Cells in the interior of complex multicellular organisms are able to respond to environmental signals through: receptors for signals sent from exterior cells that relay information about environmental changes. receptors designed to detect directly changes in the external environment. diffusion of environmental cues through the outer layers of the body. pH, temperature, or osmolarity receptors in the membranes of interior cells. Solution Ans: Cells in the interior of complex multicellular organisms are able to respond to environmental singnals through pH, temperature or osmolarity receptors in the membranes of interior cells.