APIs are the biologically active components of drugs that are responsible for the desired medical effect. Cipla were facing issues with the manual transport of the chemical ingredients required for API manufacture - it was not only slow, but dangerous as well. A.T.E. helped Cipla find a solution that saved time and reduced the risk of explosions greatly. Find out how! For more information visit us at: http://ategroup.com/ Explore the complete range of Yamada AODD pumps at http://ategroup.com/flow-technology/flow-technology/product-family/aodd-pumps/ Download the complete case study at http://ategroup.com/wp-content/uploads/case-studies/CS8-Cipla-Yamada-AODD.pdf

1. 1
Yamada AODD pump ensures safety in
API manufacturing – a case study at
Cipla Limited

2. 2
API manufacturing – challenges and
solution
 About API : APIs are substances that are biologically
active within drugs responsible for desired medical effect
in the body
 Challenges faced by Cipla
Limited
 Powder chemicals were transferred from
the storage area to the API reactor
manually
 The manual transfer of powder from
storage area to reactor was at a rate of
50 kg/h
 Open operation presented risk of static
generation leading to fire or explosions
 Solution suggested by
A.T.E.
 A Yamada AODD pump was installed in one
of the API reactors for transferring powder
chemicals
 The Yamada AODD pump transferred
powder chemicals from storage area to
reactor at a rate of 100 kg/h with 3 kg air
pressure
 Closed operation under a nitrogen blanket –
less exposure to environment and lower risk
of fire or explosion

3. 3
Powder transfer by manual method vs.
with Yamada AODD pump
Yamada AODD pump for powder
transfer application in API reactor
Manual method of powder transfer
in API reactor
Less exposure to environment – Lower risk of fire or
explosion
Up to 50 % reduction in powder transfer process
time

4. 4
Benefits
With Yamada AODD pump
 Efficiency
 Up to 50% reduction in powder transfer
process time as compared to manual process
 Safety
 The Yamada AODD pump operates under a
closed nitrogen blanket, thus, ensuring safety
by preventing any fire or explosions
 The pump is pneumatically operated; does not
require a motor
 Less Maintenance
 The pump works smoothly without choking,
which means less maintenance
Yamada AODD pump

5. 5
We found A.T.E. to be a very reliable flow technology solution
provider. We are very happy for the solution provided in API process
technology with Yamada AODD pump. We are going to replicate this
solution in other units of Cipla.
– Ajit Patil, API manufacturing, Cipla Ltd
Happy Customer

6. 6
About Cipla Ltd
 Cipla Limited is an Indian multinational pharmaceutical and
biotechnology company
 It is headquartered in Mumbai, India
 Cipla is a pioneer in API manufacturing in India for over 5 decades
 It currently manufactures more than 200 generic and complex APIs
 Cipla has a network of modern API manufacturing facilities; all approved
by the US FDA and other major international regulatory agencies

7. 7
Contact us
For more information:
A.T.E. Enterprises Private Limited
T-126, T Block, MIDC, Bhosari, Pune 411 026 India
Email: flowtech@ateindia.com
Phone: +91-20-30881100/30881200
Or visit us: www.ategroup.com

8. 8
THANK YOU