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Ketamine for neuropathic
pain
May develop after
neuronal injury
Refractory to conventional
analgesics
Affects about 7% of the
population
Neuropathic Pain
SEARCH
Databases: MEDLINE, CENTRAL, LILACS and EMBASE
18 studies
706 participants
Regimen
Intravenous ketamine
0.15 to 1.5 mg/Kg/day
Duration: up to 10 days
Effects
Pain Scale 0/10
One week after treatment:
• MD -2,14
• P<0.00001
30 days after treatment:
• MD -1.68
• p<0.00001
0
1
2
3
4
5
6
One Week 30 days
Pain reduction
Standard Treatment Standard Treatment plus ketamine
Effects
Four times more discomfort
• RR 4.06
• p=0.03
Five times more psychedelic effects
• RR 4.94
• p<0.00001
MEANING
Low-quality evidence
More studies are necessary to determine if ketamine improves
quality of life in patients with neuropathic pain

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Infografico ketamina