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Heart Disease
C o r o n a r y A r t e r y D i s e a s e
Main headlines
• What is Coronary Artery disease
• Symptoms, causes, consequences and treatments
• Engineering behind the disease
• Real case study
• The future of the disease
• Restrictions
What Is Coronary Artery Disease?
The arteries, which start out smooth and
elastic, get plaque on their inner walls,
which can make them more rigid and
narrowed. This restricts blood flow to
your heart, which can then become
starved of oxygen.
Even Egyptian Pharaohs Had It!
Heart disease is the number one killer of
men and women in the United States
today. The Centers for Disease Control
and Prevention (CDC) estimates that
about one in four Americans die from
the disease every year. This adds up to
about 610,000 individuals. In addition,
735,000 people have heart attacks each
year.
Leonardo Da Vinci
Symptoms
• Chest pain (angina)
• Shortness of breath
• Palpitations - irregular heart beats
• Weakness or dizziness
• Nausea
• Sweating
Causes
Coronary artery disease is thought to begin with damage or
injury to the inner layer of a coronary artery, sometimes as
early as childhood. The damage may be caused by various
factors, including:
• Smoking
• High blood pressure
• High cholesterol
• Diabetes or insulin resistance
• Sedentary lifestyle
consequences
• Irregular Heart Rhythm
• Heart Attack
• Enlarged Heart (Cardiomegaly)
• Heart Muscle Disease (Cardiomyopathy)
Treatments
• Aspirin and a statin, if not other things
• Cardiac catheterization
• Stent placement
• Coronary artery bypass surgery
• Heart transplant surgery
Problems
• Hard to be noticed (not diagnosed)
• Causes are relatively general
• Even after a heart attack it still hard to know
the position of the narrowed part of artery
• High likely to have a second heart attack
• Treatment methods are limited
How doctors see the disease
How engineers see the disease
Measuring pressure and velocity
Simulating the disease (CFD)
Drawing the geometry
Drawing the geometry
Drawing the geometry
Drawing the geometry
Surface construction
3D acquisition system
Final geometry
Using ANSYS software
Boundary conditions
Real case study
VIRTUheart™ project at the University of Sheffield
The future of this technology
• Explaining treatment selection
• Using models to predict the results of treatments
• Studying any patient and predict if he/she would has the disease in the future
Restrictions on that technology
• Some needed parameters could be unknown
• We can’t have a general model for everyone
• Computational time specially for emergency cases
Summary
References
• https://www.healthline.com/health/heart-disease/history
• http://www.bbc.com/news/health-28054468
• A non-invasive computational method for determining pressure drop across an arterial blockage could help
cardiologists make more-objective and accurate treatment decisions - by Paul D. Morris
• Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure
interaction modeling - by Armin Amindari
• Computational fluid dynamics modelling in cardiovascular medicine - by Paul D Morris
• Yunus cengel fluid mechanics fundamentals
Thank You

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