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CPCSEA guidelines



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CPCSEA guidelines

  1. 1. Presented by- Smita kapoor
  2. 2. • CPCSEA is a statutory Committee, • established under Chapter 4, Section 15(1) of the Prevention of Cruelty to Animals Act 1960. • India is one of the pioneering countries to institute Prevention of Cruelty to Animals Act in 1960. • Detailed rules for experimentation on animals were first enacted by the Ministry of Agriculture in 1968. • Present Committee was constituted on 30th August, 2012 • At present, Shri Hem Pande, Additional Secretary, MoEF&CC is the Chairman of the Committee.
  3. 3. To promote the humane care of animals used in biomedical and behavioral research and testing. to provide specifications that will enhance animal well being. To provide quality in gaining advanced biological knowledge that is relevant to humans and animals
  4. 4. VETERINARY CARE Adequate veterinary care must be provided and is the responsibility of a veterinarian. Daily observation. ANIMAL PROCUREMENT All animals must be acquired lawfully as per the CPCSEA guidelines. A health surveillance program for incoming animals should be carried out to assess animal quality.  Inspect for compliance with procurement specifications.
  5. 5. • QUARANTINE An effective quarantine minimizes the chance for introduction of pathogens into an established colony. A minimum duration of quarantine - Small lab animals - 1 week and - Larger animals - 6 weeks • STABILIZATION AND SEPARATION Newly received animals should be given a period for physiologic, psychologic and nutritional stabilization before their use. Duration for stabilization will depend on the type of animal, transportation and intended use. Physical separation of animals by species is recommended.
  6. 6. • SURVEILLANCE, DIAGNOSIS, TREATMENT AND CONTROL OF DISEASE Observe for signs of illness, injury, or abnormal behavior. Unexpected deaths and signs of illness should be reported. If animals are known to be exposed to an infectious agent the group should be kept intact and isolated during the process of diagnosis, treatment, and control. Diagnostic clinical laboratory may be made available.
  7. 7. • ANIMAL CARE AND TECHNICAL PERSONNEL Employ people trained in laboratory animal science. They should be provide for both formal and on-the-job training. • PERSONAL HYGIENE It is essential to maintain a high standard of personal cleanliness. Decontaminate clothing exposed to potentially hazardous microbial agents or toxic substances. Use disposable gear. No permission to eat, drink, smoke or apply cosmetics in animal rooms.
  8. 8. • ANIMAL EXPERIMENTATION INVOLVING HAZARDOUS AGENTS Institutional Biosafety Committee. The procedures must be reviewed by both the Institutional Biosafety committee and Institutional Animal Ethics Committee (IAEC). • MULTIPLE SURGICAL PROCEDURES ON SINGLE ANIMAL Multiple surgical procedures not to be practiced unless specified in a protocol only approved by the IAEC. • DURATIONS OF EXPERIMENTS No animal should be used for experimentation for more than 3 years unless adequate justification is provided.
  9. 9. • PHYSICAL RESTRAINT Brief physical restraint can be accomplished manually or with devices. Prolonged restraint of any animal should be avoided unless essential to research objectives. Less restrictive systems, such as the tether system or the pole and collar system should be used when compatible with research objectives. • The following are important guidelines for the use of restraint equipments: Not be used simply as a convenience in handling or managing animals. Minimum time. Should be given training to adapt to the equipment. Observe the animal at appropriate intervals. Veterinary care should be provided if lesions or illness associated with restraint are observed.
  10. 10. • PHYSICAL PLANT The physical condition and design of animal facility hould be well planned and properly maintained. • PHYSICAL RELATIONSHIP OF ANIMAL FACILITIES TO LABORATORY Isolated far away from human habitation. Place animal housing areas adjacent to or near laboratories but separated. • FUNCTIONAL AREAS Sufficient animal area required to: Ensure separation of species or isolation of individual projects when necessary; Receive, quarantine, and isolate animals; Provide for animal housing.
  11. 11. • PHYSICAL FACILITIES (1)Building material (2)Animal room doors (3)Floors (4)Drains (5)Storage areas (6)Experimental area (7)Corridor (8)Exterior windows • ENVIRONMENT (a) TEMPERATURE AND HUMIDITY CONTROL  18 to 29°C temperature range3 0% to70% relative humidity (b) VENTILATION
  12. 12. (c) POWER AND LIGHTING A time-controlled lighting system. Emergency power should be available in the event of power failure (d) NOISE CONTROL • ANIMAL HUSBANDRY • (a) CAGING OR HOUSING SYSTEM: Provide adequate space Comfortable environment Escape proof enclosure that confines animal safety. Easy access to food and water. Provide adequate ventilation.  Meet the biological needs of the animals. Keep the animals dry and clean.
  13. 13. • FOOD Animals should be fed palatable, non-contaminated, and nutritionally adequate food daily. • BEDDING • DESIRABLE CRITERIA Absorbent Free of toxic chemicals Ammonia binding Sterilizable Easily stored Uncontaminated Nontoxic Disposable by incineration Readily available
  14. 14. • WATER Continuous access of fresh, potable, uncontaminated drinking water. Periodic monitoring of microbial contamination. • SANITATION and CLEANLINESS Cleaning with detergents and disinfectants. Wire – bottom rodent cages should be washed at least every 2 weeks. Disinfection of cages by rinsing at a temperature of 82.20C (180 F). • WASTE DISPOSAL AND PEST CONTROL Remove regularly and frequently. Animal tissues, carcasses, and hazardous wastes should be lined with leak – proof, disposable liners. EMERGENCY, WEEKEND AND HOLIDAY CARE Animals should be cared by qualified personnel every day, including weekends and holidays.
  15. 15. • RECORD KEEPING The Animal House should maintain following records: • Animal House plans • Animal House staff record • All SOPs for animals • Breeding, stock, purchase and sales records • Minutes of institutional Animals Ethics Committee meetings • Records of experiments • Death Record • Clinical record • Water analysis report
  16. 16. • STANDARD OPERATING PROCEDURES (SOPs) The Institute shall maintain SOPs describing procedures / methods of • Animal Husbandry • Maintenance • Breeding • Animal house microbial analysis • Experimentation records. • TRANSPORT OF LABORATORY ANIMALS • The main considerations for transport of animals are: • Mode of transport • Containers • Animal density in cages • Food and water during transit • Protection from transit infections • Injuries and stress
  17. 17. OPERATIONALGUIDELINESINCPCSEA(10) Main activities (a) Registration of establishments for Breeding of animals: (b) Registration of establishments for experiments on animals: (c) Approval of Animal House Facilities: (d) Permission of Committee for Conducting Experiments: (e) Recommendation for import • Regulatory Mechanism :  Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) • To ensure that animals are not subjected to unnecessary pain or suffering before, during or after performance of experiments on them.  Sub-Committees of the CPCSEA: 1) Sub-Committee on Large Animals (SCLA). 2) Sub-Committee for selection of CPCSEA Nominees on Institutional Animals Ethics Committees.