Oren McNulty is seeking a position in a chemistry research team. He has a Master of Science in Chemistry expected in May 2015 from the University of Colorado at Denver with a 3.70 GPA. His thesis involves designing and synthesizing small molecule inhibitors of the Mcl-1 protein for cancer treatment. Previously, he established a stem cell proliferation model and used techniques like flow cytometry, PCR, and blotting in bone marrow transplant research. McNulty has skills in organic synthesis, spectroscopy, chromatography, and biology techniques. He has presented his Mcl-1 inhibitor work and co-authored a 1997 paper on human stem cell engraftment in mice.

1. Oren McNulty
omcnulty74@hotmail.com
7096 S. Kewaunee Ct.  Aurora, CO 80016.  (720) 984-3495
OBJECTIVE
To be an integral part of a highly motivated research team in chemistry. My areas of interest include drug
discovery, organic synthesis, alternative energy sources (such as biofuels) and petrochemical chemistry.
EDUCATION AND AWARDS
2011 - present: University of Colorado at Denver, Department of Chemistry, Denver, CO.
 MS in Chemistry, Expected May 2015, current GPA 3.70.
 Outstanding graduate TA.
1998 - 2002: University of Colorado at Denver, Denver, CO, 3.78 GPA overall.
 B.S., Chemistry, Biochemistry emphasis, cum laude honors, 3.70 GPA in Chemistry.
 B.S., Biology, magna cum laude honors, 3.88 GPA in Biology.
 Outstanding senior nominee, national dean’s list member, academic all-star.
RESEARCH EXPERIENCE
2012 - present: University of Colorado at Denver, Denver, CO.
Research Advisor: Professor Lisa D. Julian.
Thesis: Design and synthesis of small molecule inhibitors of the Mcl-1 protein for the treatment of cancer.
 Used structure based design to develop novel targets for synthesis.
 Synthesized eight distinct small molecules from commercially available starting materials.
 Purified and characterized compounds to greater than 95% purity.
 Partnered with the Mayo Clinic in Rochester, Minnesota in order to test the biological activity of
the novel small molecules.
1994 - 1996: University Hospital of Colorado, Bone Marrow Transplant Research Lab, Denver, CO
Supervisor: Dr. Chris Hogan.
Established a model for stem cell proliferation in NOD/scid mice using CD34+ enriched umbilical cord
blood.
 Used Flow Cytometry to analyze mouse to human cell ratios and to remove specific human cell
populations (CD34+) from the mouse bone marrow.
 Colony Forming Unit (CFU) assays were performed to analyze progenitor capabilities of engrafted
cells and to provide ample material for further PCR amplification.
 Utilized quantitative PCR to amplify human DNA sequences that were populated in the bone
marrow of NOD/scid mice.
CHEMISTRY SKILLS AND TECHNIQUES
 Proficient in transition-metal catalyzed cross-coupling reactions to form carbon-carbon bonds.
 Extensive experience with chemistry involving nitrogen-containing drug motifs such as indoles,
pyridines, and pyrroles.
 Experience with LCMS, TLC, NMR spectroscopy and IR spectroscopy to characterize compounds.
 Proficient in flash chromatography and analytical HPLC to purify and determine purity of
compounds.

2. BIOLOGY SKILLS AND TECHNIQUES
 PCR to amplify human DNA sequences.
 Flow cytometry to analyze and separate subpopulations of cells.
 Gel electrophoresis paired with southern and western blotting to determine identity and to purify
specific DNA sequences and proteins.
TEACHING EXPERIENCE
2011-2013: University of Colorado at Denver, Denver, CO.
Teaching Assistant, Organic Chemistry.
 Ran five Organic Chemistry I and II laboratory sections.
Teaching Assistant, Honors General Chemistry.
 Assisted in preparing and running five Honors Chemistry I and II laboratory sections.
Teaching Assistant, General Chemistry, Fall Semester 2011.
 Ran two General Chemistry I laboratory sections.
PRESENTATIONS & PUBLICATIONS
McNulty, O.; Moen, J.; Yan, C.; Julian, L.D. Structure-Based Design and Synthesis of Mcl-1 Inhibitors for the
Treatment of Multiple Myeloma. Western Regional Meeting of the American Chemical Society,
Westminster, CO, October 17-20, 2012.
Christopher J. Hogan, Elizabeth J. Shpall, Oren McNulty, Ian McNiece, John E. Dick, Leonard D. Schultz,
and Gordon Keller. Engraftment and Development of Human CD34+-Enriched Cells From Umbilical Cord
Blood in NOD/LtSz-scid/scid Mice: Blood Magazine, Vol. 90, No 1 (July 1), 1997: pp 85-96.
McNulty, O.; Johnson-Sasso, L.; Tyk, L.; Lin, H.; Julian, L.D. Structure-Based Design and Synthesis of Mcl-1
Inhibitors for the Treatment of Multiple Myeloma. Manuscript in Preparation.