4. Recommended Books
•Katung B G. Basic and clinical pharmacology
11th Edition (New York) Mc Graw Hills
• Howland pilchard D. , Mary J. Mycek
Lippincott’s Illustrated reviews
Pharmacology 5th Edition
•Board review series -- Katzung,
Lippincott’s
• Pharmacology by H.P. Rang & M.M. Dale (6th edition)
5. MCQ / reference book
• For MCQs
• Pre-test Pharmacology by Marshal Shlafer (one best type) 11th
Edition
• Board review series (at end of each chapter)
• Katzung
• Lippincott’s
• Reference Book.
• Hardman J. Limbird LE: Goodman and Gilman’s the
pharmacology Basis of Therapeutics 11th Edition (New York) Mc
Graw Hills
6. Books
• Multiauthor Textbook of Pharmacology and Therapeutics
( volume I and Volume II)
• Prof Maqsood Cheema, prof Akhlaq-un-Nabi Khan and Prof S.M.
Yusuf
• Clinico-basic pharmacology
A rapid review for under graduates and post graduates ---
Muhammad Shamim and Ghazala Shamim
• Nauman’s textbook of Pharmacology 2nd edition
8. Pharmacology
A science which deals with the
study of substances that interact
with living systems
&
activating or inhibiting
normal body process
9. Therapeutics
• The branch of medicine concerned with the treatment of
disease
• Therapy ------ the act of caring for someone (as by
medication or remedial training)
• Treatment designated to eliminate disease (or bodily
disorders or derangement.) e.g.,
• Anticoagulant therapy, Immunosuppressive therapy, Gene therapy:
(It is the insertion of an appropriate healthy gene into somatic cells
for treatment.)
• Physiotherapy ---- Therapy that uses physical agents:
exercise and massage and other modalities
12. Pharm; Pertaining to drug
•Pharmacopeia
An authoritative treatise ( a formal, systematic written
presentation of a subject ) on drugs with their formulas and
preparations.
• British Pharmacopeia (B.P)
• British National Formulary (B.N.F)
• United States Pharmacopeia (U.S.P)
13. Pharm: Pertaining to drug
• Pharmacy --- The art of preparing or compounding and
dispensing of medicines or preparing suitable dosage forms
for administration of drugs to man or animals.
• A shop for compounding and dispensing drugs and medical supplies
• Pharmacist --- A person licensed to compound or dispense
drugs
• Pharmaceutics -- The large scale manufacture of drugs
14. •Pharmacognosy ----
identification of drugs
The study of biological, biochemical and economic
features of natural drugs and their constituents
•Materia medica --- The science of drug
preparation and the medical use of drugs.
15. • Pharmacogenomics: (
Pharmacogenetics)
• The study of genetic variations that cause
differences in drug response among individuals
or populations.
• Pharmacodiagnosis --- The use of drugs in diagnosis
•Posology--- It is the branch of
pharmacology which deals with the
doses of drugs
16. • Pharmacotherapeutics
• The application of pharmacological information together with
knowledge of the disease for its prevention or cure
• Therapeutic evaluation
• Whether a drug is of value and how it may best be used;
• (a) formal therapeutic trials
• (b) surveillance studies for both efficacy and adverse effects
• Rational therapeutics by
• Controlled clinical trials --- To accurately evaluate therapeutic
claims
17. • Medical pharmacology --- The science of substances
used to prevent, diagnose, and treat disease.
• Clinical pharmacology
• Scientific study of drugs in man to generate data for optimum use
of drugs
• Pharmacodynamics, pharmacokinetics, evaluation of efficacy and
safety of drugs, comparative trials with other form of treatments,
and adverse effects
18. Toxicology
•That branch of pharmacology
which deals with the
undesirable effects of drugs
and chemicals on living
system
•Detection, prevention and
treatment of poisoning
19. Drug body interactions
Drug Body
(Pharmacodynamics)
(Pharmacokinetics)
• Pharmacdynamics ---
• It is the actions of drugs on the body
• pharmacological effects --- therapeutic / toxic effects produced by
the drug and its mechanism of action
• Pharmacokinetics
• It is the actions of body on the drug
• What happens with the drug in the body (absorption, distribution,
metabolism, and excretion)
21. Pharmacodynamics
• Where it acts?
(site of action)
• What are the effects ?
(pharmacological effects)
• How it acts?
(mechanism of action)
Pharmacokinetics
• Absorption
(locally or into the
blood from its site of
application)
• Distribution
(to its site of action or other non
required sites )
• Permeation
(through various membranes)
• Elimination by
Metabolism or Excretion
22. Drug (French; drogue, a dry herb)
Any substance that brings about a change in
biological function through its chemical
actions
23. Drug
•Any substance used for the
purpose of diagnosis,
prevention, relief or cure of a
disease in man or animal
• Drug (WHO, 1966)
“drug is any substance or product that is used or intended
to be used to modify or explore physiological systems or
pathological states for the benefit of the patients”
24. What is drug?
•A chemical substance of
known structure, other than a
nutrient or an essential dietary
ingredient, which, when
administered to a living
organism, produce a
biological effect.
25. Nature of drugs
• A drug is any substance that brings about a change in
biological function through its chemical actions. It reacts
with a regulator molecule called as receptor to show its
effects
• Hormones are drugs synthesized within the body
• Xenobiotics (Greek xenos; stranger)
• Chemicals not synthesized in the body ---
• Drugs synthesized in the pharmaceutical industries
• Poisons in small doses are drugs
26. Poisons and Toxins
• Poisons are drugs that have almost exclusively harmful
effects
• Toxins are poisons of biological origin ---synthesized by
plants or animals.
• Inorganic poisons ---- lead , arsenic
•Poisons in small doses are
drugs
27. Paracelsus (1493-1541)
•“All things are poisons and there is
nothing that is harmless, the dose
alone decides that something is no
poison”
•“The dose makes the
poison”
• All substances can be harmful if taken in the wrong doses
• Poisons in small doses are drugs
29. Drug / medicine
•A drug is a single chemical
substance that forms the
active ingredient of a
medicine
•Medicine = active
ingredient + excipient
30. Excipient
•An inert (or slightly active substance) used in
preparing medicines as a vehicle or
medium of administration for the
medicinal agents
•Substances in which an active
ingredient is incorporated to
formulate medicines
31. Excipient
•To deliver drugs in a stable form,
acceptable and convenient to the
patient
•May affect absorption as well as
solubility of the medicine
•Lactose, sucrose, starch,
calcium phosphate or lactate