1. 1
RESUME
Vicky M.-H. Sung, Ph.D.
ADDRESS: 12 Westdale Avenue, Wilmington, MA 01997, U.S.A.
PHONE: (978)447-5398
EMAIL: vickys7@verizon.net
CITIZENSHIP: U.S.A.
EDUCATION:
SCHOOL MAJOR DEGREE GPA YEARS
University of Southern
California, Los An-
geles, CA
Molecular Microbiol-
ogy and Immunology
Doctor of Philosophy 3.83 July 1998-September
2002
University of Oklaho-
ma, Health Science
Center, Oklahoma city,
OK
Microbiology and Im-
munology
Master of Science August 1996-May
1998
National Yang-Ming
Medical College, Tai-
pei, Taiwan, R.O.C.
Medical Technology Bachelor of Science October 1988-June
1992
WORK EXPERIENCE:
JOB TITLE ORGANIZATION
NAME
RESPONSIBILITIES SKILLS YEARS
Postdoctoral Research
Fellow
Center of Computa-
tional and Intergrative
Biology, Massachu-
setts General Hospital,
Boston, MA; Harvard
Medical School, Bos-
ton; Department of Pe-
diatrics, MassGeneral
Hospital of Children,
Boston. (Supervisor:
Dr. Brian Seed)
conduct independent
research projects, in-
cluding design and
carry out experiments,
data analysis, writing
for publications, pre-
sentations; mentoring
students for Dr. Seed;
coordinate with auto-
mation staffs to estab-
lish high throughput
screening protocols;
verifying leads from
screening,; trouble
shooting problems etc.
vector design and con-
struction phage display
library and mammalian
high throughput
screening library for
gene expressions; pro-
tein and peptide 2-D
electrophoresis; bacte-
rial and mammalian
cell sorting and flow
cytometry analysis;
fluorescence and con-
focal microscope imag-
ing, circular dichron-
ism spectrometry;
UV/VIS spectrometry;
transgene/knockout
gene constructions;
cell culture
July 2007- July 2014

2. 2
Research Associate Reeve-Irvine Research
Center, University of
California, Irvine, CA
(Supervisor: Dr. Hans
Keistead)
Set up Molecular Biol-
ogy laboratory; write a
portion of a grant and
establish a Tet-on lenti-
vial vector for gene
transduction into hu-
man embryo stem
(hES) cell derived mo-
tor neuron progenitor
cells; mentoring stu-
dents for Dr. Keistead
hES cell culture and
differentiate into motor
neurons; purity verifi-
cations for hES cell
culture system; Tet-On
lentiviral vector con-
struction for various
genes; grant writing
September 2006-June
2007
Research Associate Department of Molec-
ular Biology and Bio-
chemsitry, University
of California, Irvine,
CA (Supervisor: Dr.
David Camerini)
Manage BSL-3 labora-
tory; carry out HIV re-
lated research projects;
mentoring graduates
and undergraduates for
Dr. Camerini; con-
struct HIV genome
mutations; flow cytom-
etry maintenance; de-
sign and carry out ex-
periments; data analy-
sis; writing publica-
tions and presenta-
tions.
HIV infection/replica-
tion in T cells; puri-
fy/culture PMNs from
blood donors; flow cy-
tometry analysis for
Ca++ influx assay in
different cell types;
Trypanosoma cruzi co-
culture with HIV in
monocyte-derived
macrophages (MDM);
retroviral and lentiviral
vector construction
and gene transduction
in primary T cells
August 2004-August
2006
Research Associate Howard Hughes Med-
ical Institute and De-
partment of Molecular
Microbiology and Im-
munology, University
of Southern California,
Los Angeles, CA
(Supervisor: Dr. Mi-
chael M.C. Lai)
Establish an HCV per-
sistently and produc-
tively infected B cell
line (SB cells) from
an HCV chronically in-
fected B-lymphoma
patient; collaboration
with other scientists
for HCV research in
various aspect using
this culture system;
continue to develop
new technology and
pass the system to oth-
er scientists for HCV
infection and replica-
tion in vitro; mentor-
ing students for Dr.
Lai; writing publica-
tions and presentations
in scientific conferen-
ces; supplying data for
patent application
Establish cell lines
from organs or blood;
primary cell culture for
human hepatocytes,
karotinocytes, PMNs;
HCV core transgenic
mice; flow cytometry
analysis; viral infec-
tion with HBV, HCV,
EBV, and VSV; retro-
viral and lentiviral
gene transduction; hu-
man liver library
screening for HBV re-
ceptor/co-receptor;
Tagman Real-time RT-
PCR for viral genome
detection and quantita-
tive; confocal micro-
scopy; Northern/South-
ern/Western blotting;
metric gel based cul-
ture techniques
October 2002-August
2004

3. 3
Teaching Assistant Faculty of Medical
Technology, National
Yang-Ming Medical
University, Taipei, Tai-
wan, R.O.C.
Teaching assistant for
instructors/professors
in junior and senior
professional courses of
Medical Technology
students including
courses coordination
and tests grading;
Teaching junior and se-
nior years undergradu-
ates professional labo-
ratory courses; Student
advisor for medical
technology undergrad-
uates class 1994
Teaching medical tech-
nology professional
laboratory courses in
hematology, blood
bank, biotechnology,
clinical biochemistry;
mentoring students
August 1992-July
1994
HONORS/AWARDS:
ASBMB 2015 Child Care Grant Award, ASBMB 2015 annual meeting, held in conjunction with Experimental
Biology, EB2015, March 28-April 1, 2015.
Outstanding Professional Services For Five Years Award, Department of Pediatics, MassGeneral Hospital for
Children, June 2013.
Cambridge Who’s Who Executive, Professional and Entrepreneurial Registry. In the 2008/2009 Edition.
CROI 2006 Young Investigator Award, 13th Conference on Retroviruses and Opportunistic Infections, held at the
Colorado Convention Center in Denver, CO. February 5-9, 2006.
Manchester Who’s Who Among Executive and Professional Women in Science and Microbiology. In the
2005/2006 “ Honors Editions” of Registry.
Heidelberger Predoctoral Scholarship Award, for “Identification of Hepatitis B Virus Receptor and/or Co-recep-
tor.”, Cancer Education and Scholarships Committee of the USC/Norris Comprehensive Cancer Center, 2000-
2001.
PHI KAPPA PHI, All-University Honor Society, Outstanding Academic Achievement Award, USC Chapter,
1999-2002.
President’s Honor Roll, Outstanding Scholastic Achievement, Fall, 1995. University of Central Oklahoma, Ed-
mond, Oklahoma, 1995.
Scholarship for Outstanding Academic Performance. Taiwan Nuclear Energy Committee, 1992.
Research Scholarship for undergraduate students engaged in graduate-level research, National Science Council,
Taiwan, 1991.
PEERS REVIEWED PUBLICATIONS:
1. Sung, VM. (2015) Mechanistic Overview of ADP-ribosylation Reactions. Biochimie.113:35-46 (DOI:
10.1016/j.biochi.2015.03.016).

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2. Sung, VM and Tsai, C.L. (2014) ADP-ribosylargininyl reaction of cholix toxin is mediated through dif-
fusible intermediates. BMC Biochemistry. 15, 26.
3. Machida K, Kondo Y, Huang J, Chen YC, Cheng KT, Keck Z, Foung S, Dubuisson J, Sung VM, Lai
MM. (2008) HCV-induced immunoglobulin hypermutation reduced the affinity and neutralizing activ-
ities of antibodies against HCV envelope protein. J. Virol. 82 (13): 6711-6720.
4. Kondo Y, Sung VM, Machida K, Liu M, Lai M.M. (2007) Hepatitis C virus infects T cells and affects in-
terferon-gamma signaling in T cell lines. Virology. 361(1): 161-173.
5. Kawamura H, Govindarajan S, Aswad F, Machida K, Lai MM, Sung VM, Dennert G. (2006) HCV core
expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in
mice. Hepatology. 44(4): 936-944.
6. Machida K, Cheng KTH, Lai CK, Jeng KS, Sung VM, Lai MM. (2006) Hepatitis C virus triggers mito-
chondrial permeability transition with production of reactive oxygen species, leading to DNA damage
and STAT3 activation. J. Virol. 80(14): 7199-7207.
7. Machida K, Cheng KTH, Sung VM, Levine AM, Foung S, Lai MM. (2006) Hepatitis C virus induces
Toll-like receptor 4 expression, leading to enhances production of IFN-beta and IL-6. J. Virol. 80(2):
866-874.
8. Machida K, Cheng KTH, Pavio N, Sung VM, Lai MM. (2005) Hepatitis C virus E2-CD81 interaction in-
duces hypermutation of immunoglobulin gene in B cells. J. Virol. 79: (13): 8079-8089.
9. Machida K, Cheng KTH, Sung VM, Lee KJ, Levine AM, Lai MM. (2004) Hepatitis C virus infection
activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage
and mutations of cellular genes. J. Virol. 78 (16): 8835-8843.
10. Keck ZY, Sung VM, Perkins S, Rowe J, Paul S, Liang TJ, Lai MM, Foung SKH. (2004) Human mono-
clonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity. J.
Virol. 78 (13): 7257-7263.
11. Machida K, Cheng KTH, Sung VM, Shimodaira S, Lindsay KL, Levine AM, Lai MY, Lai MM. (2004)
Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and proto-onco-
genes. PNAS. 101(12): 4262-4267.
12. Aizaki H. Lee KJ, Sung VM, Ishiko H, Lai MM. (2004) Characterization of hepatitis C virus RNA repli-
cation complex associated with lipid rafts. Virology. 324: 450-461.
13. Sung VM, Shimodaira S, Doughty AL, Picchio GR, Can H, Yen TSB, Lindsay KL, Levine AM, Lai
MM. (2003) Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in
vivo and in vitro: the apoptotic effects of virus infection. J. Virol. 77(3): 2134-2146.
14. Sung VM. (2002) Ph.D. Dissertation. Title “Studies of Hepatitis B virus and Hepatitis C Virus Infec-
tion”, University of Southern California. ProQuest Information and Learning Company.
15. Sung VM, Lai MM. (2002) Murine retroviral pseudotype virus containing hepatitis B virus large and
small surface antigens confers specific tropism for primary human hepatocytes: a potential liver-specific
targeting system. J. Virol. 76(2): 912-917.
16. Lewis LA, Sung M-H, Gipson M, Hartman K, Dyer DW. (1998) Transport of intact porphyrin by
HpuAB, the Hemoglobin-Haptoglobin Utilization System of Neisseria meningitidis. J. Bacteriology.
180(22): 6043-6047.
SELECTED PUBLICATIONS IN NATIONAL/INTERNATIONAL MEETINGS
1. V.M. Sung and S. Kallert. Poster presentation of “Diversification of a bacterial ADP-ribosyltransferase”
in ASBMB 2015 annual meeting, March 28-April 1, in Boston, MA.

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2. V.M. Sung and C.L. Tsai. Poster presentation of “ADP-ribosylargininyl activity of cholix toxin is medi-
ated through diffusible intermediates” in ASBMB 2015 annual meeting, March 28-April 1, in Boston,
MA.
3. V.M. Sung, C.L.Tsai, H. Osago, N. Lu, M. Tsuchiya and B. Seed. Poster presentation of “Characteriza-
tion of auto-ADP-ribosylation of cholix toxin” in ASBMB 2011 meeting, April 9-13, in Washington
D.C.
4. V.M. Sung, J. Arthos and D. Camerini. Diverse effects of R5 and X4 HIV-1 gp120 signaling on primary
CD4+ T cells: Implications for viral transmission. In The 13th West Coast Retrovirus Meeting, held in
Palm Springs, California, October 5-7, 2006.
5. Ye, Y., V.M. Sung, J. De Leon, S. Phin, D. Camerini. An RNA lariat intermediate in HIV-1 cDNA syn-
thesis. In The 13th West Coast Retrovirus Meeting, held in Palm Springs, California, October 5-7,
2006.
6. V.M. Sung and D. Camerini. Differential Signaling Effects of R5 and X4 HIV-120 on primary CD4+ T
cells. In The 13th Conference on Retroviruses and Opportunistic Infections, held in Denver, Colora-
do, February 5-9, 2006.
7. Ye, Y., J. De Leon, V.M. Sung, D. Camerini. DBR1 siRNA inhibition of HIV-1 replication indicates an
RNA lariat intermediate during minus-strand transfer. In The 13th Conference on Retroviruses and
Opportunistic Infections, held in Denver, Colorado, February 5-9, 2006.
8. K. Machida, K.Cheng, S. Shimodaira, V.M. Sung, K.L. Lindsay, A.M. Levine, MY Lai, M.M. Lai. Hep-
atitis C virus induces a mutator phenotype: hypermutation of immunoglobulin and proto-oncogenes. In
10th International Symposium on Hepatitis C Virus & Related Viruses, held in Kyoto, Japan, De-
cember 2-6, 2003.
9. K. Machida, K.Cheng, V.M. Sung, J-K Lee, K.L. Lindsay, A.M. Levine, MY Lai, M.M. Lai. Hepatitis C
virus infection induces iNOS, leading to DNA breakage and enhanced mutations. In 10th International
Symposium on Hepatitis C Virus & Related Viruses, held in Kyoto, Japan, December 2-6, 2003.
10. V.M. Sung and M.M. C. Lai. Kinetics studies of the interferon-alpha action using HCV-infected B cells.
In 9th International Symposium on Hepatitis C Virus & Related Viruses, held in San Diego, July 7-
11, 2002.
11. V. M. Sung, A.L. Doughty, S. Shimodaira, T.S.B. Yen, K.L. Lindsay, A.M. Levine, M.M. C. Lai. Estab-
lishment of B-cell lymphoma cell lines persistently and productively infected with HCV by in vivo and
in vitro infection: HCV is strongly cytotoxic. In 9th International Symposium on Hepatitis C Virus &
Related Viruses, held in San Diego, July 7-11, 2002.
12. K. Machida, S. Shimodaira, V.M. Sung, K. Cheng, K.L. Lindsay, A.M. Levine, MY Lai, M.M. Lai. Hep-
atitis C virus is a potent mutator; hypermutation of immunoglobulin and oncogenes in HCV-infected
cells. In 9th International Symposium on Hepatitis C Virus & Related Viruses, held in San Diego,
July 7-11, 2002.
13. S. Shimodaira, V.M. Sung, K. Machida, M.M. Lai. HCV infection enhances somatic hypermutation of
immunoglobulin genes in B cells. In 8th International Symposium on Hepatitis C Virus & Related
Viruses, held in Paris, France, Sept. 2-5, 2001.
14. V. M. Sung, S. Shimodaira, A.L. Doughty, T.S.B. Yen, K.L. Lindsay, A.M. Levine, M.M. C. Lai. Estab-
lishment of B-cell lymphoma cell lines persistently and productively infected with HCV for viral replica-
tion and pathogenesis studies. In 9th SCBA International Symposium, held in Taipei, Taiwan, August
5-10, 2001.
15. V.M. Sung, S. Shimodaira, A.L. Doughty, T.S.B. Yen, K.L. Lindsay, A.M. Levine, M.M. C. Lai. Estab-
lishment of B-cell lymphoma cell lines persistently and productively infected with HCV. In the oral sec-

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tion of 7th International Symposium on Hepatitis C Virus & Related Viruses, held in Gold Coast,
Queensland, Australia, Dec., 3-7, 2000.
16. M.H. Sung and J.W. Murphy. Analysis of NK1.1+CD3+ T cells in Cryptococcus neoformans immunized
mice. In Oklahoma Academic of Science. Oklahoma City, Nov. 8, 1996.
17. M.H. Sung, H.H. Wang, and W.S. Hu. Detection of Various Repeated Sequences in Mycoplasma fer-
mentants, In 10th International Congress of the International Organization of Mycoplasmology
(IOM) held in Bordeaux, France, July 19-26, 1994.
18. M.H. Sung and W.S. Hu. Detection of Various Repeated Sequences in Mycoplasma fermentants and My-
coplasma pirum, In 94th General Meeting of the American Society for Microbiology in Las Vegas,
Nevada, May 23-27, 1994.
PROFESSIONAL SERVICES
I. MENTORING STUDENTS’ RESEARCH:
1. Stephanie Kallert, a senior undergraduate student from Interfaculty Institute of Biochemistry, University
Tübingen, Tübingen, Germany. March~June 2010. (Dr. Brian Seed’s lab).
2. Keely Kwok, a junior undergraduate student from the Department of Microbiology, at the University of
Massachusetts Amhers. August 2008~August 2009. (Dr. Brian Seed’s lab).
3. Quynh-Anh Pham, a junior undergraduate student from Department of Biomedical Engineering, at the
University of California-Irvine. September 2006 to June 2007. (Dr. Hans Keirstead’s Lab).
4. Carrie Ann Lee, a freshman from Massachusetts Institute of Technology receiving American Cancer So-
ciety Summer Youth Fellowship to work on AIDS research. June~August 2006. (Dr. David Camerini’s
Lab)
5. Claire Dubois, a Ph.D. student from Department of Molecular Biology and Biochemistry, at University
of California, Irvine. September 2005~December 2005. (Dr. David Camerini’s Lab)
6. Erin C. Bufalini, an undergraduate student from Department of Biology, at University of California, Ir-
vine. June 2005~2006. (Dr. David Camerini’s Lab)
7. Eugene Chow, a graduate student from Department of Biotechnology, at the University of California, Ir-
vine. February 2005 to 2006. (Dr. David Camerini’s Lab)
8. Jeffery Huang, a student graduated from University of California-Berkeley. I mentored him to learn the
molecular biology techniques in Dr. Michael Lai’ Lab. October 2003~August 2004.
9. Annie Li, an Alhambra high school student in Howard Hughes Medical Institute Summer student pro-
gram. July 2000 to 2002. She received several awards in Science Fair competitions including County
and State competitions. She now has received her doctoral degree from Cornell University.
II. SCIENTIFIC JOURNAL CLUB ORGANIZER:
I served as the CCIB (Center for Computational and Integrative Biology) Journal Club organiz-
er in 2009-2010. We had weekly journal club meeting with postdoc, graduate and undergraduate students
from different laboratories at CCIB to discuss papers published in different scientific research fields.
III. SERVE AS PEERS-REVIEW REFEREES:
I served as a referee for FEMS Microbiology Letters in August, 2015 to review manuscript FEM-
SLE-15-07-0580 for publication.

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IV. PROFESSIONAL VOLUNTEERING:
I volunteered for the American Chemical Society (ACS) Presidential Outreach Event, “Explor-
ing Our World Through Chemistry”, at the Boston Children’s Museum on August 15, 2015.
PATENT/LICENSES:
1. USC patent for the invention of “The Use of Hepatitis C virus (HCV) Persistently Infected Cell Lines
for Screening and Assaying Antiviral Drugs”. USC OTL File#3109. (http://www.usc.edu/aca-
deme/otl/3109w.htm)
2. Medical Technologist practice license No. 005883 in Taiwan, R.O.C.
PROFESSIONAL MEMBERSHIPS:
1. Member of American Society of Biochemistry and Molecular Biology (ASBMB)
2. Member of The New York Academy of Sciences (NYAS)
3. Member of American Chemical Society (ACS)
4. Member of Society of Chinese Bioscientists in America (SCBA)
5. Member of American Association for the Advancement of Science (AAAS)
6. Member of American Society for Virology (ASV)
7. Member of American Society for Microbiology (ASM)
8. Member of the Honor Society of Phi Kappa Phi
SOCIAL MEDIA:
1. LinkedIn
2. Research Gate
REFERENCES
Below is a list of the contact information of my references. Dr. Brian Seed is my mentor for the project of diver-
sifying cholix toxin catalytic fragment at MGH/Harvard Medical School. Dr, Michael M.C. Lai is my Ph.D.
mentor at USC. In his lab at University of Southern California, Health Science Center, I worked on hepatitis B
and hepatitis C virus research. I met Dr. Obšilová in the ASBMB 2015 annual meeting at Boston. She visited my
posters, and we exchanged research experiences.
1. Brian Seed, Ph.D.
Center for Computational and Integrative Biology
CPZN 7-7228 Simches Research Center
Massachusetts General Hospital
185 Cambridge Street,
Boston, MA 02114
Tel: (617) 726-5975
Email: bseed@ccib.mgh.harvard.edu
2. Michael M.C. Lai, M.D., Ph.D.
Principle Investigator
Institute of Molecular Biology

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Academia Sinica,
Taipei, Taiwan, R.O.C.
Email: michlai@gate.sinica.edu.tw
3. Veronika Obšilová, Ph.D.
Head, Department of Protein Structure
Institute of Physiology AV CR, v.v.i.
Videnska 1083, 142 20 Prague 4, Czech Republic
Email: veronika.obsilova@fgu.cas.cz
Tel: +420 241 062 191, +420 777 628 566