The papilloma virus is a non-enveloped class I double-stranded DNA virus. What would be the most likely path for replication? Host RNA polymerases will transcribe the antisense viral DNA strand to produce sense mRNA for protein production. The virus carries a reverse transcriptase to convert the DNA to RNA. Host DNA polymerase will only replicate the viral DNA. The antisense strand of the viral double-stranded DNA is used directly for protein production. Host RNA polymerases will transcribe the sense viral DNA strand to produce antisense mRNA for protein production..