Natural endocrine disruptors Synthetic endocrine disruptors

1. Endocrine Disruptors
Momin Zufa Mohd Taha
Msc Part II
(Endocrinology)

2. Introduction
• Endocrine disruptors are chemicals that can interfere with
the normal functioning of the endocrine system in humans
and animals
• Endocrine disruptors can mimic, block, or alter the
production, release, transport, metabolism, binding, or
elimination of natural hormones in the body.
• They can exert their effects by binding to hormone
receptors, interfering with hormone synthesis or
degradation, or disrupting the signaling pathways that
control hormone action.

3. Types of Endocrine Disruptors
• There are two main categories of endocrine disruptors:
1.Natural Endocrine Disruptor 2.Synthetic Endocrine disruptors
Soybean Personal care product

4. Natural Endocrine Disruptors
• Natural endocrine disruptors are
phytoestrogens are naturally
occurring compounds found in certain
plants that have a chemical structure
similar to the hormone estrogen.
• They can interact with estrogen
receptors in both humans and
animals.

5. Synthetic Endocrine Disruptors
• Synthetic endocrine
disruptors are man-made
chemicals that have
endocrine-disrupting
properties.
• They are often found in
industrial products,
pesticides, plastics,
pharmaceuticals, and
household chemicals.

6. Impact of Endocrine Disruptors
• Reproductive and Developmental Disorders
• Metabolic Disorders
• Immune System Dysfunction
• Cancer
• Neurological Effects

7. Invertebrate Endocrine disruptions
• Endocrine disruption in invertebrates can occur when they
are exposed to environmental contaminants, such as
pesticides, industrial chemicals, and pollutants.
• These chemicals can interfere with the normal functioning of
the invertebrates’ endocrine system, leading to a range of
adverse effects.
• EDCs that can impact on invertebrate include
Pesticides, pharmaceuticals, plasticizers, PCBs, Heavy
Metals, Industrial chemicals.

8. Impact of Endocrine Disruptors in
Invertebrates
• It can affect fertility, egg production, and mating behaviors.
• Developmental stages can result in deformities and
impairments in growth and metamorphosis.
• It can affect their foraging, mating, and predator avoidance
behaviors.
• Changes in hormone levels and physiological processes can
impact an invertebrate’s ability to survive and compete in its
environment.

9. • Avoid plastic containers
• Use natural cleaning products
• Filter tap water
• Minimize use of personal care product containing
paraben and pthalates
• Avoid fragrance containing products
• Use Natural pest control
• Limited canned food consumption
To reduce exposure of Endocrine Disruptors

10. Reference
• www.ncbi.nlm.nih.gov.com
• www.endocrine.org.com
• www.webmd.com
• Invertebrate endocrinology (D.B.Tembhare)

11. Thank you