This study evaluated polymorphisms in the IL8 and IL16 genes in 200 patients with acute coronary syndrome (ACS) and 50 non-ACS patients from May 2012 to August 2016 at a hospital in Portugal. The researchers investigated the association between single nucleotide polymorphisms in the IL8 and IL16 genes and the risk of developing ACS. They found an important role for SNPs in the IL16 gene, with the G allele possibly being associated with a decreased risk of ACS. No intervention was performed as part of this study.

1. Evaluation of Polymorphisms
in IL8 and IL16 Genes in
Patients with Acute Coronary
Syndrome
Journal Reading

3. CRITICAL
APPRAISAL

4. Patients with ACS (n=200) and
non-ACS (n=50) from May 2012
to Aug 2016 at Real Hospital
Portugues
POPULATION
Association between SNPs in the IL8
& IL16 genes and the risk of
developing ACS
COMPARISON
No intervention was carried out in
this study
INTERVENTION
Important role of SNP in IL16 gene
 G allele may be associated with
a decreased risk of ACS
OUTCOME

5. Critical Appraisal
Were the criteria for inclusion in the sample clearly defined?
• Yes, inclusion critera were patients with ACS and non-ACS (other cardiac
disease) from May 2012-Aug 2016
Were the study subjects and setting desribed in detail?
• Yes, subject were 200 ACS patients and 50 non-ACS patients at Real
Hospital Portugues
Was the exposure measured in a valid and reliable way?
• Yes, exposure was measured objectively as well as subject classification was
done using the same procedure
Were the objective, standard criteria used for measurement of the condition?
• Yes, diagnosis performed by the clinical team and laboratory data

6. Critical Appraisal
Were confounding factors identified?
• No, confounding factor was not identified.
Were strategies to deal with confounding factors stated?
• No.
Were the outcomes measured in a valid & reliable way?
• Yes, genotyping technique was described in a valid & reliable way.
Was appropriate statistical analysis used?
• Yes, statistical analyses used were Williams G, Chi-square, and Kruskal
Wallis tests, with value of p<0.05 were considered significant

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