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A sampling of positive marijuana studies
- 1. A Sampling of Positive Marijuana Studies Individual topic-specific modules available Summarized science Linked to published literature Created and Licensed by Bradley Pennington, D.C. mmjintheusa.com
- 2. Medical Marijuana Treating Fibromyalgia Low Back Pain 31 patients 3 months of oxycodone, naloxone hydrochloride, duloxetine Minor improvement 3 months cannabis therapy Significantly higher self- reported improvement Better pain reduction and lumbar ROM Still improved after 6 months
- 3. Marijuana Extract For Multiple Sclerosis Current drugs ease symptoms, slow disease No cure Autoimmune encephalomyelitis is similar etiology Compare Copaxone with high CBD, low THC cannabis This cannabis extract as effective as Copaxone Supports treatment of MS symptoms with cannabis No extra benefit when combined
- 4. Some Marijuana Strains Demonstrate Antibiotic Effect • Methicillin-resistant Staphylococcus aureus (MRSA) • Resistant to methicillin, penicillin, oxacillin and cefoxitin • Cannabis sativa, Thuja orientalis and Psidium guajava leaf extracts • Individually, a 50% extract of each plant leaf inhibited MRSA growth • Even more effective when used in combination at 1:1 ratio • Potential application for MRSA
- 5. Medical Marijuana States Have Lower Workplace Fatalities • Concern that legal cannabis would make workplace more dangerous • Bureau of Labor Statistics for all 50 states and DC • 19.5% reduction in workplace fatalities ages 25-44 • 5 years later showed 33.7% reduction in workplace fatalities
- 6. Marijuana And Heart Attacks Analyzed data from 1,273,897 patients with myocardial infarct 3,854 reported cannabis use Compare outcomes of users vs non users Users less likely to die Users less likely to experience shock Users less likely to require intra-aortic balloon pump Users more likely to require short term mechanical ventilation
- 7. Marijuana: Effects Of Natural vs. Synthetic Medical marijuana (MMJ) Defined as use of whole unprocessed marijuana plant or extracts Synthetic versions of marijuana have more adverse events Respiratory difficulties / hypertension / tachycardia / chest pain / muscle twitches / acute renal failure / anxiety / agitation / psychosis / suicidal ideation / cognitive impairment Natural version seems far safer
- 8. Medical Marijuana Dosages For Pain From Malignant Diseases 18 predominantly double-blind trials evaluated 15 of 18 showed cannabis had a significant effect After 2 weeks, 43% had a reduction in pain of 30% or greater Target dose was 10 administrations per day Total of about 27 mg of THC Total of about 25 mg of CBD Start low and go slow
- 9. Medical Marijuana And Osteoarthritis Pain Very common pain Combined inflammatory, nociceptive and neuropathic Synthetic medicines need 3 kinds for 3 pathways Endocannabinoid system (ECS) addresses all 3 pathways Cannabis should provide relief for all 3 types of pain Clinical evidence supportive of ECS in osteoarthritic pain
- 10. Medical Marijuana Use In The Elderly 2,736 patients began cannabis; average age 74.5 years Reasons for use: 66% pain, 60% cancer 6 months of treatment 93% reported improvement Average pain reduction from 8 to 4 on 0-10 scale 18% reduced or eliminated opioid use
- 11. Marijuana Use Seems To Protect From Liver Disease • Abusing alcohol highly associated with liver disease • Alcoholic steatosis (AS); steatohepatitis (AH); fibrosis; cirrhosis (AC) and hepatocellular carcinoma (HCC) • 319,514 patients with history of abusive alcohol use • Among alcohol users, cannabis users have significantly lower odds of developing liver disease
- 12. mmjintheusa.com • Professionally prepared • Linked to science • Topic specific • Speaker ready • Customizable • Cannabis & Cancer • Cannabis vs Opioids • Cannabis & Neurodegenerative Diseases • Amazing Benefits of Cannabis • Cannabis & Pregnancy • More ...
Editor's Notes
- This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- In this small study, 31 patients were observed who had been screened, and treated with standard medical pain control consisting of: 5 mg of oxycodone hydrochloride equivalent to 4.5 mg oxycodone and 2.5 mg naloxone hydrochloride twice a day and duloxetine 30 mg once a day. After following this regimen for 3 months, the participants were given the opportunity to utilize medical cannabis therapy for a minimum of 6 months. The standard regimen of synthetic medical analgesics provided minor patient improvements compared to their beginning points. However, medical marijuana (cannabis) therapy provided a significantly higher improvement in all patient self-recorded outcomes, including pain reduction and improvement in lumbar range of motion. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Multiple sclerosis is an autoimmune disease leading to the destruction of myelin and nerve degeneration resulting in severe physical debilitation. Myelin surrounds the nerve similar to plastic surrounding an electrical wire. The disease can be treated with immunosuppressive drugs that alleviate the symptoms and slow disease aggravation. One of those drugs currently in clinical use is called Copaxone. The purpose of this study was to compare the effectiveness of CBD with the drug Copaxone in mice. They chose a high CBD, low THC cannabis Indica (marijuana) called Avidekel. Their data showed that CBD and purified extracts of Avidekel are as efficient as Copaxone to relieve the symptoms of autoimmune encephalomyelitis in mice. In fact, the final sentence of their abstract stated: "Our data support the use of Avidekel extracts in the treatment of MS symptoms." Encephalomyelitis is inflammation of the brain and spinal cord. CBD is one of the non-psychoactive compounds of marijuana. There was no additional benefit to combining CBD extract with the synthetic drug. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Every day we discover more positive health benefits of using the natural medicinal plant cannabis (marijuana). Many of you may have heard of the devastating effects on some patients of methicillin-resistant Staphylococcus aureus (MRSA). This is a condition which resists nearly all standard antibiotics and can be deadly. This study examined the antimicrobial activity of Cannabis sativa, Thuja orientalis and Psidium guajava leaf extracts against MRSA. Each of the MRSA isolates had been shown to be resistant to methicillin, penicillin, oxacillin and cefoxitin. Used individually, a 50% extract of each plant leaf inhibited MRSA growth in this laboratory setting. That alone would be profound. But it was further found that when these plant leaf extracts were used in combination of a 1:1 ratio, even greater zones of inhibition against MRSA growth occurred. In their conclusion the authors state that the leaf extracts of C. sativa, T. orientalis and P. guajava had the potential for the control of both hospital and community acquired MRSA. Is there nothing this miracle plant won't improve? Stay tuned to find out. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Workplace fatalities by state and year were obtained from the Bureau of Labor Statistics for all 50 states and the District of Columbia for the years of 1992-2015. Historically, there was increasing concern that legalizing marijuana (cannabis) would make the workplace more dangerous, although little was known. The study published in October of 2018 in the Journal of International Drug Policy, demonstrated some astounding results. There are two findings everyone should be aware of. First, legalizing medical marijuana was associated with a 19.5% reduction in workplace fatalities for workers aged 25-44. Secondly, this relationship grew stronger over time. 5 years after coming into effect, medical marijuana laws were associated with a 33.7% reduction in the expected number of workplace fatalities. Medical marijuana laws that listed pain as a qualifying condition or allowed collective cultivation were associated with larger reductions in fatalities in that age range than those that did not. Could this unexpected improvement in the safety of the workplace via legal marijuana be the result of a reduction of opoid utilization by these patients? Quite possibly, although the authors could not attribute causes without further study. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Myocardial infarction (MI) is commonly referred to as a "heart attack". As marijuana use increases worldwide, more opportunities have arisen to determine what kind of effect it will have on those unfortunate enough to have a MI, or heart attack. This study set out to determine if the usage of marijuana had positive or negative effects on those patients. The results are surprising. Hospital records from 8 states between 1994 and 2013 were screened for diagnosis of MI. Out of 1,273,897 patients with MI, 3,854 reported use of marijuana (cannabis), and their outcomes were compared with those that did not use marijuana. Interestingly, marijuana users were significantly less likely to die, experience shock, or require an intra-aortic balloon pump placement. Marijuana users were slightly more likely to be placed on mechanical ventilation (short term). The authors were surprised that marijuana use did not create a less favorable outcome, and stated positively that it was associated with less in-hospital death after a heart attack. The short abstract is found here. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Medical marijuana (cannabis) is defined as the use of the whole, unprocessed marijuana plant or its extracts for medicinal purposes. Therefore in most medical instances synthetic versions of marijuana are not even considered. However, for educational purposes it might be wise for the patient to be aware of the difference in effects on the body. This study points out that these synthetic drugs induce more severe adverse events including: respiratory difficulties, hypertension, tachycardia, chest pain, muscle twitches, acute renal failure, anxiety, agitation, psychosis, suicidal ideation, and cognitive impairment. Chronic use of these synthetic drugs have been associated with serious psychiatric and medical conditions and even death. Many are interested in marijuana as a natural alternative to other medications. It seems that the literature supports keeping the natural component in natural medicine. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- In order to assess the effectiveness of cannabis (marijuana) preparations for relieving pain in patients with malignant diseases, a comprehensive search of the literature up to 2017 was conducted. 18 predominantly double-blind trials were chosen which compared effectiveness of cannabis to placebo. 15 of the 18 trials demonstrated that cannabis had a significant effect, with 43% of those after two weeks of treatment reporting a 30% or greater reduction on pain. Interestingly, the authors of this study stated that the target dose for relieving pain in patients with malignant disease seemed to be 10 "actuations" (number of times in day administered) with a total of about 27 mg of THC, and about 25 mg of CBD. (Please note that is approximately 2.5 mg per administration.) Two considerations should be noted. First, it is wise to "start low and go slow" as discussed in this MMJINTHEUSA article, before potentially reaching that level of daily THC. Secondly, the near similar levels of THC and CBD may demonstrate that using whole plant leaf could be of greater benefit than individual extractions where one is significantly greater than the other. Individuals should consult their medical providers for specifics regarding their medical marijuana. It is generally considered that your individual effective dose is the smallest amount necessary to achieve the result. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Osteoarthritis pain is one of the most common types of pain patients can experience. It manifests as a combination of inflammatory, nociceptive and neuropathic pain. In the standard medical model each of those pathways requires modality-specific analgesics, adding up to more medicines. However, the human body has a built in endocannabinoid system (ECS) which has been shown to affect each of those 3 pathways. This means that marijuana (cannabis) should likely provide relief for all 3 types of pain in the osteoarthritic patient. The authors of this summary state that there is clinical evidence supporting the role of the ECS in osteoarthritic pain. Hopefully as marijuana laws become less restrictive, more studies can be done on the benefits of marijuana and osteoarthritis. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Medical marijuana has slowly become increasingly utilized by all segments of the population, including among the elderly. This study aimed to assess the characteristics of elderly people using medical cannabis and to evaluate the safety and efficacy of the treatment. From January 2015 to October 2017, 2,736 patients greater than 65 years of age began cannabis (marijuana) treatment in a specialized medical cannabis clinic and completed an initial questionnaire. The average age was 74.5 years, and the most common reasons given for using medical marijuana were pain (66%) and cancer (60%). After 6 months of treatment 93% of the patients reported improvement in their condition, and the reported pain level was reduced from a median of 8 to a median of 4 on a 0-10 scale. The most common adverse events were dizziness and dry mouth, but only at 9.7% and 7.1% respectively. After six months, 18% were able to reduce or eliminate opioid use. The authors of this study found that therapeutic marijuana use was both safe and effective in the elderly population and may even decrease the use of other medications. This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.
- Abusing alcohol is highly associated with causing liver disease (ALD) characterized by alcoholic steatosis (AS), steatohepatitis (AH), fibrosis, cirrhosis (AC) and hepatocellular carcinoma (HCC). Although the combined use of cannabis (marijuana) with alcohol and the development of liver disease remains unclear, cannabis has been shown to have an anti-inflammatory effect on human physiology. The authors of this study evaluated the discharge records of 319,514 patients 18 years or older with a history of past or current abusive alcohol use. They studied the four distinct phases of progressive alcoholic liver disease with respect to 3 distinct cannabis (marijuana) exposure groups. Non-cannabis users represented 90.39%, non-dependent cannabis users represented 8.26%, and dependent cannabis users represented 1.36%. Their findings indicate that among alcohol users, those who use cannabis have significantly lower odds of developing AS, AH, AC and HCC. Strangely, dependent cannabis users had even lower odds of developing liver disease than non-dependent users. The authors give no causality to their findings. *No authors, this one or otherwise, are promoting marijuana usage as a justification for alleviating the potential negative effects of using or abusing alcohol.* This material remains the property of Bradley Pennington, D.C., sometimes operating as mmjintheusa.com, and is not to be copied, distributed, marketed, sold, or licensed without the express written consent of the aforementioned.