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Digital Health
Ryan J Shaw, PhD RN
Associate Professor
Faculty Director, Duke Mobile App Gateway
School of Nursing & School of Medicine
Duke University
Precision Health
• Today: most healthcare is based on expected response
of the average patient
• Tomorrow: healthcare will be based on individual
genomic, environmental, and lifestyle differences that
enable more precise ways to prevent and treat disease
Precision Health
Eric Green, MD, PhD – NIH NHGRI
MOBILE PHONES
> 96% of US population (88%Rural)
>95% <$30,000/year
>81% of US population have a
smart phone (71% rural)
Socioeconomic backgrounds
Most Geographic locations
Direct reach
Mobile Health
Pew 2019
Examples:
Clinical, Research & Education
KardiaMobile 6L
FDA-cleared Personal 6-lead ECG
NINR
F31NR01
8100 -
Vaughn
Pediatric PBMT
Vaughn, 2019 NINR F31NR018100 - Vaughn
PI: Susanne Haga, PhD
Partner2Lose: Using Partners to Enhance Long-
Term Weight Loss
NIDDK 1R01DK111491
PI: Voils
Site PI: Shaw
24 Months
Initiation: 6 Months Maintenance: 18 months
Visit: Double Robotics JAMMER
Collaborators & Team members
• Angel Barnes
• Qing Yang
• Jackie Vaughn
• Dori Steinberg
• Daniel Hatch
• Matthew Crowley
• Allison Vorderstrasse
• Anna Diane
• Constance Johnson
• Geoff Ginsburg
• Susanne Haga
• Lori Orlando
• Karen Judge
• Ellie Wood
• Marissa Stroo
• Katie McMillan
• Ellie Wood
• Corrine Voils
• Many more…
• Shaw, R.J., Bosworth, H.B., Silva, S., Lipkus, I.M., Davis, L.L. Sha, R.S., Johnson, C.M. (2013). Mobile health messages help sustain recent weight loss. The American Journal of Medicine, 126(11),
1002-1009. PMID: 24050486. PMCID: PMC3820279
• Shaw, R.J., McDuffie, J.R., Hendrix, C.C., Edie, A., Lindsey-Davis, L., Nagi, A., Kosinski, A.S., Williams, J.W. Jr. (2014). Effects of nurse-managed protocols in the outpatient management of adults
with chronic conditions: A systematic review and meta-analysis. Annals of Internal Medicine, 161(2), 113-121. doi: 10.7326/M13-2567. PMID: 25023250
• Shaw, R.J., Bonnet, J., Modarai, F., George, A., Shahsahebi, M. (2015). Mobile health technology for personalized primary care medicine. American Journal of Medicine, 128(6), 555-557.
doi: 10.1016/j.amjmed.2015.01.005 PMID: 25613298
• Shaw, R.J., Pollak, K., Zullig, L., Bennett, G., Hawkins, K., Lipkus, I. (2016). Feasibility and smokers’ evaluation of self-generated text messages to promote quitting. Nicotine & Tobacco Research,
18(1), doi: 10.1093/ntr/ntv268
• Shaw, R.J., Steinberg, D., Bonnet, J., Modarai, F., George, A., Cunningham, T., Mason, M., Shahsahebi, M., Grambow, S.C., Bennett, G., Bosworth, H. (2016). Mobile health devices: Will patients
actually use them? Journal of the American Medical Informatics Association, 1-5. DOI: 10.1093/jamia/ocv186
• Jain, S. H., Powers, B. W., Hawkins, J. B., & Brownstein, J. S. (2015). The digital phenotype. Nature Biotechnology, 33(5), 462.
• Coravos A, Goldsack J, C, Karlin D, R, Nebeker C, Perakslis E, Zimmerman N, Erb M, K: Digital Medicine: A Primer on Measurement. Digit Biomark 2019;3:31-71. doi: 10.1159/000500413
• Hickey, K. T., Bakken, S., Byrne, M. W., Demiris, G., Docherty, S. L., Dorsey, S. G., ... & Moore, S. M. (2019). Precision health: Advancing symptom and self-management science. Nursing outlook.
• Ferguson, C., Hickman, L., Wright, R., Davidson, P. M., & Jackson, D. (2018). Preparing nurses to be prescribers of digital therapeutics.
• Cashion, A. K., & Grady, P. A. (2015). The national Institutes of health/national Institutes of nursing research intramural research program and the development of the national Institutes of health
symptom science model. Nursing outlook, 63(4), 484-487.
• Gambhir, S. S., Ge, T. J., Vermesh, O., & Spitler, R. (2018). Toward achieving precision health. Science translational medicine, 10(430), eaao3612.
References
Digital_health_shaw_8_2_19.pptx

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Digital_health_shaw_8_2_19.pptx

  • 1. Digital Health Ryan J Shaw, PhD RN Associate Professor Faculty Director, Duke Mobile App Gateway School of Nursing & School of Medicine Duke University
  • 2.
  • 3.
  • 4. Precision Health • Today: most healthcare is based on expected response of the average patient • Tomorrow: healthcare will be based on individual genomic, environmental, and lifestyle differences that enable more precise ways to prevent and treat disease
  • 5. Precision Health Eric Green, MD, PhD – NIH NHGRI
  • 6.
  • 7.
  • 8.
  • 9. MOBILE PHONES > 96% of US population (88%Rural) >95% <$30,000/year >81% of US population have a smart phone (71% rural) Socioeconomic backgrounds Most Geographic locations Direct reach Mobile Health Pew 2019
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 19. Pediatric PBMT Vaughn, 2019 NINR F31NR018100 - Vaughn
  • 20.
  • 22.
  • 23.
  • 24. Partner2Lose: Using Partners to Enhance Long- Term Weight Loss NIDDK 1R01DK111491 PI: Voils Site PI: Shaw 24 Months Initiation: 6 Months Maintenance: 18 months
  • 25.
  • 26.
  • 28.
  • 29.
  • 30.
  • 31. Collaborators & Team members • Angel Barnes • Qing Yang • Jackie Vaughn • Dori Steinberg • Daniel Hatch • Matthew Crowley • Allison Vorderstrasse • Anna Diane • Constance Johnson • Geoff Ginsburg • Susanne Haga • Lori Orlando • Karen Judge • Ellie Wood • Marissa Stroo • Katie McMillan • Ellie Wood • Corrine Voils • Many more…
  • 32. • Shaw, R.J., Bosworth, H.B., Silva, S., Lipkus, I.M., Davis, L.L. Sha, R.S., Johnson, C.M. (2013). Mobile health messages help sustain recent weight loss. The American Journal of Medicine, 126(11), 1002-1009. PMID: 24050486. PMCID: PMC3820279 • Shaw, R.J., McDuffie, J.R., Hendrix, C.C., Edie, A., Lindsey-Davis, L., Nagi, A., Kosinski, A.S., Williams, J.W. Jr. (2014). Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: A systematic review and meta-analysis. Annals of Internal Medicine, 161(2), 113-121. doi: 10.7326/M13-2567. PMID: 25023250 • Shaw, R.J., Bonnet, J., Modarai, F., George, A., Shahsahebi, M. (2015). Mobile health technology for personalized primary care medicine. American Journal of Medicine, 128(6), 555-557. doi: 10.1016/j.amjmed.2015.01.005 PMID: 25613298 • Shaw, R.J., Pollak, K., Zullig, L., Bennett, G., Hawkins, K., Lipkus, I. (2016). Feasibility and smokers’ evaluation of self-generated text messages to promote quitting. Nicotine & Tobacco Research, 18(1), doi: 10.1093/ntr/ntv268 • Shaw, R.J., Steinberg, D., Bonnet, J., Modarai, F., George, A., Cunningham, T., Mason, M., Shahsahebi, M., Grambow, S.C., Bennett, G., Bosworth, H. (2016). Mobile health devices: Will patients actually use them? Journal of the American Medical Informatics Association, 1-5. DOI: 10.1093/jamia/ocv186 • Jain, S. H., Powers, B. W., Hawkins, J. B., & Brownstein, J. S. (2015). The digital phenotype. Nature Biotechnology, 33(5), 462. • Coravos A, Goldsack J, C, Karlin D, R, Nebeker C, Perakslis E, Zimmerman N, Erb M, K: Digital Medicine: A Primer on Measurement. Digit Biomark 2019;3:31-71. doi: 10.1159/000500413 • Hickey, K. T., Bakken, S., Byrne, M. W., Demiris, G., Docherty, S. L., Dorsey, S. G., ... & Moore, S. M. (2019). Precision health: Advancing symptom and self-management science. Nursing outlook. • Ferguson, C., Hickman, L., Wright, R., Davidson, P. M., & Jackson, D. (2018). Preparing nurses to be prescribers of digital therapeutics. • Cashion, A. K., & Grady, P. A. (2015). The national Institutes of health/national Institutes of nursing research intramural research program and the development of the national Institutes of health symptom science model. Nursing outlook, 63(4), 484-487. • Gambhir, S. S., Ge, T. J., Vermesh, O., & Spitler, R. (2018). Toward achieving precision health. Science translational medicine, 10(430), eaao3612. References

Editor's Notes

  1. Develop quantitative estimates of risk for a range of diseases by integrating environmental exposures, genetic factors, and gene-environment interactions, identification of determinants of individual variation in efficacy and safety of commonly used therapeutic, discovery of biomarkers that identify people at increased or decreased risk of developing diseases
  2. Also used in prenatal and newborn genomic analysis Cancer genome sequencing Ultra-rare genetic disease diagnostics
  3. Also used in prenatal genome sequencing
  4. Mobile phones, particularly smartphones (sophisticated internet-accessible cellular phones) and other mobile computing technologies are increasingly ubiquitous Over 285 million wireless subscribers in the US alone and over 67% of adults worldwide own a cell phone. This is in contrast to the Internet digital divide, that limited for years if not decades, the reach of computerized health behavior interventions for lower socioeconomic groups. Mobile phones are widely used among all demographic groups. The infrastructure exists. 96% of the US is covered by at least one mobile network including rural areas This allows reach across geographic location, socioeconomic backgrounds, and direct access to people
  5. mHealth may be particularly useful for chronic illness Chronic illness is the #1 health risk facing Americans. Approximately 50% of Americans have a chronic illness Leading cause of death and disability Acute -> chronic illness + extended life span = costly health care system Diabetes will become the most costly disease by 2020 Chronic illness is very difficult to manage. It requires daily if not hourly behavior change. i.e. exercise, diet, medication management, conscious choices mHealth may have significant impact on chronic illness management
  6. We tested new models of care delivery using telepresence robots. We incorporated the robots into educational offerings first and are now rolling them out into Duke Hospital.