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TURKEY - the stories of successful leaders
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Joanna Dimitrova
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Presentation for the 6th Erasmus + meeting in Poland.
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Presentation for the 6th Erasmus + meeting in Poland.
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Glycosylation is a key structural and functional element found on a wide variety of biotherapeutics. As such, alterations in glycan profile can significantly affect the efficacy of a drug through, for example, half life in the bloodstream or biological activity as well as being a potential source of immunogenicity. The glycan profile can be selected and controlled through the choice of cell line as well as control of bioreactor conditions. The use of analytical techniques that provide structural data on this type of post translational modification are vital in the development and characterisation of biologics. Techniques in glycan structural characterisation are discussed in this presentation.
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Presentation for the 6th Erasmus + meeting in Poland.
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Glycosylation is a key structural and functional element found on a wide variety of biotherapeutics. As such, alterations in glycan profile can significantly affect the efficacy of a drug through, for example, half life in the bloodstream or biological activity as well as being a potential source of immunogenicity. The glycan profile can be selected and controlled through the choice of cell line as well as control of bioreactor conditions. The use of analytical techniques that provide structural data on this type of post translational modification are vital in the development and characterisation of biologics. Techniques in glycan structural characterisation are discussed in this presentation.
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