DIOXINS AND HEALTH
DIOXINS AND HEALTHSECOND EDITIONEdited byArnold SchecterProfessor of Environmental SciencesUniversity of Texas School of P...
Copyright 6 2003 by John Wiley & Sons, Inc. All rights reserved.Published by John Wiley & Sons, Inc., Hoboken, New Jersey....
To our families
CONTENTSContributors                                                            ixPreface                                 ...
viii      CONTENTS10. E¤ects of Polychlorinated Biphenyls on Neuronal Signaling                    433       Richard F. Se...
CONTRIBUTORSEric A. Andreasen, Department of Environmental and Molecular Toxicology,   Oregon State University, Corvallis,...
x    CONTRIBUTORSMark E. Hahn, Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA 02543Lennart Harde...
CONTRIBUTORS     xiChristopher Portier, Environmental Toxicology Program, National Institute  of Environmental Health Scie...
xii   CONTRIBUTORSYing Xia, Department of Environmental Health, University of Cincinnati  Medical Center, Cincinnati, OH 4...
PREFACEIt is sometimes said that there are at least two sides to every story, andthat the truth is often somewhere in betw...
xiv    PREFACEtive as to how recent scientific data may relate to very relevant issues in humanand environmental health.   ...
PREFACE     xvthe fate of these chemicals in animal and human tissues. These data are partic-ularly important for defining ...
xvi    PREFACEreview the epidemiology of dioxins and cancer, including evidence of humancarcinogenicity. Chapter 19, by Sh...
CHAPTER 1Overview: The Dioxin DebateTHOMAS F. WEBSTERBoston University, Boston, MassachusettsBARRY COMMONERQueens College,...
2     OVERVIEW: THE DIOXIN DEBATEtroubling consequence is the possibility of reproductive, developmental, andimmunological...
SOURCES     3(PCBs) followed in the late 1920s (Table 1.1). The thermal and chemical sta-bility of PCBs, among other prope...
4      OVERVIEW: THE DIOXIN DEBATETABLE 1.1 Selected History of Dioxin and Dioxinlike Compounds1897–1899      Chloracne ch...
SOURCES         5these compounds and levels of chlorine in fuel, the nature of this relationship isstill not understood co...
6     OVERVIEW: THE DIOXIN DEBATEburning unleaded gasoline, presumably reflecting the low level of chlorine inthis fuel.46 ...
ENVIRONMENTAL FATE AND EXPOSURE       7ous, and industrial—and metal processing are the largest current estimatedsources o...
8       OVERVIEW: THE DIOXIN DEBATEa result, these two media can act as reservoirs, leading to recontamination ofother med...
BIOCHEMISTRY AND TOXICITY     9receptor family as supposed originally, it belongs to a family of basic helix-loop-helix pr...
10      OVERVIEW: THE DIOXIN DEBATEa high a‰nity for the Ah receptor and biological persistence. The relevance ofpersisten...
BIOCHEMISTRY AND TOXICITY      11growth factor receptors (EGFRs) internally from the cell membrane, providinga stimulus fo...
12      OVERVIEW: THE DIOXIN DEBATEtriosis, and cancer.8,98 It is generally thought that the Ah receptor mediatesthese e¤e...
CANCER         13                                                                          DNA damage andFigure 1.1 Some p...
14      OVERVIEW: THE DIOXIN DEBATEenhance cell proliferation via the epidermal growth factor pathway. Internal-ization of...
CANCER        15TABLE 1.2 Some Acceptable or Tolerable Daily Doses of TCDD                                Level (pg/kgOrga...
16    OVERVIEW: THE DIOXIN DEBATE                  Figure 1.2 Two possible dose–response curves.extrapolations are carried...
CANCER      17(LMS) used by the USEPA in 1985 was derived from the theory that cancerinvolves a sequence of irreversible s...
18    OVERVIEW: THE DIOXIN DEBATEtumor data might reduce the TCDD cancer slope factor estimate by a factor ofabout 2 to 3,...
CANCER        19receptor-bound dioxin.* Biological responses would not have a threshold ifthey are proportional to the amo...
20      OVERVIEW: THE DIOXIN DEBATE1.6.4   Human EffectsIs dioxin merely a powerful rodenticide? Are humans somehow exempt...
CANCER     21Qualitative Evidence for Cancer in Humans Much of the debate abouthuman e¤ects has centered on the question o...
22     OVERVIEW: THE DIOXIN DEBATEworkers was used to validate estimates of exposure made on the basis of workhistory.    ...
SENSITIVE NONCANCER EFFECTS        23significant’’ increased cancer mortality in the entire cohort as well as in a highlyex...
24    OVERVIEW: THE DIOXIN DEBATE1960s.227,228 Epidemics of reproductive and developmental problems havesince been observe...
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[Arnold  schecter,_thomas_a._gasiewicz]_dioxins_an(book_fi.org)
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