a) False The enzyme reduces the energy required to reach the highest energy transition state of the reaction b) false Substrates bind to the active site of the enzyme through hydrogen bonds, hydrophobic interactions, temporary covalent interactions (van der Waals) or a combination of all of these to form the enzyme-substrate complex. c) False d) false e) true Solution a) False The enzyme reduces the energy required to reach the highest energy transition state of the reaction b) false Substrates bind to the active site of the enzyme through hydrogen bonds, hydrophobic interactions, temporary covalent interactions (van der Waals) or a combination of all of these to form the enzyme-substrate complex. c) False d) false e) true.