SlideShare a Scribd company logo
1 of 20
Download to read offline
 People have used various compounds
(eg.pumice,oyster shells, and chalk) to clean
their teeth since around 5000BC.
 Dentrifice ingredients help to reduce caries,
plaque, gingivitis, calculus, stain, halitosis,
and hypersensitivity.
 Caries is simply the result of
demineralisation/remineralisation cycles where,
over time, demineralisation conditions prevail.
 Fluoride can be delivered in several different
chemical forms:
 Stannous fluoride(SnF2)
 Sodium fluoride(NaF)
 Sodium monofluorophosphate
 Amine fluoride
 Aluminium fluoride(AlF3)
 The chemical agents used for calculus control in dentrifice are
 Pyrophosphate: It occurs naturally in saliva and plays a role in
inhibiting calculus formation. These molecules chelate calcium,
slowing the rate of nucleation (crystal formation) and
calcification of plaque.
 Sodium hexametaphosphate (HMP): sodium HMP is a large
polyphosphate molecule and has multiple calcium binding sites in
one molecule. Sodium HMP is too large of a molecule to enter
into tooth enamel, so there is no danger of it entering between
enamel rods and sequestering calcium from sound enamel. It is
sometimes called a calcium surface – active builder.
 Zinc: positively charged zinc ion (Zn2+) inhibits crystal growth by
substituting for calcium in the crystal lattice of calcium
phosphate.
 Gantrez: gantrez is a copolymer of methylvinyl ether(PVM) and
maleic acid (MA) and acts as a chelating agent.
• Bleaching products that contain hydrogen peroxide or
carbamide peroxide(ie, dental office bleaching trays)
address intrinsic stains as well as extrinsic stains.
Extrinsic stain: Extrinsic (surface) stains can be relatively
easily removed on a daily basis by proper tooth brushing
with a dentrifrice. The abrasivity of dentrifrice is
measured in terms of Relative dentin abrasivity, or RDA.
The lower the RDA, the less abrasive the dentrifrice. The
international standards organisation (ISO) states that a
dentrifrice should not exceed an RDA of 250, which is
considered safe for hard tissue.
Intrinsic stain: intrinsic stains are stains and
discolourations that are located below the enamel
surface. Bleaching is usually used to remove or minimize
intrinsic discolourations.
 Stannous: Stannous fluoride by being bactericidal and non specific
interaction with the bacterial membrane causes membrane
disruption. Stannous ion’s inhibition of metabolic enzymes, which
further lead to reduction of bacterial growth, prevention of bacterial
adhesion to oral surfaces(eg.enamel) and reduction in bacterial
hypoproducts.
 Triclosan: triclosan is a broad spectrum antibacterial agent that
inserts into and distrupts the bacterial membrane. Being a nonpolar
molecule, it has an affinity for the hydrophobic environment of lipid
bilayer.
 Zinc: it has mild antibacterial properties inhibiting cell division and
slowing the growth cycle. When it is added with dentrifrice
formulation it present some challenges such as poor bioavailability
and an unpleasant taste.
 Chlorhexidine: chlorhexidine disrupts bacterial membranes,
resulting in bacterial death. It is used as an ingredient in mouth wash
and dentrifrice. it has some side effects such as poor taste and
staining.
 It is generally treated in one of the two ways.
 Chemical desensitization of the tooth nerve endings
 Tubule occluding agents or barriers to reduce dentin permeability
 Calcium carbonate creates a basic environment. Calcium
phosphate salts are less soluble at higher PH(more basic),
therefore the combination of high local calcium
concentration at the dentin tubule at basic PH promotes
rapid precipitation of calcium phosphate salts.
 Strontium(Sr2+) is a metal ion, and in the oral cavity it can
form insoluble metal salts that can plug dentin tubules.
 Stannous ion is also a tubule occluding agent that treats
dentin hypersensitivity through hydrolysis and oxidation
reactions.
 Humactants – glycerin and sorbitol
 Binders – referred as thickeners.
o They provide texture and determine how “thick” or “runny” the
dentrifrice is.
o Xanthun gum, carboxymethyl cellulose(CMC) carbomers, carrageenan,
and synthetic cellulose are commonly used.
 Buffers:: they help to maintain PH constant.
Eg:Trisodium phosphates, and sodium citrate.
 Flavours and sweeteners: to improve dentrifrice taste. Eg:peppermint,
saccharin, and xylitol.
 Surfactants: they create foaming and aid in the cleaning process by
helping to loosen plaque and debris. Eg: sodium lauryl sulfate(SLS).
 Colours/visuals: the colouring agents are added to provide dentrifrice with
pleasing colours.
o Opacity of a paste dentrifrice - titanium dioxide
o Mica - sparky appearance
 Any tooth brush, regardless of the brushing method used, does not
completely remove interdental plaque biofilms.
 Dental floss: floss is made from nylon filaments or plastic mono filaments
and comes in waxed, unwaxed, thick, thin, and flavoured varieties.
 Waxed dental floss was thought to leave a waxy film on proximal surfaces,
thus contributing to biofilm accumulation and gingivitis.
 Disposable single use floss holders with prethreaded floss are also
available.
 Powered flossing devices are also available. The devices have shown to be
safe and effective, but no better at plaque biofilm removal than holding the
floss in the fingers.
 Uses:
o Removal of adherent plaque and food debris from the
interproximal embrassure
o Polishing of tooth
o Stimulating and massaging the inter dental pappilae
oHelping in locating the following
Subgingival calculus deposits
Overhanging margins of the restorations
Proximal carious lesions
oVehicle for application of polishing or theraupeutic
agents to interproximal and subgingival areas.
Disadvantages:
oIt is time consuming
oRequires skill
oCarries the risk of tissue damage if not used properly
Spool method:
Circle or loop method:
 In this method, a loop or circle of the floss is
made from about 12-18 inches long piece and
both ends are tied securely with the three
knots. All the fingers except the thumbs of
both the hands are placed within the loop and
the floss is held tightly by both the hands
having about 1-2 inches of floss between
fingers of both the hands.
 Floss holders may also be used for holding the
floss, especially in patients lacking manual
dexterity. Powered flossing devices are also
available which moves the pestrung floss in
short motions.
 The floss is then passed gently through each
contact area with a firm back and forth motion.
 Once the floss is apical to the contact area, it is
wrapped around the proximal surface of one
tooth and slipped gently under the marginal
gingiva.
 The floss is then moved firmly along the tooth up
to the contact area and gently down into the
sulcus again, repeating this stroke for 2-3 times.
 Then move the floss across the interdental
gingiva and repeat the procedure on the
adjacent tooth until the whole dentition is
covered.
Interdental cleaning devices: concave root
surfaces such as the mesial aspect of the
maxillary first bicuspid and furcations are often
present in periodontal patients who have
experienced significant attachment loss and
recession, they are not cleaned well with dental
floss
 Interdental brushes: a wide variety of interdental cleaning devices are
available for removing microbial plaque biofilm from between the teeth.
The most common types are conical or cylindrical brushes, tapered
wooden tooth picks that are round or triangular in cross section, and
single-tufted brushes.
o interdental brushes of any style are inserted through the
interproximal spaces and moved back and forth between the teeth
with short strokes.
o single tufted brushes provide access to furcation areas, or isolated
areas of deep recession and work well on the lingual surfaces of
mandibular molars and premolars, these areas are often missed when
using a tooth brush and floss.
 Wooden or rubber tips: they are used either with or without a handle.
 triangular wooden tips are also available; this design is most useful in
the anterior areas when used from buccal surfaces of the teeth.
 rubber tips are conical and mounted on handles or the ends of the
tooth brushes; they are reusable and can be easily adapted to all
proximal surfaces in the mouth.
 plastic tips that resemble wooden or rubber tips are also available and
are used in the same way.
 They are 5 or 6mm long
 Soft, triangular wooden or plastic picks are placed in the
interdental space with the base of the triangle resting on
the gingiva and the sides in contact with the proximal
surfaces of the tooth.the pick Is then repeatedly moved in
and out of the embrassure several times to remove the
biofilm. The disadvantage of this is they do not reach well
in to the posterior areas or lingual surfaces.
 Rubber tips should be placed into the embrassure space
resting on the gingiva, and used in a circular motion.
Home/self - applied irrigation:
The body of evidence on the oral
irrigators(also called water flosser and dental
water jet) consistently has been shown to
significantly reduce gingivitis, bleeding on
probing, and periodontal pathogens.
 The mechanism of action of irrigation occurs through the direct
application of pulse stream of water or other solution.
 Pulsating devices have been shown to be 3 times as effective as
continuous - stream irrigating syringe.
 clinical efficacy have been done using water flosser with 1200-1400
pulsations per minute set on a medium to a high pressure setting (50-90
psi)
 Oral irrigators with varying pulsation and pressure are available, but like
other self-care products, research from one product brand should not be
extrapolated to other brands since they may have used a different
pressure setting and pulsation rate.
 Two zones of hydrokinetic activity: the impact zone in which the solution
reaches into the subgingival sulcus.
 Home irrigation has been demonstrated to penetrate subgingivally with
both a jet tip and soft, site-specific, subgingival tip.
 Supragingival irrigation is irrigation with a jet tip
placed above the gingival margin resulting in
penetrtion of a solution into the subgingival
sulcus to approximately 50%
 The jet tip is generally used for full - mouth
irrigation.
 Supragingival tips enhanced with soft, tapered
bristles.
 Irrigation with soft, site - specific tip is called
subgingival irrigation.
 The subgingival tip is used for the localised
irrigation of a specific site such as deep pocket,
furcation, implant, or crown and bridge.
 Removal of plaque biofilm and reductions in
calculus, gingivitis, bleeding on probing,
probing depth, periodontal pathogens, and
inflammatory mediators.
 Home irrigation has been studied and found
safe and effective for those with gingivitis,
implants, crown and bridge, orthodontics,
intermaxillary fixation, and diabetes; patients
who are non complaint with dental floss; and
in periodontal maintanance.

More Related Content

What's hot

Plaque control for handicap children
Plaque control for handicap childrenPlaque control for handicap children
Plaque control for handicap childrenshadman zakir
 
Mechanical ways of plaque control
Mechanical ways of plaque controlMechanical ways of plaque control
Mechanical ways of plaque controlSneha Arya
 
Mechanical plaque control
Mechanical plaque control Mechanical plaque control
Mechanical plaque control Robenzz Dhakal
 
Mechanical plaque control
Mechanical plaque control Mechanical plaque control
Mechanical plaque control drkeeru
 
Other oral hygiene aids
Other oral hygiene aidsOther oral hygiene aids
Other oral hygiene aidsMsLofton
 
Prevention of dental caries
Prevention of dental cariesPrevention of dental caries
Prevention of dental cariesSarahdentist
 
Mechanical and chemical plaque control
Mechanical and chemical plaque controlMechanical and chemical plaque control
Mechanical and chemical plaque controlFAISALKODUNGOOKARAN
 
Modern toothbrushes and interdental aids
Modern toothbrushes and interdental aidsModern toothbrushes and interdental aids
Modern toothbrushes and interdental aidsNiraj Regmi
 
Lect.5 pulp treatment final
Lect.5 pulp treatment finalLect.5 pulp treatment final
Lect.5 pulp treatment finalAmeer Al-Ameedee
 
Chemical Plaque Control
Chemical Plaque ControlChemical Plaque Control
Chemical Plaque Controlshabeel pn
 
Dental prophylaxis
Dental prophylaxisDental prophylaxis
Dental prophylaxiskilichophy
 

What's hot (20)

Plaque control for handicap children
Plaque control for handicap childrenPlaque control for handicap children
Plaque control for handicap children
 
Chemical plaque control
Chemical plaque controlChemical plaque control
Chemical plaque control
 
Mechanical ways of plaque control
Mechanical ways of plaque controlMechanical ways of plaque control
Mechanical ways of plaque control
 
Mechanical plaque control
Mechanical plaque control Mechanical plaque control
Mechanical plaque control
 
mechanisms of Plaque control
mechanisms of Plaque controlmechanisms of Plaque control
mechanisms of Plaque control
 
Mechanical plaque control
Mechanical plaque control Mechanical plaque control
Mechanical plaque control
 
Plaque control
Plaque controlPlaque control
Plaque control
 
Other oral hygiene aids
Other oral hygiene aidsOther oral hygiene aids
Other oral hygiene aids
 
Prevention of dental caries
Prevention of dental cariesPrevention of dental caries
Prevention of dental caries
 
Toothbrush b
Toothbrush   bToothbrush   b
Toothbrush b
 
Tooth brush
Tooth brush   Tooth brush
Tooth brush
 
Mechanical and chemical plaque control
Mechanical and chemical plaque controlMechanical and chemical plaque control
Mechanical and chemical plaque control
 
Modern toothbrushes and interdental aids
Modern toothbrushes and interdental aidsModern toothbrushes and interdental aids
Modern toothbrushes and interdental aids
 
Lect.5 pulp treatment final
Lect.5 pulp treatment finalLect.5 pulp treatment final
Lect.5 pulp treatment final
 
Chemical Plaque Control
Chemical Plaque ControlChemical Plaque Control
Chemical Plaque Control
 
PLAQUE CONTROL
PLAQUE CONTROLPLAQUE CONTROL
PLAQUE CONTROL
 
How to control plaque
How to control plaqueHow to control plaque
How to control plaque
 
Dental prophylaxis
Dental prophylaxisDental prophylaxis
Dental prophylaxis
 
Toothbrush
ToothbrushToothbrush
Toothbrush
 
PLAQUE DISCLOSING AGENTS
PLAQUE DISCLOSING AGENTSPLAQUE DISCLOSING AGENTS
PLAQUE DISCLOSING AGENTS
 

Similar to Dentrifrices

Plaque control and disclosing agents ppt
Plaque control and disclosing agents pptPlaque control and disclosing agents ppt
Plaque control and disclosing agents pptNikhat Mohammadi
 
Preventive And Interceptive Orthodontics
Preventive And Interceptive OrthodonticsPreventive And Interceptive Orthodontics
Preventive And Interceptive Orthodonticsshabeel pn
 
Prevention of dental diseases
Prevention of dental diseasesPrevention of dental diseases
Prevention of dental diseasesIAU Dent
 
mechanical-plaque-control PEDO
mechanical-plaque-control PEDOmechanical-plaque-control PEDO
mechanical-plaque-control PEDOParth Thakkar
 
Mechanical plaque control
Mechanical plaque controlMechanical plaque control
Mechanical plaque controlnaseemashraf2
 
Interdental aids powerpoint presentation
Interdental aids powerpoint presentationInterdental aids powerpoint presentation
Interdental aids powerpoint presentationLeena Parmar
 
Modern plaque control .pdf
Modern plaque control .pdfModern plaque control .pdf
Modern plaque control .pdfssuser22cd2e
 
Creating Awareness On Dental Problems
Creating Awareness  On Dental ProblemsCreating Awareness  On Dental Problems
Creating Awareness On Dental Problemskothasatish
 
Dental Preparation.pptx
Dental Preparation.pptxDental Preparation.pptx
Dental Preparation.pptxSabbir Ahmed
 
problem assso with oral cavity
problem assso with oral cavityproblem assso with oral cavity
problem assso with oral cavityShikha Popali
 
9.plaque control
9.plaque control9.plaque control
9.plaque controlsmidspedo
 
Lect.7. Tooth bleaching and occlusion
Lect.7.  Tooth bleaching and occlusionLect.7.  Tooth bleaching and occlusion
Lect.7. Tooth bleaching and occlusionAmeer Al-Ameedee
 

Similar to Dentrifrices (20)

D.p.h. 08
D.p.h. 08D.p.h. 08
D.p.h. 08
 
Plaque control and disclosing agents ppt
Plaque control and disclosing agents pptPlaque control and disclosing agents ppt
Plaque control and disclosing agents ppt
 
Home oral hygiene
Home oral hygieneHome oral hygiene
Home oral hygiene
 
Preventive And Interceptive Orthodontics
Preventive And Interceptive OrthodonticsPreventive And Interceptive Orthodontics
Preventive And Interceptive Orthodontics
 
Prevention of dental diseases
Prevention of dental diseasesPrevention of dental diseases
Prevention of dental diseases
 
Oral prophylaxis
Oral prophylaxisOral prophylaxis
Oral prophylaxis
 
mechanical-plaque-control PEDO
mechanical-plaque-control PEDOmechanical-plaque-control PEDO
mechanical-plaque-control PEDO
 
Mechanical plaque control
Mechanical plaque controlMechanical plaque control
Mechanical plaque control
 
Dental Pharmacology
Dental PharmacologyDental Pharmacology
Dental Pharmacology
 
Oral physiotherapy
Oral physiotherapyOral physiotherapy
Oral physiotherapy
 
Interdental aids powerpoint presentation
Interdental aids powerpoint presentationInterdental aids powerpoint presentation
Interdental aids powerpoint presentation
 
Modern plaque control .pdf
Modern plaque control .pdfModern plaque control .pdf
Modern plaque control .pdf
 
Creating Awareness On Dental Problems
Creating Awareness  On Dental ProblemsCreating Awareness  On Dental Problems
Creating Awareness On Dental Problems
 
Dental Preparation.pptx
Dental Preparation.pptxDental Preparation.pptx
Dental Preparation.pptx
 
problem assso with oral cavity
problem assso with oral cavityproblem assso with oral cavity
problem assso with oral cavity
 
9.plaque control
9.plaque control9.plaque control
9.plaque control
 
Interdental aids
Interdental aidsInterdental aids
Interdental aids
 
Plaque control.pptx
Plaque control.pptxPlaque control.pptx
Plaque control.pptx
 
Oral hygiene
Oral hygieneOral hygiene
Oral hygiene
 
Lect.7. Tooth bleaching and occlusion
Lect.7.  Tooth bleaching and occlusionLect.7.  Tooth bleaching and occlusion
Lect.7. Tooth bleaching and occlusion
 

Recently uploaded

internship ppt on smartinternz platform as salesforce developer
internship ppt on smartinternz platform as salesforce developerinternship ppt on smartinternz platform as salesforce developer
internship ppt on smartinternz platform as salesforce developerunnathinaik
 
call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️
call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️
call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️9953056974 Low Rate Call Girls In Saket, Delhi NCR
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions  for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions  for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptxVS Mahajan Coaching Centre
 
Introduction to AI in Higher Education_draft.pptx
Introduction to AI in Higher Education_draft.pptxIntroduction to AI in Higher Education_draft.pptx
Introduction to AI in Higher Education_draft.pptxpboyjonauth
 
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxPOINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxSayali Powar
 
Proudly South Africa powerpoint Thorisha.pptx
Proudly South Africa powerpoint Thorisha.pptxProudly South Africa powerpoint Thorisha.pptx
Proudly South Africa powerpoint Thorisha.pptxthorishapillay1
 
Roles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in PharmacovigilanceRoles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in PharmacovigilanceSamikshaHamane
 
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdfFraming an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdfUjwalaBharambe
 
Historical philosophical, theoretical, and legal foundations of special and i...
Historical philosophical, theoretical, and legal foundations of special and i...Historical philosophical, theoretical, and legal foundations of special and i...
Historical philosophical, theoretical, and legal foundations of special and i...jaredbarbolino94
 
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)eniolaolutunde
 
Alper Gobel In Media Res Media Component
Alper Gobel In Media Res Media ComponentAlper Gobel In Media Res Media Component
Alper Gobel In Media Res Media ComponentInMediaRes1
 
Hierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of managementHierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of managementmkooblal
 
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdfEnzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdfSumit Tiwari
 
Pharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdfPharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdfMahmoud M. Sallam
 
Computed Fields and api Depends in the Odoo 17
Computed Fields and api Depends in the Odoo 17Computed Fields and api Depends in the Odoo 17
Computed Fields and api Depends in the Odoo 17Celine George
 
Solving Puzzles Benefits Everyone (English).pptx
Solving Puzzles Benefits Everyone (English).pptxSolving Puzzles Benefits Everyone (English).pptx
Solving Puzzles Benefits Everyone (English).pptxOH TEIK BIN
 

Recently uploaded (20)

internship ppt on smartinternz platform as salesforce developer
internship ppt on smartinternz platform as salesforce developerinternship ppt on smartinternz platform as salesforce developer
internship ppt on smartinternz platform as salesforce developer
 
call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️
call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️
call girls in Kamla Market (DELHI) 🔝 >༒9953330565🔝 genuine Escort Service 🔝✔️✔️
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions  for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions  for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
 
Introduction to AI in Higher Education_draft.pptx
Introduction to AI in Higher Education_draft.pptxIntroduction to AI in Higher Education_draft.pptx
Introduction to AI in Higher Education_draft.pptx
 
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxPOINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
 
ESSENTIAL of (CS/IT/IS) class 06 (database)
ESSENTIAL of (CS/IT/IS) class 06 (database)ESSENTIAL of (CS/IT/IS) class 06 (database)
ESSENTIAL of (CS/IT/IS) class 06 (database)
 
Proudly South Africa powerpoint Thorisha.pptx
Proudly South Africa powerpoint Thorisha.pptxProudly South Africa powerpoint Thorisha.pptx
Proudly South Africa powerpoint Thorisha.pptx
 
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
TataKelola dan KamSiber Kecerdasan Buatan v022.pdfTataKelola dan KamSiber Kecerdasan Buatan v022.pdf
TataKelola dan KamSiber Kecerdasan Buatan v022.pdf
 
Roles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in PharmacovigilanceRoles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in Pharmacovigilance
 
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdfFraming an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
 
Historical philosophical, theoretical, and legal foundations of special and i...
Historical philosophical, theoretical, and legal foundations of special and i...Historical philosophical, theoretical, and legal foundations of special and i...
Historical philosophical, theoretical, and legal foundations of special and i...
 
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)
 
Alper Gobel In Media Res Media Component
Alper Gobel In Media Res Media ComponentAlper Gobel In Media Res Media Component
Alper Gobel In Media Res Media Component
 
Model Call Girl in Tilak Nagar Delhi reach out to us at 🔝9953056974🔝
Model Call Girl in Tilak Nagar Delhi reach out to us at 🔝9953056974🔝Model Call Girl in Tilak Nagar Delhi reach out to us at 🔝9953056974🔝
Model Call Girl in Tilak Nagar Delhi reach out to us at 🔝9953056974🔝
 
Hierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of managementHierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of management
 
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdfEnzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
 
Pharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdfPharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdf
 
9953330565 Low Rate Call Girls In Rohini Delhi NCR
9953330565 Low Rate Call Girls In Rohini  Delhi NCR9953330565 Low Rate Call Girls In Rohini  Delhi NCR
9953330565 Low Rate Call Girls In Rohini Delhi NCR
 
Computed Fields and api Depends in the Odoo 17
Computed Fields and api Depends in the Odoo 17Computed Fields and api Depends in the Odoo 17
Computed Fields and api Depends in the Odoo 17
 
Solving Puzzles Benefits Everyone (English).pptx
Solving Puzzles Benefits Everyone (English).pptxSolving Puzzles Benefits Everyone (English).pptx
Solving Puzzles Benefits Everyone (English).pptx
 

Dentrifrices

  • 1.
  • 2.  People have used various compounds (eg.pumice,oyster shells, and chalk) to clean their teeth since around 5000BC.  Dentrifice ingredients help to reduce caries, plaque, gingivitis, calculus, stain, halitosis, and hypersensitivity.
  • 3.  Caries is simply the result of demineralisation/remineralisation cycles where, over time, demineralisation conditions prevail.  Fluoride can be delivered in several different chemical forms:  Stannous fluoride(SnF2)  Sodium fluoride(NaF)  Sodium monofluorophosphate  Amine fluoride  Aluminium fluoride(AlF3)
  • 4.  The chemical agents used for calculus control in dentrifice are  Pyrophosphate: It occurs naturally in saliva and plays a role in inhibiting calculus formation. These molecules chelate calcium, slowing the rate of nucleation (crystal formation) and calcification of plaque.  Sodium hexametaphosphate (HMP): sodium HMP is a large polyphosphate molecule and has multiple calcium binding sites in one molecule. Sodium HMP is too large of a molecule to enter into tooth enamel, so there is no danger of it entering between enamel rods and sequestering calcium from sound enamel. It is sometimes called a calcium surface – active builder.  Zinc: positively charged zinc ion (Zn2+) inhibits crystal growth by substituting for calcium in the crystal lattice of calcium phosphate.  Gantrez: gantrez is a copolymer of methylvinyl ether(PVM) and maleic acid (MA) and acts as a chelating agent.
  • 5. • Bleaching products that contain hydrogen peroxide or carbamide peroxide(ie, dental office bleaching trays) address intrinsic stains as well as extrinsic stains. Extrinsic stain: Extrinsic (surface) stains can be relatively easily removed on a daily basis by proper tooth brushing with a dentrifrice. The abrasivity of dentrifrice is measured in terms of Relative dentin abrasivity, or RDA. The lower the RDA, the less abrasive the dentrifrice. The international standards organisation (ISO) states that a dentrifrice should not exceed an RDA of 250, which is considered safe for hard tissue. Intrinsic stain: intrinsic stains are stains and discolourations that are located below the enamel surface. Bleaching is usually used to remove or minimize intrinsic discolourations.
  • 6.  Stannous: Stannous fluoride by being bactericidal and non specific interaction with the bacterial membrane causes membrane disruption. Stannous ion’s inhibition of metabolic enzymes, which further lead to reduction of bacterial growth, prevention of bacterial adhesion to oral surfaces(eg.enamel) and reduction in bacterial hypoproducts.  Triclosan: triclosan is a broad spectrum antibacterial agent that inserts into and distrupts the bacterial membrane. Being a nonpolar molecule, it has an affinity for the hydrophobic environment of lipid bilayer.  Zinc: it has mild antibacterial properties inhibiting cell division and slowing the growth cycle. When it is added with dentrifrice formulation it present some challenges such as poor bioavailability and an unpleasant taste.  Chlorhexidine: chlorhexidine disrupts bacterial membranes, resulting in bacterial death. It is used as an ingredient in mouth wash and dentrifrice. it has some side effects such as poor taste and staining.
  • 7.  It is generally treated in one of the two ways.  Chemical desensitization of the tooth nerve endings  Tubule occluding agents or barriers to reduce dentin permeability  Calcium carbonate creates a basic environment. Calcium phosphate salts are less soluble at higher PH(more basic), therefore the combination of high local calcium concentration at the dentin tubule at basic PH promotes rapid precipitation of calcium phosphate salts.  Strontium(Sr2+) is a metal ion, and in the oral cavity it can form insoluble metal salts that can plug dentin tubules.  Stannous ion is also a tubule occluding agent that treats dentin hypersensitivity through hydrolysis and oxidation reactions.
  • 8.  Humactants – glycerin and sorbitol  Binders – referred as thickeners. o They provide texture and determine how “thick” or “runny” the dentrifrice is. o Xanthun gum, carboxymethyl cellulose(CMC) carbomers, carrageenan, and synthetic cellulose are commonly used.  Buffers:: they help to maintain PH constant. Eg:Trisodium phosphates, and sodium citrate.  Flavours and sweeteners: to improve dentrifrice taste. Eg:peppermint, saccharin, and xylitol.  Surfactants: they create foaming and aid in the cleaning process by helping to loosen plaque and debris. Eg: sodium lauryl sulfate(SLS).  Colours/visuals: the colouring agents are added to provide dentrifrice with pleasing colours. o Opacity of a paste dentrifrice - titanium dioxide o Mica - sparky appearance
  • 9.  Any tooth brush, regardless of the brushing method used, does not completely remove interdental plaque biofilms.  Dental floss: floss is made from nylon filaments or plastic mono filaments and comes in waxed, unwaxed, thick, thin, and flavoured varieties.  Waxed dental floss was thought to leave a waxy film on proximal surfaces, thus contributing to biofilm accumulation and gingivitis.  Disposable single use floss holders with prethreaded floss are also available.  Powered flossing devices are also available. The devices have shown to be safe and effective, but no better at plaque biofilm removal than holding the floss in the fingers.  Uses: o Removal of adherent plaque and food debris from the interproximal embrassure o Polishing of tooth o Stimulating and massaging the inter dental pappilae
  • 10. oHelping in locating the following Subgingival calculus deposits Overhanging margins of the restorations Proximal carious lesions oVehicle for application of polishing or theraupeutic agents to interproximal and subgingival areas. Disadvantages: oIt is time consuming oRequires skill oCarries the risk of tissue damage if not used properly
  • 12. Circle or loop method:  In this method, a loop or circle of the floss is made from about 12-18 inches long piece and both ends are tied securely with the three knots. All the fingers except the thumbs of both the hands are placed within the loop and the floss is held tightly by both the hands having about 1-2 inches of floss between fingers of both the hands.  Floss holders may also be used for holding the floss, especially in patients lacking manual dexterity. Powered flossing devices are also available which moves the pestrung floss in short motions.
  • 13.  The floss is then passed gently through each contact area with a firm back and forth motion.  Once the floss is apical to the contact area, it is wrapped around the proximal surface of one tooth and slipped gently under the marginal gingiva.  The floss is then moved firmly along the tooth up to the contact area and gently down into the sulcus again, repeating this stroke for 2-3 times.  Then move the floss across the interdental gingiva and repeat the procedure on the adjacent tooth until the whole dentition is covered.
  • 14. Interdental cleaning devices: concave root surfaces such as the mesial aspect of the maxillary first bicuspid and furcations are often present in periodontal patients who have experienced significant attachment loss and recession, they are not cleaned well with dental floss
  • 15.  Interdental brushes: a wide variety of interdental cleaning devices are available for removing microbial plaque biofilm from between the teeth. The most common types are conical or cylindrical brushes, tapered wooden tooth picks that are round or triangular in cross section, and single-tufted brushes. o interdental brushes of any style are inserted through the interproximal spaces and moved back and forth between the teeth with short strokes. o single tufted brushes provide access to furcation areas, or isolated areas of deep recession and work well on the lingual surfaces of mandibular molars and premolars, these areas are often missed when using a tooth brush and floss.  Wooden or rubber tips: they are used either with or without a handle.  triangular wooden tips are also available; this design is most useful in the anterior areas when used from buccal surfaces of the teeth.  rubber tips are conical and mounted on handles or the ends of the tooth brushes; they are reusable and can be easily adapted to all proximal surfaces in the mouth.  plastic tips that resemble wooden or rubber tips are also available and are used in the same way.
  • 16.  They are 5 or 6mm long  Soft, triangular wooden or plastic picks are placed in the interdental space with the base of the triangle resting on the gingiva and the sides in contact with the proximal surfaces of the tooth.the pick Is then repeatedly moved in and out of the embrassure several times to remove the biofilm. The disadvantage of this is they do not reach well in to the posterior areas or lingual surfaces.  Rubber tips should be placed into the embrassure space resting on the gingiva, and used in a circular motion.
  • 17. Home/self - applied irrigation: The body of evidence on the oral irrigators(also called water flosser and dental water jet) consistently has been shown to significantly reduce gingivitis, bleeding on probing, and periodontal pathogens.
  • 18.  The mechanism of action of irrigation occurs through the direct application of pulse stream of water or other solution.  Pulsating devices have been shown to be 3 times as effective as continuous - stream irrigating syringe.  clinical efficacy have been done using water flosser with 1200-1400 pulsations per minute set on a medium to a high pressure setting (50-90 psi)  Oral irrigators with varying pulsation and pressure are available, but like other self-care products, research from one product brand should not be extrapolated to other brands since they may have used a different pressure setting and pulsation rate.  Two zones of hydrokinetic activity: the impact zone in which the solution reaches into the subgingival sulcus.  Home irrigation has been demonstrated to penetrate subgingivally with both a jet tip and soft, site-specific, subgingival tip.
  • 19.  Supragingival irrigation is irrigation with a jet tip placed above the gingival margin resulting in penetrtion of a solution into the subgingival sulcus to approximately 50%  The jet tip is generally used for full - mouth irrigation.  Supragingival tips enhanced with soft, tapered bristles.  Irrigation with soft, site - specific tip is called subgingival irrigation.  The subgingival tip is used for the localised irrigation of a specific site such as deep pocket, furcation, implant, or crown and bridge.
  • 20.  Removal of plaque biofilm and reductions in calculus, gingivitis, bleeding on probing, probing depth, periodontal pathogens, and inflammatory mediators.  Home irrigation has been studied and found safe and effective for those with gingivitis, implants, crown and bridge, orthodontics, intermaxillary fixation, and diabetes; patients who are non complaint with dental floss; and in periodontal maintanance.