The document outlines guidelines from the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) for laboratory animal facilities. It discusses the goals of providing humane care for research animals and avoiding unnecessary pain. It also covers requirements for veterinary care, quarantine of new animals, disease surveillance, diagnosis and treatment, and control of disease. Institutional Animal Ethics Committees (IAEC) must be formed to monitor animal experiments and ensure ethical practices, with a CPCSEA nominee overseeing compliance.

1. CPCSEA GUIDELINES
Presented by – Unmesh Wankhade
Branch – Pharmaceutical Quality Assurance (2nd Year)

2. CONTENT
• CPCSEA guidelines for laboratory animal facility
• Goals
• Veterinary care
• Quarantine
• Surveillance
• Diagnosis
• Treatment
• Control of disease

3. CPCSEA
• Committee for the Purpose of Control and
Supervision of Experiments on Animals
(CPCSEA)
• Statutory body formed by the Act of the Indian
Parliament under the Prevention of Cruelty to
Animals Act, 1960
• Formed in 1964
• Revived in 1998, under the committed
chairpersonship of Menka Gandhi
• Head quarters at Chennai

4. Ministry of
Environment and
Forests (Animal
Welfare)
CPCSEA
IAEC IBSC / IBC
IAEC - Institutional Animals Ethics Committee
IBSC / IBC – Institutional Biosafety Ethical Committee

5. IAEC & IBSC–
• IAEC as defined in “Breeding of and Experiments on Animals (Control and Supervision)
Rules, 1998”
• Institutional Animals Ethics Committee (IAEC)" means a body comprising of a group of
persons recognized and registered by the Committee for the purpose of control and
supervision of experiments on animals performed in an establishment which is constituted
and operated in accordance with procedures specified for the purpose by the Committee
• IAEC should focus mainly on ensuring ethical and methodical handling of animals during and
after experiments, so that they have less suffering
• Institutional Biosafety Committee (IBSC) is to be constituted in all centers engaged in genetic
engineering research and production activities.
INSTITUTIONAL ANIMALS ETHICS COMMITTEE (IAEC)
AND INSTITUTIONAL BIOSAFETY COMMITTEE (IBSC)

6. CPCSEA & IAEC
• Role of CPCSEA is to monitor animal experiments through ethics
committees set up in institutions (IAEC)
• CPCSEA nominee is important link between CPCSEA and IAEC
• IAEC scrutinize all project proposals for experimentation on animals
1. For small animals give the final approval
2. For large animals make its recommendation to SCLA.
(Sub Committee on Large Animals)

7. Objective of CPCSEA and functions of CPCSEA The 4R’s :
Replacement
Reduction
1.Refinement
1.Rehabilitation

8. • Goals of these guidelines is to promote the human care of animal
used in biomedical and behavioral research and testing.
• To avoid unnecessary pain before, during and after experiment .
• To provide guideline for –
1. Housing, care, breeding and maintenance.
2. Source of experimental animals.
3. Acceptable experimental procedures for anesthesia and euthanasia.

9. VETERINARY CARE
• Adequate veterinary care must be provided and is the responsibility
of a veterinarian.
• Accurate information on problems in animal health, behaviour, and
well being is conveyed to the attending veterinarian.
• The veterinarian can also help the establishment in designing
appropriate policies and procedures for ancillary aspects of
veterinary care such asvaccination anddisease monitoring and
surveillance, quarantine and isolation

10. QUARANTINE, STABILIZATION AND SEPARATION
• Quarantine is the separation of newly received
• Duration at quarantine in small lab animals is from one week to
one month
• Large animals allowed up to 6 weeks (cat, dog, monkey, etc)
• Physical separation of animals by species is recommended
• Separation by housing different species in separate rooms (cages
that have filtered air or separate ventilation)

11. • All animals should be observed for signs of illness, injury, or abnormal behaviour by animal
house staff.
• Animals that show signs of a contagious disease should be isolated from healthy animals in the
colony
• The isolation, quarantine and stabilization programs for newly arrived animals.
• Preventive medicine programs such as vaccinations
• Training of animal care and research staff is essential to prevent spread of animal diseases
• Diagnostic laboratory services must be available and used as appropriate.
• he veterinarian must have authority to use appropriate treatment or control measures,
including euthanasia in consultation with at least one more additional veterinarian if
required, following diagnosis of an animal disease or injury
SURVEILLANCE, DIAGNOSIS, TREATMENT
AND CONTROL OF DISEASE

12. THANK YOU