difficult to explain. Why does optimism play a
24. mediational role in the relationship of pain to life
satisfaction while support mediates the relationship
of pain to depressive symptoms? The reasons remain
unclear. Follow-up analyses with different samples
of older adults experiencing OA are necessary for
two reasons. First, such analyses would either
replicate or refute these findings. And second, if
the present findings are supported, differences in the
Optimism, pain, social support in well-being 95
sample may shed light on the mechanisms by which
these unique and interesting findings have occurred.
Longitudinal, as opposed to the cross-sectional data
used in the present study, are suggested in order to
provide a more rigorous test of mediation in follow-
up research. In addition to these limitations, other
limitations to the present study do exist, a few of
which will be highlighted next.
Limitations and future research
The small, non-random nature of our sample may
result in somewhat limited generalizability.
Replication of this study with a more representative
sample may provide stronger statistical evidence for
the role of support and optimism as mediators of
pain in well-being in samples of older adults
with OA. However, our demonstration of
significant patterns of association in such a small
sample indicates that the interplay of these
variables should be a fruitful arena for further
investigation.
25. In addition, the self-report nature of the measures
means that shared method variance could be a
problem. Future research could replicate this study
with additional observed measures of physical
functioning in order to assess the role of physical
impairment and symptoms in well-being while still
taking into account personality and social relations
factors.
In addition, the findings suggest that future
research might examine whether other health related
stressors such as physical limitations, account for
more of the variance in well-being than pain. In this
way, the physical symptoms of OA might be better
understood in terms of how they affect the overall
experience of the patient.
Additional suggestions for future research include
investigating the role of other dispositional variables
in the well-being outcomes of OA patients, in an
effort to provide insight into how to better improve
the well-being of individuals suffering from pain.
For example, the personality variable of hardiness is
negatively linked to both self-reported and objective
measures of health in older adults (Wallace et al.,
2001). This may indicate the importance of person-
ality as a resource that allows older adults to
compensate for losses and changes as they age
(Baltes, 1996). Finally, longitudinal work is sug-
gested to look at the significance of all three areas of
life (social, personality, and physical) in their
relationships to well-being. As mentioned above,
optimism and support may be a powerful factor in
contributing to well-being due to its value in
compensating for other losses in later life.
26. Interventions
Although follow-up research is necessary, the pre-
sent findings lead us to suggest further research into
two approaches to intervention aimed at improving
the well-being of older adults experiencing OA.
While pain is a symptom of OA that is difficult to
control entirely, our findings of support acting as a
mediator of pain to depressive symptoms and of
optimism mediating the role of pain in life satisfac-
tion suggests that focusing on these two psychosocial
facets may be an efficacious way to approach
intervention strategies. For example, a focus
might be placed on working with OA patients and
their partners or close family members to strengthen
relationships as well as raise awareness in the
patient of the social support available to them.
Zautra, Hamilton, and Yocum (2000) report that,
in their sample of older women experiencing
rheumatoid arthritis, interventions designed to
enhance social engagement not only improved
psychological well-being immediately, but also
increased illness coping capacity when assessed
four months later. In addition, interventions might
focus on increasing positive outcome expectancies, a
psychosocial factor considered to be less stable in
samples experiencing a chronic condition
(Benyamini, 2005).
Conclusion
In summary, our results indicate that pain has a
complex relationship with facets of well-being, both
life satisfaction and freedom from depressive symp-
toms, in older adults experiencing OA. That is, the
27. effect of pain on perceptions of well-being is
influenced by both personality and social relations
variables. Being optimistic appears to mediate the
relationship of pain in life satisfaction while support
appears to mediate pain in relation to depressive
symptoms. While the mediational role of support in
health context and well-being relationships is well-
documented, the mediational role of optimism is
much more recent. Thus, investigation of these
findings in additional samples of older adults
experiencing OA, as well as other chronic illness
samples is suggested in order to better understand
these findings.
This is one of the only studies to look at the role of
support, pain, and optimism together in an OA
sample. This investigation has afforded us some
insight into some aspects of life that allow older
adults to maintain a sense of well-being in the face
of the challenging disease of OA. Although all
three variables had been established as individually
important to well-being, the contribution of the
present results lies in showing the importance
of both optimism and support in well-being
independent of other factors, as well as serving as a
mediator of physical factors in relation to depressive
symptoms and life satisfaction. We have demon-
strated the joint contribution of both positive social
relationships as well as a positive outlook on life
96 V. M. Ferreira & A. M. Sherman
in contributing to the well-being of older adults
with OA.
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98 V. M. Ferreira & A. M. Sherman
contentserver__4_.pdf
36. The Relationships among Hope, Pain, Psychological
Distress, and Spiritual Well-Being in Oncology Outpatients
Blake Rawdin, MD, MPH,
1
Carrie Evans, MA,
2
and Michael W. Rabow, MD
3
Abstract
Objective: Limited research in Taiwan and Europe suggest that
hope is inversely correlated with certain di-
mensions of the pain experience. However, the relationship
between hope and pain among oncology out-
patients in the United States has not been evaluated. The aims
of this study were to investigate the relationship
between hope and cancer pain, after accounting for key
psychological, demographic, and clinical characteristics.
Design: We enrolled a convenience sample of 78 patients who
were receiving concurrent oncologic and
symptom-focused care in a comprehensive cancer center. Patient
demographic and clinical information was
obtained from patient report and medical record review. Patients
completed the Herth Hope Index, the Brief
Pain Inventory, the Hospital Anxiety and Depression Scale, and
the Steinhauser Spiritual Concern Probe.
Results: Levels of hope were not associated with age, gender, or
the presence of metastatic disease. Herth Hope
Index scores were negatively correlated with average pain
intensity (p = 0.02), worst pain intensity (p < 0.01),
pain interference with function (p < 0.05), anxiety (p < 0.01),
37. and depression (p < 0.01), and were positively cor-
related with spiritual well-being scores (p < 0.01). However,
after controlling for depression and spiritual well-
being with regression analysis, the relationship between pain
intensity and hope was no longer significant.
Conclusions: While an association exists between the patients’
experience of pain and levels of hope in this
study, adjustment for depression and spiritual well being
eliminates the relationship initially observed.
Although the causal relationships have yet to be determined, in
our study hope had a stronger connection to
psycho-spiritual factors, than to pain experiences or severity.
Introduction
Maintaining hope in the face of serious illness has longbeen a
goal of patients, families, and clinicians. How-
ever, relatively little is known about the factors that sustain
hope.1,2 Even so, hope is a key clinical and perhaps thera-
peutic variable, affecting cancer patients’ adjustment and
coping skills, overall well-being, immune function, and
quality of life.3–10 Conversely, lack of hope and hopelessness
is associated with physical illness, depression, and wish to
hasten death.11,12 Therefore, developing greater understand-
ing of the demographic and clinical factors that might be as-
sociated with or influence a patient’s degree of hope could
lead to strategies to identify patients at higher risk for hope-
lessness or factors that could be targeted by interventions to
improve hope and coping with cancer.
Defining and operationalizing hope is a complex endeavor
as the term has many different interpretations, meanings, and
usages. Qualitative investigations of hope within nursing lit-
erature have helped describe and define the concept in terms
of its sources, attributes, and goals. According to the
38. conceptual model developed by Dufault and Martocchio,
hope is a ‘‘multidimensional dynamic life force characterized
by
a confident yet uncertain expectation of achieving a future good
which, to the hoping person, is realistically possible and
personally significant.’’ Furthermore, hope is described as a
‘‘complex of many thoughts, feelings, and actions that change
with time.’’ Based on extensive research, Dufault and Mar-
tocchio conceptualized hope as composed of two spheres,
‘‘generalized hope’’ and ‘‘particularized hope,’’ each consist-
ing of six shared dimensions: cognitive, temporal, affective,
behavioral, affiliative, and contextual.13
As described in reviews by Butt14 and by Chi,15 a number of
studies have investigated the role of hope in different popu-
lations of cancer patients using qualitative and/or quantita-
tive methods. Various instruments have been used to measure
hope, most common of which is the Hearth Hope Scale and its
more concise counterpart, the Herth Hope Index (HHI). Of the
1Department of Psychiatry, 2School of Nursing, 3Division of
General Internal Medicine, University of California, San
Francisco, San Francisco,
California.
Accepted September 21, 2012.
JOURNAL OF PALLIATIVE MEDICINE
Volume 16, Number 2, 2013
ª Mary Ann Liebert, Inc.
DOI: 10.1089/jpm.2012.0223
167
39. studies that have quantitatively assessed the relationship be-
tween hope and cancer pain, findings have varied.16–21 Some
research has evidenced direct negative correlations between
pain severity and hope.16,18,22 Other studies, however, show
no significant direct correlations between hope scores and
pain intensity or duration.17,20 For example, a cross-sectional
study of hospitalized cancer patients in Norway found HHI
scores correlated negatively with several of the interference
items on the Brief Pain Inventory (BPI), but not with pain
severity per se.20 A study investigating the association be-
tween pain and hope levels in hospitalized Taiwanese cancer
patients concluded that HHI scores did not differ between
patients with and without cancer pain. However, among
those patients with pain, hope levels correlated with patients’
beliefs about their pain symptoms rather than the pain itself
(i.e., pain duration, intensity, and relief ), suggesting that
cognitive and emotional processing may mediate the rela-
tionship between pain and hope.17
To our knowledge, none of the studies focused on hope and
pain levels to date have included metrics of both psycholog-
ical and spiritual well-being. According to Chochinov and
others, spirituality can play a significant role in maintaining
hope, and it has been recognized by the Institute of Medicine
as an important aspect of supportive care at end of life.22–25
Research has also provided empirical support for the hy-
pothesis that spiritual well-being might help to bolster psy-
chological functioning and adjustment to illness.15,26–28
Because the prior literature has delivered inconsistent re-
sults and primarily focused on inpatients, the goal of this
study was to examine the relationship between pain and hope
among oncologic outpatients, while also controlling for psy-
cho-spiritual factors and other potentially significant clinical
and demographic variables. It was also important to evaluate
40. the relationship between hope and pain among patients in the
US, because prior published studies were set in Europe and
Asia.
Methods
Patients and setting
Patients (n = 78) were recruited from the Symptom Man-
agement Service (SMS), an oncologic outpatient consultation
service at the University of California, San Francisco (UCSF)
Helen Diller Family Comprehensive Cancer Center. Patients
were included if they were able to complete surveys in En-
glish, able to provide informed consent, were >18 years of
age, and had a diagnosis of cancer. Patients with diagnoses of
dementia or psychosis were excluded. Institutional Review
Board approval was received before data collection began.
Medical records were reviewed to confirm cancer diagnoses
and to investigate the presence of metastatic disease.
Study instruments
Patients were recruited in the SMS clinic waiting area. After
obtaining written informed consent, patients completed a
demographic questionnaire, the HHI, BPI, Hospital Anxiety
and Depression Scale (HADS), and Steinhauser Spiritual
Concern Probe (SSCP). We selected these measures based on
the frequency of their use in the literature, ease of adminis-
tration, and construct validity and internal consistency
ratings.
The HHI is a 12-item score questionnaire that uses a 4-point
Likert scale to assess level of hope.29 The HHI, developed in
the oncology setting to operationalize and quantify hope for
research and clinical purposes, is based upon Dufault and
Martocchio’s conceptual framework of hope. Through psy-
41. chometric validation studies using factor analysis, Herth suc-
cessfully identified three subscales—temporality and future,
positive readiness and expectancy, and interconnectedness.
These three subscales correspond to the cognitive-temporal,
affective-behavioral, and affiliative-contextual dimensions
elucidated in the Dufault and Martocchio model.13 Total
HHI score ranges from 12 to 48 with higher scores corre-
sponding to higher levels of hope. Overall scores provide a
validated and reliable measure of global hope for cancer pa-
tients with an alpha coefficient of 0.97 and a reliability coeffi-
cient of 0.91.29
The BPI is a valid and reliable scale for assessing both pain
intensity and pain interference with daily activities, using an
11-item questionnaire.30 The first part consists of four ques-
tions that addresses pain severity (where zero refers to ‘‘no
pain’’ and 10 to pain as ‘‘bad as you can imagine’’), whereas
the second part asks about pain interference with seven as-
pects of function (where zero refers to ‘‘does not interfere’’ and
10 to ‘‘completely interferes’’). The questionnaire in our study
was based on pain experienced over the past week, as in the
long version of the BPI.
The HADS is a tool designed for physically ill patients to
measure anxiety and depression. It avoids reliance on the
physical symptoms of psychiatric disease that result from the
physical illness itself. This 14-item scale has been widely
validated for use with cancer patients.31
The SSCP uses a 5-point Likert scale to evaluate a patient’s
sense of spiritual well-being by asking to what degree the
patient feels ‘‘at peace.’’ Higher scores signify greater spiritual
well-being. It has been validated as a screen for spiritual
distress, associated with both religious and meaning-making
elements of spirituality.32
42. Statistical analysis
Data analyses were conducted using SPSS for Mac Release
20.0.0 (SPSS, Inc., Chicago, IL). Descriptive statistics were
generated to assess the sample in terms of demographics and
clinical characteristics. Pearson’s product moment correla-
tions between levels of hope and cancer pain intensity, anxi-
ety, depression, spiritual well-being, and demographic
variables were determined. Based on the patient sample size,
the study achieved power to detect a moderate correlation
(r = 0.25–0.30) at 80% power.33 All tests were two-tailed with
an alpha = 0.05.
A multivariate linear regression model was constructed to
evaluate the effects of potential confounders that might sys-
tematically bias the association found between pain intensity
and HHI scores in the univariate analysis. Each of the vari-
ables of interest had skewness values less than twice their
standard errors, consistent with normal distributions. Hence,
we proceeded with parametric analyses. The dependent var-
iable in the model was HHI score. The predictors were se-
lected by including demographic and clinical variables
deemed important a priori (i.e., age, gender, education, mar-
ital status, religion, and the presence of metastatic disease),
then clinical predictor variables most highly correlated in the
168 RAWDIN ET AL.
univariate correlational analyses (HADS scores, SSCP score,
worst pain in the last week, and pain interference with mood
and function). Multicollinearity was assessed for these vari-
ables with the use of correlation matrices and variance infla-
tion factors, as well as the possibility of interaction between
pain variables included in the model and depression scores.
43. The final model for the sake of parsimony retained only those
factors found to be statistically significant predictors with a p
value of < 0.05. An overall goodness of fit of the regression
model was calculated.
Results
Patient enrollment
From a convenience sample of SMS patients, 95 patients
were approached to participate and 78 (82%) agreed to par-
ticipate, provided written informed consent, and completed
the questionnaires. Eleven patients (12%) were not enrolled in
the study because they either did not meet the inclusion cri-
teria (n = 4) or declined to participate (n = 7). In addition, six
surveys (6%) were not included in the sample because the
questionnaire was inadequately completed, whether due to
inadvertent omission of key survey elements (n = 2), patients’
time constraints (n = 2), or the patients’ feeling ‘‘too ill’’ to
continue (n = 2). Of the seven patients (7%) who declined to
participate, four did so out of concerns about privacy and/or
reluctance to participate in research more generally. The other
three cited feeling ‘‘too ill’’ or ‘‘too stressed-out.’’
Demographic characteristics
The sample consisted of 64% women and 36% men with a
mean age of 57.6 years (standard deviation [SD] = 13.0)
(Table 1). Nearly 60% of the sample patients were between
the ages of 40 and 64; 32% were ‡ 65 years of age and 9%
were < 40. Representative of the SMS patient population,
69.2% of patients self-identified as white, 10.3% African
American, and 7.7% Asian. The sample patients were highly
educated with 83% having completed college or graduate
school. Over half (52.6%) of the sample patients were mar-
44. ried or partnered. In terms of religious affiliation, 37.2%
identified as Christian, 14.1% as Jewish, 11.5% as Buddhist,
7.7% as other (usually denoted as ‘‘spiritual’’ by patients),
and 29.5% as ‘‘none.’’
Clinical characteristics
The three most common cancer diagnoses were breast
(28.2%), gynecologic (16.7%), and prostate (15.4%), which is
reflective of the proportions within the SMS at large. Two-
thirds of the patients (66.7%) had metastatic disease.
The majority (87.2%) of the sample patients had pain due to
the cancer or its treatment. The mean pain score among those
with pain over the past week was 3.4 (SD = 2.5) (Table 2). The
mean level of pain at the time of the survey and at its worst
was 2.8 (SD = 2.7) and 4.7 (SD = 3.4), respectively. The mean
total HHI score was 38.2 (SD = 5.09). The mean level of spiri-
tual well-being was 3.3 (SD = 1.01).
Patients had a mean score of 14.3 on the HADS (SD = 6.3)
with 6.6 on the depression subscale (SD = 3.5) and 7.7 on the
anxiety subscale (SD = 3.8). Nearly 50% of patients had scores
in the normal range on the HADS anxiety subscale, 28% had
borderline scores, and 23% had abnormal scores (Table 3). On
the HADS depression subscale, 56% of patients had levels in
the normal range, 31% of patients scored in the borderline
range, and 12% in the abnormal range.
Associations between levels of hope
and demographics, clinical characteristics,
symptoms, and spiritual well-being scores
Among the demographic variables (i.e., age, gender, eth-
nicity, marital status, religion, and education level), only ed-
ucation level showed a significant univariate correlation with
45. HHI scores (Table 3). Higher education level was associated
with higher HHI scores (r = 0.26, p = 0.02). HHI was not as-
sociated with the presence of metastatic disease.
Among pain variables, total HHI scores were negatively
correlated with ratings of worst pain over the last week (r =
- 0.28, p = 0.01), average pain over the last week (r = - 0.27,
p = 0.01), and with all BPI pain interference items except level
Table 1. Descriptive Data for the Sample
Characteristic n %
Gender
Women 50 64.10%
Men 28 35.90%
Education
Middle school 1 1.28%
High school 12 15.38%
College 39 50.00%
Graduate degree 26 33.33%
Marital Status
Single 37 47.44%
Married/partnered 41 52.56%
Religion
Buddhist 9 11.54%
Christian 29 37.18%
Jewish 11 14.10%
Hindu 0 0%
Muslim 0 0%
None 23 29.49%
Other 6 7.69%
46. Primary Cancer
Brain 3 3.85%
Breast 22 28.21%
Gastrointestinal 3 3.85%
Gynecologic 13 16.67%
Head/Neck 8 10.26%
Hematologic 2 2.56%
Lung 5 6.41%
Other 5 6.41%
Prostate 12 15.38%
Urological 5 6.41%
Age
age < 40 7 8.97%
age 40-64 46 58.97%
age 65 + 25 32.05%
Metastatic Disease
No 26 33.33%
Yes 52 66.67%
Ever Had Pain Related
to Present Illness?
No 10 12.82%
Yes 68 87.18%
HOPE, PAIN, DISTRESS, AND SPIRITUAL WELL-BEING IN
ONCOLOGY OUTPATIENTS 169
of interference with relationships: work (r = - 0.23, p = 0.04),
sleep (r = - 0.25, p = 0.03), enjoyment (r = - 0.25, p = 0.02),
ability to walk (r = - 0.28, p = 0.01), mood (r = - 0.33, p =
0.004),
and general function (r = - 0.28, p = 0.01).
47. Depression and anxiety each were negatively correlated
and spiritual well-being positively correlated with total HHI
scores with correlations of - 0.56, - 0.48, and 0.52, respec-
tively, each with p values of < 0.001.
The multivariate linear regression models constructed to
predict HHI score (Table 4) indicate that spiritual well-being
scores and depression scores were statistically significant
predictors of hope. In the final model (Table 4B) SSCP score
had a b coefficient of 1.55 ( p < 0.01), and HADS depression
score had a b coefficient of - 0.63 ( p < 0.01). The overall ad-
justed R2 for the model was 0.38, p < 0.001. Pain intensity, BPI
functional interference scores, gender, education, marital
status, religious affiliation, metastatic disease, and HADS
anxiety scores though initially included in the model were
ultimately not statistically significant, and hence not retained
in the final regression model. Of note, there were no signifi-
cant multiplicative interactions found between pain severity
scores and HADS depression scores.
Discussion
This study is unique in that it is one of the few to examine
the relationship between hope and pain among cancer out-
patients in the United States, and to our knowledge, the only
one of these to also consider spirituality. We also utilized
multivariate linear regression to assess confounding by vari-
ous demographic and clinical factors. We found that symp-
toms of depression and spiritual well-being independently
predicted levels of hope, eclipsing the univariate correlation
between pain severity and hope initially observed.
The pain and levels of hope found in this study are similar
to those found in prior literature, which suggests some degree
48. of generalizability. The mean hope level found in this study’s
patient population was in the upper range but comparable to
those found in other studies with HHI scores ranging between
32.5 and 39.17–20,34–36 The average pain score in the study
population was also well within the range found in other
Table 2. Scores for Pain, Hope, Depression,
Anxiety, and Spiritual Well-Being
N Mean SD Min Max
BPI
Average Pain Over
the Last Week
78 3.38 2.45 0 9
Current Level of Pain 78 2.79 2.68 0 9
Worst Pain in Last Week 78 4.67 3.35 0 10
HHI 78 38.22 5.09 28 48
SSCP 77 3.32 1.01 1 5
HADS (Total Score) 77 14.28 6.33 2 31
HADS - Depression Subscale* 77 7.66 3.84 0 15
HADS - Anxiety Subscale* 77 6.62 3.5 1 16
*HADS subscale scores between 0 and 7 is ‘‘normal,’’ 8–10 is
‘‘borderline abnormal,’’ and 11–21 is ‘‘abnormal.’’
Table 3. Univariate Correlations with HHI
r p-value* n
Demographics
49. Married 0.14 0.24 78
Higher Educational Level 0.26 0.02 78
Male Gender 0.06 0.60 78
Age 0.09 0.42 78
Clinical Characteristics
Metastatic Cancer 0.10 0.38 78
Presence of pain due to cancer - 0.01 0.91 78
Worst pain over last 1 week - 0.28 0.01 78
Average pain over last 1 week - 0.27 0.01 78
Pain right now - 0.2 0.08 78
Pain Interference With Function
Work - 0.23 0.04 78
Relationships - 0.20 0.08 78
Sleep - 0.25 0.03 78
Enjoyment - 0.25 0.02 78
Ability to Walk - 0.28 0.01 78
Mood - 0.33 < 0.01 77
General Function - 0.28 0.01 78
HADS (Total Score) - 0.62 <0.01 78
Depression subscale - 0.56 <0.01 77
Anxiety subscale - 0.48 <0.01 77
SSCP 0.52 <0.01 77
*Bold indicates p < 0.05.
Table 4A. Initial Multivariate Linear Regression
Model for HHI Score
Regression variables ß (SE) p-value
Age - 0.05 (0.04) 0.26
Gender (0 = female; 1 = male) - 1.29 (1.04) 0.22
50. Marital status (0 = single;
1 = married)
1.68 (1.00) 0.10
Metastatic cancer (0 = no; 1 = yes) 1.02 (1.03) 0.33
Any religious affiliation
(0 = no; 1 = yes)
- 0.08 (1.10) 0.95
Education (0-less than college;
1 = at least college degree)
2.48 (1.43) 0.09
Pain (worst in last week) - 0.09 (0.23) 0.69
SSCP 1.46 (0.62) 0.02
HADS- Depression Score - 0.55 (0.16) <0.01
HADS- Anxiety Score - 0.23 (0.19) 0.24
Pain interference w/ general
function
- 0.01 (0.26) 0.97
Pain interference w/ mood 0.16 (0.27) 0.57
R = 0.70, R2 = 0.49; adj R2 = 0.40.
F(12,62) = 5.03; p < 0.001.
Table 4B. Final Multivariate Linear Regression
Model for HHI Score
ß (SE) p-value
51. SSCP 1.55 (0.53) <0.01
HADS- Depression Score - 0.63 (0.15) <0.01
R = 0.63, R2 = 0.39; adj R2 = 0.38.
F(2,73) = 23.72; p < 0.001.
170 RAWDIN ET AL.
related studies.17,21,34,35 Our results expand on the existing
research in this field by incorporating additional psycho-
spiritual factors into the assessment of the relationship be-
tween pain and hope. These findings clarify the suggestion in
recent literature that hope is related most closely to psycho-
social elements of the pain experience, rather than pain
intensity.20,21
Among its limitations, our study was cross-sectional. To
further explore the causal links between hope, pain, and psycho-
spiritual factors, a longitudinal study would be ideal.
Additionally, this study was limited by the recruitment pool
available within the study site, and the demographics of our
population under-represented certain minority groups. This
study did not control for certain cancer-related symptoms ex-
perienced by patients, such as nausea, dry mouth, insomnia,
anorexia, weight loss, and fatigue, which are other potential
confounders of the relationship between pain and hope. Also,
we
did not control for patients’ beliefs regarding their prognoses,
although we did record diagnoses and were able to control for
the presence of metastases. A final limitation of this study is
that
we minimized the time burden on patients by using a single-
item
probe of spiritual well-being. To further explore the complex
52. dimensions of spiritual beliefs would require more extensive
quantitative measures than the SSCP or qualitative methods.
The lack of congruency between the univariate correlations
and multivariate modeling in this study highlights the im-
portance of measuring and accounting for factors in multiple
domains simultaneously. Based on our findings, we deduce
that depressive symptoms and spiritual well-being mediate
patients’ experiences of pain, influencing their beliefs about,
attitudes toward, and interpretations of pain. As the experi-
ence of pain is a subjective phenomenon, the affective and
cognitive filtering of pain likely matters more than measure-
able nociceptive and neuropathic intensity in relationship to
levels of hope.37,38
This study buttresses the notion forwarded by other re-
searchers that patients may maintain a sense of hope even
while cancer pain and other symptoms progress, as a function
of cognitive-affective and psycho-spiritual resources and re-
siliency.39 On a practical note, this study suggests that when
confronted with a patient who seems to have ‘‘lost hope,’’ the
physician should look beyond pain measures and explore
psychological adjustment and spiritual concerns. Further-
more, interventions to sustain or promote hope among cancer
patients with pain should carefully consider the role of mental
and spiritual health and well-being.
Acknowledgments
This research was supported by the School of Medicine and
the Department of Psychiatry at University of California, San
Francisco, as well as National Institutes of Health (NIH)
training grant R25060482. The authors would like to express
their deep appreciation to Professor Christine Miaskowsi for
reviewing and editing a draft of this manuscript, and to Jodi
Ross, who assisted with data collection. We also thank the
53. participants and staff of the UCSF Helen Diller Family Com-
prehensive Cancer Center.
Author Disclosure Statement
No competing financial interests exist.
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Address correspondence to:
58. Blake Rawdin, MD, MPH
University of California, San Francisco
Langley Porter Hospital and Clinics
401 Parnassus Avenue
Box 0984-RTP
San Francisco, CA 94143
E-mail: [email protected]
172 RAWDIN ET AL.
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read_and_evaluate_the_following_research_articles1.docx
Read and evaluate the following research articles:
· Rawdin, B., Evans, C., & Rabow, M. W. (2013). The
relationships among hope, pain, psychological distress, and
spiritual well-being in oncology outpatients. Journal of
Palliative Medicine, 16(2), 167-172. doi:10.1089/jpm.2012.0223
Link to Article
· Ferreira, V. M., & Sherman, A. M. (2007). The relationship of
optimism, pain and social support to well-being in older adults
with osteoarthritis. Aging & Mental Health, 11(1), 89-98.
59. doi:10.1080/13607860600736166
Link to Article
Apply the concepts explored in the articles above by writing a
2-3 page paper in APA format using proper spelling and
grammar. Your paper should address the following:
1. Examine the concept of psychological well-being as it relates
to the experience of pain and stress.
2. Explore how optimism, hope, distress, and social support
play a role in how people experience pain and stress. Be sure to
discuss how these elements of psychological well-being
contribute to overall physical and mental health.
3. Be sure to reference specific concepts from the articles. Use
in-text citations and provide APA formatted References as
appropriate.
Please refer to Rasmussen's APA Guide located on
the Resourcestab for information regarding APA format as well
as APA referencing and citation procedures.
Submit your completed assignment to the drop box below.
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Jstudent_exampleproblem_101504
Lesson II
Getting Started with Stats
60. Why Might You Be Involved in Doing Statistical
Research?Manager as research-based decision
makerSubordinate employee as researcherManager as research
services buyer/evaluatorManager as evaluator of secondary data
sourcesResearch specialist
Research Defined
A systematic inquiry at providing information to solve
managerial problemsBeginning researchers should understand
that research is a process of reasoning with factsI like to “let
the data speak to me.”What did you find from your articles for
tonight?
There is much you can do, but what SHOULD you do?
What is the decision dilemma we face?
What can research tell us/accomplish?
How do we define “best”? What type of study do we need to do?
Reporting
Descriptive
Explanatory
Predictive
Research Defined continued…
Basic vs. applied research
Basic – aims to discover new knowledge in a more general
sense; scientists
Applied – an effort to solve an immediate problem; to make a
particular management decision Primary vs. Secondary
61. researchInitial research vs. Problem solvingSurvey vs.
Experimental research
Research Defined continued…
The Role of Statistics in Research“Statistical thinking is
necessary…for effective decision making in various facets of
business”The science of collecting, organizing, presenting,
analyzing, and interpreting data to assist in making more
effective decisionsCan be to capture a population’s
characteristics & make inferences from a sample’s
characteristicsMany firms have data they don’t mine for regular
decision making insights.
Some ExamplesYou work for Books R Us and have been asked
to look at their sales data to see how to boost sales.What
questions do we need to ask?
To what purpose will the research be put
How do I shape my research to provide valid, quantifiable
results?
If I do an opinion survey, how many people do I need to ask?
How do I craft my questions?
How have similar studies been conducted in the past?
Questions to Ponder…What types of research does your
organization use?How can research help your organization save
money?Do you feel that the amount of research being conducted
has increased or decreased over the past 10 years?How has the
Internet changed the quality of quantity of research?
62. Creating a Research Plan and Design
Time Series Data for the Economy – in class exercise.
Research DesignsThe general research process contains three
major stages:
Exploration of the situation
Collection of data
Analysis and interpretation of the resultsWhat questions do the
data prompt you to ask?Research study idea: What events
triggered changes in key indicators (i.e., oil prices)? How do
variables interrelate (i.e., inflation, personal taxes & GDP?)
Research DesignsThe essentials of a research design
What data do we need?
Is the data available?
Do we need to “massage” it?
Is it longitudinal vs. cross sectional (which was the Econ data
and the Gas price data)?Quantitative vs. qualitative data
Research Methods
Exploratory StudiesUseful when we lack a clear idea of the
problemSaves time and money Relies more heavily on
qualitative techniquesAn exploratory study is finished when we
have achieved the following:
Established the major dimensions of the task
Defined a set of investigative questions to guide a detailed
63. research design
Developed several hypotheses about possible causes of the
management dilemma May use a focus group.
Case StudiesMuch of what you’ve done so far at UOP has been
of this nature.Can be qualitative or quantitative.Will tend to use
primary data, but can also use secondary data
What kind of data is the Gas Station data?
What kind of data are the Econ stats?
You might need to interview people – what questions do you
ask & how ask them?
Descriptive StudiesMore formalized study with clearly stated
hypothesis or investigative questionsDescriptions of phenomena
associated with a subject population - subjectsDiscovery or
associations among different variables – correlational studyHow
is this different from a causational study?
Need to ask: Do the variables interact/effect each other?
In other words, can the “dependent variable” impact or effect
the “independent variable”
Causal StudiesHow one variable affects, or is responsible for,
changes in another variablePossible variable relationships
Symmetrical – no direct link, but fluctuate together
Reciprocal – when 2 variables mutually influence or reinforce
each other
Asymmetrical – changes in one variable are responsible for
changes in another
64. Questions to Ponder…When is it appropriate to use exploratory
research?Descriptive research is usually used in the marketing
and sales business functions. What other areas might
descriptive research be used?When conducting causal research,
how can researchers keep variables constant throughout the
entire research period?What factors should be considered when
conducting a longitudinal study?Can decision-making be
accomplished by using only cross-sectional research?
Theory Building
TheoryTheory – set of systematically interrelated concepts,
definitions, and propositions that are advanced to explain and
predict factsOur ability to make rational decisions is measured
by the degree to which we combine fact and theory, each of
which is necessary for the other to be of valueFor our purposes,
it is helpful to do a literature search of studies that are similar
in nature to see what “guiding principles” we can glean – we
will not be looking to expand the academic literature by coming
up with a new theory.
Reasoning
Deductive reasoning – form of inference; the conclusion must
necessarily follow for the reasons given; imply the conclusion
and represent a proofFor a deduction to be correct, it must be
both true and valid:
Premises (reasons) given for the conclusion must agree with the
real world (true)
The conclusion must necessarily follow from the premises
66. Guide the study
Identifies relevant factors
Leads to data collection
Frames work in which to organize conclusions
Refining the Research Problem
Operational DefinitionsRequires the use of concepts, constructs,
and definitions; building blocks of theoryConcept – a generally
accepted collection of meanings or characteristics associated
with certain events, objects, conditions, situations, and
behaviorsThe success of research hinges on:
How clearly we conceptualize and how well others understand
the concepts we use
The challenge is to develop concepts that others will clearly
understand
Concepts and Constructs
Constructs Is an image or idea specifically invented for a given
research and/or theory building purposeOperational definitions
– stated in terms of specific testing or measurement
criteriaVariables – used as a synonym for construct; a symbol to
which we assign numerals and values
BenchmarkingA search for best practices that leads to superior
67. performance; measurementApplied to many areas
goods and services
business processes
performance measuresKey steps in benchmarking
planning, analysis, integration, action, and maturityTypes of
benchmarking
internal, competitive, functional, and generic
Let’s Develop a Bus. Research Problem: Sell More Phone/Data
LinesConstruct
Market share of lines
Install timeframe
Sales activity level
Pricing
Customer service quality Benchmarks
Market breakeven %
% of orders installed in X time frame
10 new appoint/wk.
10% below SBC Price
2 hr. response time
Learning ObjectivesWhat is the Difference between Descriptive
and Inferential Statistics?What is a Binomial Distribution and
how it relates to StatsWhat is the Variance and Standard
DeviationAn Introduction to the Concept of a Z Distribution
Table
StatisticsThe science of collecting, organizing, presenting,
68. analyzing, and interpreting data to assist in making more
effective decisionsDescriptive stats – methods for organizing,
summarizing, and presenting data in an informative
wayInferential stats – methods used to determine something
about a population, based on sample
Descriptive StatisticsWith Descriptive Statistics you are simply
describing “what is” or “what the data show.”For example,
“60% of people survey said they prefer Coke”. Or “Both Social
Security and Defense Spending make up 21% of the federal
budget.”
Example of Gas Price DataGas Station NameDayDateTime of
DayLocationGas Price Gas AmericaMonday3/8/2010Morning
21st and Franklin Rd.$2.58 BP Gas
StationTuesday3/9/2010Afternoon21st and Post Rd.$2.75 BP
Gas StationSunday3/7/2010Morning21st and Post Rd.$2.59
Admiral Gas StationTuesday3/9/2010AfternoonE. 21st
Street.$2.59 Marathon Gas StationMonday3/8/2010Evening21st
and Mithoeffer Rd.$2.69 Shell Gas
StationTuesday3/9/2010Afternoon21st and Post Rd.$2.75 Circle
KTuesday3/9/2010Afternoon96th & Meridean$2.75 Meijer Gas
StationSaturday3/6/2010MorningRockville & Raceway$2.62
Speedway Gas StationTuesday3/9/2010AfternoonRockville &
Girlschool$2.69 Speedway Gas
StationTuesday3/9/2010MorningSt. Rd. 32$2.67
69. Each row is a “case”. Variables are across the top. Which one
is a quantitative measure? Which is qualitative? See p. 4 and 5
*
Inferential StatisticsWith Inferential Statistics you are asking
the data to “speak to you” to infer from the sample data certain
characteristics about the population we are studying. For
example, the formula to the right measures the variation or
dispersion of data above and below the population mean.
2 = S (x- µ)2
N
70. µ
Variance of a Population
How Long does it Take to Catch a Fish?
µ
Let’s take 4 samples on different parts of the lake to estimate
“The Truth”.
30 seconds
30 min.
1 hour
2 hours
The Impact of StatisticsPositive
Data translation into useful information
Answers questions of uncertainty
Constructive hedgingNegative
Misleading
71. Abusive
Preemptive bias
The Impact of Statistics continued…Personal
“You might not want to use statistics, but statistics are being
used on you”
Buyer behavior
Product availability
Wage determination
Actuarial tables’ influence on insurance products
Queuing theory
Variables
Types of Variables
Categorical Places individual into one of several groups or
categories
Attribute – gender, age, ethnicity, education levelQuantitative:
Takes Numerical values, allowing adding and calculating
averages
Continuous – can take on fractional values; infinite number of
values b/n units on the scale; always an approximate; height
Types of Variables Variable – trait, attribute that can take on
different values at different timesConstant variable – doesn’t
changeQualitative – based on qualities that can be classified but
not measured; difference of types of kinds; genderQuantitative
– measurable differences in amountDiscrete – no possible
72. values b/n adjacent units on the scale (whole #’s); dichotomous;
marital status
Flip a coin 10 times.: Either heads or tails (1 or 0)
Results in a Binomial Distribution
Analogy: Product either perfect or imperfect.
We can run statistical tests to predict the probability of H or T,
Good or Bad
Types of Variables continued…Control – most important in
research study; most difficult implications of studyIndependent
– research systematically manipulates; experimental treatment;
measure to observe effect of dependant variableDependant –
researcher measures to observe the effects of independent
variableIntervening or modifying – originates within subject;
psychological or emotional reaction; can cause errors in study;
fear, anxiety, anger, etc. Need to control by getting to know
people, developing rapportExtraneous or confounding – Appears
to be related, but in fact is not related. Can lead to false
conclusions.
Make a List of Variables for Gas Price Data…Make a list of the
variables for your team project.What type of variable are
they?How will you collect the data? What do you know about
the data source? – Would someone dispute this data, recommend
other data to consider, or a different research design to analyze
it?
What Type of Data?
73. Levels of Measurement Measurement – procedure for assigning
a value (numbers) to an observation (variable) according to
certain rulesNominal – categories are mutually exclusive
Male vs. Female, Yes vs. NoOrdinal – categories have a logical
order
Likert Scale, 1 – 5, Strongly Agree to Strongly Disagree (is Bob
a good prof.?)Interval – equal distance between categories
Time, temp.Ratio – True Zero point exits
Height, weight, distance
Ratio AnalysisHandout of moving average of GDP.Analyze the
Books R Us data – 3 week moving average. (This is on “Books
R US Raw Data” excel file.How do we put this into a research
question that allows us to collect & analyze data?How will we
measure the data we collect?
Role of Statistics
The Language of Statistics DistributionBar GraphHistogram
Pareto ChartTime PlotCross-sectional dataQuartileBox
PlotVariance Coefficient of VariationResistant MeasureDegrees
of freedom
Definitions in StatisticsPopulationSampleStandard deviation
Normal DistributionStatistic versus
parameterRandomMeanMedianModeRight Skew Left
SkewStemplot
74. hypothesis test! = FactorialH0 = Null hypothesisH1 = Alternate
hypothesis
Measures of Central TendencyCentral Tendency – the tendency
of a set of data to center around certain numerical valuesMean –
computed by summing all the observations in the sample and
dividing the sum by the number of observations; considers the
magnitude of each observation Median – is the observation that
divides the distribution into equal parts; most typical
observation in a distributionMode – the observation that occurs
most frequently; if all the values are different, there is no mode
Means, Medians, and Modes
Age252830303334
Mean =30
Median = 30
Mode = 30
Mean
Median
Mode
Frequency
SX
N
75. µ =
25+28+30+30+33+34
6
= 30
Measures of Central TendencyThe idea is that the sum of the
differences between any given observed value & the mean =
0S(X –
up to 0?
Calculate Deviation Scores
25 28 30 33 34
-2 +3
-5 +4xx - µ25(25-30)-528(28-30)-230(30-30)030(30-
30)033(33-30)334(34-30)4180/6=300
Population Variance & Population Standard
DeviationPopulation variance – can be used to compare
dispersion in 2 or more sets of observations
On average, 1 standard deviation in student’s ages is 3.0 years
from the mean of 30 years. Population Standard deviation –
square root of the variance (the more alike they are, more
reliable they are)
The value s = 3.0 indicates, that on average, observations fall
76. 3.0 units + or - from the mean
9 = 3
= S (x- µ)2
N
Measures of Dispersion
2 = S (x- µ)2
N
= 54 = 9 variance
6
9 = the measure of variability that indicated how much all of the
scores in a distribution typically deviate or vary from the mean
Population variance also know as ‘mean deviation’ (mean of
squared deviation from the mean)xx - µ(x- µ)225-52528-
2430003000333934416180054
Sample Variance
Properties of the “s”
Gives a measure of dispersion relative to the mean
Sensitive to each score in the distribution
If a score is moved closer to the mean, then the standard
deviation will decrease, if the score shifts away from mean, the
standard deviation increases
3. Tends to underestimate the population variance, so provide
77. an appropriate correction by subtracting 1 from total
observations (n-1)
Sample Variance Example
s2 = S (X - X )2
n – 1 Sample
variance formula
54
(5-1)
Variance: 13.5 yrs
Standard Deviation: 13.5 = 3.67 yrsxx - x(x-x)2x225-
52562528-247843000900333910893441611561500544554
Let’s Analyze Class AgesMean and Standard Deviation For 5
Learning
TeamsTeam1Team2Team3Team4Team524353135443134244427
302427312547222442272924212125
78. Calculate means and Standard Deviations.
Create a bar chart
Create a histo gram
Create a Pareto Chart
*
Bar Chart
Chart1Team1Team2Team3Team4Team5
Bar Chart
32.2
28.75
26
33
28.8
Class agesMean and Standard DeviationFor 5 Learning
TeamsClass
AverageTeam1Team2Team3Team4Team5243531354431342444
27302427312547222442272924212125Mean32.228.75263328.8
29.92Sample Stand
Deviation8.70057469376.70198975433.08220700159.14330356
058.84307638787.4238534468Coefficient of
Var0.2702041830.23311268710.11854642310.27706980490.307
05126350.2481234441Note that you go to "Insert" then
"Function" then "Average"to get the formula for the mean.For