Dr. Mark Allen, Ph.D., and Dr. Alina Fong Ph.D. presented during the Pink 4 conference in Rome, Italy in September 2017. Exploring new strategies, such as EPIC Treatment, to treat concussions and lasting concussion symptoms by understanding and addressing the core problem, the impairments in the brain.
For more information please visit: www.cognitivefxusa.com or contact us at info@cognitivefxusa.com or 385-375-8590.
Medtronic Deep Brain Stimulation is an adjustable, reversible treatment option for movement disorders caused by Parkinson's disease and essential tremor, and it may help to manage dystonia symptoms
More info at: www.myndlift.com
This technique has generated a lot of buzz lately. But what is it really?
A short, fun and colorful way to explore neurofeedback, how it works, in addition to research and skepticism behind it.
Medtronic Deep Brain Stimulation is an adjustable, reversible treatment option for movement disorders caused by Parkinson's disease and essential tremor, and it may help to manage dystonia symptoms
More info at: www.myndlift.com
This technique has generated a lot of buzz lately. But what is it really?
A short, fun and colorful way to explore neurofeedback, how it works, in addition to research and skepticism behind it.
Machine learning applications in clinical brain computer interfacingJenny Midwinter
Brain computer interfaces (BCIs) provide alternative communication channels from the brain to external devices for severely disabled individuals and can be used to induce and guide adaptive plasticity for recovery after central nervous system trauma. Clinical BCI effectiveness depends on robust and accurate modeling of the relationship between brain signals and behaviour. Dr. Boulay will give a brief survey of BCI technologies and discuss common BCI paradigms and implementations, with an emphasis on clinical BCI brain signals and machine-learning applications.
* From the Ottawa AI/ML Meetup June 2018.
Interventions to Improve Cognitive Functioning After TBILoki Stormbringer
Traumatic injury to the brain can affect the core of what makes us
human—our cognition and emotion. The injuries are acute but may result
in chronic burdens for individuals and families as well as society. Effective
approaches to improving functioning are needed, and the benefits may
be far-reaching. We discuss some basic principles to guide current prac-
tice, as well as major directions for continuing advancement of ways to
improve functioning after injury. Interventions are more likely to be effec-
tive when we take into account multiple levels of brain functioning, from
neurons to pharmacological systems to social networks. Training of cogni-
tive functions is of special importance, and benefits may synergize with
pharmacologic and other approaches that modify biology. The combina-
tion of physical and experiential trauma deserves special consideration,
with effects on cognition, emotion, and other substrates of behavior.
Directing further research toward key frontiers that bridge neuroscience
and rehabilitation will advance the development of clinically effective
interventions.
Inner Engineering Medical Research findings- Isha Inner Engineering is technology for well being. Many researches have been done those who went for this practice.
Annovis Bio is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits
more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing
Phase 2a study in AD patients and a second Phase 2a study in early PD and early AD patients.
Neurological Pupil Index as an Indicator of Irreversible Cerebral Edema: A Ca...NeurOptics, Inc.
Assessing the pupillary light reflex (PLR) is acore component of neurological assessments. Changes in pupil size and reactivity can provide early recognition of neurological decline and facilitate lifesaving interventions.
Innowave Freedom Clearing House /freedom Nano users can have single-click access to Neuroshield™,
Neuroshield™ is a Clinical Decision Support Tool for Neurological Disorders, A comprehancive tool to
evealuate Qualitative and Quantitative conditions of the Human Brain. Neuroshield™ is a product from
“In-Med Prognostics“Is a company with leadership in, reliable and data-driven brain health diagnostic and
prognostic tools
What’s next: The future of non-invasive neurotechnologySharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
3-4pm. What’s next: The future of non-invasive neurotechnology
- Dr. Bruce Cuthbert, Director of Adult Translational Research and Treatment Development at the NIMH
- Charles Fisher, President of Fisher Wallace Laboratories
- Chair: James Cavuoto, Editor and Publisher at Neurotech Reports
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
Machine learning applications in clinical brain computer interfacingJenny Midwinter
Brain computer interfaces (BCIs) provide alternative communication channels from the brain to external devices for severely disabled individuals and can be used to induce and guide adaptive plasticity for recovery after central nervous system trauma. Clinical BCI effectiveness depends on robust and accurate modeling of the relationship between brain signals and behaviour. Dr. Boulay will give a brief survey of BCI technologies and discuss common BCI paradigms and implementations, with an emphasis on clinical BCI brain signals and machine-learning applications.
* From the Ottawa AI/ML Meetup June 2018.
Interventions to Improve Cognitive Functioning After TBILoki Stormbringer
Traumatic injury to the brain can affect the core of what makes us
human—our cognition and emotion. The injuries are acute but may result
in chronic burdens for individuals and families as well as society. Effective
approaches to improving functioning are needed, and the benefits may
be far-reaching. We discuss some basic principles to guide current prac-
tice, as well as major directions for continuing advancement of ways to
improve functioning after injury. Interventions are more likely to be effec-
tive when we take into account multiple levels of brain functioning, from
neurons to pharmacological systems to social networks. Training of cogni-
tive functions is of special importance, and benefits may synergize with
pharmacologic and other approaches that modify biology. The combina-
tion of physical and experiential trauma deserves special consideration,
with effects on cognition, emotion, and other substrates of behavior.
Directing further research toward key frontiers that bridge neuroscience
and rehabilitation will advance the development of clinically effective
interventions.
Inner Engineering Medical Research findings- Isha Inner Engineering is technology for well being. Many researches have been done those who went for this practice.
Annovis Bio is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Alzheimer’s in Down Syndrome (AD-DS). Annovis is believed to be the only company developing a drug for AD, PD and AD-DS that inhibits
more than one neurotoxic protein and improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. The company expects its treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. Annovis has an ongoing
Phase 2a study in AD patients and a second Phase 2a study in early PD and early AD patients.
Neurological Pupil Index as an Indicator of Irreversible Cerebral Edema: A Ca...NeurOptics, Inc.
Assessing the pupillary light reflex (PLR) is acore component of neurological assessments. Changes in pupil size and reactivity can provide early recognition of neurological decline and facilitate lifesaving interventions.
Innowave Freedom Clearing House /freedom Nano users can have single-click access to Neuroshield™,
Neuroshield™ is a Clinical Decision Support Tool for Neurological Disorders, A comprehancive tool to
evealuate Qualitative and Quantitative conditions of the Human Brain. Neuroshield™ is a product from
“In-Med Prognostics“Is a company with leadership in, reliable and data-driven brain health diagnostic and
prognostic tools
What’s next: The future of non-invasive neurotechnologySharpBrains
(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)
3-4pm. What’s next: The future of non-invasive neurotechnology
- Dr. Bruce Cuthbert, Director of Adult Translational Research and Treatment Development at the NIMH
- Charles Fisher, President of Fisher Wallace Laboratories
- Chair: James Cavuoto, Editor and Publisher at Neurotech Reports
Learn more here:
http://sharpbrains.com/summit-2014/agenda/
DBC - Klinikka (Pty) Ltd. South Africa - a presentation on the value proposit...Greg Steele
Klinikka (Pty) Ltd, the DBC Sub License Holder in South Africa, have shared with us this presentation. Another insightful way to explain the value proposition of the DBC Back Treatment Program. #physiogym #backpain #DBCBusiness
For what basis is neuropsychiatry a developing field?SanityPharma
Furthermore, it is also applied to clinical cases with no known biological reason by the current neurological indications. We are at a time in science where the association between the body and psychological well-being is owned and progressively proof-based.
Medtronic Deep Brain Stimulation is an adjustable, reversible treatment option for movement disorders caused by Parkinson's disease and essential tremor, and it may help to manage dystonia symptoms, parkinsons disease risk factors, parkinsons disease medicine India. Parkinson treatment in Mumbai, Parkinson treatment in Hyderabad,
Mental imagery technique recently used as motor imagery. Theories of mental imagery developed by psychologists till date and use of this technique in the improvement of function has lot of evidences.
Since its original inception, Clinician Group has continually expanded its battery of assessment solutions and added new features (such as benchmarking and a comparison modules). With Clinician Group, our assessment solutions have become a preeminent provider of psychological, Annual Wellness Visits and Neurocognitive Assessment programs with services expanding to therapists, general practitioners, researchers and a host of other medical professionals.
Clinician Group help to improve Nationwide Access and the Quality of Health Care Services by providing Innovative New Electronic Assessments and Specialty Healthcare Providers across all geographic regions. Their main goal is to promote Total Patient Care while opening the seeds of communication between the patient and their healthcare provider.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
8. Concussions Have Fooled
Even the Best of Us…
Q: Most Neuropsychologists giving standardized paper/pencil batteries have
misdiagnosed their patients based solely on the outcome of these tests.
Why?
A: A concussion doesn’t affect whether you get a question right or wrong. In
fact, most mTBIs will do exceptionally well on these tests.
However, a concussion takes a toll on how efficiently the brain is working to
get the right answer.
IN SUMMARY: fMRI is not concerned with right or wrong, but, rather, what it
is COSTING your brain to get the right answer.
9. When solving this
problem
are we measuring
what it costs the brain
to find the answer?
OR
Are we simply measuring
If we can get the
correct answer?
10.
11. Mac Donald et al JAMA
Neurology, 2017
Fool Me Twice – Shame On Me
14. fNCI Standardized Test Battery3
• fNCI is a specialized fMRI
testing and norming system
that includes a set of 6
standardized neurocognitive
tests2
• Stimulus materials and timings
refined to elicit maximum
BOLD signal
1. Iterative pilot testing and
protocol refinement
2. Retest stability validation
3. Cross-scanner stability testing
15. Individual patient activation values contextualized within normal curve of age-
matched healthy control sample for 60 functional brain regions
fNCI Normative Reference Atlas3
23. Retest Comparisons for No-Treatment
Patients and Healthy Controls
• 27/270 PCS patients randomly
selected to compare with 27
patients with no NVC focused
treatment and 13 healthy controls
• Patients with no NVC treatment
show random change in SIS at Scan 2
• Healthy controls remain within
normal limits at both scan times and
show high retest reliability (r = .87)
29. 1. Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010). Glial and
neuronal control of brain blood flow. Nature, 468(7321), 232–243.
2. Ellis, M. J., Ryner, L. N., Sobczyk, O., Fierstra, J., Mikulis, D. J., Fisher, J. A., … Mutch, W. A. C. (2016).
Neuroimaging Assessment of Cerebrovascular Reactivity in Concussion: Current Concepts, Methodological
Considerations, and Review of the Literature. Frontiers in Neurology, 7, 61.
3. Allen, M. D., & Fong, A. K. (2008). Clinical application of standardized cognitive assessment using fMRI. I.
Matrix reasoning. Behavioural neurology, 20(3-4), 127-140.
References