Pyridazine is a heterocyclic organic compound with the formula C4H4N2. It contains a six-membered ring with two adjacent nitrogen atoms and is aromatic. Pyridazine derivatives have been synthesized and tested for various pharmacological activities, including anti-inflammatory, diuretic, antiasthmatic, antimicrobial, and anticancer effects. Specifically, 3,6-dichloro-pyridazine and N,N-(diphenylamino)-pyridazine have been studied for their activities. Pyridazine derivatives show potential as biologically active molecules and may help in developing new drugs to treat various conditions.

1. Submitted by-Dheeraj
Kumar(BP301312)&Harish
Santoshi(BP301315)

2.  Pyridazine is a heterocyclic organic compound
with molecular formula C4H4N2. It contains six
membered ring system with two adjacent
nitrogen atoms and is aromatic.It is colourless
compound with melting point 208o c.

3.  CHEMICAL FORMULA :- C4H4N2
 MOLECULAR MASS :- 80.09 g/mol
 DENSITY :- 1.11 g/cm3
 BOILING POINT :- 208 0c
 MELTING POINT :- -8 0c
 APPERANCE :- COLOURLESS LIQUID
 SOLUBILITY IN WATER:- MISCIBLE
 ISOMERIC FORM:-PYRIMIDINE & PYRAZINE
 PYRAZINE PYRIMIDINE

4. Pyridazine are rare in nature possibly
reflecting the scarcity of naturally
occurring hydrazine which are building
blocks for synthesis of heterocyclic.

5.  A large number of pyridazine derivatives are
synthesised and tested for their pharmacological
activity.Some of the important pyridazine derivatives
which posses pharmacological activities and studied by
us are 3,6-dicholoro-pyridazine and N,N-(diphenyl
amino)-pyridazine.

6.  1 m mole of 3,6-dichloro pyridazine is mixed
with 2 m moles of aniline.The mixture was
dissolved in DMF/toluene and refluxed for 8
hours. After 8 hours when the reaction
completes, the reaction mixture is
recrystallized with suitable solvent.

8.  1) Anti-Inflammatory and Analgesic :-
 Inhibition of P38 kinase enzyme which is involved in
the regulation of TNF and IL.
 2)Diuretic Activity:-
 Some compounds have excellent diuretic activity and
different characters from known diuretics like
thiazides, carbonic anhydrase inhibitors or furosemide

9.  3)Antiasthmatic Activity :-
 The pyrido-[2,3-d]pyridazinones were act as potent
and selective Type-IV Phosphodiesterase (PDE)
Inhibitors These PDE-inhibitors are promising drugs
in the management of asthma and inflammation.
 4)Antimicrobial Activities:-
 Infectious diseases caused by microbes like bacteria,
fungi and viruses. The purpose of microorganisms is to
survive and many of them have determinants of
resistance. The anti-microbial effects of some fused
pyridazine derivatives showed potential antimicrobial
activity.

10.  5)Anticancer Activity :-
 Cancer in an uncontrolled proliferation of abnormal
cells. These mutated cells attack adjoining tissues and
sometimes transfer through the blood or lymph
distribution to other body organs causing metastases,
which are the main cause of death from cancer. A
considerable fraction of cancers can be cured by
surgery combined with radiotherapy or chemotherapy,
particularly if they are detected early. The
pyridopyridazine derivatives inhibited cascade of
signals which regulate proliferation. Inhibition of
proliferation could be achieved by inhibition of cyclin-
dependent kinases.
 Along with above mentioned
pharmacological actions pyridazine derivatives also
possess antitubecular, antihypertensive and
antidiabetic activities.

11.  Increasing interest in the pyridazines and
pyridopyridazines has been observed. These
pyridazinne derivatives are showing wide
spectrum of biological activities. Recently the
pyridazinone moiety has been comprehensively
studied in the search for novel and selective
drugs. Several biological activities of
pyridopyridazines derivatives and may act as
important biological active pharmacophores in
medicinal chemistry. This moiety may help in
exploring new pathways to discover new drugs
of potential therapeutic value.

12. SUBMITTED BY-DHEERAJ KUMAR
(BP301312) &
HARISH SANTOSHI
(BP301315)