Microbiology

1. DEPARTMENTOFveterinaryMicrobiology
SINDHAGRICULTUREUNIVERSITYTANDOJAM
Subject:Micro-202
Date:7th
December202
RegistrationNumber2K18-av-91
Topic:Actinobacillus

2. FamilyPasteurellaceae&Bordetella
First
Actinobacillusspp.
 Pasteurellamultocida
 Mannheimia(formerlyPasteurella)haemolytica
 Bibersteiniatrehalosi
 Histophliussomni(formerlyHaemophilussomnus)
 Haemophilusspp.
 Avibacterium(formerlyHaemophilus)paragallinarum
Actinobacillus
 9speciesassociatedwithanimals
 mucosalmembranesofURT,GIT,&genitaltract
 Gram-negative,pleomorphicrods“Morsecode

3. APP:VirulenceFactors&Pathology
 RTXtoxins(“RepeatsinToXins)
 Serotypes1&5 ApxI,ApxII&ApxIV highlyvirulent
 ApxI–hemolytic(CAMP-positivereaction),inhibitmacrophagefunction
Actinobacillusequulisubsp.equuli
SleepyFoalDisease&
Pathogenesis–neonatalfoals(30%offoaldeaths)
o normalmucousmembranefloraofhorses(&pigs)
o Transmissionatparturition,umbilical
o Septicemia–canbelethal
 Survivorsdevelopmicroabscesses–lungs,kidneys&joints