Alkaloids of Taxol

2. Alkaloids of Taxol
Presented by
Ankosh R. Wanole
M. Pharm. 1st Year
Department of Pharmaceutical Sciences
Rashtrasant Tukadoji Maharaj, Nagpur University
Nagpur

3. Definitions:
Alkaloids are applied to basic nitrogen plant product mostly optically
active possessing nitrogen heterocyclic as their structural units with a
pronounced psychological (therapeutic) action derived from amino acid.
Alkaloids are a class of basic naturally occurring organic compound that
contain at least one nitrogen atom.
This group also includes some related compound with natural acidic
properties
Alkaloids

4. Taxol, the blockbuster anticancer molecule from nature
Taxol is a diterpenoid alkaloid obtained from bark of plant Taxus Brevifolia belonging
to the family Taxaceae. It is a potent antineoplastic agent.
• Taxol , organic compound with a complex multi- ring
molecule that occurs in the bark of Pacific yew trees (Taxus
Brevifolia).
• It is active against certain cancers of the lung, ovary, breast,
head, and neck, disrupting cell division and interfering with
separation of the nuclear chromosomes.

5. Taxol
Full Name- Taxus Brevifolia
Molecular Formula - C47H51NO14
Another Name Of Taxon - Pactitaxel ,
is a chemotherapy drug

6. Biological Source:
Nitrogen
containing substance, bark of Taxus
brevifolia family - taxaceae.
It is a tetracyclic diterpenoid and a taxane
diterpenoid. It is functionally related to a
baccatin .
Paclitaxel is a chemotherapeutic agent
marketed under the brand name Taxol
among others.

7. Litmus Test:
It is a simple test to determine whether a
substance is acidic or basic.
Red litmus paper turns blue in a basic solution,
while blue litmus paper turns red in an acidic
solution.

12. First step concerns
triethylsilylation of C-7 OH;
additionally C-10 hydroxyl
group has to be acetylated.
This semi product may be
coupled in reaction with
enantiomeric O-protected N-
benzoyl-α- hydroxy-B-amino acid.
After deprotection of
hydroxyl groups with HCl,
Taxol is obtained with yield
up to 90%
10-dercely bacaan
Taxol

13. Microtubule disassembly
Microtubule assembly
Alpha tubulin
Beta tubulin
Taxol, prevents disassembly of
microtubule

15. Taxol is a common chemotherapy
medication for
• breast cancer
• ovarian cancer
• lung cancer