Breast Cancer during pregnancy

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],2/46

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],3/46

[object Object],[object Object],[object Object],Saunders CM,Baum M Breast cancer and pregnancy review .J R Soc Med 1993;86:162-5 7/46

[object Object],- Painless mass - Nipple discharge - Inflammatory breast 9/46

Histopathology LN Status Receptor status 11/46

Histopathology Invasive ductal ca Invasive lobular ca Inflammatory breast ca Middleton LP , et al. Breast carcinoma in pregnant women.Assissment of clinicopathologic & immunohistochemical features. Cancer 2003;98:1055-60 12/46

[object Object],[object Object],[object Object],Histopathology Middleton LP , et al. Cancer 2003;98:1055-60 13/46

[object Object],[object Object],[object Object],Receptor status Elledge RM ,et al ER , PR and Her-2/neu protien in breast cancer from pregnant patients. Cancer 1993;71:2499-506 14/46

[object Object],[object Object],LN status Isaac J . Cancer of the breast in pregnancy. Surg clin North Am 1995;75:47-51 15/46

[object Object],[object Object],[object Object],Moore HCF, Foster Jr Rs. Breast cancer and pregnancy Semin oncol.2000;27:646-53 17/46

[object Object],[object Object],[object Object],Sorosky JI ,Scott-conner. Breast cancer complicating pregnancy.Obst Gynecol clin North Amer 1998;25(2):353-63 18/46

Radiation effect Dose dependant Gestational age 20/46

< 0.1 Gy > 3 Gy Dose No effect Fetal malformation 21/46

Teratogenic Gestational age 16 w 2 w Abortion 25 w Sterility malignancy Mole RH.childhood cancer after prenatal exposure to diagnostic x-ray examinations in Britain. Br J Cancer 1990;62:152-68 22/46

[object Object],[object Object],[object Object],[object Object],Nicklas A, Baker M. Imaging strategies in pregnant caner patients. Semin oncol 2000;27:623-32 23/46

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],24/46

Surgery Chemotherapy Radiotherapy 26/46

[object Object],[object Object],[object Object],[object Object],[object Object],Surgical Rx 27/46

[object Object],Chemotherapy 28/46 teratogenic ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Chemotherapy 29/46

[object Object],[object Object],[object Object],[object Object],Radiotherapy Woo JC et al Breast cancer in pregnancy: a literature review. Arch Surg 2003;138:91-8 30/46

[object Object],[object Object],[object Object],Mother and fetal outcome Petrek JA et al. Prognosis of pregnancy associated breast cancer. Cancer 1991;67:869-72 32/46

[object Object],[object Object],[object Object],[object Object],Mother and fetal outcome 33/46

[object Object],[object Object],[object Object],[object Object],Supportive drug 34/46

[object Object],[object Object],[object Object],[object Object],Supportive drug 35/46

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Petrek JA et al. Prognosis of pregnancy associated breast cancer. Cancer 1991;67:869-72 37/46

Petrek JA et al. Prognosis of pregnancy associated breast cancer. Cancer 1991;67:869-72

[object Object],[object Object],39/46

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],40/46

[object Object],[object Object],Bonadonna G, Valgussa P. Adjuvant systemic therapy for resectable breast cancer . J Clin Oncol 1985:3:259–75. 41/46

[object Object],[object Object],[object Object],42/46

[object Object],[object Object],[object Object],[object Object],[object Object],44/46

[object Object],Berry et al . Management of breast cancer during pregnancy using a standardized protocol J Clin Oncol 1999 45/46

Breast Cancer during pregnancy

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