The Pharmacy and Therapeutics Committee (PTC) is responsible for establishing drug policies and formularies for hospitals. The PTC frames guidelines for drug selection, use, and monitoring. It aims to promote rational drug use and ensure drug safety. The PTC is composed of physicians, pharmacists, nurses and administrators. It meets regularly to review new drugs, adverse drug reactions, educational programs, and other drug-related issues. The PTC advises the hospital on drug policies and procedures to optimize patient care and safety.

1. Pharmacy and
Therapeutic Committee
Dr. Subhash R. Yende
Asst. Professor
Gurunanak College of
Pharmacy,
Nagpur

2. Introduction
 The pharmacy and therapeutics committee is a
policy framing and recommending body to the
medical staff and the administration of hospital on
matters related to therapeutic use of drugs
 It is responsible for framing policies and procedures
for selection, procurement, dispensing, labeling,
availability, administration, and control of drugs
throughout the hospital.
 This committee is composed of physicians,
pharmacists and other health care professionals
selected with the guidance of the medical staff.
 It encourages rational use of drug in the hospital
and also monitors issues relating to drug safety.
2Dr. Subhash R. Yende, GNCP, Nagpur

3. Objective of the PTC:
Advisory :
 Recommends the adoption of policies or assist in
formulation of policies regarding evolution,
selection and therapeutic use of drugs.
 Medical staff and hospital administration regarding
use of drug including investigational drug.
 Drugs to be stocked in hospital patient care areas
 Effective drug distribution and control procedures
Dr. Subhash R. Yende, GNCP, Nagpur 3

4. Educational :
 Formulation of functions, for the complete current
knowledge of the matter related to the drugs and
their use to professional staff
 Evaluates the problems related to Distribution and
administration of medications
 Develops and compiles a formulary of drugs and
prescriptions of formulations
 Establishes or plans suitable educational schemes
for the hospital’s professional staff on the matters
related to the use of drugs
Drug safety and adverse drug monitoring :
 PTC exert vigilance on safety aspect and ADR
monitoring
Dr. Subhash R. Yende, GNCP, Nagpur 4

5. Organization of PTC
 Composition of PTC might vary from hospital to
hospital.
 It may composed of :
1. At least three physicians from the medical staff
2. A pharmacist
3. A representative of the nursing staff
4. An hospital administrator with his or her
designated an ex-officio member of the committee.
 One of the physicians may be appointed as the
chairman of PTC.
 The pharmacist is designated as the Secretary of
the committee.
Dr. Subhash R. Yende, GNCP, Nagpur 5

6. PTC
Medical Staff
(Chairman)
Hospital Administrator
(Director)
Pharmacist
(Secretary)
Dr. Subhash R. Yende, GNCP, Nagpur 6
PTC Sub Committees
Neo-plastics
Anti-infectives
CVS drugs – Diuretics, Hypotensives Vasodilators,
Spasmolytics, Antticoagulants
GI drugs – Atonomic, Laxatives
CNS drugs – Analgesics, Anticonvulsants,
Respiratory Stimulants, Sedatives
Endocrinology Agents – Antidiabetics, Hormones,
Thyroid

7.  PTC should meet regularly at least six times in the
year, and when necessary.
 The committee should invite to its meetings
persons within or outside the hospital who can
contribute specialized or unique knowledge, skills
and judgments.
 The agenda and the supplementary materials
should be prepared by the Secretary and furnished
to the committee members well in advance so that
the members can study them properly before the
meeting
 Minutes of meeting should be prepared by
Secretary and maintained in permanent record of
hospital
 Recommendation of committee shall be presented
to medical staff or its appropriate committee forDr. Subhash R. Yende, GNCP, Nagpur 7

8. A typical Agenda may consists of –
 Minutes of the previous meeting
 Review of the contents of the Hospital Formulary
 Information regarding new drugs which may have
become commercially available.
 Review and/or adoption of investigational drugs
currently under processing in the hospital.
 Review of side effects, adverse drug reactions,
toxic effects, drug interactions of drugs reported by
various units of hospital.
 Review of “Drug Safety” in the hospital.
 Reports of various sub‐committees.
 Report of medical audit.
 Any other matter with the permission of chair
Dr. Subhash R. Yende, GNCP, Nagpur 8

9. Functions of PTC
 To advise the medical staff and hospital
administrator in all matter related to use of drug
(including Investigational drug)
 To recommend for adoption of suitable policies
regarding selection, procurement, storage,
prescription, dispensing and use of medicine
 To develop and prepare hospital drug formulary
 To develop norms and guideline for revision of
formulary at regular interval and procedure for,
addition of new drugs, deletion of old drugs,
duplication of drug or its combination
 To suggest measures to evaluate clinical data
regarding new drug or agent
Dr. Subhash R. Yende, GNCP, Nagpur 9

10.  To establish or plan suitable educational
programme for hospital professional matter related
to drug use
 To review reported adverse drug reaction to drug
administered to the patients in the hospital
 To evaluate problem related to the procurement,
storage, distribution and administration of drug in
hospital
 To develop and establish generic and therapeutic
substitution guideline for the hospital
 To advise pharmacy regarding drug distribution and
control procedure, Developing Drug Information
System, Maintenance of drug standard and quality
control, maintenance of records and disposal of
Expiry Drugs
Dr. Subhash R. Yende, GNCP, Nagpur 10

11. Policies of PTC
The use of drug in hospital is controlled by different policies,
which includes-
1. Proposal of new drug for hospital formulary shall be
submitted on Formulary request form to pharmacy
department.
2. Drug evaluated and approved by committee will assigned
to one of the following categories-
◦ Formulary Drug
◦ Drug approved on conditional trial period
◦ Specialized formulary drug
◦ Investigational drug
3. Non Formulary drug will not be stocked in pharmacy
4. Rules and regulation which governs pharma
representatives activity
5. Pharmacy dept authorized to dispense drug as per
policies and procedure of PTC Dr. Subhash R. Yende, GNCP, Nagpur 11

12. 6. Pre signing of blank prescription or drug order is
prohibited
7. Drug recall
8. Inpatients prescription:
 Routine drug order
 IV orders
 Total Parenteral nutrition (TPN)
 Self medication
 Medication brought to hospital by patients
 Automatic stop order
 Discharge prescription
9. Outpatients prescription:
Hospitalized patient at discharge, clinic patients and
employees prescription may only be written on hospital
prescription form
 Information required
 Special requirement for cotrol drug
Dr. Subhash R. Yende, GNCP, Nagpur 12

13.  All Drug Orders for narcotics, sedatives, hypnotic
anticoagulants, and antibiotics shall be
automatically discontinued after 48 hours unless
the order indicates an exact number of doses to be
administered, or the attending physician, re-orders
the medication.
 All orders for narcotics, sedative and hypnotics
must be rewritten every 24 hours.
Dr. Subhash R. Yende, GNCP, Nagpur 13
Automatic stop orders for Dangerous
Drugs:

14. Role of PTC in Developing “Emergency
Drug Lists”
 The Time Factor is necessary for the Pharmacy
and Therapeutics Committee of a hospital to get
prepared boxes containing emergency drugs which
should be always available readily for use at the
bed‐side.
 List of such drugs and other supplies should
compiled by Committee, and it should find their
place in “Emergency Kits”.
 After the emergency boxes have been placed in
the wards, it is very essential and compulsory that
a system is developed whereby they are checked
daily either by the hospital pharmacists or by
nursing supervisor responsible for the ward.
Dr. Subhash R. Yende, GNCP, Nagpur 14

15. ◦ Aminophylline 0.25
g/ml
◦ Amylnitrite glass
capsules for
inhalation
◦ Atropine sulphate
0.4mg/ml
◦ Caffeine sodium
benzoate 0.5g/2
ml.
◦ Calcium Gluconate
1 g/10 ml
◦ Digoxin 0.25
mg/ml
◦ Diphenylhydantoin
sodium 50 mg/ml
◦ Epinephrine Hcl/1
mg/ml
◦ Heparin 10.000
units/ml
◦ Hydrocortisone
100mg
◦ Magnesium
sulphate injection
10%, 50%
◦ Isoproterenol
1:100
◦ Mannitol injection
25%
◦ Nalorphine Hcl-10
mg/2ml
◦ Neostigmine
methyl sulphate
0.25mg/ml
◦ Norepinephrine
Injection 0.2%
◦ Pentobarbitone
50mg/ml
◦ Pentzocine
◦ Phenylephrine Hcl
10mg/ml
◦ Pheomethazone
inj
◦ Picrotoxin Inj.
3mg/ml
◦ Procainamide
100mg/ml.
◦ Protmine sulphate
20mg/ml
◦ Saline for Injection
09% 30ml
◦ Sodium molar
lactate solution
◦ Water for injection
20ml
Dr. Subhash R. Yende, GNCP, Nagpur 15
Drugs for emergency box:

16. Supplies To Be Maintained In Emergency Box:
 Syringes of various range
 Needles
 Files for breaking the ampoule
 Airway equipment
Supplies for cabinet utility room
 Oxygen catheters
 Razor with blades
 Resuscitation tube.
Other emergency supplies
 Burn sheets
 Dextranand tubing
 Resuscitation carts.
Dr. Subhash R. Yende, GNCP, Nagpur 16

17. Reference
 William E Hassan, Hospital Pharmacy, Fourth
edition, Philadelphia: Lea & Febiger.
 RK Goyal & RK Parikh. Text book of Hospital
Pharmacy, B S Shah Prakashan Ahmedabad.
 AB Budhrani, R. Usman, M Sharma, P Kumar.
Concise Course in Pharmacy Practice. S. Vikas
and Company.
 https://www.slideshare.net/apollojames/pharmacy-
and-therapeutic-committee-81224362
 https://www.slideshare.net/rameshganpisetti/pharm
acy-and-therapeutic-committee-134693292
17Dr. Subhash R. Yende, GNCP, Nagpur