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Corneal Diseases
Presented By:
Muhammad Akbar Raashid Qadri
MS Healthcare Management, Public Health
Scholar, Clinical Optometrist
Congenital abnormalities of cornea
Microcornea
• A congenital condition
• The corneal diameter is <10 mm
(or <9 mm in newborns).
• Unilater or bilateral
• It is believed to arise due to arrest of
growth of the cornea in the 5th
gestational month.
Megalocornea
• Large corneal diameter > 13mm
• Bilateral
• Usually X-linked
• 90% of the affected individuals are
Males
• High Myopia andAstigmatism
Cornea plana
Severe decrease in corneal
curvature resulting in reduced
refractive power of the cornea
( 20D – 30D)
• Rare
• Bilateral
• Hypermetropia
Corneal ectasia
Are a group of uncommon, noninflammatory, eye disorders characterised by
• bilateral thinning of the central, paracentral, or peripheral cornea
• Most common
1. Keratoconus
2. Keratoglubous
3. Pellucid marginal degeneration
• a progressive, non- inflammatory,
• bilateral, asymmetric disease
• characterized by paraxial stromal thinning
and weakening that leads to corneal
surface distortion.
• Onset = around puberty, slow progression
thereafter until the 3rd & 4th decades of
life
• Role of heredity
• Most pts. do not have positive family Hx.
Keratoconus
“the condition in which the entire cornea
is
abnormally thin”
Or
Generalized thinning of cornea
Keratoglobus
Pellucid marginal degeneration
• Inferior corneal thinning ( sometimes
superior cornea too)
• Bilateral
• Onset: 20 years to 40 years
• Cresent shape band of inferior
cornea extending from 4 – 8 o’clock
• Intact epithelium
Punctate epithelial erosions
OTiny ,slightly depressed,
epithelial defects which stain with
Fluorescence but not with rose
Bengal
OPEE are non specific and may
develop in a wide variety of
keratopathies
Epithelial Oedema
Sign of Epithelial Oedema
are:
1. Endothelial
decompensation
2. Severe acute elevation of
IOP
Pannus
O Inflammatory or degenerative
ingrowth of fibro vascular
tissue from limbus
Bacterial Keratitis
Pathogens which can produce corneal
infection in intact epithelium
O Neisseria gonorrhoeae
O Corynebacterium diphtheriae.
O Haemophilus
FUNGAL KERATITIS
Filamentous FUNGAL
KERATITIS
O Aspergillus
O Fusarium
Candida keratitis
Usually develops in pre-existing
corneal disease or
immunocompromised patient
O Yellow-white ulcer
O Dense suppuration
ACANTHAMOEBA KERATITIS
O Perineural infilterates
O radial keratoneuritis
O Infilterates coalesce –ring abcess,
O ulceration
O hypopyon
Herpes Simplex Keratitis
Primary ocular herpes:
O Blepharoconjunctivitis
O Keatitis
O punctate epithelial
Dendritic Ulcer
O Opaque cells arranged in a course
punctate or stellate pattern
O Central desquamation leads to a
linear
PHLYCTENULOSIS
O Predominantly affects children
O hypersensitivity reaction to
staphylococcal or other bacterial
antigen
O Photophobia
O lacrimation
O blepharospasm
Corneal Chemical Injuries
O Chemical (alkali and acid) injury of
the conjunctiva and cornea is a true ocular emergency and
requires immediate intervention
O Early recognition and treatment ensures the best possible
outcome for this potentially blinding condition
Alkali Burns
O Alkalies can penetrate tissues more
rapidly than acids
O They saponify the fatty acids of
cell cell membranes, penetrate the
corneal stroma and
destroy proteoglycan ground
substance and collagen bundles
Acid Burns
O Acids can penetrate tissues less than
Alkalies
O Acids are generally less harmful than
alkali substances
O They cause damage by denaturing and
precipitating proteins in the tissues
Management
O Eye wash with normal saline
O pain-relieving medication
O topical antibiotics to reduce the risk of infection.
O lubricants
O anti-inflammatory medication
Thermal Eye Injury
Thermal trauma is any burn-related injury that can potentially lead to
serious outcomes
Causes
O Fire
O radiant heat
O Radiations
O electrical contact
Thank
You

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Corneal Diseases / abnormalities

  • 1. Corneal Diseases Presented By: Muhammad Akbar Raashid Qadri MS Healthcare Management, Public Health Scholar, Clinical Optometrist
  • 2. Congenital abnormalities of cornea Microcornea • A congenital condition • The corneal diameter is <10 mm (or <9 mm in newborns). • Unilater or bilateral • It is believed to arise due to arrest of growth of the cornea in the 5th gestational month.
  • 3. Megalocornea • Large corneal diameter > 13mm • Bilateral • Usually X-linked • 90% of the affected individuals are Males • High Myopia andAstigmatism
  • 4. Cornea plana Severe decrease in corneal curvature resulting in reduced refractive power of the cornea ( 20D – 30D) • Rare • Bilateral • Hypermetropia
  • 5. Corneal ectasia Are a group of uncommon, noninflammatory, eye disorders characterised by • bilateral thinning of the central, paracentral, or peripheral cornea • Most common 1. Keratoconus 2. Keratoglubous 3. Pellucid marginal degeneration
  • 6. • a progressive, non- inflammatory, • bilateral, asymmetric disease • characterized by paraxial stromal thinning and weakening that leads to corneal surface distortion. • Onset = around puberty, slow progression thereafter until the 3rd & 4th decades of life • Role of heredity • Most pts. do not have positive family Hx. Keratoconus
  • 7. “the condition in which the entire cornea is abnormally thin” Or Generalized thinning of cornea Keratoglobus
  • 8. Pellucid marginal degeneration • Inferior corneal thinning ( sometimes superior cornea too) • Bilateral • Onset: 20 years to 40 years • Cresent shape band of inferior cornea extending from 4 – 8 o’clock • Intact epithelium
  • 9. Punctate epithelial erosions OTiny ,slightly depressed, epithelial defects which stain with Fluorescence but not with rose Bengal OPEE are non specific and may develop in a wide variety of keratopathies
  • 10. Epithelial Oedema Sign of Epithelial Oedema are: 1. Endothelial decompensation 2. Severe acute elevation of IOP
  • 11. Pannus O Inflammatory or degenerative ingrowth of fibro vascular tissue from limbus
  • 12. Bacterial Keratitis Pathogens which can produce corneal infection in intact epithelium O Neisseria gonorrhoeae O Corynebacterium diphtheriae. O Haemophilus
  • 14. Candida keratitis Usually develops in pre-existing corneal disease or immunocompromised patient O Yellow-white ulcer O Dense suppuration
  • 15. ACANTHAMOEBA KERATITIS O Perineural infilterates O radial keratoneuritis O Infilterates coalesce –ring abcess, O ulceration O hypopyon
  • 16. Herpes Simplex Keratitis Primary ocular herpes: O Blepharoconjunctivitis O Keatitis O punctate epithelial Dendritic Ulcer O Opaque cells arranged in a course punctate or stellate pattern O Central desquamation leads to a linear
  • 17. PHLYCTENULOSIS O Predominantly affects children O hypersensitivity reaction to staphylococcal or other bacterial antigen O Photophobia O lacrimation O blepharospasm
  • 18. Corneal Chemical Injuries O Chemical (alkali and acid) injury of the conjunctiva and cornea is a true ocular emergency and requires immediate intervention O Early recognition and treatment ensures the best possible outcome for this potentially blinding condition
  • 19. Alkali Burns O Alkalies can penetrate tissues more rapidly than acids O They saponify the fatty acids of cell cell membranes, penetrate the corneal stroma and destroy proteoglycan ground substance and collagen bundles
  • 20. Acid Burns O Acids can penetrate tissues less than Alkalies O Acids are generally less harmful than alkali substances O They cause damage by denaturing and precipitating proteins in the tissues
  • 21. Management O Eye wash with normal saline O pain-relieving medication O topical antibiotics to reduce the risk of infection. O lubricants O anti-inflammatory medication
  • 22. Thermal Eye Injury Thermal trauma is any burn-related injury that can potentially lead to serious outcomes Causes O Fire O radiant heat O Radiations O electrical contact