SMALLPOX

1. Dimas Fujiansyah - 2108260090
POXVIRUSES

2. Table of contents
Introduction
01
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Classification
02
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Variola (Smallpox) Virus
03
Morphology
04
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Viral replication
05
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3. Table of contents
Pathogenesis and Immunity
06
Laboratory Diagnosis
07
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4. Introduction
Largest and most complex
viruses that occur in humans,
birds, animals, and insects. These
viruses belong to family
Poxviridae.

5. Classification
02

6. The family Poxviridae, based on
whether they infect [insect or
vertebrate] hosts, has been
classified into two subfamilies,
Chordopoxvirinae and
Entomopoxvirinae.
Classification

7. Chordopoxvirinae
Yatapoxviruses
Orthopoxviruses Parapoxviruses Molluscipoxviruses

8. The genus Orthopoxvirus
includes the pox viruses of
mammals, such as smallpox
(variola), vaccinia,
monkeypox, cowpox, buffalopox,
rabbitpox, mousepox, and
camelpox viruses.
[Most of the poxviruses that
cause diseases in humans
belong to the genera
Orthopoxvirus]
Orthopoxviruses

9. Variola (Smallpox) Virus
Smallpox caused by variola
virus has been eradicated
from the world in 1980
following an intensive
worldwide campaign by the
World Health Organization
(WHO).

10. Morphology
04

11. Variola Virus Shows Following Features
 The variola virus is a large, brick-shaped
virus measuring 300×200×200 nm,
almost visible by light microscopy.
 The virion consists of protein (90%), lipid
(5%), and DNA (3%).
 The viral genome double-stranded,&
linear DNA
 The extracellular virion possesses
envelope.

12. Viral
replication
05

14. NOTE
 Susceptibility to physical
and chemical reagents:
Variola virus is most
stable at low
temperature and low
humidity
 resistant to action of 50%
glycerol and 1% phenol.

15. Pathogenesis
and Immunity
06

16. Pathogenesis of small pox
 Smallpox caused by variola virus
 by respiratory route through inhalation of nasal,
oral, or pharyngeal drop-lets, y direct contact with
infected skin or fomites
 The virus replicates in the lymphoid tissues
 Infection of the reticuloendothelial cells

17. Host immunity
 Virus-specific T cells control the spread of viruses
by causing lysis of infected cells in the
reticuloendothelial cells in the skin

18. Laboratory
Diagnosis
07

19. The main criteria for clinical
diagnosis of smallpox
included :
• characteristic smallpox
lesions of the skin

20. TERIMA KASIH

21. DAFTAR PUSTAKA
1. Parija, Subhash Chandra (2012) Textbook of
Microbiology and Immunology Second Edition. E-Book.