2. CURRENT SCENARIO
• People are living longer and getting sicker
• By 2020 the WHO estimates that unipolar
depression will be the leading cause of
disability, responsible for 1 in 10 years of life,
worldwide
• Pharmaceutical company
7. DEFINITIONS OF PREVENTION
• Primary prevention
– Prevention of disease before it occurs
• Secondary prevention
– Prevention of recurrence or exacerbation of a disease that
has been diagnosed
• Tertiary prevention
– Reduction in the amount of disability caused by a disease
to achieve highest level of function
4/20/2014 7
8. IOM (1994) DEFINITIONS
• Prevention
– Prevention to ward off the
initial onset of a mental
disorder
• Treatment
– Identification of an
individuals with mental
disorders and the standard
treatment for those
disorders
• Maintenance
– Intervention that are
oriented to reduce relapse
and recurrence and to
provide rehabilitation
4/20/2014 8
9. EARLY INTERVENTION IN SCHIZOPHRENIA
Universal Prevention
• Raising the awareness,
promoting referrals
from PC physicians
• PUFA, especially
omega-3 in fish oil,
and vitamin D
Selective Prevention
(targeted prevention)
• Prenatal infection or
malnutrition, perinatal or
obstetric complications, older
paternal age, winter season of
birth, separation from primary
caretakers during the first year
of life, absence of protective
family environments,
childhood physical and sexual
abuse, urbanicity, cannabis
use, unemployment, never-
married marital status, and
history of migration
Indicated Prevention
• PACE: CBT +
risperidone;
• PRIME: Olanzapine;
• RAP: Antipsychotics
vs. antidepressants;
• OPUS: Standard vs.
integrated treatments;
• EDIE: Cognitive
therapy;
• GRNS: Amisulpiride;
• VGH: Omega-3
Mohammadreza Mokhtari, Rajaprabhakaran Rajarethinam. Early Intervention and the Treatment of Prodrome in Schizophrenia: A Review of Recent Developments. Journal of Psychiatric Practice. 2013;19(5):375-85
PACE: Personal Assessment and Crisis Evaluation; PRIME: Prevention through Risk Identification, Management, and Education; RAP: Recognition and
Prevention; EDIE: Early Detection and Intervention Evaluation; GRNS: German Research Network on Schizophrenia; VGH: Vienna General Hospital
10. ULTRA HIGH RISK (UHR)
FOR PSYCHOSIS
1) Attenuated Psychotic Symptoms (APS)
– Sub threshold, attenuated forms of positive psychotic
symptoms
2) Brief Limited Intermittent Psychotic Symptoms (BLIPS)
– episodes of frank psychotic symptoms that have not lasted
longer than a week and have spontaneously abated
3) Trait and State Risk Factor (Trait)
– first-degree relative with a psychotic disorder or
– schizotypal personality disorder in addition to a
significant decrease in functioning
Trait<APS<BLIPS
B. Nelson, K. Yuen, A.R. Yung. Ultra high risk (UHR) for psychosis criteria: Are there different levels of risk for transition to psychosis?Schizophrenia Research 125 (2011) 62–68
11. CONS OF PREVENTIVE INTERVENTIONS
• Low predictive value
– High false positive rates
• Stigmatization and labelling of at risk individuals can
cause unnecessary anxiety and demoralization about
prognosis
– Unnecessary treatment of individuals who are not
truly at risk
• Pre-emptive use of antipsychotics, with potentially
serious metabolic and neurological side effects.
Mohammadreza Mokhtari, Rajaprabhakaran Rajarethinam. Early Intervention and the Treatment of Prodrome in Schizophrenia: A Review of Recent Developments. Journal of Psychiatric Practice. 2013;19(5):375-85
13. EARLY AND LATE INITIAL PRODROMAL STATE:
A CLINICAL STAGING APPROACH
14. 4/20/2014 14
MODEL OF MENTAL HEALTH SERVICES
MODEL BASIC
CONCEPT
TARGET
POPULATION
COMPONENTS PRACTICES EXAMPLES
Institution /
Hospital-based
Mainly
medically
oriented
Mentally ill
person
Custodial
Curative
Whole of life
Minimal outreach
/ aftercare
Admission
Diagnosis
Treatment
Discharge
HBUK
De-institutional
community
based
Mainly
psychosocial
Mentally ill
person
In closing of
mental hospital
Treatment in the
community
Arranged social
environment
Train living and
coping skills
Surrogate
parent
model
Integrated /
decentralization
Wellness
concept
Healthy
At risk
Mentally ill
Promotive
Preventive
Curative
Rehab
Mental health
promotion
Early detection
Treatment
Psychosocial
rehab
As proposed
by WHO
(1990)
15. 4/20/2014 15
to those involved in any planning and
implementation towards improving mental
health and well being of entire population
for population at risks of developing
psychosocial problems
for the mentally disordered in the provision
of care and protection by the family,
community and relevant agencies
To provide a
basis in developing
strategies
To improve mental
health services
To improve
psychiatric services
NATIONAL MENTAL HEALTH POLICY
16. 4/20/2014 16
“Mental Health And Mental Health services”
“Life Skills For Mental Health”
“Mental Disorders In Primary Care”
Module 1
Module 2
Module 3
TRAINING MODULE
17. 4/20/2014 17
MENTAL HEALTH PROMOTION
MATERIALS
32 various topics of mental health
Some 200,000 leaflets covering 13 various
topics e.g. mental health, mental illness, mental
health for children, misunderstanding of mental
illness, stigma and mental illness, stress etc
"Apakah itu Kesihatan Mental" (1997) and
"Tangani Tekanan Mental"(1998)
Posters
Leaflets
Television
documentaries
19. 4/20/2014 19
MENTAL HEALTH SERVICES
IN EXISTING CLINICS
• By Sept 1999, 129 clinics nationwide have establish:
– Health talks on mental health topics
– Early detection
– Treatment and referral to psychiatrists
– Follow up of stable cases
– Home visits (defaulter tracing, check drug compliance,
administer injection)
– Counseling
– Health education for patient, family and community
– Training (echo and in-service/attachments)
Editor's Notes
The world has changed over the last 50 years
The main causes of illness and death have shifted from infectious diseases to long term chronic diseases
PACE: Personal Assessment and Crisis Evaluation; PRIME: Prevention through Risk Identification, Management, and Education; RAP: Recognition and Prevention; EDIE: Early Detection and Intervention Evaluation; GRNS: German Research Network on Schizophrenia; VGH: Vienna General Hospital
The fact that BLIPS patients are at the highest risk of transition over the short term is consistent with the “early” versus “late” prodrome model
B. Nelson, K. Yuen, A.R. Yung. Ultra high risk (UHR) for psychosis criteria: Are there different levels of risk for transition to psychosis? Schizophrenia Research 125 (2011) 62–68