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Mixed Odontogenic
Tumors
This group of tumors
is composed of
proliferating
odontogenic
epithelium in a
cellular
ectomesenchyme
resembling the dental
papilla.

Clinical features

Histopathology




Posterior mandible 70%.



Small (asymptomatic) – Large
(Local swelling / failure of
eruption).
Well defined RL with sclerotic
borders.



50% assoc. with unerupted teeth.
Encapsulated.



.has general features of

ameloblastic fibroma but containing
enamel and dentin.




5-12 yrs.



Premolar/molar region of both jaws



Well defined unilocular RL with
calcified radiopaque material
(mixed).



The most common odontogenic
tumor.



Developmental anomaly
(hamartoma).

Treatment

Males.



2-Ameloblastic Fibroodontoma.

1st & 2nd decade.


1-Ameloblastic
Fibroma.



types

3-Odontoma


2nd decade.



Maxilla.

Conservative
surgical excision.
20% recurrence
(some surgeons
recommend
more aggressive
approach).

Conservative
curettage.

Foci of enamel & dentin
in epithelial structure.

Prognosis is
excellent





Compound: enamel,
dentin, & cementum
arranged in recognizable
tooth forms.
Complex: enamel,
dentin, & cementum
arranged in a random
manner (no resemblance
to tooth).

-Compound odontoma:
Multiple small & malformed
tooth-like structures are
formed creating a “bag of
marbles” radiographic
appearance.
-complex odontoma:
Conglomerate mass of ename
& dentin, which bears no

Simple local
excision.
Prognosis is
Excellent.


Compound (anterior maxilla).



Complex (posterior of both jaws).



Assoc. with unerupted tooth / block
eruption.



Odontogenic differentiation is fully
expressed.



Mostly radiodense.



RL with well defined, smooth
contours / later a well defined
radiopaque appearance.



Compound shows apparent tooth
shapes while complex appears as a
uniform opaque mass.



Asymptomatic.



Arise from altered fibroblast or
myofibroblast that produce excess
of mucopolysaccharides &
incapable of producing mature
collagen.

4-odontogenic
myxoma.


Benign, locally aggressive in bone
or soft tissues.



20-40 yrs.



Female.



Posterior mandible 28%



Unencapsulated, locally
infiltrating tumor.



Small (unilocular)

anatomic resemblance of tooth.





Stellate, spindle-shaped
& round cells in myxoid
stroma with few collagen
bundles.
It might be confused with
chondromyxoid fibroma
or with myxoid change in
an enlarged dental
follicle or papilla.

Small:
Curettage.
Large:
Surgical excision.
25% recurrence.
Prognosis is
good



Purely RL.



Well circumscribed, expanding,
detructive lesion.



Maxillary lesion may extend to
sinus, nasal cavity, orbit, or cranial
cavity.


5-Cementoblastoma
(true cementum)

Large (multilocular).

Teeth displacement / root
resorption.



2nd & 3rd decades.



Roots of mandibular posterior teeth.



Slow growing / local expansion.



Asymptomatic (may be pain).



Radiographically: ball of dense
material attached to the end of root.
(opaque lesion). Opaque spicules
radiate from the central mass.





Mineralized materials.
Multinucleated giant
cells.
This lesion resemble
Osteoblastoma.

Done by/ Mahdi 207 for ever
‫دعواتكم شباب‬



Surgical removal
(of tooth together
with mass).
Prognosis is
excellent

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Mixed odontogenic tumor

  • 1. Mixed Odontogenic Tumors This group of tumors is composed of proliferating odontogenic epithelium in a cellular ectomesenchyme resembling the dental papilla. Clinical features Histopathology   Posterior mandible 70%.  Small (asymptomatic) – Large (Local swelling / failure of eruption). Well defined RL with sclerotic borders.  50% assoc. with unerupted teeth. Encapsulated.  .has general features of  ameloblastic fibroma but containing enamel and dentin.   5-12 yrs.  Premolar/molar region of both jaws  Well defined unilocular RL with calcified radiopaque material (mixed).  The most common odontogenic tumor.  Developmental anomaly (hamartoma). Treatment Males.  2-Ameloblastic Fibroodontoma. 1st & 2nd decade.  1-Ameloblastic Fibroma.  types 3-Odontoma  2nd decade.  Maxilla. Conservative surgical excision. 20% recurrence (some surgeons recommend more aggressive approach). Conservative curettage. Foci of enamel & dentin in epithelial structure. Prognosis is excellent   Compound: enamel, dentin, & cementum arranged in recognizable tooth forms. Complex: enamel, dentin, & cementum arranged in a random manner (no resemblance to tooth). -Compound odontoma: Multiple small & malformed tooth-like structures are formed creating a “bag of marbles” radiographic appearance. -complex odontoma: Conglomerate mass of ename & dentin, which bears no Simple local excision. Prognosis is Excellent.
  • 2.  Compound (anterior maxilla).  Complex (posterior of both jaws).  Assoc. with unerupted tooth / block eruption.  Odontogenic differentiation is fully expressed.  Mostly radiodense.  RL with well defined, smooth contours / later a well defined radiopaque appearance.  Compound shows apparent tooth shapes while complex appears as a uniform opaque mass.  Asymptomatic.  Arise from altered fibroblast or myofibroblast that produce excess of mucopolysaccharides & incapable of producing mature collagen. 4-odontogenic myxoma.  Benign, locally aggressive in bone or soft tissues.  20-40 yrs.  Female.  Posterior mandible 28%  Unencapsulated, locally infiltrating tumor.  Small (unilocular) anatomic resemblance of tooth.   Stellate, spindle-shaped & round cells in myxoid stroma with few collagen bundles. It might be confused with chondromyxoid fibroma or with myxoid change in an enlarged dental follicle or papilla. Small: Curettage. Large: Surgical excision. 25% recurrence. Prognosis is good
  • 3.   Purely RL.  Well circumscribed, expanding, detructive lesion.  Maxillary lesion may extend to sinus, nasal cavity, orbit, or cranial cavity.  5-Cementoblastoma (true cementum) Large (multilocular). Teeth displacement / root resorption.  2nd & 3rd decades.  Roots of mandibular posterior teeth.  Slow growing / local expansion.  Asymptomatic (may be pain).  Radiographically: ball of dense material attached to the end of root. (opaque lesion). Opaque spicules radiate from the central mass.    Mineralized materials. Multinucleated giant cells. This lesion resemble Osteoblastoma. Done by/ Mahdi 207 for ever ‫دعواتكم شباب‬  Surgical removal (of tooth together with mass). Prognosis is excellent