The presentation discusses about how to use minitab software.

1. USING MINITAB
By: CHETAN DHAL
M.Pharm III Sem (QA)
Deptt of Pharmaceutics
F/O Pharmacy
Jamia Hamdard
N.Delhi - 110062

2. MINITAB FOR OPTIMIZATION OF CONDITIONS
• For the purpose there are several designs viz
a) Factorial design
b) Response surface
c) Mixture
d) Taguchi
• Different design have different applications. Usually for optimization of
analytical method CCD (central composite design) under the category
Response surface suits best.
• The reason behind using this method is that it helps in covering the central
points; axial points; and the far off points so that a circle form covering the
axial points.

3. Open minitab and do to create response
surface design and select.

4. Select central composite
design; one can change the no
of factors by clicking the arrow
it represents the no of factors
to be analyzed
Select and open Display available
designs; click oK; select and open
designs and click ok. After this the
rest of 3 option enables. Click on
factors and put the names just by
selecting A and B; add specific values
against the columns in front of them
and click OK.

5. After clicking OK to the factor dialog
box. Click ok to the main dialog box. A
work sheet will appear.
One can double click the
“worksheet 1 **” bar to enlarge
the worksheet

6. Suppose you have 3 response to be optimized based on the 2 factors
previously selected. Add Response A; Response B; Response C to the
work sheet by selecting suitable column after factor B. Add specific
values to these responses

7. Once you have finished adding responses to the work sheet
you need to analyze them. Go to stat then DOE then Response
surface and select analyze response surface designs.
NOTE: THIS OPTION WILL ENABLE SUCCESSIVELY. IN THE START
OF EXPERIMENT THIS REMAINS DISABLED

8. One by one select all the
responses. Go to graph and select
four in one type. Click OK.
Different graphs will appear.
• Now go to the option OVERLAID
CONTOUR PLOT and select. A
window appears. Click the
button with 2 arrow if you wish
to optimize all the responses
other wise select particular ones.
Now go to the option contours.
This dialog box will appear and
put desired lower and higher
limits and select OK.

9. Clicking ok will
generate
something called as
overlaid contour
plot. The white
zone is design
space and grey
zone is undesired
space. Select any
point in desired
space it will give
results referring to
the limits set while
generating overlaid
contour plot.

10. One can also optimize the conditions by selecting
response optimized in the response surface list.
• Select all the factors by
clickin n double arrow
button. This will enable
setup button. Click on setup
button. Another window
appears.
Set goal; give values to the responses and click ok.

11. After clicking ok a optimized condition with maximum
desirability appears. These are the optimized conditions
This completes understanding Response surface design for optimization

12. THANK YOU