Liposome B pharm 7th Semester NDDS Targeted Drug Delivery System

1. LIPOSOME
FAIZABAD ROAD, BARABANKI
TOPIC
Presented To :- Mrs Anjali Singh Presented By: -Alok Verma
( B.Pharm 4th Year)

2. CONTENTS
INTRODUCTION
STRUCTURES OF LIPOSOME
CLASSIFICATION
METHODS OF PREPARATION
ADVANTAGES & DISADVANTAGES
APPLICATIONS
REFERENCES
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3. • Liposomes are spherical shaped small vesicles .
• They can be produced from cholesterols, non toxic surfactants,
glycolipids, long chain fatty acids and even membrane proteins.
• Liposomes are the drug carrier loaded with different variety of
molecules such as small drug molecules, proteins, nucleotides and
even plasmids.
• Liposomes are made of molecules with hydrophilic head and
hydrophobic ends that form hollow spheres.
INTRODUCTION
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4. STRUCTURES OF LIPOSOME
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5. STRUCTURAL COMPONENTS OF
LIPOSOMES
The main components of liposomes are :
1. Phospholipids
2. Cholesterol
Phospholipids are the major structural components of biological
membranes. The most common phospholipid used in liposomal
preparation is PC.
Phospholipids
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6. Phosphatidylcholine is an amphipatic molecule containing
-A hydrophilic polar head group, phosphocholine
-A glycerol bridge
-A pair of hydrophobic acyl hydrocarbon chains.
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Cholesterol
• Cholesterol acts as a fluidity buffer.
• It can be incorporated into phospholipid membranes in very high
concentration up to 1:1 or even 2:1 ratios of cholesterol to phospholipids.
• Cholesterol itself does not form a bilayer structure.

7. CLASSIFICATION OF LIPOSOME
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8. METHODS OF PREPARATION
LIPOSOME PASSIVE LOADING
TECHNIQUE
ACTIVE LOADING
TECHNIQUE
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Loading of the entrapped agent
before/during the manufacture
procedure.
Certain types of compounds with
ionisable those with the both
manufacturing procedure lipid and
water solubility can be introduced
into the liposome after the intact
vesicle.

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ACTIVE LOADING
PASSIVE LOADING

10. • Liposomes are biocompatible, completely biodegradable & non-toxic.
• Liposomes supply both a lipophilic environment and aqueous in one
system and are therefore suitable for delivery of hydrophobic,
amphipathic, and hydrophilic drugs and agents.
• Liposomes have ability to protect their encapsulated drug from the
external environment.
• Liposomes are increased efficacy and therapeutic index of drug
(Amphotericin B).
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ADVANTAGES

11. • Production cost is high.
• Leakage and fusion of encapsulated drug.
• Sometimes phospholipid undergoes oxidation and hydrolysis like
reaction.
• Short half-life.
• Low solubility.
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DISADVANTAGES

12. • Liposomes can target a drug to the intended site of action in the body
(site-specific delivery).
• Reduction in the toxic effect and enhancement of the effectiveness of
drugs.
• Liposome as a tumour therapy.
• They are used in antifungal and antiviral therapy
• They are used in immunology.
• Liposomal Vaccine
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APPLICATIONS

13. • Tripathi DK and Alexander Amit ; A Text Book of “NOVEL DRUG
DELIVERY SYSTEM” , Third Edition 2019 , Published by BSP Book
Private Limited .
• D.M. Bramhankar & Sunil B. Jaiswal Biopharmaceutics &
Pharmacokinetics (First edition 2005) pg. no- 360-361.
• Vyas S.P. & Khar R.K. , “Targeted & Controlled Drug Delivery” CBS
Publication 2008 , Page No – 173.
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REFERENCES

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THANK YOU !