This document lists 50 published works by Dr. Sven Korte, including research papers, book chapters, conference abstracts and posters presented between 1996-2015. The publications cover a wide range of topics related to using marmoset and cynomolgus monkeys as models for biomedical research and toxicology studies. Many of the publications describe developing and validating techniques for procedures in monkeys such as intravenous infusion, blood pressure monitoring, CSF collection and behavioral observations. The list demonstrates Dr. Korte's extensive experience over nearly 20 years in applying non-human primates, especially marmosets and cynomolgus monkeys, as models for pre-clinical safety testing.
1. PUBLISHED WORK
Dr. rer. nat Sven Korte
I. Citable Posters, Congress Abstracts Research Papers, Book Chapters and Books
1) S.H. KORTE
The abundance of Asterias rubens (LINNAEUS) in the euthrophication gradient of the
Flensburg Fjord – a sublitorale and ecological free land study under special consideration
of possible oxygen deficiency
Diploma, University of Kassel, Germany (1996)
2) S.H. KORTE
A free land study monitoring the population and specific ecological pressure vectors
of the abundance of Asterias rubens (LINNAEUS) in the euthrophication gradient of the Flensburg Fjord
Dissertation, University of Kassel, Germany (1998)
3) P. Nowak, S. Korte, U. Zühlke, A. Wiederhold, B. Niggemann, G. Weinbauer, W. Müller and F. Vogel,
Covance Laboratories GmbH, Kesselfeld 29, D-48163 Münster, Germany.
PROLONGED INFUSION IN MARMOSET MONKEYS: FEASIBILITY OF A PORT-CATHETER
TECHNIQUE
Society of Toxicology, 41th
Annual Meeting, 2002
The Toxicologist, Oxford University Press, Volume 60, Number 1, March 2002
4) U Zühlke, S Korte, B Niggemann, A Fuchs, W Müller, Covance Laboratories GmbH, Kesselfeld 29, D-
48163 Münster, Germany.
THE COMMON MARMOSET (Callithrix jacchus) AS A MODEL IN BIOTECHNOLOGY
13th
Primate Symposium, 26 – 27 February 2002, Münster, Germany
Primate Models in Pharmaceutical Drug Development
Waxmann Verlag GmbH, 2002, Münster, New York, München, Berlin, pp .119-125
5) S Korte, U Zühlke, P Nowak, S Tippkötter, A Wiederhold, B Niggemann, G Weinbauer, W Müller and
F Vogel, Covance Laboratories GmbH, Münster, Germany.
FEASIBILITY OF LONG-TERM CONTINUOUS INTRAVENOUS INFUSION IN UNRESTRAINED
MARMOSET MONKEYS
Society of Toxicology, 42th
Annual Meeting, 2003
The Toxicologist, Oxford University Press, Volume 72, Number S-1, March 2003
6) GF Weinbauer, U Zühlke, S Korte, P Nowak, A Fuchs, W Müller, Covance Laboratories GmbH,
Münster, Germany. THE MARMOSET (CALLITHRIX JACCHUS) AS A PRIMATE MODEL IN
TOXICOLOGY: THE COVANCE EXPERIENCE
Japanese Society of Toxicology, Annual Meeting, 2003
7) S Korte, U Zühlke, J Kaspareit, S Friderichs-Gromoll, W Müller, F Vogel, GF Weinbauer, Covance
Laboratories GmbH, Münster, Germany. REFERENCE CONTROL DATA FOR THE COMMON
MARMOSET (CALLITHRIX JACCHUS): A COMPARISON WITH MACAQUES.
Society of Toxicology, 43th
Annual Meeting, 2004
The Toxicologist, Oxford University Press, Volume 78, Number S-1, March 2004 : page 205
8) B Niggemann, U Korte, S Korte, F Vogel and GF Weinbauer, Covance Laboratories GmbH, Münster,
Germany. OCULAR TOXICITY TESTING IN THE NONHUMAN PRIMATE: INCIDENCES OF
SPONTANEOUS LESIONS IN THE CYNOMOLGUS MONKEY AND THE MARMOSET.
Japanese Society of Toxicology, Annual Meeting, 2004, Osaka, Japan
(9) P Nowak, S Korte, F Vogel, W Müller, Covance Laboratories GmbH, Münster, Germany:
VALIDATION OF A NEWLY INVENTED PORT CATHETER SYSTEM FOR CONTINUOUS INFUSION
STUDIES
Society of Toxicology, 44th
Annual Meeting, 2005
2. The Toxicologist, Oxford University Press, Volume 84, Number S-1, March 2005
(10) S Korte, D Eastman, U Zühlke, GF Weinbauer, Covance Laboratories GmbH, Münster, Germany:
SCREENING STUDIES WITH OILY VEHICLES FOR ORAL DRUG DELIVERY IN THE MARMOSET (CALLITHRIX JACCHUS)
AND THE CYNOMOLGUS (MACACA FASCICULARIS) MONKEY
Society of Toxicology, 45th
Annual Meeting, 2006
The Toxicologist, Oxford University Press, March 2006
(11) S Korte, A Fuchs, G. F. Weinbauer, E. Moscardo and A. Giarola: MODIFIED IRWIN TEST AS DIAGNOSTIC
TOOL TO MONITOR NEUROBEHAVIOURAL CHANGES IN MONKEYS. Annual Meeting of the Safety Pharmacology
SOCIETY (SPS) 2006 IN SAN DIEGO; OCTOBER 2006, USA.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
VOLUME 56, ISSUE 2, SEPTEMBER-OCTOBER 2007, PAGE E47
(12) B. NIGGEMANN, S. KORTE, S. SRIVASTAV, W. MÜLLER, GF. WEINBAUER
Ocular Toxicity Testing in Nonhuman Primates
16th
Primate Symposium, 13 – 14 June 2006, Münster, Germany
Novel Approches Towards Primate Toxicology, Waxmann Verlag GmbH, 2006, Münster, New York, München,
Berlin, pp .2002-217
(13) A.FUCHS; S.KORTE, G.F. WEINBAUER
Marmosets (Callithrix jacchus) as model for developmental and reproductive toxicity (DART) evaluation
Society of Toxicology, 46th
Annual Meeting, 2007
The Toxicologist, Oxford University Press, March 2007
(14) High Definition Oscillometry (HDO): A new method for non-invasive blood pressure
measurements in conscious and sedated common marmosets.
Schmelting, Barthel; Egner, Beate; Korte, Sven
H.; Weinbauer, Gerhard; AALAS, 2007
J Am Ass Lab Animal Sci Vol 46(4), 144
(15) Tidal volume and respiratory rate: Evaluation of safety pharmacology aspects in deeply sedated marmoset
monkeys
Sven Korte, Barthel Schmelting, Brian Marshall
Society of Toxicology, 47th
Annual Meeting, 2008
The Toxicologist, Oxford University Press, March 2008
(16) Schmelting B, Egner B, Korte SH, Weinbauer G 2007. Non-invasive blood pressure determination for
continuous anaesthesia monitoring in nonhuman primates. J Am Ass Lab Animal Sci. Vol 47(1), 53
17) Non-invasive blood pressure monitoring in Macaca fascicularis: High Definition Oscillometry versus
implanted telemetric devices.
B Schmelting, M. Niehoff, B Egner, SH Korte, GF Weinbauer
Society of Toxicology, 47th
Annual Meeting, 2008
The Toxicologist, Oxford University Press, March 2008
18) Non-invasive blood pressure determination in Macaca fascicularis and Callithrix jacchus by High Definition
Oscillometry
B Schmelting, M. Niehoff, B Egner, SH Korte, GF Weinbauer
Annual Meeting of the Safety Pharmacology Society (SPS) 2008 in Madison, Wisconsin, USA.
19) Feasibility and variability of testicular volume monitoring in the marmoset monkey (Callitrix jacchus)
GF Weinbauer, S Korte, CM Luetjens
Society of Toxicology, 48th
Annual Meeting, 2009
The Toxicologist Volume 108, Number 1, Oxford University Press, March 2009
20) Feasibility of repeated intra-articular administration in the marmoset monkey (Callitrix jacchus)
S Korte, G.F. Weinbauer
Society of Toxicology, 48th Annual Meeting, 2009
The Toxicologist, Volume 108, Number 1, Oxford University Press, March 2009
3. 21) B. Schmelting , M. Niehoff , B. Egner , S.H. Korte & G.F. Weinbauer
High Definition Oscillometry: a novel technique for non-invasive blood pressure monitoring in the cynomolgus
monkey (Macaca fascicularis)
Journal of Medical Primatology, doi:10.1111/j.1600-26894.2009.00344. 05 March 2009
22) S Korte, GF Weinbauer, A Fuchs, P Nowak
Continuous intravenous infusion in free ranging pregnant cynomolgus monkeys
Covance Laboratories GmbH, Muenster, Germany
ACT 2010
23) S Korte, CM Luetjens, C Rose, GF Weinbauer
Covance Laboratories GmbH, Muenster, Germany
Automated behavioral observations of socially housed cynomolgus monkeys treated with amphetamine and
diazepam
SOT 2010, Salt Lake City
24) S Korte, U Zuehlke, W Müller
Covance Laboratories GmbH, Muenster, Germany
Implementation of ETS 123 Requirements for the Housing of Marmoset Monkeys (Callithrix jacchus) over the
Conduct of Regulatory Required Toxicity Studies
Eurotox 2010
25) G.F. Weinbauer, C. Rose, S. Korte, C.M. Luetjens,
Covance Laboratories GmbH, Muenster, Germany
Quantitative recording of spontaneous locomotor activity in socially housed cynomolgus monkeys
JSOT 2010
26) C Rose*, J.E. van der Harst**, R.C. de Heer**, B.M. Spruijt**, S Korte*
* Covance Laboratories GmbH, Muenster, Germany
** Delta Phenomics BV, Utrecht, The Netherlands
Quantified tracking and monitoring of Diazepam treated socially housed Cynomolgus Monkeys
SOT 2011 Washington DC
27) S Korte, P Nowak, J Kaspareit, S Friderichs-Gromoll, E Buse
Covance Laboratories GmbH, Muenster, Germany
Intravenous continuous infusion studies with implanted port catheter systems in free ranging Cynomolgus
monkeys – a 20 year experience report - 2011
SOT 2011 Washington DC
28) First in Monkey (FIM) performed tracking of magnetic capsule inside the gastrointestinal tract with 3D-
MAGMA
H. Richert**, S. Korte*, S. Abert**,
*Covance Laboratories GmbH, Muenster, Germany, **Matesy GmbH, Jena, Germany
SOT 2011
29) Quantified tracking and monitoring of diazepam treated socially housed cynomolgus monkeys.
Rose C, de Heer RC, Korte S, van der Harst JE, Weinbauer GF, Spruijt BM.
Regul Toxicol Pharmacol. 2011 Oct 23. [Epub ahead of print]
PMID:
22051156
[PubMed - as supplied by publisher]
30) ITO Proceedings: A European Perspective of Best Practice in NHP Intravenous Infusion Models
SH Korte(1), P Nowak(1), AN Alexander(2), AM Brooks(2)
(1) Covance Laboratories GmbH, Münster, Germany
(2) Covance Laboratories Inc., Madison, Wisconsin, USA
31) ITO Proceedings: Feasibility of continuous and prolonged intravenous infusion in freely moving pregnant
cynomolgus monkeys
SH Korte(1), A Brooks(2), A Alexander(2), P Nowak(1), A Fuchs(1), GF Weinbauer(1)
4. (1)
Covance Laboratories GmbH, Münster, Germany
(2)
Covance Laboratories Inc, Madison, USA
32) Korte S, Nowak P, Luft J, Niggemann B (2014): The Marmoset. In: O Green, G Healing (Eds.) Non-Clinical
Vascular Infusion Technology, Volume II, CRC Press, Taylor & Francis Group, Boca Raton, London, New
York, p285-306.
33) SOT 2012 San Fransisco, USA: Computer tomography in non human primates. A feasibility study for pre-
clinical safety evaluation in geriatric cynomolgus monkeys
S Korte 1), M Wozniak 2), B Niggemann 1)
34) SOT 2012 San Fransisco, USA: Prolonged and continuous intravenous infusion toxicity studies in the
marmoset monkey using a port catheter system
P Nowak, S Korte, B Niggemann and J Luft
Covance Laboratories GmbH, Muenster, Germany
35) JSOT 2012 Cynomolgus monkey background data from lumbar and cisterna magna CSF collection.
W Frings, S Korte, B Niggemann
36) ACT 2012, Orlando, USA: REFERENCE CONTROL DATA FOR THE COMMON MARMOSET
(CALLITHRIX JACCHUS): A COMPARISON WITH MACAQUES.
S Korte, B Niggemann
37) ACT 2012, Orlando, USA: Continuous ambulatory intrathecal infusion study in the cynomolgus monkey:
The outcome of unexpected adverse effects in vehicle (L-arginine) treated control animals
S Korte, B Niggemann
38) SOT 2013: 12 week intrathecal administration study in port catheterized juvenile cynomolgus monkeys. S
Korte, M Butt, C Rose, M Niehoff
39) SOT 2013: Surgical alternatives for multiple CSF sampling in conscious cynomolgus monkeys: a novel
approach. J Sternberg, S Korte, C Rose
40) SOT 2013: Feasibility study of EEG measurements in chair restrained cynomolgus monkeys. Rose C., Korte
S and Niggemann B.
41) SOT 2013: Body weight changes in mice during restrained intravenous bolus versus continuous infusion.
van Wijk H, Brooks A, Korte, S, Alexander, A
42) "DIFFERENTIAL RESPONSES TO JNJ-37822681, A SPECIFIC AND FAST DISSOCIATING
DOPAMINE D2 RECEPTOR ANTAGONIST, IN CYNOMOLGUS MONKEY AND SPRAGUE DAWLEY
RAT GENERAL TOXICOLOGY STUDIES: CLINICAL OBSERVATIONS, PROLACTIN LEVELS,
MAMMARY HISTOPATHOLOGY FINDINGS AND TOXICOKINETICS" J. Appl. Toxicol. (2013)
Eric J. de Waal, Maria Desmidt, Sven Korte, Marc Niehoff, Kevan Chase, Wayne Arrowsmith, Ann Lampo
43) ACT 2013: Evaluation of Pachymetry Data for the Measurement of Corneal Thickness in Cynomolgus
Monkeys. S. Korte, C.M. Luetjens and B. Niggemann
44) ACT 2013: A Feasibility Project: Long-Term Intraventricular CSF Sampling in a Cynomolgus Monkey
Via a Port Catheter System. S. Korte, J. Sternberg, C. Rose, B. Niggemann and W. Frings
45) SOT 2014: Dermal administration in toxicity studies using the cynomolgus monkey. Korte, S., Niggemann,
B.
46) SOT 2014: Surgical and non-surgical options for dosing of centrally administered compounds and CSF
sampling in toxicity studies using cynomolgus monkeys. Rose, C., Korte, S., Runge F., Niggemann, B.
(47) SOT 2014: Comparison of cynomolgus and marmoset monkeys for pre-clinical testing of
biopharmaceuticals. Frings, Korte, Niggemann
5. (48) SOT 2015: Diagnostic magnetic resonance imaging in the scope of biologics safety assessment in
nonhuman primates – A case of spontaneous obstructive pancreatic necrosis and pyloric stenosis in a
cynomolgus monkey. Korte, S., Wozniak, M., Runge, F., Kaspareit, J, Mecklenburg, L.
(49) ACT 2015: Method Enhancement for Intrathecal lumbar bolus delivery and CSF sampling in the
anesthetized cynomolgus monkey for the safety Assessment of Oligonucleotides. S KORTE , K. RASMUSSEN,
S GROTE-WESSELS, R MILLOTT-VON LAER, A VON KEUTZ, F RUNGE
(50) ACT 2015: Standardized Neurological and Physical Diagnostics during Intrathecal Drug Delivery of
Cynomolgus Monkeys: You Better Know the Background Findings. S KORTE, MO NIEHOFF, A VON
KEUTZ, F RUNGE
(51) Book editor: The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment (2015),
Edition: 1st Edition, Publisher: Academic Press, Elsevier, Editors: Blümel J, Korte S, Schenck E, Weinbauer GF,
pp.3-16
(52) Book chapter: Considering the Use of Callithrix jacchus Chapter 23; Luetjens CM, Kaspareit J, Korte S,
Wistuba J; in book: The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment, Edition
(2015): 1st Edition, Publisher: Academic Press, Elsevier, Editors: Blümel J, Korte S, Schenck E, Weinbauer GF,
pp.3-16.
(53) Book chapter: Study Design Considerations, technical procedural aspects, scheduling, and dosing sampling
volumes; W FRINGS, M NIEHOFF, S KORTE; in book: The Nonhuman Primate in Nonclinical Drug
Development and Safety Assessment, Edition (2015): 1st Edition, Publisher: Academic Press, Elsevier, Editors:
Blümel J, Korte S, Schenck E, Weinbauer GF, pp.3-16.
(54) Book chapter: Basic Physiology of Callithrix jacchus; K MÄTZ-RENSING, S KORTE; in book: The
Nonhuman Primate in Nonclinical Drug Development and Safety Assessment, Edition (2015): 1st Edition,
Publisher: Academic Press, Elsevier, Editors: Blümel J, Korte S, Schenck E, Weinbauer GF, pp.3-16.
(55) Book chapter: Gaps and Future Challenges; J BLUEMEL, S KORTE, E SCHENCK, GF WEINBAUER; in
book: The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment, Edition (2015): 1st
Edition, Publisher: Academic Press, Elsevier, Editors: Blümel J, Korte S, Schenck E, Weinbauer GF, pp.3-16.
(56) Book chapter: Juvenile Toxicity Testing: experience Using Nonhuman Primate Models; Gerhard F.
Weinbauer, Sven H. Korte; in . Gerhard F. Weinbauer, Friedhelm Vogel (Eds.)
Primate Biologics Research at a Crossroads; 2015, 174 Seiten, E-Book (PDF), ISBN 978-3-8309-7961-6
(57) Book chapter: Marmoset, S Korte, P Nowak, J Luft, B Niggemann; in book; Non-Clinical Vascular Infusion
Technology, Volume II: The Techniques (2013); Owen P. Green, Guy Healing (Eds.); December 26, 2013 by
CRC Press , SBN 9781439874455 - CAT# K13451.
(58) SOT 2016: Diagnostic Tools to Enhance Long-Term Intrathecal Delivery Studies in Nonhuman Primates. S.
Korte, M.O. Niehoff and F.T. Ludwig, Covance Preclinical Services GmbH, Münster, Germany.
(59) SOT 2016: Long-Term Intrathecal Bolus Administration Studies in Cynomolgus Monkeys:
Expected Background Findings, Procedure-Related Observations and Recommended Procedures. M.O. Niehoff,
S. Korte and F.T. Ludwig, Covance Preclinical Services GmbH, Münster, Germany.
(60) SOT 2016: Emerging Biologics Development Methods: Free-Ranging Cynomolgus Monkeys Undergoing
Continuous Intravenous Infusion with an Implanted Port Catheter System–A Method Transfer in Courtesy
to the “Refinement” in the 3 Rs. C. Miller1, S. Korte2, A. Salva1, N. Snippe2, F. Runge2 and H. vanWijk1 : 1.
Covance Laboratories, Harrogate, UK; 2. Covance Preclinical Services, GmbH, Münster, Germany.
(61) Korte S, Vuillemont BR, Wright TL, Adams EL, Boyd R, Butt MT; Tox Sci 2016. Safety evaluation of
CNS administered biologics - study design, data interpretation, and translation to the clinics.
(62) ESTP 2016: S. Friderichs-Gromoll, S. Korte, J. Kaspareit, T. Pfaff: Always know your vehicle: Sulfuric-
acid based vehicle induced nephrotoxicity and pancreas toxicity in Cynomolgus Monkeys.
6. (63) ACT 2016. Korte S1), Wozniak M2), Runge F1), Voß T1), v. Keutz A1): Enhanced imaging has proven to
be a safety net during the conduct of regulatory studies with nonhuman primates: The value of hard data before
necropsy
II. Invited Lectures and Oral Presentations
1) Invited Speaker European Marmoset Research Group (EMRG), Paris, France, 2002
2) Invited Speaker EMRG – Barcelona, Spain 2006
4) Session Chair SOT 2011, Washington DC, USA
5) Invited Speaker ITO (infusion Technical Organisation), Barcelona, Spain, 2012
6) Session Chair SOT 2012, San Fransisco, USA
7) Invited Speaker SOT 2012, San Fransisco, USA
8) Invited Speaker juv. Tox symposium Beerse, Belgium 2013
9) Invited speaker European Primate Veterinarians, Göttingen, Germany, 2013
10) Session Chair SOT 2014, Phoenix, USA, 2014
11) Speaker Safety Pharamcology Session: Quantitative behavioral monitoring of socially housed
cynomolgus monkey, SOT 2014, Phoenix, USA.
12) Symposium session chair and invited speaker, ACT (American Colleague of Toxicology),
Orlando, USA, 2014
13) ITO , Harrogate NY, UK, 2014
14) CE course chair and invited speaker, SOT, San Diego, USA, 2015
15) Invited Speaker ITO (infusion Technical Organisation), Cologne, Germany, 2015
16) Sponsor Exhibitor Session Speaker, New Orleans, SOT 2016
7. (63) ACT 2016. Korte S1), Wozniak M2), Runge F1), Voß T1), v. Keutz A1): Enhanced imaging has proven to
be a safety net during the conduct of regulatory studies with nonhuman primates: The value of hard data before
necropsy
II. Invited Lectures and Oral Presentations
1) Invited Speaker European Marmoset Research Group (EMRG), Paris, France, 2002
2) Invited Speaker EMRG – Barcelona, Spain 2006
4) Session Chair SOT 2011, Washington DC, USA
5) Invited Speaker ITO (infusion Technical Organisation), Barcelona, Spain, 2012
6) Session Chair SOT 2012, San Fransisco, USA
7) Invited Speaker SOT 2012, San Fransisco, USA
8) Invited Speaker juv. Tox symposium Beerse, Belgium 2013
9) Invited speaker European Primate Veterinarians, Göttingen, Germany, 2013
10) Session Chair SOT 2014, Phoenix, USA, 2014
11) Speaker Safety Pharamcology Session: Quantitative behavioral monitoring of socially housed
cynomolgus monkey, SOT 2014, Phoenix, USA.
12) Symposium session chair and invited speaker, ACT (American Colleague of Toxicology),
Orlando, USA, 2014
13) ITO , Harrogate NY, UK, 2014
14) CE course chair and invited speaker, SOT, San Diego, USA, 2015
15) Invited Speaker ITO (infusion Technical Organisation), Cologne, Germany, 2015
16) Sponsor Exhibitor Session Speaker, New Orleans, SOT 2016