By: Qurat-ul-ain Ophthalmic Medical Technologist/ MBA Health & Hospital management

1. UVEITIS
By: Qurat-ul-ain
Ophthalmic Medical
Technologist/ MBA Health &
Hospital management

2. UVEITIS
CLASSIFICATION
Uveitis
Anterior Intermediate Posterior Pan-uveitic

3. • Crohn’s disease, Sarcoidosis, Spondylo-arthritis,
Sympathetic ophthalmia
Non-infectious
• Brucellosis, Lyme disease, Syphilis, Tuberculosis
Infectious
• Inflammatory Bowel disease, multiple sclerosis,
Sarcoidosis, reactive arthritis
Associated with systemic disease
• Rifabutin, Quinolones,
Drug related side-effects
Etiolog
y

4. Immunologic
factors
Genetic factors
Infectious agents
T- cells, Th1 and Th17
HLA-B27 and PTPN-22
genotype
Herpes simplex, varicella
zoster
PATHOPHYSIOLO
GY

5. ANTERIOR
UVEITIS
• Symptoms:
Acute: pain, redness, photophobia, consensual
photophobia, excessive tearing, decreased vision.
Chronic: decreased vision, ERM, floaters, few
acute symptoms ( juvenile idiopathic arthritis).
• Signs:
Critical. Cells and flare in the anterior chamber,
ciliary flush, keratic precipitates (KP).
Fine KP
, small non-granulomatous,
granulomatous KP
.
Low IOP (sec. to ciliary body hyposecretion),
elevated IOP (herpetic lens-induced).
Fibrin, hypopyon, iris nodules, iris atrophy, iris
heterochromia, iris synechiae, band keratopathy,
uveitis in a quite eye and CME.
Includes iridocyclitis and iris.
Inflammation of the ciliary body.
This condition can occur as a
single episode and subside with
proper treatment.

6. INTERMEDIATE
UVEITIS
• Symptoms:
Painless floaters, decreased vision, minimal
photophobia, external inflammation. Most
often bilateral & classically affects patients
15 to 40 years.
• Signs:
Critical: vitreous cells and cellular aggregates
floating predominantly in the inferior vitreous
(snowballs). Younger patients may present
with vitreous hemorrhage. White exudative
material over the inferior ora-serrata and pars
plana is suggestive of pars-planitis.
Other: peripheral retinal vascular sheathing,
peripheral neovascularization, mild AC
inflammation, CME, PSC, band keratopathy,
sec. glaucoma, ERM, exudative RD. post.
Synechiae.

7. POSTERIOR
UVEITIS
Symptoms:
Vary according to the location of the
focus & presence of vitritis.
Patient with a peripheral lesion may complain of
floaters whereas patient with a lesion on macula
may complain of impaired central vision.
Signs:
o Retinitis
o Choroiditis
o vasculitis

8. PANUVEITIS
Severe diffuse inflammation of both anterior and
posterior segments. Often bilateral.
Endophthalmitis or posterior scleritis should be
considered in patients with posterior uveitis and
significant pain.
Signs:
Cells in posterior vitreous, vitreous haze, retinal of
choroidal inflammatory lesions, retinal vasculitis,
retinal neovascularization, CME, ERM and choroidal
neovascular membrane.

9. INVESTIGATIONS:
• Skin test
• Serology test
• Enzyme assay
• HLA tissue typing
• Imaging
• FA
• ICG
• US
• OCT
• Biopsy
• Radiology

10. TREATMENT:
• Mydriatics
• Topical steroids
• Periocular steroids
• Systemic steroids
• Anti-metabolites
• Immune modulators

11. THANK YOU!