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TSX-V: IGX 
OTCQX: IGXT 
Innovation In Drug Delivery 
An introduction to unique pharmaceutical delivery technologies 
November 2014
FORWARD LOOKING STATEMENTS 
To the extent any statements made in this presentation contain information that is not historical, these statements are 
forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 
21E of the Securities Exchange Act of 1934, as amended. We have based these forward-looking statements on our 
current expectations and projections about future events. Our actual results could differ materially from those 
discussed in, or implied by, these forward-looking statements. Forward-looking statements are identified by words 
such as "believe," "anticipate," "expect," "intend," "plan," "will," "may" and other similar expressions. In addition, any 
statements that refer to expectations, projections or other characterizations of future events or circumstances are 
forward-looking statements. Forward-looking statements include, but are not necessarily limited to, risks and 
uncertainties, including the difficulty of predicting U.S. Food and Drug Administration and Canadian Therapeutic 
Products Directorate approvals, acceptance and demand for new pharmaceutical products, the impact of competitive 
products and pricing, new product development and launch, reliance on key strategic alliances, availability of raw 
materials and finished products, the regulatory environment, tax rate assumptions, the outcome of legal proceedings, 
fluctuations in operating results and other risks detailed from time to time in the Company's filings with the Securities 
and Exchange Commission and the Ontario Securities Commission. IntelGenx undertakes no obligation to update or 
revise any forward-looking statement. 
2
INNOVATIVE DELIVERY TECHNOLOGY 
FOCUSING ON ORAL DRUG DELIVERY 
VERSAFILM™ VERSATAB™ ADVERSA™ 
Rapid and convenient dosage form for more 
immediate activity 
Programmable drug release over an extended 
period of time 
Controlled absorption in the oral cavity 
to maximize bioavailability 
INTELGENX DEVELOPS AND MANUFACTURES FASTER AND MORE EFFICIENT 
DRUG DELIVERY SYSTEMS FOR TOP PHARMACEUTICALS 
3
UNIQUE TECHNOLOGIES 
INNOVATIVE DELIVERY TECHNOLOGY 
TECHNOLOGY FOCUSED 
Develop novel and high performance drug delivery systems – focus on oral film products. 
TARGET HIGH-VALUE DIFFERENTIATED OPPORTUNITIES 
• Use proprietary drug delivery technologies to develop products offering a 
therapeutic benefit to patients. 
• Identify unique drug-repurposing opportunities. 
• Pursue high technological entry barrier products and first-to-file opportunities. 
• Develop products addressing unmet therapeutic needs. 
4
VALUE PROPOSITION 
PROVIDE COMPREHENSIVE PHARMACEUTICAL SERVICES TO INDUSTRY 
PARTNERS: 
 Pharmaceutical Research and Development 
 Clinical monitoring; clinical supply manufacturing 
 Regulatory services 
 Process development and technology transfer 
 Commercial product supply 
REVENUE STREAM CONSISTING OF: 
 Upfront payments 
 R&D milestone payments 
 Sales milestone payments 
 Royalties on sales 
 Manufacturing revenue 
5
PRECLINICAL PILOT STUDY PIVOTAL STUDY FILING LAUNCH 
PRODUCT PORTFOLIO 
Forfivo XL® Major Depressive 
Disorder 
INT0001 Hypertension 
INT0024 
Idiopathic Pulmonary 
Fibrosis (Pacific) 
INT0008 Migraine (RedHill) 
INT0027 
Opiod Dependence 
(Par) 
INT0037 Undisclosed (Par) 
INT0039 Undisclosed (Par) 
INT0007 Erectile Dysfunction 
INT0036 
Central Nervous 
System (CNS) 
INT0010 Pain 
Launched Q4 2012 
Q1 2013 
Q3 2013 
A ROBUST PRODUCT PIPELINE ACROSS 3 TECHNOLOGY PLATFORMS 
6
INTELGENX PARTNERSHIPS 
INTELGENX HAS STRATEGIC PARTNERSHIPS IN PLACE WITH MULTIPLE COMPANIES 
7
VersaTabTM 
Addressable market for 
pipeline VersaTabTM 
products. 
SIGNIFICANT MARKET POTENTIAL 
VersaFilmTM 
Opportunity to convert 
existing tablet market 
into film technology 
$8.1 
Billion 
$2.7 
Billion 
ADDRESSABLE MARKET FOR PRODUCT PIPELINE 
~$10B 
Combined, 
addressable market 
for product pipeline 
8
2013 Metroprolol 
Sales 
$1.2B 
Pentoxifylline - NAC 
$1.1B 
VERSATAB TM 
MULTILAYER TABLET TECHNOLOGY 
• Linear release profile; 
controlled erosion of inactive 
cover layers 
• Multiple actives with 
independent release profiles 
• Separation of active 
ingredients - avoidance of 
chemical incompatibility in 
fixed-dose combinations 
• Cost-effective manufacturing 
Depression Hypertension 
Idiopathic Pulmonary 
Fibrosis Addressable 
Market 
Wellbutrin XL & 
Bupropion XL Sales 
$391M 
PRECLINICAL PILOT STUDY 
PIVOTAL 
STUDY 
FILING LAUNCH 
Forfivo XL 
Major 
Depressive 
Disorder 
INT0001 Hypertension 
INT0024 
Idiopathic 
Pulmonary 
Fibrosis 
(Pacific) 
VERSATAB® 
PRODUCTS 
Launched Q4 2012 ® 
VersaTab® 
Addressable 
Market ~$2.7B 
9
FORFIVO XL® COMMERCIALIZATION GROWTH OPPORTUNITY 
Current Market for 
Bupropion 
$3.0B 
• High dose version of 
Wellbutrin XL® 
• Provides a once-daily, 
bupropion 450 mg dose in a 
single tablet 
• Indicated for the treatment of 
major depressive disorder 
• Launched commercially 
October 2012 in partnership 
with Edgemont 
Pharmaceuticals 
• Negotiations on Paragraph IV 
with Wockhardt progressing 
well 
Wellbutrin XL® 
Market 
$236M 
2013 Sales 
Forfivo XL 
$2.7M 
FORFIVO XL® SCRIPT GROWTH 
® 
VERSATAB TM 
VersaTab® 
Addressable 
Market ~$2.7B 
$1,200,000 
$900,000 
$600,000 
$300,000 
10 
$0 
4,000 
3,000 
2,000 
1,000 
0 
~$1.1M 
October 
Gross Sales 
3,038 
October 
Prescriptions 
10/31/12 2/28/13 6/28/13 10/31/13 2/28/14 6/30/14 10/31/14
VERSAFILM TM 
ADVANTAGES OF FILM TECHNOLOGY 
VersaFilm™ 
Rapidly disintegrating pharmaceutical films 
for buccal or systemic drug delivery 
® 
VersaFilm 
Addressable 
Market ~$8.1B 
Improved product performance: 
• Fast delivery translates into 
rapid onset of action 
• Improved bioavailability 
• Buccal (topical) or systemic 
drug exposure 
Improved patient compliance: 
• Convenient delivery improving 
compliance for pediatric and 
geriatric patients where 
swallowing is an issue 
Increased barrier for generic 
competition: 
• Limited number of competitors 
11
VERSAFILM TM 
ADVANTAGES OF FILM TECHNOLOGY 
IMPROVED PRODUCT PERFORMANCE: 
• Fast delivery translates into rapid onset of action 
• Improve bioavailability 
• Buccal or systemic drug exposure 
IMPROVED PATIENT COMPLIANCE: 
• Convenient delivery improving compliance for pediatric and geriatric patients where 
swallowing is an issue 
INCREASED BARRIER FOR GENERIC COMPETITION: 
• Limited number of competitors 
VERSAFILM™ ~$2.9B ADDRESSABLE MARKET 
RAPIDLY DISINTEGRATING PHARMACEUTICAL FILMS FOR BUCCAL OR SYSTEMIC DRUG DELIVERY 
12
$1.3B 
VERSAFILM TM 
ADDRESSABLE MARKETS 
• Demonstrated ability to 
achieve bioequivalence 
® 
• Two applications currently 
under review at FDA: 
one ANDA, and one 
505(b)(2)NDA 
• Comprehensive 
VersaFilm™ development 
pipeline 
• Limited number of 
competitors, strong IP 
position 
Opioid Dependence Migraine Erectile Dysfunction 
Targeted Rizatriptan 
Market 
$230M 
Targeted Cialis 
Sales 
® 
Targeted Suboxone 
Sales 
$1.4B 
® 
VersaFilm 
Addressable 
Market ~$8.1B 
13 
PRECLINICAL PILOT STUDY 
PIVOTAL 
STUDY 
FILING LAUNCH 
INT0008 
Migraine 
(RedHill) 
INT0027 
Opiod 
Dependence 
(Par) 
INT0007 
Erectile 
Dysfunction 
INT0036 CNS 
INT0037 
Undisclosed 
(Par) 
INT0039 
Undisclosed 
(Par) 
Q1 2013 2015 
VERSAFILM 
PRODUCTS 
Q3 2013 2017 
Q4 2016 Q4 2017
ATTRACTIVE LIFECYCLE MANAGEMENT OPPORTUNITY 
Suboxone® Rx Quantities (Millions) 
80 
60 
40 
20 
0 
Film Tablet 
2008 2009 2010 2011 2012 2013 
VersaFilm 
Addressable 
Market ~$8.1B 
• Demonstrated ability to 
achieve bioequivalence 
• Two applications currently 
under review at FDA: 
one ANDA, and one 
505(b)(2)NDA 
• Comprehensive 
VersaFilm™ development 
pipeline 
• Limited number of 
competitors, strong IP 
position 
® 
VERSAFILM TM 
14 
Suboxone® 
Sublingual Film 
Suboxone® 
Sublingual Tablets
1.4 
1.05 
0.7 
0.35 
0. 
Buprenorphine plasma profile 
Test product Test product 
0. 12. 24. 36. 48. 60. 72. 
Mean concentration (ng/mL) 
Time (hrs) 
® 
VERSAFILM TM 
Suboxone 
Addressable 
Market ~$1.4B 
Completed development with 
successful pivotal 
bioequivalency study. 
Abbreviated New Drug 
Application (ANDA) 
submitted to FDA in July 
2013. 
Marketing approval 
anticipated 2016. 
Attractive partnership deal 
with Par Pharmaceutical 
P4 litigation with Reckitt 
Benckiser progressing well 
150. 
120. 
90. 
60. 
30. 
0. 
Naloxone plasma profile 
Test product reference product (Suboxone 8/2mg) 
0. 6. 12. 18. 24. 
Mean concentration (pg/mL) 
Time (hrs) 
OPIOD DEPENDENCE - BUPRENORPHINE/NALOXONE 
15
MIGRAINE FILM BIOEQUIVALENT TO MAXALT MLT® 
Rizatriptan® 
Addressable 
Market $230M 
Successfully completed 
development and stability 
testing 
Filed 505(b)(2)NDA in March 
2013 
Co-development and 
licensing agreement in place 
with RedHill Biopharma 
Negotiations with 
commercialization partner 
ongoing 
18.0 
13.5 
9.0 
4.5 
0.0 
Orally disintegrating film containing Rizatriptan bioequivalent 
with orally disintegrating tablet (Maxalt MLT®) 
VersaFilm Rizatriptan 
0.0 3.0 6.0 9.0 12.0 15.0 
Rizatriptan Pl. Conc. (ng/mL) 
Time (hrs) 
Maxalt MLT® 
VERSAFILM TM 
16
VERSAFILM TM 
Cialis® 
Addressable 
Market ~$1.3B 
CP pending for OTC 
approval 
Formulation development 
ongoing. 
Worldwide patent application. 
Pilot BE study on 10 mg 
strength suggests BE with 
RLD. 
Confirmatory pilot BE study 
on 20 mg strength 
completed. 
Successful pilot BE study (10 mg strength) 
BIOEQUIVALENCE ACHIEVED IN TADALAFIL 
17
VERSAFILM TM 
CNS FILM INT0036 – A fast acting version of an existing schizophrenia treatment. 
Schizophrenia 
~$5.2B Market1 
Successfully completed pilot 
scale PhI study 
INT0036 demonstrated a 
significantly improved 
pharmacokinetic profile 
against the reference product 
1 According to Datamonitor 
Healthcare schizophrenia 
forecast published July 13, 
2012 
30,000 
22,500 
15,000 
7,500 
0 
VersaFilm INT0036 
0 15 30 45 60 
Rizatriptan Pl. Conc. (ng/mL) 
Time (min) 
RLD
VERSAFILM TM 
A STRONG PLATFORM FOR GROWTH AND INNOVATION 
• Addressable market of approximately $8.1 billion 
• Strong intellectual property protection 
• Successful pivotal bioequivalency studies 
• 3 film products close to FDA approval 
• Limited number of competitors 
• Life cycle management opportunity
OPERATIONAL INITIATIVES 
DEVELOPING FILM MANUFACTURING CAPABILITIES TO INCREASE PROFITABILITY 
20 
• Significantly increase IntelGenx' revenue stream 
• Better protection of IntelGenx' IP. 
• Eliminate dependency of IntelGenx on external manufacturing partners 
by establishing commercial film manufacturing capability. 
• Give clients the advantage to obtain all services from one source (one-stop- 
shopping). 
• Increase R&D capabilities and investments with expanded laboratories 
and technologies.
KEY MILESTONES 
SUGGESTS NEAR TERM CATALYSTS 
2014 2015 2016 2017 
Develop 
• 2014, Identify a second 
supplier for Rizatriptan 
• 2014, Submit application for 
Rizatriptan in Europe 
• 2014, Acceptance of ANDA for 
INT0027 triggering a milestone 
payment from Par 
• 2014, Clarity on ForFivo XL 
litigation with WockHardt 
Position 
• 2015, Anticipated approval for migraine 
VersaFilmTM 
• 2015, Anticipated submission of ANDA for 
Antihypertensive VersaTabTM 
• 2016, Anticipated tentative approval for 
opioid dependence VersaFilm™ 
• 2016, Commence manufacturing capabilities 
of VersaFilm™ 
Grow 
• 2016, Anticipated submission of 
505(b)(2) NDA for ED VersaFilm™ 
• 2017, Anticipated launch for opioid 
dependence VersaFilm™ 
• 2017, Anticipated approval for ED 
VersaFilm™ 
21
VISIONARY, EXPERIENCED LEADERSHIP 
Horst G. Zerbe, Ph.D. 
Chairman, President and CEO 
• Founder of IntelGenx 
• 30+ years Industry Experience 
• Holds over 40 patents in drug delivery, and numerous 
scientific publications 
• Previously President Smartrix Tech. Inc. and VP R&D at 
LTS Lohmann, USA 
Nadine Paiement, M.Sc. 
Director R&D 
Paul Simmons, AFCA 
Chief Financial Officer 
Alexandre Serrano, Ph.D. 
Associate Director, Bus. Dev. 
• Co-inventor of IntelGenx Trilayer Technology 
• 10 years experience in product development and technology 
transfer 
• Previously R&D Manager at Smartrix Tech. Inc. 
• 25 + years multinational business and finance experience 
• Proven track record of exceeding targets in delivering 
corporate growth 
• Held CFO and VP Finance positions with several European 
corporations 
• Responsible for Strategic Alliances, Licensing, Acquisitions, 
and Intellectual Property 
• Ph.D. in Neuroscience (University of Montreal) 
• Previously actively involved in in-licensing at AstraZeneca 
Montreal 
65+ YEARS OF COMBINED INDUSTRY EXPERIENCE 
22
A SOLID PLATFORM FOR GROWTH 
CORE TECHNOLOGIES ADDRESS LARGE MARKET POTENTIAL 
VERSAFILM™ VERSATAB™ ADVERSA™ 
• Continue to grow commercialization efforts of Forfivo XL to drive revenue growth 
• Develop delivery technology product platforms in pipeline towards commercialization 
• Continue to develop distribution channel relationships 
• Leverage VersaFilm manufacturing expertise to enhance profitability 
23
TSX-V: IGX 
OTCQX: IGXT 
Innovation In Drug Delivery 
Thank You

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IntelGenx Corporate Presentation

  • 1. TSX-V: IGX OTCQX: IGXT Innovation In Drug Delivery An introduction to unique pharmaceutical delivery technologies November 2014
  • 2. FORWARD LOOKING STATEMENTS To the extent any statements made in this presentation contain information that is not historical, these statements are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. We have based these forward-looking statements on our current expectations and projections about future events. Our actual results could differ materially from those discussed in, or implied by, these forward-looking statements. Forward-looking statements are identified by words such as "believe," "anticipate," "expect," "intend," "plan," "will," "may" and other similar expressions. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances are forward-looking statements. Forward-looking statements include, but are not necessarily limited to, risks and uncertainties, including the difficulty of predicting U.S. Food and Drug Administration and Canadian Therapeutic Products Directorate approvals, acceptance and demand for new pharmaceutical products, the impact of competitive products and pricing, new product development and launch, reliance on key strategic alliances, availability of raw materials and finished products, the regulatory environment, tax rate assumptions, the outcome of legal proceedings, fluctuations in operating results and other risks detailed from time to time in the Company's filings with the Securities and Exchange Commission and the Ontario Securities Commission. IntelGenx undertakes no obligation to update or revise any forward-looking statement. 2
  • 3. INNOVATIVE DELIVERY TECHNOLOGY FOCUSING ON ORAL DRUG DELIVERY VERSAFILM™ VERSATAB™ ADVERSA™ Rapid and convenient dosage form for more immediate activity Programmable drug release over an extended period of time Controlled absorption in the oral cavity to maximize bioavailability INTELGENX DEVELOPS AND MANUFACTURES FASTER AND MORE EFFICIENT DRUG DELIVERY SYSTEMS FOR TOP PHARMACEUTICALS 3
  • 4. UNIQUE TECHNOLOGIES INNOVATIVE DELIVERY TECHNOLOGY TECHNOLOGY FOCUSED Develop novel and high performance drug delivery systems – focus on oral film products. TARGET HIGH-VALUE DIFFERENTIATED OPPORTUNITIES • Use proprietary drug delivery technologies to develop products offering a therapeutic benefit to patients. • Identify unique drug-repurposing opportunities. • Pursue high technological entry barrier products and first-to-file opportunities. • Develop products addressing unmet therapeutic needs. 4
  • 5. VALUE PROPOSITION PROVIDE COMPREHENSIVE PHARMACEUTICAL SERVICES TO INDUSTRY PARTNERS:  Pharmaceutical Research and Development  Clinical monitoring; clinical supply manufacturing  Regulatory services  Process development and technology transfer  Commercial product supply REVENUE STREAM CONSISTING OF:  Upfront payments  R&D milestone payments  Sales milestone payments  Royalties on sales  Manufacturing revenue 5
  • 6. PRECLINICAL PILOT STUDY PIVOTAL STUDY FILING LAUNCH PRODUCT PORTFOLIO Forfivo XL® Major Depressive Disorder INT0001 Hypertension INT0024 Idiopathic Pulmonary Fibrosis (Pacific) INT0008 Migraine (RedHill) INT0027 Opiod Dependence (Par) INT0037 Undisclosed (Par) INT0039 Undisclosed (Par) INT0007 Erectile Dysfunction INT0036 Central Nervous System (CNS) INT0010 Pain Launched Q4 2012 Q1 2013 Q3 2013 A ROBUST PRODUCT PIPELINE ACROSS 3 TECHNOLOGY PLATFORMS 6
  • 7. INTELGENX PARTNERSHIPS INTELGENX HAS STRATEGIC PARTNERSHIPS IN PLACE WITH MULTIPLE COMPANIES 7
  • 8. VersaTabTM Addressable market for pipeline VersaTabTM products. SIGNIFICANT MARKET POTENTIAL VersaFilmTM Opportunity to convert existing tablet market into film technology $8.1 Billion $2.7 Billion ADDRESSABLE MARKET FOR PRODUCT PIPELINE ~$10B Combined, addressable market for product pipeline 8
  • 9. 2013 Metroprolol Sales $1.2B Pentoxifylline - NAC $1.1B VERSATAB TM MULTILAYER TABLET TECHNOLOGY • Linear release profile; controlled erosion of inactive cover layers • Multiple actives with independent release profiles • Separation of active ingredients - avoidance of chemical incompatibility in fixed-dose combinations • Cost-effective manufacturing Depression Hypertension Idiopathic Pulmonary Fibrosis Addressable Market Wellbutrin XL & Bupropion XL Sales $391M PRECLINICAL PILOT STUDY PIVOTAL STUDY FILING LAUNCH Forfivo XL Major Depressive Disorder INT0001 Hypertension INT0024 Idiopathic Pulmonary Fibrosis (Pacific) VERSATAB® PRODUCTS Launched Q4 2012 ® VersaTab® Addressable Market ~$2.7B 9
  • 10. FORFIVO XL® COMMERCIALIZATION GROWTH OPPORTUNITY Current Market for Bupropion $3.0B • High dose version of Wellbutrin XL® • Provides a once-daily, bupropion 450 mg dose in a single tablet • Indicated for the treatment of major depressive disorder • Launched commercially October 2012 in partnership with Edgemont Pharmaceuticals • Negotiations on Paragraph IV with Wockhardt progressing well Wellbutrin XL® Market $236M 2013 Sales Forfivo XL $2.7M FORFIVO XL® SCRIPT GROWTH ® VERSATAB TM VersaTab® Addressable Market ~$2.7B $1,200,000 $900,000 $600,000 $300,000 10 $0 4,000 3,000 2,000 1,000 0 ~$1.1M October Gross Sales 3,038 October Prescriptions 10/31/12 2/28/13 6/28/13 10/31/13 2/28/14 6/30/14 10/31/14
  • 11. VERSAFILM TM ADVANTAGES OF FILM TECHNOLOGY VersaFilm™ Rapidly disintegrating pharmaceutical films for buccal or systemic drug delivery ® VersaFilm Addressable Market ~$8.1B Improved product performance: • Fast delivery translates into rapid onset of action • Improved bioavailability • Buccal (topical) or systemic drug exposure Improved patient compliance: • Convenient delivery improving compliance for pediatric and geriatric patients where swallowing is an issue Increased barrier for generic competition: • Limited number of competitors 11
  • 12. VERSAFILM TM ADVANTAGES OF FILM TECHNOLOGY IMPROVED PRODUCT PERFORMANCE: • Fast delivery translates into rapid onset of action • Improve bioavailability • Buccal or systemic drug exposure IMPROVED PATIENT COMPLIANCE: • Convenient delivery improving compliance for pediatric and geriatric patients where swallowing is an issue INCREASED BARRIER FOR GENERIC COMPETITION: • Limited number of competitors VERSAFILM™ ~$2.9B ADDRESSABLE MARKET RAPIDLY DISINTEGRATING PHARMACEUTICAL FILMS FOR BUCCAL OR SYSTEMIC DRUG DELIVERY 12
  • 13. $1.3B VERSAFILM TM ADDRESSABLE MARKETS • Demonstrated ability to achieve bioequivalence ® • Two applications currently under review at FDA: one ANDA, and one 505(b)(2)NDA • Comprehensive VersaFilm™ development pipeline • Limited number of competitors, strong IP position Opioid Dependence Migraine Erectile Dysfunction Targeted Rizatriptan Market $230M Targeted Cialis Sales ® Targeted Suboxone Sales $1.4B ® VersaFilm Addressable Market ~$8.1B 13 PRECLINICAL PILOT STUDY PIVOTAL STUDY FILING LAUNCH INT0008 Migraine (RedHill) INT0027 Opiod Dependence (Par) INT0007 Erectile Dysfunction INT0036 CNS INT0037 Undisclosed (Par) INT0039 Undisclosed (Par) Q1 2013 2015 VERSAFILM PRODUCTS Q3 2013 2017 Q4 2016 Q4 2017
  • 14. ATTRACTIVE LIFECYCLE MANAGEMENT OPPORTUNITY Suboxone® Rx Quantities (Millions) 80 60 40 20 0 Film Tablet 2008 2009 2010 2011 2012 2013 VersaFilm Addressable Market ~$8.1B • Demonstrated ability to achieve bioequivalence • Two applications currently under review at FDA: one ANDA, and one 505(b)(2)NDA • Comprehensive VersaFilm™ development pipeline • Limited number of competitors, strong IP position ® VERSAFILM TM 14 Suboxone® Sublingual Film Suboxone® Sublingual Tablets
  • 15. 1.4 1.05 0.7 0.35 0. Buprenorphine plasma profile Test product Test product 0. 12. 24. 36. 48. 60. 72. Mean concentration (ng/mL) Time (hrs) ® VERSAFILM TM Suboxone Addressable Market ~$1.4B Completed development with successful pivotal bioequivalency study. Abbreviated New Drug Application (ANDA) submitted to FDA in July 2013. Marketing approval anticipated 2016. Attractive partnership deal with Par Pharmaceutical P4 litigation with Reckitt Benckiser progressing well 150. 120. 90. 60. 30. 0. Naloxone plasma profile Test product reference product (Suboxone 8/2mg) 0. 6. 12. 18. 24. Mean concentration (pg/mL) Time (hrs) OPIOD DEPENDENCE - BUPRENORPHINE/NALOXONE 15
  • 16. MIGRAINE FILM BIOEQUIVALENT TO MAXALT MLT® Rizatriptan® Addressable Market $230M Successfully completed development and stability testing Filed 505(b)(2)NDA in March 2013 Co-development and licensing agreement in place with RedHill Biopharma Negotiations with commercialization partner ongoing 18.0 13.5 9.0 4.5 0.0 Orally disintegrating film containing Rizatriptan bioequivalent with orally disintegrating tablet (Maxalt MLT®) VersaFilm Rizatriptan 0.0 3.0 6.0 9.0 12.0 15.0 Rizatriptan Pl. Conc. (ng/mL) Time (hrs) Maxalt MLT® VERSAFILM TM 16
  • 17. VERSAFILM TM Cialis® Addressable Market ~$1.3B CP pending for OTC approval Formulation development ongoing. Worldwide patent application. Pilot BE study on 10 mg strength suggests BE with RLD. Confirmatory pilot BE study on 20 mg strength completed. Successful pilot BE study (10 mg strength) BIOEQUIVALENCE ACHIEVED IN TADALAFIL 17
  • 18. VERSAFILM TM CNS FILM INT0036 – A fast acting version of an existing schizophrenia treatment. Schizophrenia ~$5.2B Market1 Successfully completed pilot scale PhI study INT0036 demonstrated a significantly improved pharmacokinetic profile against the reference product 1 According to Datamonitor Healthcare schizophrenia forecast published July 13, 2012 30,000 22,500 15,000 7,500 0 VersaFilm INT0036 0 15 30 45 60 Rizatriptan Pl. Conc. (ng/mL) Time (min) RLD
  • 19. VERSAFILM TM A STRONG PLATFORM FOR GROWTH AND INNOVATION • Addressable market of approximately $8.1 billion • Strong intellectual property protection • Successful pivotal bioequivalency studies • 3 film products close to FDA approval • Limited number of competitors • Life cycle management opportunity
  • 20. OPERATIONAL INITIATIVES DEVELOPING FILM MANUFACTURING CAPABILITIES TO INCREASE PROFITABILITY 20 • Significantly increase IntelGenx' revenue stream • Better protection of IntelGenx' IP. • Eliminate dependency of IntelGenx on external manufacturing partners by establishing commercial film manufacturing capability. • Give clients the advantage to obtain all services from one source (one-stop- shopping). • Increase R&D capabilities and investments with expanded laboratories and technologies.
  • 21. KEY MILESTONES SUGGESTS NEAR TERM CATALYSTS 2014 2015 2016 2017 Develop • 2014, Identify a second supplier for Rizatriptan • 2014, Submit application for Rizatriptan in Europe • 2014, Acceptance of ANDA for INT0027 triggering a milestone payment from Par • 2014, Clarity on ForFivo XL litigation with WockHardt Position • 2015, Anticipated approval for migraine VersaFilmTM • 2015, Anticipated submission of ANDA for Antihypertensive VersaTabTM • 2016, Anticipated tentative approval for opioid dependence VersaFilm™ • 2016, Commence manufacturing capabilities of VersaFilm™ Grow • 2016, Anticipated submission of 505(b)(2) NDA for ED VersaFilm™ • 2017, Anticipated launch for opioid dependence VersaFilm™ • 2017, Anticipated approval for ED VersaFilm™ 21
  • 22. VISIONARY, EXPERIENCED LEADERSHIP Horst G. Zerbe, Ph.D. Chairman, President and CEO • Founder of IntelGenx • 30+ years Industry Experience • Holds over 40 patents in drug delivery, and numerous scientific publications • Previously President Smartrix Tech. Inc. and VP R&D at LTS Lohmann, USA Nadine Paiement, M.Sc. Director R&D Paul Simmons, AFCA Chief Financial Officer Alexandre Serrano, Ph.D. Associate Director, Bus. Dev. • Co-inventor of IntelGenx Trilayer Technology • 10 years experience in product development and technology transfer • Previously R&D Manager at Smartrix Tech. Inc. • 25 + years multinational business and finance experience • Proven track record of exceeding targets in delivering corporate growth • Held CFO and VP Finance positions with several European corporations • Responsible for Strategic Alliances, Licensing, Acquisitions, and Intellectual Property • Ph.D. in Neuroscience (University of Montreal) • Previously actively involved in in-licensing at AstraZeneca Montreal 65+ YEARS OF COMBINED INDUSTRY EXPERIENCE 22
  • 23. A SOLID PLATFORM FOR GROWTH CORE TECHNOLOGIES ADDRESS LARGE MARKET POTENTIAL VERSAFILM™ VERSATAB™ ADVERSA™ • Continue to grow commercialization efforts of Forfivo XL to drive revenue growth • Develop delivery technology product platforms in pipeline towards commercialization • Continue to develop distribution channel relationships • Leverage VersaFilm manufacturing expertise to enhance profitability 23
  • 24. TSX-V: IGX OTCQX: IGXT Innovation In Drug Delivery Thank You

Editor's Notes

  1. IGXT is a company that has developed proprietary drug delivery technologies for oral drug delivery and is using these technologies to develop novel pharmaceutical products
  2. During this presentation, I will be making certain forward looking statements
  3. Our technologies include an oral film technology that we use to achieve rapid delivery of an active in the oral cavity, An extended release tablet technology for once-daily administration, and A mucoadhesive tablet technology for the controlled release of actives into the oral cavity with the aim to achieve controlled oral absorption
  4. Therapeutic benefits include simplifying dose regimen, increased bioavailability, less side effects
  5. Our current project pipeline includes 9 projects, 3 involving Versatab technology, 5 involving Versatab technology, and 1 Adversa project
  6. The combined addressable market for the pipeline is 5.6 billion dollars, of which 2.9 are related to films, and 2.7 bn to tablets.
  7. Therapeutic benefits include simplifying dose regimen, increased bioavailability, less side effects