6. anti drenergic

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Pharmacology
Third Year

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6. anti drenergic

  1. 1. Adrenergic-Blocking Agents These drugs bind to adrenergic receptors, but inhibit or block stimulation of the sympathetic nervous system (SNS) Adrenergic Blocking Agents Classified by the type of adrenergic receptor they block  Alpha1 blockers  Alpha2 blockers  Beta1 blockers (Specefic)  Beta1 + beta2 blockers(Non specefic)
  2. 2. Therapeutic uses of alpha blockers Alph1 blockers Phenoxybenzamine(Irreversable) prazocin, terazocin, doxazocin Alfuzosin(Alpha1a blocker) Uses • hypertension. • Benign prostatic hypertropy ( BPH) • Note: Alph2 blocker yohimbin is used as sexual stimulant
  3. 3. Adverse effects of alph1 blockers  Hypotension  Orthstatic hypotension  Note. Alfuzocin has less side effect Nonspecific Beta Blockers Beta blockers that block both beta1 and beta2 receptors e.g Propranolol, Alpranolol,  Oxpranolol, Pindolol, Labetolol.
  4. 4. Specific beta1 blockers( cardioselective) They are Atenolol, Acebutolol,  Metoprolol Eesmolol Eesm - olol Aten - olol, ‫لو‬ Metop - rolol Acebu - tolol, ‫يسمون‬ ‫الضاحكون‬ ‫بيت‬
  5. 5. Beta Blockers Therapeutic use  Hypertension,  angina,  Myocardial infarction (MI),  arrhythmia,  migraine,  anxiety,  glaucoma( timolol),  thyrotoxicosis,  tremors.
  6. 6.  Contraindications:,  Congestive cardiac failure (CCF),  heart block,  hypotension  Bronchial asthma
  7. 7. Adverse effects of beta blockers Bronchconstriction, Arrhythmia ( when stopped abruptly), mask the signs of hypoglycaemia in insulin dependent Diabetes mellitus , fatigue Depression (atenolol)

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