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The NLRC4 inflammasome is assembled and activated within a macrophage following infection
with a pathogen. However, TLR5 on this same macrophage does not become activated. What
does this information tell you about the pathogen?
a) The pathogen infects neighboring non-immune cells.
b) The pathogen is found in the macrophage's nucleus.
c) The pathogen is found in the macrophage's cytosol.
d) The pathogen cannot infect macrophages.
e) The pathogen does not express the PAMP that serves as a ligand for TLR5.

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The NLRC4 inflammasome is assembled and activated within a macrophage.pdf

  • 1. The NLRC4 inflammasome is assembled and activated within a macrophage following infection with a pathogen. However, TLR5 on this same macrophage does not become activated. What does this information tell you about the pathogen? a) The pathogen infects neighboring non-immune cells. b) The pathogen is found in the macrophage's nucleus. c) The pathogen is found in the macrophage's cytosol. d) The pathogen cannot infect macrophages. e) The pathogen does not express the PAMP that serves as a ligand for TLR5.