SlideShare a Scribd company logo
1 of 9
New Hepatitis C Guidelines
(AASLD, IDSA, IAS-USA)
Dr. Ahsan
MBBS,FCPS (Medicine)
Senior Registrar Medical Unit-1
• The Evidence based consensus
recommendations for the screening, treatment
and management of patients with HCV were
developed by a panel of 27 liver disease and
infectious disease specialists and a patient
advocate.
• Available Online on;

• www.hcvguidelines.org
Types of Recommendations
• "Recommended”: when regimen is favored for
most patients
• "Alternative" when optimal in a particular
subset of patients in that category.
• "Not Recommended" When a treatment is
clearly inferior or is deemed harmful, such
regimens should not be administered to
patients with HCV infection
IFN ineligible
IFN ineligible is defined as one or more of the below:
• Intolerance to IFN
• Autoimmune hepatitis and other autoimmune disorders
• Hypersensitivity to PEG or any of its components
• Decompensated hepatic disease
• History of depression, or clinical features consistent with
depression
• A baseline neutrophil count below 1500/μL, a baseline
platelet count below 90,000/μL or baseline hemoglobin
below 10 g/dL
• A history of preexisting cardiac disease
SOFOSBUVIR
• Sofosbuvir (Tab. Sovaldi 400mg) is a prodrug
of a nucleotide analogue inhibitor of the HCV
NS5B RNA-dependent RNA polymerase.
• NEUTRINO, COSMOS trial: Genotype 1,4
• VALENCE
, POSITRON, FISSION, FUSION, PROTON
, ELECTRON : Genotype 2,3
• Approved By FDA In DEC 2013.
SIMEPREVIR
• Simeprevir (150 mg daily), a specific inhibitor
of the HCV NS3/4A serine protease.
• COSMOS TRIAL: GENOTYPE 1
Genotype 3 Recommendations
• It is anticipated that safer and more effective
IFN-free regimens will be available by 2015.

More Related Content

What's hot

Hepatitis C - Recent advances
Hepatitis C - Recent advancesHepatitis C - Recent advances
Hepatitis C - Recent advancesSubhasish Deb
 
Harvoni and Hepatitis C revised
Harvoni and Hepatitis C revisedHarvoni and Hepatitis C revised
Harvoni and Hepatitis C revisedThomas Huang
 
Hepatitis c infection, causes, treatment, and prevention
Hepatitis c infection, causes, treatment, and preventionHepatitis c infection, causes, treatment, and prevention
Hepatitis c infection, causes, treatment, and preventionNada Sami
 
Who.hcv treatment guidelines 2016
Who.hcv treatment  guidelines 2016Who.hcv treatment  guidelines 2016
Who.hcv treatment guidelines 2016Buruh harian lepas
 
Best Practices in the Management of HCV. 2015
Best Practices in the Management of HCV. 2015Best Practices in the Management of HCV. 2015
Best Practices in the Management of HCV. 2015hivlifeinfo
 
Challenges in HCV Management
Challenges in HCV Management Challenges in HCV Management
Challenges in HCV Management drnkhokhar
 
Hepatitis C : Complete Overview and Recent Updates 2019
Hepatitis C : Complete Overview and Recent Updates 2019Hepatitis C : Complete Overview and Recent Updates 2019
Hepatitis C : Complete Overview and Recent Updates 2019Chetan Ganteppanavar
 
Chronic hepatitis b
Chronic hepatitis bChronic hepatitis b
Chronic hepatitis bBSMMU
 
CHRONIC HEPATITIS B
CHRONIC HEPATITIS BCHRONIC HEPATITIS B
CHRONIC HEPATITIS BFarhad Safi
 

What's hot (20)

HBV EASL 2017
HBV EASL 2017HBV EASL 2017
HBV EASL 2017
 
Hepatitis c
Hepatitis cHepatitis c
Hepatitis c
 
Hepatitis C - Recent advances
Hepatitis C - Recent advancesHepatitis C - Recent advances
Hepatitis C - Recent advances
 
Harvoni and Hepatitis C revised
Harvoni and Hepatitis C revisedHarvoni and Hepatitis C revised
Harvoni and Hepatitis C revised
 
Hepatitis c infection, causes, treatment, and prevention
Hepatitis c infection, causes, treatment, and preventionHepatitis c infection, causes, treatment, and prevention
Hepatitis c infection, causes, treatment, and prevention
 
HCV guidance may_24_2018b
HCV guidance may_24_2018bHCV guidance may_24_2018b
HCV guidance may_24_2018b
 
HCV Story ---by Mohammed Hussien
HCV Story ---by Mohammed HussienHCV Story ---by Mohammed Hussien
HCV Story ---by Mohammed Hussien
 
Hcv 4 ttt
Hcv 4 tttHcv 4 ttt
Hcv 4 ttt
 
Who.hcv treatment guidelines 2016
Who.hcv treatment  guidelines 2016Who.hcv treatment  guidelines 2016
Who.hcv treatment guidelines 2016
 
Best Practices in the Management of HCV. 2015
Best Practices in the Management of HCV. 2015Best Practices in the Management of HCV. 2015
Best Practices in the Management of HCV. 2015
 
Challenges in HCV Management
Challenges in HCV Management Challenges in HCV Management
Challenges in HCV Management
 
Hepatitis C : Complete Overview and Recent Updates 2019
Hepatitis C : Complete Overview and Recent Updates 2019Hepatitis C : Complete Overview and Recent Updates 2019
Hepatitis C : Complete Overview and Recent Updates 2019
 
Treatment of HCV Genotype 4
Treatment of HCV Genotype 4Treatment of HCV Genotype 4
Treatment of HCV Genotype 4
 
Basics of Hepatitis C
Basics of Hepatitis CBasics of Hepatitis C
Basics of Hepatitis C
 
Chronic hepatitis b
Chronic hepatitis bChronic hepatitis b
Chronic hepatitis b
 
Hepatitis C
Hepatitis CHepatitis C
Hepatitis C
 
Hapetitus B Presentation
Hapetitus B PresentationHapetitus B Presentation
Hapetitus B Presentation
 
Chronic hepatitis B
Chronic hepatitis BChronic hepatitis B
Chronic hepatitis B
 
Spectrum of HCV infection
Spectrum of HCV infectionSpectrum of HCV infection
Spectrum of HCV infection
 
CHRONIC HEPATITIS B
CHRONIC HEPATITIS BCHRONIC HEPATITIS B
CHRONIC HEPATITIS B
 

Similar to Hepatitis c new guidelines 2014 by aasld idsa sofosbuvir

MANAGEMENT OF CHRONIC HEPATITIS B INFECTION 2021 - from diagnosis to treatment
MANAGEMENT OF CHRONIC HEPATITIS B INFECTION  2021 - from diagnosis to treatmentMANAGEMENT OF CHRONIC HEPATITIS B INFECTION  2021 - from diagnosis to treatment
MANAGEMENT OF CHRONIC HEPATITIS B INFECTION 2021 - from diagnosis to treatmentNimzingLadep
 
impact of different clinical trials on recent hypertension guidelines
impact of different clinical trials on recent hypertension guidelinesimpact of different clinical trials on recent hypertension guidelines
impact of different clinical trials on recent hypertension guidelinesSupratip Kundu
 
lab investigations in OMFS
lab investigations in OMFSlab investigations in OMFS
lab investigations in OMFSbhanupriya149
 
Acute liver failure.pptx
Acute liver failure.pptxAcute liver failure.pptx
Acute liver failure.pptxCutiePie71
 
Aasld guidelines for diagnosis & treatment of chronic hepatitis b
Aasld guidelines for diagnosis & treatment of chronic hepatitis bAasld guidelines for diagnosis & treatment of chronic hepatitis b
Aasld guidelines for diagnosis & treatment of chronic hepatitis bsreejith246
 
Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced case
 Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced case Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced case
Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced caseDr. Sumit KUMAR
 
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptxAgnesTamrin
 
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptxmoneralwsaby
 
Autoimmune hepatitis
Autoimmune hepatitisAutoimmune hepatitis
Autoimmune hepatitisAhmed Ghany
 
RECENT RETROVIRAL DISEAAE GUIDELINES
RECENT RETROVIRAL DISEAAE GUIDELINESRECENT RETROVIRAL DISEAAE GUIDELINES
RECENT RETROVIRAL DISEAAE GUIDELINESAshutosh Pakale
 
Management of Chronic Hepatitis B in Non-Pregnant adults
Management of Chronic Hepatitis B in Non-Pregnant adultsManagement of Chronic Hepatitis B in Non-Pregnant adults
Management of Chronic Hepatitis B in Non-Pregnant adultsWajahat Sher Dil Khan
 
Preparation for transplantation (mih)
Preparation for transplantation (mih)Preparation for transplantation (mih)
Preparation for transplantation (mih)FarragBahbah
 
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptxsubhankar16
 

Similar to Hepatitis c new guidelines 2014 by aasld idsa sofosbuvir (20)

EASL guideline for hepatitis C
EASL guideline for hepatitis CEASL guideline for hepatitis C
EASL guideline for hepatitis C
 
Hepatitis c
Hepatitis cHepatitis c
Hepatitis c
 
MANAGEMENT OF CHRONIC HEPATITIS B INFECTION 2021 - from diagnosis to treatment
MANAGEMENT OF CHRONIC HEPATITIS B INFECTION  2021 - from diagnosis to treatmentMANAGEMENT OF CHRONIC HEPATITIS B INFECTION  2021 - from diagnosis to treatment
MANAGEMENT OF CHRONIC HEPATITIS B INFECTION 2021 - from diagnosis to treatment
 
impact of different clinical trials on recent hypertension guidelines
impact of different clinical trials on recent hypertension guidelinesimpact of different clinical trials on recent hypertension guidelines
impact of different clinical trials on recent hypertension guidelines
 
hepatorenal syndrome
hepatorenal syndromehepatorenal syndrome
hepatorenal syndrome
 
Sharing the Cure: Best Practices for Primary Care Providers to Improve HCV Pr...
Sharing the Cure: Best Practices for Primary Care Providers to Improve HCV Pr...Sharing the Cure: Best Practices for Primary Care Providers to Improve HCV Pr...
Sharing the Cure: Best Practices for Primary Care Providers to Improve HCV Pr...
 
HBV Is Primary! Your Role in the "Call to Action" to Eliminate Viral Hepatiti...
HBV Is Primary! Your Role in the "Call to Action" to Eliminate Viral Hepatiti...HBV Is Primary! Your Role in the "Call to Action" to Eliminate Viral Hepatiti...
HBV Is Primary! Your Role in the "Call to Action" to Eliminate Viral Hepatiti...
 
lab investigations in OMFS
lab investigations in OMFSlab investigations in OMFS
lab investigations in OMFS
 
Acute liver failure.pptx
Acute liver failure.pptxAcute liver failure.pptx
Acute liver failure.pptx
 
Aasld guidelines for diagnosis & treatment of chronic hepatitis b
Aasld guidelines for diagnosis & treatment of chronic hepatitis bAasld guidelines for diagnosis & treatment of chronic hepatitis b
Aasld guidelines for diagnosis & treatment of chronic hepatitis b
 
Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced case
 Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced case Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced case
Hepatocellular Carcinoma (HCC): Updated Treatment Approaches in advanced case
 
HCV infection.pptx
HCV infection.pptxHCV infection.pptx
HCV infection.pptx
 
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
 
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
 
Autoimmune hepatitis
Autoimmune hepatitisAutoimmune hepatitis
Autoimmune hepatitis
 
RECENT RETROVIRAL DISEAAE GUIDELINES
RECENT RETROVIRAL DISEAAE GUIDELINESRECENT RETROVIRAL DISEAAE GUIDELINES
RECENT RETROVIRAL DISEAAE GUIDELINES
 
chronic hep.pptx
chronic hep.pptxchronic hep.pptx
chronic hep.pptx
 
Management of Chronic Hepatitis B in Non-Pregnant adults
Management of Chronic Hepatitis B in Non-Pregnant adultsManagement of Chronic Hepatitis B in Non-Pregnant adults
Management of Chronic Hepatitis B in Non-Pregnant adults
 
Preparation for transplantation (mih)
Preparation for transplantation (mih)Preparation for transplantation (mih)
Preparation for transplantation (mih)
 
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx2022 Guideline for the Management of Heart Failure Clinical Update.pptx
2022 Guideline for the Management of Heart Failure Clinical Update.pptx
 

Recently uploaded

ROSE CASE SPINAL SBRT BY DR KANHU CHARAN PATRO
ROSE  CASE SPINAL SBRT BY DR KANHU CHARAN PATROROSE  CASE SPINAL SBRT BY DR KANHU CHARAN PATRO
ROSE CASE SPINAL SBRT BY DR KANHU CHARAN PATROKanhu Charan
 
Varicose Veins Treatment Aftercare Tips by Gokuldas Hospital
Varicose Veins Treatment Aftercare Tips by Gokuldas HospitalVaricose Veins Treatment Aftercare Tips by Gokuldas Hospital
Varicose Veins Treatment Aftercare Tips by Gokuldas HospitalGokuldas Hospital
 
Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...
Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...
Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...jiyav969
 
Is Rheumatoid Arthritis a Metabolic Disorder.pptx
Is Rheumatoid Arthritis a Metabolic Disorder.pptxIs Rheumatoid Arthritis a Metabolic Disorder.pptx
Is Rheumatoid Arthritis a Metabolic Disorder.pptxSamar Tharwat
 
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...Ishita Kashyap
 
TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...
TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...
TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...marcuskenyatta275
 
Sonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptxSonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptxpalsonia139
 
Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341
Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341
Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341Sherrylee83
 
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best supplerCas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best supplerSherrylee83
 
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depthsUnveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depthsYash Garg
 
Failure to thrive in neonates and infants + pediatric case.pptx
Failure to thrive in neonates and infants  + pediatric case.pptxFailure to thrive in neonates and infants  + pediatric case.pptx
Failure to thrive in neonates and infants + pediatric case.pptxclaviclebrown44
 
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...Avani bhatt
 
Signs It’s Time for Physiotherapy Sessions Prioritizing Wellness
Signs It’s Time for Physiotherapy Sessions Prioritizing WellnessSigns It’s Time for Physiotherapy Sessions Prioritizing Wellness
Signs It’s Time for Physiotherapy Sessions Prioritizing WellnessGokuldas Hospital
 
Hemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.Gawad
Hemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.GawadHemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.Gawad
Hemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.GawadNephroTube - Dr.Gawad
 
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...bkling
 
Renal Replacement Therapy in Acute Kidney Injury -time modality -Dr Ayman Se...
Renal Replacement Therapy in Acute Kidney Injury -time  modality -Dr Ayman Se...Renal Replacement Therapy in Acute Kidney Injury -time  modality -Dr Ayman Se...
Renal Replacement Therapy in Acute Kidney Injury -time modality -Dr Ayman Se...Ayman Seddik
 
Tips and tricks to pass the cardiovascular station for PACES exam
Tips and tricks to pass the cardiovascular station for PACES examTips and tricks to pass the cardiovascular station for PACES exam
Tips and tricks to pass the cardiovascular station for PACES examJunhao Koh
 
TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...
TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...
TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...marcuskenyatta275
 
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...Health Kinesiology Natural Bioenergetics
 

Recently uploaded (20)

ROSE CASE SPINAL SBRT BY DR KANHU CHARAN PATRO
ROSE  CASE SPINAL SBRT BY DR KANHU CHARAN PATROROSE  CASE SPINAL SBRT BY DR KANHU CHARAN PATRO
ROSE CASE SPINAL SBRT BY DR KANHU CHARAN PATRO
 
Varicose Veins Treatment Aftercare Tips by Gokuldas Hospital
Varicose Veins Treatment Aftercare Tips by Gokuldas HospitalVaricose Veins Treatment Aftercare Tips by Gokuldas Hospital
Varicose Veins Treatment Aftercare Tips by Gokuldas Hospital
 
Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...
Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...
Vip ℂall Girls Shalimar Bagh Phone No 9999965857 High Profile ℂall Girl Delhi...
 
Is Rheumatoid Arthritis a Metabolic Disorder.pptx
Is Rheumatoid Arthritis a Metabolic Disorder.pptxIs Rheumatoid Arthritis a Metabolic Disorder.pptx
Is Rheumatoid Arthritis a Metabolic Disorder.pptx
 
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
HIFI* ℂall Girls In Thane West Phone 🔝 9920874524 🔝 💃 Me All Time Serviℂe Ava...
 
TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...
TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...
TEST BANK For Huether and McCance's Understanding Pathophysiology, Canadian 2...
 
Sonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptxSonia Journal club presentation (2).pptx
Sonia Journal club presentation (2).pptx
 
Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341
Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341
Sell pmk powder cas 28578-16-7 from pmk supplier Telegram +85297504341
 
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best supplerCas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
Cas 28578-16-7 PMK ethyl glycidate ( new PMK powder) best suppler
 
Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices...
Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices...Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices...
Making Patient-Centric Immunotherapy a Reality in Lung Cancer: Best Practices...
 
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depthsUnveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
Unveiling Alcohol Withdrawal Syndrome: exploring it's hidden depths
 
Failure to thrive in neonates and infants + pediatric case.pptx
Failure to thrive in neonates and infants  + pediatric case.pptxFailure to thrive in neonates and infants  + pediatric case.pptx
Failure to thrive in neonates and infants + pediatric case.pptx
 
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
Premium ℂall Girls In Mumbai👉 Dail ℂALL ME: 📞9833325238 📲 ℂall Richa VIP ℂall...
 
Signs It’s Time for Physiotherapy Sessions Prioritizing Wellness
Signs It’s Time for Physiotherapy Sessions Prioritizing WellnessSigns It’s Time for Physiotherapy Sessions Prioritizing Wellness
Signs It’s Time for Physiotherapy Sessions Prioritizing Wellness
 
Hemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.Gawad
Hemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.GawadHemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.Gawad
Hemodialysis: Chapter 1, Physiological Principles of Hemodialysis - Dr.Gawad
 
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
Let's Talk About It: Ovarian Cancer (The Emotional Toll of Treatment Decision...
 
Renal Replacement Therapy in Acute Kidney Injury -time modality -Dr Ayman Se...
Renal Replacement Therapy in Acute Kidney Injury -time  modality -Dr Ayman Se...Renal Replacement Therapy in Acute Kidney Injury -time  modality -Dr Ayman Se...
Renal Replacement Therapy in Acute Kidney Injury -time modality -Dr Ayman Se...
 
Tips and tricks to pass the cardiovascular station for PACES exam
Tips and tricks to pass the cardiovascular station for PACES examTips and tricks to pass the cardiovascular station for PACES exam
Tips and tricks to pass the cardiovascular station for PACES exam
 
TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...
TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...
TEST BANK For Lewis's Medical Surgical Nursing in Canada, 4th Edition by Jane...
 
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
Unlocking Holistic Wellness: Addressing Depression, Mental Well-Being, and St...
 

Hepatitis c new guidelines 2014 by aasld idsa sofosbuvir

  • 1. New Hepatitis C Guidelines (AASLD, IDSA, IAS-USA) Dr. Ahsan MBBS,FCPS (Medicine) Senior Registrar Medical Unit-1
  • 2. • The Evidence based consensus recommendations for the screening, treatment and management of patients with HCV were developed by a panel of 27 liver disease and infectious disease specialists and a patient advocate. • Available Online on; • www.hcvguidelines.org
  • 3.
  • 4. Types of Recommendations • "Recommended”: when regimen is favored for most patients • "Alternative" when optimal in a particular subset of patients in that category. • "Not Recommended" When a treatment is clearly inferior or is deemed harmful, such regimens should not be administered to patients with HCV infection
  • 5. IFN ineligible IFN ineligible is defined as one or more of the below: • Intolerance to IFN • Autoimmune hepatitis and other autoimmune disorders • Hypersensitivity to PEG or any of its components • Decompensated hepatic disease • History of depression, or clinical features consistent with depression • A baseline neutrophil count below 1500/μL, a baseline platelet count below 90,000/μL or baseline hemoglobin below 10 g/dL • A history of preexisting cardiac disease
  • 6. SOFOSBUVIR • Sofosbuvir (Tab. Sovaldi 400mg) is a prodrug of a nucleotide analogue inhibitor of the HCV NS5B RNA-dependent RNA polymerase. • NEUTRINO, COSMOS trial: Genotype 1,4 • VALENCE , POSITRON, FISSION, FUSION, PROTON , ELECTRON : Genotype 2,3 • Approved By FDA In DEC 2013.
  • 7. SIMEPREVIR • Simeprevir (150 mg daily), a specific inhibitor of the HCV NS3/4A serine protease. • COSMOS TRIAL: GENOTYPE 1
  • 9. • It is anticipated that safer and more effective IFN-free regimens will be available by 2015.